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Search Results: 1 - 10 of 4130 matches for " Masatake Tanaka "
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A high prevalence of extreme hyperferritinemia in acute hepatitis patients
Kazuhiro Kotoh,Akihiro Ueda,Masatake Tanaka
Hepatic Medicine: Evidence and Research , 2009,
Abstract: Kazuhiro Kotoh, Akihiro Ueda, Masatake Tanaka, Masayuki Miyazaki, Masaki Kato, Motoyuki Kohjima, Munechika Enjoji, Makoto Nakamuta, Ryoichi TakayanagiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoda, JapanAbstract: Although the mechanism underlying acute liver failure (ALF) has not been clarified, recent reports indicate overactivation of macrophages is involved in its progression. In diseases in which activated macrophages participate in the progression, elevated serum ferritin concentration counts among the characteristic laboratory findings. If activated macrophages play a key role in the development of ALF, serum ferritin levels might reflect the severity of acute liver injury. To confirm this, we evaluated the correlation between the serum ferritin concentration and other laboratory measurements in patients with acute hepatitis including ALF. One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF. Serum ferritin concentrations correlated with serum alanine transferase activity as a whole. Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others. Although most patients with ALF had high levels of serum ferritin, not a few patients without ALF showed similar results. The serum ferritin level was generally increased in acute hepatitis patients, probably reflecting the degree of macrophage activation in the liver. Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF. Keywords: acute hepatitis, acute liver failure, ferritin, macrophage
Antithrombin III injection via the portal vein suppresses liver damage
Masayuki Miyazaki,Masaki Kato,Masatake Tanaka,Kosuke Tanaka
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i16.1884
Abstract: AIM: To investigate the effects of antithrombin III (AT III) injection via the portal vein in acute liver failure. METHODS: Thirty rats were intraperitoneally challenged with lipopolysaccharide (LPS) and D-galactosamine (GalN) and divided into three groups: a control group; a group injected with AT III via the tail vein; and a group injected with AT III via the portal vein. AT III (50 U/kg body weight) was administrated 1 h after challenge with LPS and GalN. Serum levels of inflammatory cytokines and fibrin degradation products, hepatic fibrin deposition, and hepatic mRNA expression of hypoxia-related genes were analyzed. RESULTS: Serum levels of alanine aminotransferase, tumor necrosis factor-α and interleukin-6 decreased significantly following portal vein AT III injection compared with tail vein injection, and control rats. Portal vein AT III injection reduced liver cell destruction and decreased hepatic fibrin deposition. This treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme oxygenase-1. CONCLUSION: A clinically acceptable dose of AT III injection into the portal vein suppressed liver damage, probably through its enhanced anticoagulant and anti-inflammatory activities.
A high prevalence of extreme hyperferritinemia in acute hepatitis patients
Kazuhiro Kotoh, Akihiro Ueda, Masatake Tanaka, et al.
Hepatic Medicine: Evidence and Research , 2009, DOI: http://dx.doi.org/10.2147/HMER.S4393
Abstract: high prevalence of extreme hyperferritinemia in acute hepatitis patients Original Research (6896) Total Article Views Authors: Kazuhiro Kotoh, Akihiro Ueda, Masatake Tanaka, et al. Published Date September 2009 Volume 2009:1 Pages 1 - 7 DOI: http://dx.doi.org/10.2147/HMER.S4393 Kazuhiro Kotoh, Akihiro Ueda, Masatake Tanaka, Masayuki Miyazaki, Masaki Kato, Motoyuki Kohjima, Munechika Enjoji, Makoto Nakamuta, Ryoichi Takayanagi Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoda, Japan Abstract: Although the mechanism underlying acute liver failure (ALF) has not been clarified, recent reports indicate overactivation of macrophages is involved in its progression. In diseases in which activated macrophages participate in the progression, elevated serum ferritin concentration counts among the characteristic laboratory findings. If activated macrophages play a key role in the development of ALF, serum ferritin levels might reflect the severity of acute liver injury. To confirm this, we evaluated the correlation between the serum ferritin concentration and other laboratory measurements in patients with acute hepatitis including ALF. One hundred consecutive patients with acute liver injury were enrolled, of whom 19 fulfilled the criteria for ALF. Serum ferritin concentrations correlated with serum alanine transferase activity as a whole. Interestingly, the correlation was strong in patients infected by hepatitis viruses, but weak in others. Although most patients with ALF had high levels of serum ferritin, not a few patients without ALF showed similar results. The serum ferritin level was generally increased in acute hepatitis patients, probably reflecting the degree of macrophage activation in the liver. Overactivation of macrophages appears to be essential, but not sufficient, for the development of ALF.
Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia
Masayuki Miyazaki,Masatake Tanaka,Akihiro Ueda,Tsuyoshi Yoshimoto
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i44.4928
Abstract: Drug-induced hypersensitivity syndrome (DIHS) is a severe reaction usually characterized by fever, rash, and multiorgan failure, occurring 2-6 wk after drug introduction. It is an immune-mediated reaction involving macrophage and T-lymphocyte activation and cytokine release. A 54-year-old woman was diagnosed with rheumatic arthritis and initiated salazosulfapyridine by mouth. About 10 d later, she had a high fever, skin rash and liver dysfunction. She was admitted to hospital and diagnosed with a drug eruption. She was treated with oral prednisolone 30 mg/d; however, she developed high fever again and her blood tests showed acute liver failure and cytopenia associated with hyperferritinemia. She was diagnosed with acute liver failure and hemophagocytosis caused by DIHS. She was transferred to the Department of Medicine and Bioregulatory Science, Kyushu University, where she was treated with arterial steroid injection therapy. Following this treatment, her liver function improved and serum ferritin immediately decreased. We hypothesized that an immune-mediated reaction in DIHS may have generated over-activation of macrophages and T-lymphocytes, followed by a cytokine storm that affected various organs. The measurement of serum ferritin might be a useful marker of the severity of DIHS.
Gold as a novel catalyst in the 21st century: Preparation, working mechanism and applications
Masatake Haruta
Gold Bulletin , 2004, DOI: 10.1007/BF03215514
Abstract: Gold can be deposited as nanoparticles on a variety of support materials by coprecipitation or deposition-precipitation of Au(OH)3, grafting of organo-gold complexes such as dimethyl-Au(III)-acetylacetonate, mixing of colloidal Au particles, and vacuum deposition. Owing to the moderate adsorption of at least one of reactants (for example, CO) on the edges and corners of Au nanoparticles and to the activation of the counter reactant (for example, O2) at the perimeter interface with the supports, supported Au nanoparticle catalysts exhibit unique and practically useful catalytic properties at relatively low temperature below 473K. They have already been commercially used for deodorizers in rest rooms in Japan and will find growing applications in indoor air quality control, pollutant emission control, production of hydrogen energy carrier, and innovations in chemical processes. Cluster science of Au may also open an exciting area of research showing some magic numbers for dramatic changes in reactivity.
Gold as a key element for green nanotechnology
Masatake Haruta
Gold Bulletin , 2001, DOI: 10.1007/BF03214810
Abstract:
Nitric Oxide Reduction with Hydrogen, Carbon Monoxide, and Hydrocarbons over Gold Catalysts
Atsushi Ueda,Masatake Haruta
Gold Bulletin , 1999, DOI: 10.1007/BF03214783
Abstract: The reactivity of nitric oxide with reducing gases, using supported gold catalysts is reviewed and assessed in comparison with the use of other precious metal catalysts. Applications for this technology in the purification of exhaust gases are envisaged.
Effects of Cultural Conditions on High Temperature Tolerance of Lentinula edodes Mycelia
Md. Arif Mahmud,Masatake Ohmasa
Pakistan Journal of Biological Sciences , 2008,
Abstract: The effects of several cultural conditions on high temperature tolerance of vegetative mycelia of five Lentinula edodes strains were investigated. Mycelium of longer culture age (70 days) was significantly shown high temperature tolerance compared to mycelium of shorter culture ages (14 and 30 days) for four strains, whereas SA142 that showed reverse. When the culture plates were pretreated at 30 and 33°C for 48 h incubation before heat treatment (40°C, 8 h), mycelia of L. edodes strains were shown high temperature tolerance. Effects of nutritional factors in BM (basic medium) for the high temperature tolerance of L. edodes strains were also investigated. While yeast extract (as nitrogen source) and starch (as carbon source) were added to BM media, as a result cultured vegetative mycelia of L. edodes strains were significantly shown high temperature tolerance against heat treatment (40°C, 6 and 8 h). Further more, addition of bases (adenine + cytosine), vitamin (biotin) and organic acid (tartaric acid) to BM media, consequently vegetative mycelia of some L. edodes strains were also effective to increase high temperature tolerance.
Objective Assessment of Skin Tightening Using Multisource, Phase-Controlled Radiofrequency in Asians  [PDF]
Yohei Tanaka
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2013, DOI: 10.4236/jcdsa.2013.31016
Abstract:

Background: Radiofrequency has been proven to penetrate deeper than optical light sources independent of skin color allowing a safer treatment for the Asian skin type. Many studies have indicated the efficacy of various types of devices, but have not included a sufficient objective evaluation. Multisource radiofrequency uses multiple phase controlled radiofrequency generators with real time impedance control, allowing painless, deeper dermal heating with better adaptation to differences in individual skin impedance. In this study we used three-dimensional imaging for the objective evaluation of facial skin tightening by multisource phase-controlled radiofrequency. Methods: Twenty Japanese patients were treated with a multisource phase-controlled radiofrequency device. Three-dimensional imaging was performed with a Canfield Scientific Vectra camera and software, and quantitative volume measurements were taken to evaluate the change in the post-treatment volume. The patients then provided subjective assessments. Results: Objective assessments of the treated cheek volume evaluated by a three-dimensional color schematic representation with quantitative volume measurements showed significant improvement three months after the final treatment. The mean volume reduction at the last post-treatment visit was 3.878 ± 2.86 mL. The post-treatment volume was significantly reduced compared to the pretreatment volume in all of the volunteers (P = 0.0007). Ninety-five percent of volunteers reported satisfaction with the improvement of skin laxity, and ninety percent of volunteers reported satisfaction with the improvement of wrinkles, such as the nasolabial folds. Conclusions: The advantages of these multisource phase-controlled radiofrequency treatments are its high efficacy for skin tightening associated with minimal level of discomfort, minimal side effects, and low cost. Taken together,

Matrix Isolation and Computational Study on the Photolysis of CHCl2COCl  [PDF]
Nobuaki Tanaka
Open Journal of Physical Chemistry (OJPC) , 2014, DOI: 10.4236/ojpc.2014.43014
Abstract:

UV light photolysis of dichloroacetyl chloride (CHCl2COCl) has been investigated by infrared spectroscopy in cryogenic Ar, Kr, Xe, and O2 matrices. The formation of CHCl3 and CO was found to be the dominant process over the ketene formation. The C-C bond cleaved products CHCl2 and COCl were also observed. As the number of the chlorine atom substitution to methyl group of acetyl chloride increased, the C-C bond cleaved product yield in the triplet state increased, which can be attributed to an internal heavy-atom effect where the intersystem crossing rate was enhanced.

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