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Search Results: 1 - 10 of 1926 matches for " Masayuki Miyazaki "
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Antithrombin III injection via the portal vein suppresses liver damage
Masayuki Miyazaki,Masaki Kato,Masatake Tanaka,Kosuke Tanaka
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i16.1884
Abstract: AIM: To investigate the effects of antithrombin III (AT III) injection via the portal vein in acute liver failure. METHODS: Thirty rats were intraperitoneally challenged with lipopolysaccharide (LPS) and D-galactosamine (GalN) and divided into three groups: a control group; a group injected with AT III via the tail vein; and a group injected with AT III via the portal vein. AT III (50 U/kg body weight) was administrated 1 h after challenge with LPS and GalN. Serum levels of inflammatory cytokines and fibrin degradation products, hepatic fibrin deposition, and hepatic mRNA expression of hypoxia-related genes were analyzed. RESULTS: Serum levels of alanine aminotransferase, tumor necrosis factor-α and interleukin-6 decreased significantly following portal vein AT III injection compared with tail vein injection, and control rats. Portal vein AT III injection reduced liver cell destruction and decreased hepatic fibrin deposition. This treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme oxygenase-1. CONCLUSION: A clinically acceptable dose of AT III injection into the portal vein suppressed liver damage, probably through its enhanced anticoagulant and anti-inflammatory activities.
Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia
Masayuki Miyazaki,Masatake Tanaka,Akihiro Ueda,Tsuyoshi Yoshimoto
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i44.4928
Abstract: Drug-induced hypersensitivity syndrome (DIHS) is a severe reaction usually characterized by fever, rash, and multiorgan failure, occurring 2-6 wk after drug introduction. It is an immune-mediated reaction involving macrophage and T-lymphocyte activation and cytokine release. A 54-year-old woman was diagnosed with rheumatic arthritis and initiated salazosulfapyridine by mouth. About 10 d later, she had a high fever, skin rash and liver dysfunction. She was admitted to hospital and diagnosed with a drug eruption. She was treated with oral prednisolone 30 mg/d; however, she developed high fever again and her blood tests showed acute liver failure and cytopenia associated with hyperferritinemia. She was diagnosed with acute liver failure and hemophagocytosis caused by DIHS. She was transferred to the Department of Medicine and Bioregulatory Science, Kyushu University, where she was treated with arterial steroid injection therapy. Following this treatment, her liver function improved and serum ferritin immediately decreased. We hypothesized that an immune-mediated reaction in DIHS may have generated over-activation of macrophages and T-lymphocytes, followed by a cytokine storm that affected various organs. The measurement of serum ferritin might be a useful marker of the severity of DIHS.
Greater omentum gastrointestinal stromal tumor with PDGFRA-mutation and hemoperitoneum
Yoko Murayama,Masayuki Yamamoto,Ryuichiro Iwasaki,Tamana Miyazaki
World Journal of Gastrointestinal Oncology , 2012, DOI: 10.4251/wjgo.v4.i5.119
Abstract: Although gastrointestinal stromal tumor (GIST) occurs generally in the digestive tract, omental GIST is very rare. We report the first case of an adult greater omental GIST with a new platelet-derived growth factor receptor α gene (PDGFRA)-mutation with hemoperitoneum. A 43-year-old man was admitted to our hospital complaining of acute abdominal pain. Abdominal contrast-enhanced computed tomography revealed a huge mass in the right abdominal cavity, and a large accumulation of fluid in the pelvic cavity, suggesting hemoperitoneum. We diagnosed the rupture as an intra-abdominal tumor, and an emergency tumorectomy was performed with resection of the greater omentum. This tumor was located in the distal right side of the greater omentum, and showed no continuity with the gastric wall. The tumor occurred primarily in the greater omentum. The resected tumor was about 19 cm × 12 cm × 14 cm in diameter, and weighed 1529 g. Histologically, the tumor was composed of epithelioid-shaped cells with high cellularity, and was positive for CD117 and CD34, and negative for S-100, α-smooth muscle actin. The mitosis was 6/50 under high power field. This case showed exon 18 mutation of PDGFRA with 846 (Asp to Glu) substitution, 848 (Asn to Lys) substitution. This is the first report of this PDGFRA mutation in omental GIST, and this might play an important role in the tumorigenesis of this case. Based on these findings, the tumor was diagnosed as high risk GIST primarily occurring in the greater omentum. The patient was treated with imatinib at a dose of 400 mg/d as adjuvant chemotherapy, and has been followed up for 24 mo with no evidence of recurrence.
Wrinkled 1 (WRI1) Homologs, AP2-Type Transcription Factors Involving Master Regulation of Seed Storage Oil Synthesis in Castor Bean (Ricinus communisL.)  [PDF]
Daichi Tajima, Ayami Kaneko, Masatsugu Sakamoto, Yumena Ito, Nong Thi Hue, Masayuki Miyazaki, Yushi Ishibashi, Takashi Yuasa, Mari Iwaya-Inoue
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.42044
Abstract: Among APETALA2 (AP2)-type plant specific transcription factor family, WRINKLED1 (WRI1), has appeared to be a master gene transcriptionally regulating a set of carbon metabolism- and fatty acid synthesis (FAS)-related genes responsible for seed specific triacylglycerols (TAGs) storage in oil plants. B3 type transcription factors, such as ABI3 and FUS3, are known to be involved in seed development, such as seed storage protein synthesis and maturation. Based on the recent whole genome sequence data of castor bean (Ricinus communis L.), putative WRI1 homologs (RcWRI1, RcWRI2) specifically expressed in castor bean seed have been identified by comparing organ specific expression profiles among seed development-related transcription factors, seed storage specific genes (Ricin, RcOleosin) and a set of FAS genes including genes for sucrose synthase (RcSUS2), biotin carboxyl carrier protein (a subunit of acetyl-CoA carboxylase, RcBCCP2) and ketoacyl-acyl carrier protein synthase (RcKAS1). Immunoreactive signals with WRI1, FUS3 and ABI5-related polypeptides were also detected in seed specifically, consistent with the expression profiles of seed development-related genes. The WRI1 binding consensus sites, [CnTnG](n)(7)[CG], designated as the AW-box, were found at the promoter region of RcBCCP2 and RcKAS1. Thus, RcWRI1 possibly play a pivotal role in seed specific TAGs storage during seed development by directly activating FAS -related genes.
Practical Use of Gemcitabine and Cisplatin Combination Therapy as First-Line Treatment for Japanese Patients with Advanced Biliary Tract Cancer  [PDF]
Hisato Kawakami, Isamu Okamoto, Wataru Okamoto, Masayuki Takeda, Shinya Ueda, Toshihiro Kudo, Shin-ichi Nishina, Yasuhito Fujisaka, Masaki Miyazaki, Junji Tsurutani, Takayasu Kurata, Kazuhiko Nakagawa
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.46121
Abstract:

Gemcitabine and cisplatin combination therapy (GC) is accepted as a standard treatment for advanced biliary tract cancer (BTC). However, little information is available regarding such treatment in the clinical practice setting in Japan. We retrospectively examined the clinical data of patients with unresectable or recurrent BTC who received GC as first-line treatment. The regimen consisted of cisplatin (25 mg/m2) and gemcitabine (1000 mg/m2) administered intravenously on days 1 and 8 of repeated 3-week cycles. Twenty patients were analyzed. A total of 148 cycles of GC was administered, with a median of 8 and a range of 1 to 18 cycles. Treatment delay and dose reduction were noted in 35 (24%) and 41 (28%) of the 148 cycles, respectively. The major adverse events of grade 3 or 4 included neutropenia (50%), leukopenia (45%), anemia (30%), and thrombocytopenia (15%). Nonhematologic toxicities included nausea (10%), appetite loss (10%), and fatigue (10%). Median progression-free and overall survival times were 6.9 and 12.3 months, respectively. Gallbladder cancer showed a significantly higher response rate than did other types of BTC (chi-squaretest, P = 0.002). GC was thus effective and well tolerated as first-line chemotherapy for Japanese patients with advanced BTC in the clinical practice setting.

A Comment on Reis  [PDF]
Kenji Miyazaki
Theoretical Economics Letters (TEL) , 2011, DOI: 10.4236/tel.2011.13019
Abstract: This note gives a counterexample on Reis [1]. Using a certain family of utility functions, this note not only gives a sharper representation than that of Reis but also demonstrates that interest rate inelastic money demand does not lead to superneutrality. This implies that superneutrality does not exist when uncerinty is introduced.
Incentives in Public and Privatized Firms under Incomplete Contracting Situations  [PDF]
Takeshi Miyazaki
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.23059
Abstract: It is argued that incentives for employees in the public service agencies will necessarily be weak because of the multiple dimensions of products, multiple principals, incomplete contract, and socializing. Some empirical studies refer to incomplete contracting situations as part of the cause of the diminishing of the public sector. This work investigates the effects of privatization and ownership shares on incentive schemes for employees who work for public or privatized firms under incomplete contracting situations. Two main results are obtained. First, the incentive intensity of public firms decreases as the government has more ownership shares, and the social benefit declines. Second, privatized firms offer their employees higher-powered incentive contracts than do public firms.
Clustering Properties of Galaxies at z~4 in the Subaru/XMM Deep Survey Field
Masami Ouchi,Kazuhiro Shimasaku,Sadanori Okamura,Mamoru Doi,Hisanori Furusawa,Masaru Hamabe,Masahiko Kimura,Yutaka Komiyama,Masayuki Miyazaki,Satoshi Miyazaki,Fumiaki Nakata,Maki Sekiguchi,Masafumi Yagi,Naoki Yasuda
Physics , 2001, DOI: 10.1086/323598
Abstract: We study the clustering properties of about 1200 z~4 Lyman Break Galaxy (LBG) candidates with i'<26 which are selected by color from deep BRi' imaging data of a 618 arcmin^2 area in the Subaru/XMM-Newton Deep Field taken with Subaru Prime Focus Camera. The contamination and completeness of our LBG sample are evaluated, on the basis of the Hubble Deep Field North (HDFN) objects, to be 17% and 45%, respectively. We derive the angular correlation function over theta = 2''-1000'', and find that it is fitted fairly well by a power law, omega(theta)=A_omega theta^{-0.8}, with A_omega = 0.71 +/- 0.26. We then calculate the correlation length r0 (in comoving units) of the two-point spatial correlation function xi(r) = (r/r0)^{-1.8} from A_omega using the redshift distribution of LBGs derived from the HDFN, and find r0=2.7 (+0.5/-0.6) h^{-1} Mpc in a Lambda-dominated universe (Omega_m=0.3 and Omega_Lambda=0.7). This is twice larger than the correlation length of the dark matter at z~4 predicted from an analytic model by Peacock & Dodds but about twice smaller than that of bright galaxies predicted by a semi-analytic model of Baugh et al. We find an excess of omega(theta) on small scales (theta < 5'') departing from the power law fit over 3 sigma significance levels. Interpreting this as due to galaxy mergers, we estimate the fraction of galaxies undergoing mergers in our LBG sample to be 3.0 +/- 0.9%, which is significantly smaller than those of galaxies at intermediate redshifts.
Statistical Properties of Lyman Break Galaxies at z~4
Masami Ouchi,Kazuhiro Shimasaku,Sadanori Okamura,Mamoru Doi,Hisanori Furusawa,Masaru Hamabe,Masahiko Kimura,Yutaka Komiyama,Masayuki Miyazaki,Satoshi Miyazaki,Fumiaki Nakata,Maki Sekiguchi,Masafumi Yagi,Naoki Yasuda
Physics , 2001,
Abstract: We study the luminosity function and the correlation function of about 1200 z~4 Lyman break galaxies (LBGs) with i'<26 that are photometrically selected from deep BRi' imaging data of a 618 arcmin^2 area in the Subaru/XMM-Newton Deep Field taken with Subaru Prime Focus Camera. The contamination and completeness of our LBG sample are evaluated, on the basis of the Hubble Deep Field-North (HDF-N) objects, to be 17% and 45%, respectively. We derive the UV (rest 1700A) luminosity functions (LFs) and find a large population of UV-luminous galaxies at z~4. The LFs of the red and blue subsamples imply that the bright LBGs are redder in the UV continuum than the average color of the LBGs. Then we calculate the correlation function over theta = 2''-1000'' and find that it is fitted fairly well by a power law, omega(theta)=A_omega theta^(-0.8), with A_omega=0.71 +/- 0.26. We estimate the correlation length r_0 (in comoving units) of the two-point spatial correlation function xi(r) = (r/r_0)^(-1.8) to be r_0=2.7 +0.5/-0.6 h^(-1) Mpc (Omega_m=0.3 and Omega_Lambda=0.7). The correlation function shows an excess of omega (theta) on small scales (theta < 5''), departing from the power-law fit at > 3 sigma significance level. Interpreting this as being due to galaxy mergers, we evaluate the fraction of galaxies undergoing mergers to be 3.0 +/- 0.9%, which is significantly smaller than those of galaxies at intermediate redshifts.
Self Assembly of Honeycomb TiO2 Coatings by Tea-Leaf Extracts as the Dispersoids  [PDF]
Masayuki Kamei
World Journal of Condensed Matter Physics (WJCMP) , 2011, DOI: 10.4236/wjcmp.2011.13010
Abstract: Photo catalytic TiO2 coatings with well defined honeycomb structure were successfully self-assembled on glass substrates by a simple “dip and burn solgel method“. The crux of this new method is that the starting material for the sol-gel coating (the water solution of ammonium titanium citrate) was “doped” with “tea-leaf extracts”. Tea-leaf extracts were completely dissolved in the water solution of ammonium titanium citrate and nucleate uniformly during the drying procedure of the coating precursor formation. This uniformly dispersed nucleation of the “tea-leaf extracts (tannin, catechin…)” were extracted during calcinations and leaving honeycomb-cell like nano-structure in the TiO2 coatings. Self-assembled cells were uniformly distributed in the TiO2 coatings and the diameter of the cells was in the range of 200 - 1000 nm. Fine honeycomb structures were clearly observed with microscopic observations.
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