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Search Results: 1 - 10 of 973 matches for " Masaya Kubota "
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Nutraceutical Approach for Preventing Obesity-Related Colorectal and Liver Carcinogenesis
Masahito Shimizu,Masaya Kubota,Takuji Tanaka,Hisataka Moriwaki
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13010579
Abstract: Obesity and its related metabolic abnormalities, including insulin resistance, alterations in the insulin-like growth factor-1 (IGF-1)/IGF-1 receptor (IGF-1R) axis, and the state of chronic inflammation, increase the risk of colorectal cancer (CRC) and hepatocellular carcinoma (HCC). However, these findings also indicate that the metabolic disorders caused by obesity might be effective targets to prevent the development of CRC and HCC in obese individuals. Green tea catechins (GTCs) possess anticancer and chemopreventive properties against cancer in various organs, including the colorectum and liver. GTCs have also been known to exert anti-obesity, antidiabetic, and anti-inflammatory effects, indicating that GTCs might be useful for the prevention of obesity-associated colorectal and liver carcinogenesis. Further, branched-chain amino acids (BCAA), which improve protein malnutrition and prevent progressive hepatic failure in patients with chronic liver diseases, might be also effective for the suppression of obesity-related carcinogenesis because oral supplementation with BCAA reduces the risk of HCC in obese cirrhotic patients. BCAA shows these beneficial effects because they can improve insulin resistance. Here, we review the detailed relationship between metabolic abnormalities and the development of CRC and HCC. We also review evidence, especially that based on our basic and clinical research using GTCs and BCAA, which indicates that targeting metabolic abnormalities by either pharmaceutical or nutritional intervention may be an effective strategy to prevent the development of CRC and HCC in obese individuals.
Primary Follicular Lymphoma of the Duodenum with Erosions as Atypical Macroscopic Features
Keiko Takeuchi,Masaya Iwamuro,Atsushi Imagawa,Yoshitsugu Kubota,Katsuya Miyatani,Katsuyoshi Takata,Hiroyuki Okada
Case Reports in Medicine , 2012, DOI: 10.1155/2012/582607
Abstract: A 52-year-old Japanese woman who was eventually diagnosed with primary follicular lymphoma of the duodenum showed atypical endoscopic features, namely, erosions with peripheral whitish edematous mucosa. Initial biopsy specimens taken from the erosions revealed insufficient numbers of lymphoma cells for histological diagnosis. Subsequent biopsy specimens from the peripheral mucosa containing the whitish enlarged villi showed infiltration of the lymphoma cells forming lymphoid follicles, which led us to the appropriate diagnosis. This case indicates that endoscopists should take biopsy samples from the peripheral mucosa with whitish enlarged villi rather than erosions in the rare instances that erosions appear as the main macroscopic feature of intestinal follicular lymphoma.
C57BL/KsJ-db/db-ApcMin/+ Mice Exhibit an Increased Incidence of Intestinal Neoplasms
Kazuya Hata,Masaya Kubota,Masahito Shimizu,Hisataka Moriwaki,Toshiya Kuno,Takuji Tanaka,Akira Hara,Yoshinobu Hirose
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12118133
Abstract: The numbers of obese people and diabetic patients are ever increasing. Obesity and diabetes are high-risk conditions for chronic diseases, including certain types of cancer, such as colorectal cancer (CRC). The aim of this study was to develop a novel animal model in order to clarify the pathobiology of CRC development in obese and diabetic patients. We developed an animal model of obesity and colorectal cancer by breeding the C57BL/KsJ- db /db (db/db) mouse, an animal model of obesity and type II diabetes, and the C57BL/6J- ApcMin/+ (Min/+) mouse, a model of familial adenomatous polyposis. At 15 weeks of age, the N9 backcross generation of C57BL/KsJ- db /db- ApcMin/+ (db/db-Min/+) mice developed an increased incidence and multiplicity of adenomas in the intestinal tract when compared to the db/m-Min/+ and m/m-Min/+ mice. Blood biochemical profile showed significant increases in insulin (8.3-fold to 11.7-fold), cholesterol (1.2-fold to 1.7-fold), and triglyceride (1.2-fold to 1.3-fold) in the db/db-Min/+ mice, when compared to those of the db/m-Min/+ and m/m-Min/+ mice. Increases (1.4-fold to 2.6-fold) in RNA levels of insulin-like growth factor (IGF)-1, IRF-1R, and IGF-2 were also observed in the db/db-Min/+ mice. These results suggested that the IGFs, as well as hyperlipidemia and hyperinsulinemia, promoted adenoma formation in the db/db-Min/+ mice. Our results thus suggested that the db/db-Min/+ mice should be invaluable for studies on the pathogenesis of CRC in obese and diabetes patients and the therapy and prevention of CRC in these patients.
Surgical treatment of HCC in a patient with lamivudine-resistant hepatitis B cirrhosis with adefovir dipivoxil
Takashi Akima, Masaya Tamano, Hidetsugu Yamagishi, Keiichi Kubota, Takahiro Fujimori, Hideyuki Hiraishi
World Journal of Hepatology , 2010,
Abstract: We describe a 77-year-old woman with chronic hepatitis B who became resistant to lamivudine. She was started on adefovir (10 mg daily) while still continuing lamivudine therapy. Four mo later her liver function improved and serum Hepatitis B virus (HBV)-DNA level became undetectable. Three years after the start of additional adefovir treatment, hepatocellular carcinoma (HCC) was detected and the patient underwent a successful hepatectomy. Our findings suggest that the addition of adefovir to ongoing lamivudine therapy cannot completely suppress hepatocarcinogenesis, but is useful for improving liver function in patients with lamivudine-resistant HBV-related cirrhosis, allowing HCC surgery.
Workaholism as a Risk Factor for Depressive Mood, Disabling Back Pain, and Sickness Absence
Ko Matsudaira, Akihito Shimazu, Tomoko Fujii, Kazumi Kubota, Takayuki Sawada, Norimasa Kikuchi, Masaya Takahashi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075140
Abstract: Objectives Although it is understood that work-related factors, including job demands, job control, and workplace support, are associated with workers' health and well-being, the role played by personal characteristics, especially workaholism, has not been fully investigated. This study examined workaholism's associations with psychological ill health, low back pain with disability, and sickness absence among Japanese workers. Methods A cross-sectional Internet survey was conducted using self-administered questionnaires. Data from 3,899 Japanese workers were analyzed. Workaholism was measured using the Dutch Workaholism Scale (DUWAS). Scores were divided into tertiles, where respondents were classified into three groups (high, middle, and low). Depressive mood as a measure of psychological ill health was assessed using the SF-36 mental health subscale, and low back pain using a standardized question. Sickness absence, except that due to physical injuries, was categorized either as absence due to mental health problems or to physical/somatic problems including the common cold. Multiple logistic regression analyses were conducted to examine the association between workaholism and depressive mood, low back pain with disability, and sickness absence, adjusting for demographic characteristics, job demand, job control, and workplace support. Results Compared to the low workaholism group, the middle and high workaholism groups had significantly higher odds for depressive mood (Odds ratio (OR) = 1.93 and 3.62 for the middle and high groups, respectively), disabling back pain (ORs = 1.36 and 1.77 for the middle and high groups, respectively). Workaholism was more strongly associated with sickness absence due to mental health problems than that for other reasons (ORs = 1.76 vs. 1.21 for the middle group and 3.52 vs. 1.37 for the high groups). Conclusions Workaholism is significantly associated with poor psychological health, disabling back pain, and sickness absence, particularly from mental health problems. Therefore, workaholism must be considered when addressing well-being of workers.
Numerical Study of Axial Magnetic Effects on a Turbulent Thermal Plasma Jet for Nanopowder Production Using 3D Time-Dependent Simulation  [PDF]
Masaya Shigeta
Journal of Flow Control, Measurement & Visualization (JFCMV) , 2018, DOI: 10.4236/jfcmv.2018.62010
Abstract: 3D time-dependent simulations are performed using a computational method suitable for thermal plasma flows to capture a turbulent field induced by a thermal plasma jet and steep gradients in nanopowder distributions. A mathematical model with a simple form is developed to describe effectively simultaneous processes of growth and transport of nanopowder in/around a thermal plasma flow. This growth-transport model obtains the spatial distributions of the number density and mean diameter of nanopowder with a lower computational cost. The results show that an argon thermal plasma jet induces multi-scale vortices even far from itself. A double-layer structure of high-temperature thicker vortex rings surrounded by low-temperature thinner vortex rings is generated in the upstream region. As the vortex rings flow downstream, the high-temperature thicker vortex rings deform largely whereas the low-temperature thinner vortex rings break up into smaller vortices. Nanopowder is generated at the fringe of plasma and transported widely outside the plasma region. The nanopowder grows up collectively by coagulation decreasing particle number as well as homogeneous nucleation and heterogeneous condensation. When a uniform magnetic field is applied in the axial direction, a longer and straighter thermal plasma jet is obtained because of Lorentz force and Joule heating. Larger nanopowder is produced around the plasma because turbulent diffusions of silicon vapor and nanoparticles by vortices are suppressed as well.
NF-κB Inducing Kinase, a Central Signaling Component of the Non-Canonical Pathway of NF-κB, Contributes to Ovarian Cancer Progression
Masaya Uno, Yasunori Saitoh, Kanako Mochida, Eri Tsuruyama, Tohru Kiyono, Issei Imoto, Johji Inazawa, Yasuhito Yuasa, Toshiro Kubota, Shoji Yamaoka
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088347
Abstract: Ovarian cancer is one of the leading causes of female death and the development of novel therapeutic approaches is urgently required. Nuclear factor-κB (NF-κB) is constitutively activated in several types of cancer including ovarian cancer and is known to support the survival of cancer cells. However, molecular mechanisms of persistent activation of NF-κB in ovarian cancer remain largely unknown. We report here that, in addition to the previously reported canonical activation, NF-κB is activated through the noncanonical pathway in ovarian cancer cells. RNA interference-mediated silencing of NF-κB inducing kinase (NIK), a central regulator of the noncanonical pathway, reduced the NF-κB2/p52 DNA binding activity and NF-κB-dependent reporter gene expression as well as NF-κB target gene expression. Notably, anchorage-dependent and -independent cell growth was impaired in NIK-depleted cells. Depletion of NIK also suppressed tumor formation in the nude mouse xenograft assay. These results indicate that NIK plays a key role in constitutive NF-κB activation and the progression of ovarian cancer cells and suggest that NIK represents an attractive therapeutic target for ovarian cancer.
Enhanced Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Hypertensive Rats
Takahiro Kochi,Masahito Shimizu,Tomohiko Ohno,Atsushi Baba,Takafumi Sumi,Masaya Kubota,Yohei Shirakami,Hisashi Tsurumi,Takuji Tanaka,Hisataka Moriwaki
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140714700
Abstract: Metabolic syndrome is associated with an increased risk of colorectal cancer. This study investigated the impact of hypertension, a component of metabolic syndrome, on azoxymethane (AOM)-induced colorectal carcinogenesis using SHRSP/Izm (SHRSP) non-diabetic/hypertensive rats and SHRSP.Z- Leprfa/IzmDmcr (SHRSP-ZF) diabetic/hypertensive rats. Male 6-week-old SHRSP, SHRSP-ZF, and control non-diabetic/normotensive Wister Kyoto/Izm (WKY) rats were given 2 weekly intraperitoneal injections of AOM (20 mg/kg body weight). Two weeks after the last injection of AOM, the SHRSP and SHRSP-ZF rats became hypertensive compared to the control WKY rats. Serum levels of angiotensin-II, the active product of the renin-angiotensin system, were elevated in both SHRSP and SHRSP-ZF rats, but only the SHRSP-ZF rats developed insulin resistance, dyslipidemia, and hyperleptinemia and exhibited an increase in adipose tissue. The development of AOM-induced colonic preneoplastic lesions and aberrant crypts foci, was significantly accelerated in both SHRSP and SHRSP-ZF hypertensive rats, compared to WKY normotensive rats. Furthermore, induction of oxidative stress and exacerbation of inflammation were observed in the colonic mucosa and systemically in SHRSP and SHRSP-ZF rats. Our findings suggest that hypertension plays a role in the early stage of colorectal carcinogenesis by inducing oxidative stress and chronic inflammation, which might be associated with activation of the renin-angiotensin system.
Multiple Equilibria between Fertility Rates and Pension Levels Based on the Target Level of Government Debt  [PDF]
Hideki Nakamura, Masaya Yasuoka
Theoretical Economics Letters (TEL) , 2011, DOI: 10.4236/tel.2011.13020
Abstract: We show that when the government has a target debt level, multiple equilibria exist in the relationship between fertility rates and pension levels. One is associated with a high fertility rate and a high pension level. The other is associated with a low fertility rate and a low pension level. If the government fails to provide adequate security for individuals during their retirement years, it would result in a failure of coordination between the government and individuals.
Acute Normalization of Thyroxine Induced Hallucinations and Delusions  [PDF]
Yuko Furuhashi, Masaya Ishikawa
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.35066
Abstract: The association between disorders of thyroid function and psychiatric symptoms is well established. Generally, hypo-thyroidism is recognized as being able to induce psychotic symptoms. However, psychotic symptoms without affective and cognitive disturbances are rare in hyperthyroidism. We presented a patient with Graves’ disease who suffered from delusions and hallucinations without affective and cognitive disturbances following abrupt normalization of thyroid function. Furthermore, the patient was clinically and biochemically euthyroid when the psychotic symptoms developed. There was resolution of psychotic symptoms in this case. It is suggested that the abrupt change of thyroxine may cause susceptible individuals to become transient psychotic state.
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