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Oncofertility in Gynecologic Malignant Tumors  [PDF]
Masataka Adachi, Kouji Banno, Iori Kisu, Megumi Yanokura, Moito Iijima, Takashi Takeda, Kiyoko Umene, Yuya Nogami, Eiichiro Tominaga, Daisuke Aoki
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.614128
Abstract: Long-term survival is the priority in treatment of patients with malignant tumors. In the field of gynecology, fertility preservation has also recently become an important objective due to improved treatment outcomes and different needs of patients. Methods for fertility preservation include cervical conization, ovarian protection against radiation or chemotherapy for ovarian cancer since the ovary is hypersensitive to cancer therapies, treatment of gynecological cancer during pregnancy, and cryopreservation of oocytes, embryos or ovarian tissue before treatment of malignant tumors. Radical trachelectomy for early cervical cancer and treatment with medroxy progesterone acetate for early endometrial carcinoma are also options for fertility preservation, but the efficacy and risk of recurrence have yet to be fully evaluated. The first childbirth following uterine transplantation was also achieved last year and this success has expanded the potential for pregnancy and delivery among cancer survivors.
Continued Diagnostic Difficulties in Preoperatively Differentiating Lipiodized Oil and Residual Metallic Material: A Case Report  [PDF]
Masashi Haraguchi, Shinichiro Ito, Kohei Kotera, Aya Fukushima, Toshio Fukuda, Hirotaka Tokai, Kazumasa Noda, Masataka Hirabaru, Toshiyuki Adachi, Nobuhiro Tada, Keiji Inoue, Shinya Onizuka, Shigeki Minami
Case Reports in Clinical Medicine (CRCM) , 2016, DOI: 10.4236/crcm.2016.54023
Abstract: Retained foreign objects in the abdomen and pelvis are serious clinical problems yet the imaging required can present difficulties. Prolonged retention of lipiodized oil used for hysterosalpingography over years is very rare. However, lipiodized oil had previously been misdiagnosed as residual metallic material. We are reporting a case in which the latest computed tomography (CT) equipment seemed inadequate for obtaining a clear pre-operative diagnosis. Here, we describe the case of a 33-year-old Japanese female whose pelvis had contained retained lipiodized oil that had been suspected as residual metallic material. The preoperative diagnosis was very difficult and included three-dimensional computed tomography (3D-CT) of unclear results despite expectations of resolution. By laparoscopic surgery, we removed a cyst of approximately 2 cm containing a yellowish oily fluid. Postoperatively, we demonstrated that the fluid was lipiodized oil. A postoperative experiment to attempt distinguishing lipiodized oil from metal through gemstone spectral CT imaging did not offer clarity either. Distinguishing between retained lipiodized oil and metallic material in the abdominal cavity may still present unexpected difficulties even with the latest medical equipments.
A Single-Center Open-Label Single-Arm Study Evaluating Efficacy and Safety of Skin Adhesive EpinexusTM in Surgical Patients  [PDF]
Kazuo Kishi, Noriko Aramaki-Hattori, Yoshiaki Sakamoto, Keisuke Okabe, Tetsu Hayashida, Maiko Takahashi, Yuko Kitagawa, Masataka Saito, Takeya Adachi, Aki Honda, Hiromitsu Jinno
Modern Plastic Surgery (MPS) , 2017, DOI: 10.4236/mps.2017.74004
Abstract: Existing skin adhesives may, however, cause inflammatory response to toxicity of formaldehyde generated as hydrolysate of polycyanoacrylate (the main ingredient), delay in wound closure due to the adhesive’s flowing into the wound from the edges, or a wide scar. EpinexusTM (Mitsui Chemicals, Inc.), the skin adhesive used for this study, was developed to prevent these risks. For the method of this study, This was a single-center, open-label, single-arm, intervention study of an acrylate skin adhesive, EpinexusTM. The primary endpoint was safety. The secondary endpoints were wound closure, cosmetic outcome (Manchester Scar Scale), and usability. Failures and adverse events were also appropriately evaluated. As a result, there were no particular adverse events such as inflammatory findings, which demonstrated that there is no problem in safety. Some common adverse events were observed, but no adverse events for which a causal relationship cannot be ruled out or failures. As a conclusion, there was no problem in wound closure, cosmetic outcome, or usability. This was a pilot study of EpinexusTM of an ongoing, single-center, open-label, parallel-group, comparative study in 60 subjects comparing EpinexusTMwith an existing skin adhesive, Dermabond? Advanced.
Double bundle arthroscopic Anterior Cruciate Ligament reconstruction with remnant preserving technique using a hamstring autograft
Mitsuo Ochi, Mohamed M Abouheif, Wirat Kongcharoensombat, Atsuo Nakamae, Nobuo Adachi, Masataka Deie
Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology , 2011, DOI: 10.1186/1758-2555-3-30
Abstract: We used the far anteromedial (FAM) portal for creation of the femoral tunnels, with a special technique for its preoperative localization using three dimensional (3D) CT. The central anteromedial (AM) portal was used to make a longitudinal slit in the ACL remnant to allow visualization of the tips of the guide pins during anatomical creation of the tibial tunnels within the native ACL tibial foot print. The use of curved hemostat allow retrieval of the wire loop from the apertures of the femoral tunnels through the longitudinal slit in the ACL remnant thereby, guarding against impingement of the reconstruction graft against the ACL remnant as well as the roof of the intercondylar notch.Our technique allows for anatomical double bundle reconstruction of the ACL while maximally preserving the ACL remnant without the use of intra-operative image intensifier.It is well known that the remnant of the anterior cruciate ligament (ACL) is able to enhance the revascularization and cellular proliferation of the graft, and to preserve the proprioceptive function of the graft construct. Therefore, it seems reasonable to assume that preserving the tibial remnant as much as possible would be a source of reinnervation, and revascularization of the ACL substitute [1,2].However remnant preservation might be technically difficult, because it might hinder the visualization of the tip of the guide pin used as the first step of the creation of the anatomical tibial tunnel. This is especially true while drilling the posterolateral (PL) tibial bone tunnel because it is located posterior to the anteromedial (AM) bundle insertion. Therefore making a longitudinal slit in ACL remnant would allow better visualization of the tip of the guide pin during anatomical creation of the tibial tunnel [3,4], and avoid the risk of radiation exposure associated with the image intensifier which might be used for anatomical tunnel localization in case of remnant preservation [5,6].Additionally remnant preser
Intra-articular angiolipoma of the knee: a case report
Makoto Nishimori, Masataka Deie, Nobuo Adachi, Atsushi Kanaya, Atsuo Nakamae, Mitsuo Ochi
Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology , 2010, DOI: 10.1186/1758-2555-2-10
Abstract: Angiolipomas are uncommon benign soft-tissue tumors that typically arise in the subcutaneous tissues of young patients [1]. The forearm is decidedly the most common location, with almost two thirds of all angiolipomas found here [2]. A recent review of the literature revealed several reports of these tumors occurring in locations other than subcutaneous regions [3-5].Intra-articular angiolipoma of the knee is a very rare cause of knee pain, hemarthrosis and dysfunction. To our knowledge, there has been no reported case of intra-articular angiolipoma of the knee in English. We report on this exceedingly rare case and review the previous angiolipoma reports.A 30-year-old man presented to our clinic complaining of a recurrent swollen and painful knee over a period of 6 months without significant trauma. Examination revealed swelling and ballottement of the patella in the right knee joint, and aspiration of bloody joint fluid suggested a hemorrhage. The range of motion of the knee was limited to between 0 and 130 degrees with terminal flexion pain. There was no point of tenderness and instability of the knee. A plain x-ray showed no atrophic or degenerative change of the knee. Magnetic resonance imaging (MRI) showed a 2.5 cm polylobulated tumor localized in the dorsal area of the posterior cruciate ligament (PCL). MRI of the tumor exhibited a slightly high signal intensity, in contrast to muscle on T1-weighted images, a fluctuating high and low signal intensity with low signal septa around the tumor on T2-weighted images and an inhomogeneous signal, enhanced moderately on T1-weighted images with gadolinium (Gd)-enhancement (Fig 1).Arthroscopy revealed a polypoidal nodule measuring 20 × 20 × 10 mm and resembling a bunch of grapes, in the posterior portion of the PCL. The macroscopic appearance of the mass was consistent with synovial hemangioma and lipoma (Fig 2). A complete excision of the mass was easily performed using standard infra-patellar arthroscopic portals with
A New Algorithm for Generalized Least Squares Factor Analysis with a Majorization Technique  [PDF]
Kohei Adachi
Open Journal of Statistics (OJS) , 2015, DOI: 10.4236/ojs.2015.53020
Abstract: Factor analysis (FA) is a time-honored multivariate analysis procedure for exploring the factors underlying observed variables. In this paper, we propose a new algorithm for the generalized least squares (GLS) estimation in FA. In the algorithm, a majorization step and diagonal steps are alternately iterated until convergence is reached, where Kiers and ten Berge’s (1992) majorization technique is used for the former step, and the latter ones are formulated as minimizing simple quadratic functions of diagonal matrices. This procedure is named a majorizing-diagonal (MD) algorithm. In contrast to the existing gradient approaches, differential calculus is not used and only elmentary matrix computations are required in the MD algorithm. A simuation study shows that the proposed MD algorithm recovers parameters better than the existing algorithms.
MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients
Takuya Niimoto, Tomoyuki Nakasa, Masakazu Ishikawa, Atsushi Okuhara, Bunichiro Izumi, Masataka Deie, Osami Suzuki, Nobuo Adachi, Mitsuo Ochi
BMC Musculoskeletal Disorders , 2010, DOI: 10.1186/1471-2474-11-209
Abstract: IL-17 producing cells were expanded from CD4+T cell. MiRNA microarray was performed to identify the miRNAs in the differentiation of IL-17 producing cells. Quantitative polymerase chain reaction was performed to examine the expression patterns of the identified miRNAs in the PBMC and synovium from RA and osteoarthritis (OA) patients. Double staining combining in situ hybridization and immunohistochemistry of IL-17 was performed to analyze the expression pattern of identified miRNA in the synovium.Six miRNAs, let-7a, miR-26, miR-146a/b, miR-150, and miR-155 were significantly up regulated in the IL-17 producing T cells. The expression of miR-146a and IL-17 was higher than in PBMC in the patients with low score of Larsen grade and short disease duration. MiR-146a intensely expressed in RA synovium in comparison to OA. MiR-146a expressed intensely in the synovium with hyperplasia and high expression of IL-17 from the patients with high disease activity. Double staining revealed that miR-146a expressed in IL-17 expressing cells.These results indicated that miR-146a was associated with IL-17 expression in the PBMC and synovium in RA patients. There is the possibility that miR-146a participates in the IL-17 expression.Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation and subsequent joint destruction [1]. The infiltration of macrophages, T cells and B cells in RA synovium plays a crucial role in RA pathogenesis including proliferation of the lining cells, and production of inflammatory cytokines such as tumor necrosis factor- (TNF-)α, and interleukin-1- (IL-1-)β. However, the pathogenesis of RA has not been completely elucidated.The discovery of a new linage of CD4+ effector T helper type17 cells (Th17cells) that selectively produce IL-17 has provided exciting new insights into immune regulation, host defense, and pathogenesis of autoimmune and other chronic inflammatory disorders including of RA [2-4]. IL-17 is a proinflammatory cytokine, which i
Effect of Ultrasonic Irradiation Conditions on Metal Surface during Multifunction Cavitation  [PDF]
Masataka Ijiri, Toshihiko Yoshimura
Materials Sciences and Applications (MSA) , 2018, DOI: 10.4236/msa.2018.98050
Abstract: Processing using multifunction cavitation (MFC) has recently enabled functional characteristics to be imparted to various materials. It is possible to process a material surface in the same manner as with conventional water jet (WJ) peening; however, the cavitation bubble temperature is different. To further improve this MFC technology, we examine the surface re-forming of low alloy steel (JIS-SCM435) using MFC with various modes of ultrasonic waves. The ultrasonic equipment used for MFC processing includes dual, single, pulse and frequency modulation (FM) ultrasonic modes. Improvement of the residual stress and corrosion resistance was confirmed for all modes. The dual mode showed the maximum values of residual compressive stress and surface potential. The sound pressure at the machining spot was the highest with dual mode, and the temperature in the bubble generated by the WJ nozzle was highest and the amount of dissolved oxygen was lowest. Improvement of the residual stress and corrosion resistance was promoted because the temperature and pressure in the bubble interior during processing was higher than in the other modes.
Regulation of Adrenal Aldosterone Production by Serine Protease Prostasin
Takehiro Ko,Yutaka Kakizoe,Naoki Wakida,Manabu Hayata,Kohei Uchimura,Naoki Shiraishi,Taku Miyoshi,Masataka Adachi,Shizuka Aritomi,Tomoyuki Konda,Kimio Tomita,Kenichiro Kitamura
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/793843
Abstract: A serine protease prostasin has been demonstrated to have a pivotal role in the activation of the epithelial sodium channel. Systemic administration of adenovirus carrying human prostasin gene in rats resulted in an increase in plasma prostasin and aldosterone levels. However, the mechanism by which the elevation of prostasin levels in the systemic circulation stimulated the plasma aldosterone levels remains unknown. Therefore, we examined if prostasin increases the aldosterone synthesis in a human adrenocortical cell line (H295R cells). Luciferase assay using CYP11B2 promoter revealed that prostasin significantly increased the transcriptional activity of CYP11B2. Prostasin significantly increased both CYP11B2 mRNA expression and aldosterone production in a dose-dependent manner. Surprisingly, treatment with camostat mesilate, a potent prostasin inhibitor, had no effect on the aldosterone synthesis by prostasin and also a protease-dead mutant of prostasin significantly stimulated the aldosterone production. A T-type/L-type calcium channel blocker and a protein kinase C (PKC) inhibitor significantly reduced the aldosterone synthesis by prostasin. Our findings suggest a stimulatory effect of prostasin on the aldosterone synthesis by adrenal gland through the nonproteolytic action and indicate a new role of prostasin in the systemic circulation.
Electrode Property of Sintered Ceramic Based on CaMnO3 in LiOH Aqueous Solution  [PDF]
Takao Esaka, Yuhta Adachi
Journal of Materials Science and Chemical Engineering (MSCE) , 2014, DOI: 10.4236/msce.2014.24002
Abstract: Sintered ceramics of Ca0.9A0.1MnO3-δ(A = La, Nd, Sm, Gd and Y) were studied on their cathode properties in LiOHaq. solution. After firing, the samples were obtained as high conductivity sintered (porous) materials composed of an orthorhombic perovskite-type phase. Next, charge discharge performances of the electrodes consisting of the sintered sample were investigated. The discharge capacity of Ca0.9Y0.1MnO3-δwas 185 mAh·g-1on the 1st cycling, and the 1st charging was possible by 130 mAh·g-1. However, the 2nd discharge capacity remarkably decreased to lower than 50 mAh·g-1. Considering no obvious charging property on the previous La-substituted sample of Ca0.9La0.1MnO3-δ, it would mean that change of the substituent for CaMnO3 affects the electrochemical property. The roll of lithium ions, the effect of the cut-off potential range on the cycle performance would be discussed leading to the charge/discharge results of the cell (-)Zn/LiOHaq./Ca0.9Y0.1MnO3-δ(+).
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