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Search Results: 1 - 10 of 295 matches for " Masayoshi Katano "
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Striking Similarity in the Gene Expression Levels of Individual Myc Module Members among ESCs, EpiSCs, and Partial iPSCs
Masataka Hirasaki, Keiko Hiraki-Kamon, Masayoshi Kamon, Ayumu Suzuki, Miyuki Katano, Masazumi Nishimoto, Akihiko Okuda
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083769
Abstract: Predominant transcriptional subnetworks called Core, Myc, and PRC modules have been shown to participate in preservation of the pluripotency and self-renewality of embryonic stem cells (ESCs). Epiblast stem cells (EpiSCs) are another cell type that possesses pluripotency and self-renewality. However, the roles of these modules in EpiSCs have not been systematically examined to date. Here, we compared the average expression levels of Core, Myc, and PRC module genes between ESCs and EpiSCs. EpiSCs showed substantially higher and lower expression levels of PRC and Core module genes, respectively, compared with those in ESCs, while Myc module members showed almost equivalent levels of average gene expression. Subsequent analyses revealed that the similarity in gene expression levels of the Myc module between these two cell types was not just overall, but striking similarities were evident even when comparing the expression of individual genes. We also observed equivalent levels of similarity in the expression of individual Myc module genes between induced pluripotent stem cells (iPSCs) and partial iPSCs that are an unwanted byproduct generated during iPSC induction. Moreover, our data demonstrate that partial iPSCs depend on a high level of c-Myc expression for their self-renewal properties.
Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis
Masayoshi Katano, Kazuki Okamoto, Mitsumi Arito, Yuki Kawakami, Manae S Kurokawa, Naoya Suematsu, Sonoko Shimada, Hiroshi Nakamura, Yang Xiang, Kayo Masuko, Kusuki Nishioka, Kazuo Yudoh, Tomohiro Kato
Arthritis Research & Therapy , 2009, DOI: 10.1186/ar2587
Abstract: Neutrophils stimulated by GM-CSF were divided into four subcellular fractions: cytosol, membrane/organelle, nuclei, and cytoskeleton. Then, proteins were extracted from each fraction and digested by trypsin. The produced peptides were detected using matrix-assisted laser desorption ionisation-time-of-flight mass spectrometry (MALDI-TOF MS).We detected 33 peptide peaks whose expression was upregulated by more than 2.5-fold in GM-CSF stimulated neutrophils and identified 11 proteins out of the 33 peptides using MALDI-TOF/TOF MS analysis and protein database searches. One of the identified proteins was neutrophil gelatinase-associated lipocalin (NGAL). We confirmed that the level of NGAL in SF was significantly higher in patients with RA than in those with osteoarthritis. We next addressed possible roles of the increased NGAL in RA. We analysed proteome alteration of synoviocytes from patients with RA by treatment with NGAL in vitro. We found that, out of the detected protein spots (approximately 3,600 protein spots), the intensity of 21 protein spots increased by more than 1.5-fold and the intensity of 10 protein spots decreased by less than 1 to 1.5-fold as a result of the NGAL treatment. Among the 21 increased protein spots, we identified 9 proteins including transitional endoplasmic reticulum ATPase (TERA), cathepsin D, and transglutaminase 2 (TG2), which increased to 4.8-fold, 1.5-fold and 1.6-fold, respectively. Two-dimensional electrophoresis followed by western blot analysis confirmed the upregulation of TERA by the NGAL treatment and, moreover, the western blot analysis showed that the NGAL treatment changed the protein spots caused by post-translational modification of TERA. Furthermore, NGAL cancelled out the proliferative effects of fibroblast growth factor (FGF)-2 and epidermal growth factor (EGF) on chondrocytes from a patient with RA and proliferative effect of FGF-2 on chondrosarcoma cells.Our results indicate that GM-CSF contributes to the pathogenesis
Pathology of Kaposi's sarcoma-associated herpesvirus infection
Hideki Hasegawa,Harutaka Katano
Frontiers in Microbiology , 2011, DOI: 10.3389/fmicb.2011.00175
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) is a human herpesvirus, classified as a gamma-herpesvirus. KSHV is detected in Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and some cases of multicentric Castleman’s disease (MCD). Similar to other herpes viruses, there are two phases of infection, latent and lytic. In KSHV-associated malignancies such as KS and PEL, KSHV latently infects almost all tumor cells. Quantitative PCR analysis revealed that each tumor cell contains one copy of KSHV in KS lesions. The oncogenesis by KSHV has remained unclear. Latency-associated nuclear antigen (LANA)-1 plays an important role in the pathogenesis of KSHV-associated malignancies through inhibition of apoptosis and maintenance of latency. Because all KSHV-infected cells express LANA-1, LANA-1 immunohistochemistry is a useful tool for diagnosis of KSHV infection. KSHV encodes some homologs of cellular proteins including cell-cycle regulators, cytokines, and chemokines, such as cyclin D, G-protein-coupled protein, interleukin-6, and macrophage inflammatory protein-1 and -2. These viral proteins mimic or disrupt host cytokine signals, resulting in microenvironments amenable to tumor growth. Lytic infection is frequently seen in MCD tissues, suggesting a different pathogenesis from KS and lymphoma.
Stream grazers determine their crawling direction on the basis of chemical and visual/tactile microalgal cues
Izumi Katano,Hideyuki Doi
PeerJ , 2015, DOI: 10.7287/peerj.preprints.350v1
Abstract: This study aimed to determine the association of herbivore behavior with cues from producers. We used stream grazer Glossosoma larvae and determined their crawling direction in relation to the chemical and visual cues from microalgae. The experimental treatments included control (no cue), particulate (chemical and visual/tactile cues), and dissolved (chemical cue) cues from microalgae. The experimental water samples were randomly placed into either arms of a Y-shaped channel, and the crawling direction of the grazers was determined. Although the grazers crawled toward the arm containing either particulate or dissolved cues, they preferred the arm with particulate cues. This suggested that grazers responded well when both visual/tactile (i.e., drifting algal cells) and chemical cues (algal smell) were present, and that visual/tactile cues were more important for foraging. In natural habitats, grazers detect cues from both producers and predators and use them to maximize fitness by avoiding predation and obtaining food.
Stream grazers determine their crawling direction on the basis of chemical and particulate microalgal cues
Izumi Katano,Hideyuki Doi
PeerJ , 2015, DOI: 10.7717/peerj.503
Abstract: This study aimed to determine the association between herbivore behavior and cues from producers. We used stream grazer Glossosoma larvae and determined their crawling direction in relation to chemical and visual cues from microalgae. The experimental treatments included control (no cue), particulate (chemical and particulate cues), and dissolved (chemical cue) cues from microalgae. The experimental water samples were randomly placed into either arm of a Y-shaped channel, and the crawling direction of the grazers was determined. Although the grazers crawled toward the arm containing either particulate or dissolved cues, they preferred the arm with particulate cues. This suggested that grazers responded well to both particulate (i.e., drifting algal cells) and chemical (algal smell) cues, and that particulate cues were more important for foraging. In natural habitats, grazers detect cues from producers and change their behaviors to maintain a balance between top-down and bottom-up cues.
Selective changes in the α-adrenoceptor-mediated contraction in the senescent rat urinary bladder  [PDF]
Tomomi Aita, Akira Ishihata, Akiko Yamada, Yumi Katano
Health (Health) , 2012, DOI: 10.4236/health.2012.429115
Abstract: The urinary bladder is innervated and functionally regulated by the autonomic nervous system. In order to elucidate the mechanism of functional changes in aged rat urinary bladder, we studied the influence of senescence on, 1) the α-adrenergic contractile response to phenylephrine in the urinary bladder body and trigone, 2) the muscarinic contractile response to carbachol in the body and trigone. The binding characteristics of [3H]quinuclidinyl benzilate (QNB) to muscarinic cholinoceptors were compared in young and aged bladder. Bladders from young (2 - 3 month-old) and aged (27 month-old) male Fischer 344 rats were isolated, cut into strips and mounted in the organ bath, then the developed tension was recorded. Histologically, the aged bladder did not show pathologic changes such as inflammation and hypertrophy. Carbachol-induced contraction in aged rat bladder was identical to that obtained in young rat. In the receptor binding assay, [3H]QNB maximal binding capacity and Kd value were not significantly changed in aged bladder. In contrast, a selective α-adrenergic agonist phenylephrine, elicited greater contractions both in the aged body and trigone than those in young rats. The augmentation of α-adrenoceptor-mediated contractions in aged bladder may induce urinary dysfunction such as voiding difficulty.
A Typical Case of Posterior Reversible Encephalopathy Syndrome Associated with Postpartum Eclampsia-HELLP Syndrome  [PDF]
Hiroshi Takagi, Kazutoshi Matsunami, Satoshi Ichigo, Takuma Katano, Atsushi Imai
Open Journal of Obstetrics and Gynecology (OJOG) , 2016, DOI: 10.4236/ojog.2016.66045
Abstract: Background: Posterior reversible encephalopathy syndrome (PRES) is a reversible syndrome characterized by seizures, headache, altered mentation, and loss of vision associated with white matter changes on imaging. Case: A 37-year-old multigravida woman had a severe, immediate postpartum eclampsia-HELLP syndrome (hemolysis, elevated liver enzyme levels, low platelet count) with PRES characterized by generalized seizures and altered mental status. Magnetic resonance brain imaging showed high-intensity lesions in non-posterior portions including the frontal lobe and cingulated gyrus, which resolved completely after 2 weeks along with complete symptom regression. Conclusions: Cases of postpartum PRES without involvement of posterior brain regions after eclampsia-HELLP syndrome are very rare. Patients with PRES do not always show typical manifestations. The importance of a prompt diagnosis is emphasized, as is the crucial role of rapid blood pressure reduction.
A User Proprietary Obfuscate System for Positions Sharing in Location-Aware Social Networks  [PDF]
Wei Cherng Cheng, Masayoshi Aritsugi
Journal of Computer and Communications (JCC) , 2015, DOI: 10.4236/jcc.2015.35002

A user’s trajectory can be maliciously monitored by adversaries when they share the positions in location-aware social networking applications which require users to update their own locations continuously. An adversary infers user’s locations from the trajectories, and gleans user’s private information through them via location-aware social networking applications and public available geographic data. In this paper, we propose a user proprietary obfuscate system to suit situations for position sharing and location privacy preserving in location-aware social network. Users transform the public available geographic data into personal obfuscate region maps with pre-defined profile to prevent the location leaking in stationary status. Our obfuscation with size restricted regions method tunes user’s transformed locations fitting into natural movement and prevents unreasonable snapshot locations been recorded in the trajectory.

Role of carotenoid β-cryptoxanthin in bone homeostasis
Masayoshi Yamaguchi
Journal of Biomedical Science , 2012, DOI: 10.1186/1423-0127-19-36
Abstract: Bone is a dynamic tissue that preserves skeletal size, shape, and structural integrity and to regulate mineral homeostasis. Bone homeostasis is maintained through a balance between osteoblastic bone formation and osteoclastic bone resorption. Aging and numerous pathological processes induce decrease in bone formation and increase in bone resorption, leading to osteoporosis, a devastating bone disease [1]. Osteoporosis, which is induced with decrease in bone mass, is widely recognized as a major public health problem [1]. The most dramatic expression of the disease is represented by fractures of the proximal femur for which the number increases as the population ages [2].Nutritional factors may have the potential effect to prevent bone loss with increasing age. There is growing evidence that the supplementation of nutritional and food factors may have the preventive effect on bone loss that is induced in animal model of osteoporosis and in human subjects [3-6]. Chemical compounds in food and plants, which regulate on bone homeostasis, have been to be worthy of notice in maintaining of bone health and prevention of bone loss with increasing age [7-13].Carotenoids (carotene and xanthophyll) are present in fruit and vegetables. Carotenoids, which are a provitamin A, may have an anabolic effect on bone metabolism. Vitamin A (retinol, retinal, and retinoic acid), which is formed from carotenoids in animal and human, has been shown to have a role in the regulation of bone cells and it may have an anabolic effect on bone [14-16]. However, vitamin A is also known to have a detrimental effect on bone at high doses [17-20]. In laboratory animals, high levels of vitamin A lead to accelerated bone resorption, bone fractures, and osteoporotic bone lesions [17].Beta (β)-cryptoxanthin, a kind of xanthophyll, is abundant in Satsuma mandarin orange (Citrus unshiu MARC.). Of various carotenoids, β-cryptoxanthin has been found to have a potential-anabolic effect on bone due to stimulat
Biological implications of coeruleospinal inhibition of nociceptive processing in the spinal cord
Masayoshi Tsuruoka
Frontiers in Integrative Neuroscience , 2012, DOI: 10.3389/fnint.2012.00087
Abstract: The coeruleospinal inhibitory pathway (CSIP), the descending pathway from the nucleus locus coeruleus (LC) and the nucleus subcoeruleus (SC), is one of the centrifugal pain control systems. This review answers two questions regarding the role coeruleospinal inhibition plays in the mammalian brain. First is related to an abnormal pain state, such as inflammation. Peripheral inflammation activated the CSIP, and activation of this pathway resulted in a decrease in the extent of the development of inflammatory hyperalgesia. During inflammation, the responses of the dorsal horn neurons to graded heat stimuli in the LC/SC-lesioned rats did not produce a further increase with the increase of stimulus intensity in the higher range temperatures. These results suggest that the function of CSIP is to maintain the accuracy of intensity coding in the dorsal horn because the plateauing of the heat-evoked response in the LC/SC-lesioned rats during inflammation is due to a response saturation that results from the lack of coeruleospinal inhibition. The second concerns attention and vigilance. During freezing behavior induced by air-puff stimulation, nociceptive signals were inhibited by the CSIP. The result implies that the CSIP suppresses pain system to extract other sensory information that is essential for circumstantial judgment.
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