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Search Results: 1 - 10 of 2219 matches for " Masahiro Matsumura "
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How Do Weekly Magazines Provide Information on Urogenital Cancer to the Public in Aged Societies?  [PDF]
Masayoshi Nagata, Tomoko Matsumura, Masahiro Kami
Open Journal of Urology (OJU) , 2013, DOI: 10.4236/oju.2013.36045

Little information on cancer coverage rather than newspaper and television is available. Japanese weekly magazines have a circulation of over 2,700,000 per week. To examine how they delivered urogenital cancer information to the public, cancer-related articles and advertisements in six major Japanese weekly magazines from 2009 to 2010 was analyzed. 1.8% of total articles and advertisements were cancer-related. Prostate cancer (n = 119) was the second-most common topic, following lung cancer (n = 145), whereas only three articles were published on kidney or bladder cancer. The 53 articles on therapies for prostate cancer comprised radiotherapy (n = 29), surgery (n = 16), chemotherapy (n = 4), and others (n = 4). All 42 comments or interviews were cited in the article on prostate cancer, while 26 of them were attributed to only two famous doctors. Although cancer coverage in weekly magazines could be useful to spread information on prostate cancer, we should recognize their considerable bias based on a disproportionate emphasis.

Alteration of the Systemic and Microcirculation by a Single Oral Dose of Flavan-3-Ols
Kodai Ingawa, Nozomi Aruga, Yusuke Matsumura, Masahiro Shibata, Naomi Osakabe
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094853
Abstract: Several systematic reviews have reported that flow mediated dilatation (FMD) was significantly increased in subjects after ingestion of chocolate that contains flavan-3-ols; however, the mechanisms responsible for this effect are not clear. In this study, we evaluated the effects of a single oral dose of flavan-3-ols on the systemic circulation and microcirculation in the cremaster muscle using intravital video microscopy in vivo. The cremaster muscle in rats was spread over a plastic chamber and a gastric tube was placed into the stomach. Blood flow in the cremasteric artery was determined using a laser Doppler flowmeter, while blood pressure and heart rate were measured by the tail-cuff method. Red blood cell velocity in arterioles and blood flow in the artery were significantly increased 5 min after the administration of 10 mg/kg flavan-3-ols compared with distilled water treatment. The number of capillaries recruited in the cremaster muscle was also significantly increased 15 min after treatment. Microscopic observation confirmed that increased shear stress on endothelial cells was maintained during the measurement period. The mean arterial blood pressure and heart rate were also significantly elevated soon after administration and returned to baseline before the end of the observation period. Plasma nitrate and nitrite levels, and NO phosphorylation of aortic tissue were significantly increased at 60 min after administration of flavan-3-ols. According to these results, a single oral dose of flavan-3-ols elevates blood pressure and flow transiently, and these effects induce NO production through increased shear stress on endothelial cells.
Bacterial Cells as Model Factories  [PDF]
Ichiro Matsumura
American Journal of Operations Research (AJOR) , 2013, DOI: 10.4236/ajor.2013.31A007

Bacteria, like industrial engineers, must manage processes that convert low value inputs into high value outputs. Bacteria are not intelligent, so they utilize self-organizing production systems to accelerate life-sustaining chemical processes. Here I explore two questions. First, can businesses apply the principles of self-organization? Second, can operations researchers contribute to our understanding of biological systems? I explain biochemical concepts in plain terms, illustrated with a few informative laboratory evolution experiments, and describe the organizing principles that underlie complex biological systems. I describe the new disciplines of synthetic biology and metabolic engineering, which offer opportunities for interdisciplinary collaboration between life scientists and operations researchers.

Clinical and pathobiological heterogeneity of asthma—Mechanisms of severe and glucocorticoid-resistant asthma  [PDF]
Yasuhiro Matsumura
Health (Health) , 2013, DOI: 10.4236/health.2013.52A046

It is increasingly recognized that asthma represents a syndrome, and there is clinical and pathobiological heterogeneity. Many genes are reported to be associated with asthma, and may be involved in the disease heterogeneity. Diverse cells, such as T helper 1 (Th1)-cells, Th2-cells, Th17-cells, airway epithelial cells, and innate and adaptive immunity associated cells, contribute to the pathobiology of asthma independently of each other or they can also coexist and interact. Although, generally, Th2 immunity is important in most asthma endotypes, non- Th2-driven inflammation tends to be difficult to manage. Recently, increased attention has been focused on severe asthma and glucocorticoid (GC)-resistant (GC-R) asthma, in which diverse inflammatory processes may be involved. Treatment approaches should take into account pathological differences.

Improved Recovery of Exfoliated Colonocytes from Feces Using Newly Developed Immunomagnetic Beads
Yoshikatsu Koga,Masahiro Yasunaga,Satoshi Katayose,Yoshihiro Moriya,Takayuki Akasu,Shin Fujita,Seiichiro Yamamoto,Hideo Baba,Yasuhiro Matsumura
Gastroenterology Research and Practice , 2008, DOI: 10.1155/2008/605273
Abstract: We demonstrated the feasibility of a new methodology for isolating colonocytes from feces. To reduce costs and improve the recovery rate of colonocytes from feces, we attempted to develop new immunomagnetic beads. Several sizes of magnetic beads were prepared and tagged with a monoclonal antibody against EpCAM. We made several new monoclonal antibodies against EpCAM, and each monoclonal antibody was tagged to the magnetic beads. In the simulation, the most efficient recovery of HT-29 cells was obtained using the smallest size of beads. Also, beads tagged with a monoclonal antibody with a higher affinity against EpCAM had a higher recovery rate. Similar results were obtained when the smallest size of beads with the highest-affinity monoclonal antibody was applied to clinical samples. The newly developed immunomagnetic beads may be useful for isolating colorectal cancer cells from feces, enabling the cytological or molecular biological diagnosis of CRC.
Data mining of mental health issues of non-bone marrow donor siblings
Morihito Takita, Yuji Tanaka, Yuko Kodama, Naoko Murashige, Nobuyo Hatanaka, Yukiko Kishi, Tomoko Matsumura, Yukio Ohsawa, Masahiro Kami
Journal of Clinical Bioinformatics , 2011, DOI: 10.1186/2043-9113-1-19
Abstract: A 47-year-old woman whose younger sister had undergone allogenic hematopoietic stem cell transplantation 20 years earlier was interviewed as a NDS. The text data from the interview transcriptions was analyzed using Scenario Mapping. Four clusters of words and six keywords were identified. Upon review of the word clusters and keywords, both the subject and researchers noticed that the subject has had mental health issues since the disease onset to date with being a NDS. The issues have been alleviated by her family.This single subject study suggested the advantages of data mining in clinical follow-up for mental health issues of patients and/or their families.Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been established as a treatment for hematologic malignancies such as leukemia and malignant lymphoma and is the only way to cure patients with advanced stage hematologic malignancies [1,2]. In Japan, allo-HSCTs were conducted on 2,242 cases in 2008 with a total of 33% of donors for the allo-HSCTs being siblings or relatives [3]. Several reports demonstrated that donating bone marrow or hematopoietic stem cells in peripheral blood can affect the donor's safety and quality of life, thus the donor's safety and quality of life should be carefully considered during allo-HSCT [4,5].Undergoing allo-HSCT also increases the likelihood of patients and their families developing mental health issues [6-10]. Donor selection from relatives can occasionally cause psychological conflicts between a donor and other relatives, including non-donor siblings (NDS), which would result in difficult management for continuous medical follow-up. This is a practical concern but has not been well studied in previous reports [11,12].Data mining allows processing a large, multidisciplinary data set. Its effective applications into medical fields are highly desired since health care information has been dramatically increased and diversified [13,14]. Currently, the data mining
Forecasting Japan's Physician Shortage in 2035 as the First Full-Fledged Aged Society
Koichiro Yuji, Seiya Imoto, Rui Yamaguchi, Tomoko Matsumura, Naoko Murashige, Yuko Kodama, Satoru Minayo, Kohzoh Imai, Masahiro Kami
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050410
Abstract: Introduction Japan is rapidly becoming a full-fledged aged society, and physician shortage is a significant concern. The Japanese government has increased the number of medical school enrollments since 2008, but some researchers warn that this increase could lead to physician surplus in the future. It is unknown how many physicians will be required to accommodate future healthcare needs. Materials and Methods We simulated changes in age/sex composition of the population, fatalities (the number of fatalities for the consecutive five years), and number of physicians from 2010 to 2035. Two indicators were defined: fatalities per physician and fatalities by physician working hour, based on the data of the working hours of physicians for each tuple of sex and age groups. We estimated the necessary number of physicians in 2035 and the number of new physicians to maintain the indicator levels in 2010. Results The number of physicians per 1,000 population is predicted to rise from 2·00 in 2010 to 3·14 in 2035. The number of physicians aged 60 years or older is expected to increase from 55,375 (20% of physicians) to 141,711 (36%). In 2010 and 2035, fatalities per physician were 23·1 and 24·0 for the total population, and 13·9 and 19·2 for 75 years or older, respectively. Fatalities per physician working hour are predicted to rise from 0·128 to 0·138. If working hours are limited to 48 hours per week in 2035, the number of fatalities per physician working hour is expected to be 0·196, and the number of new physicians must be increased by 53% over the current pace. Discussion The number of physicians per population continues to rise, but the estimated supply will not fulfill the demand for healthcare in the aging society. Strategies to increase the number of physicians and improve working conditions are urgently needed.
Existence of Fine Structure inside Spin Gap in CeRu2Al10
Hiroshi Tanida,Daiki Tanaka,Masafumi Sera,Chikako Moriyoshi,Yoshihiro Kuroiwa,Tomoaki Takesaka,Takashi Nishioka,Harukazu Kato,Masahiro Matsumura
Physics , 2010,
Abstract: We investigate the magnetic field effect on the spin gap state in CeRu2Al10 by measuring the magnetization and electrical resistivity. We found that the magnetization curve for the magnetic field H//c shows a metamagnetic-like anomaly at H*~4 T below T_0=27 K, but no anomaly for H//a and H//b. A shoulder of the electrical resistivity at Ts~5 K for I//c is suppressed by applying a longitudinal magnetic field above 5 T. Many anomalies are also found in the magnetoresistance for Hkc below ~5 K. The obtained magnetic phase diagram consists of at least two or three phases below T_0. These results strongly indicate the existence of a fine structure at a low energy side in a spin gap state with the excitation energy of 8 meV recently observed in the inelastic neutron scattering experiments.
Anisotropic Transport Properties of CeRu$_2$Al$_{10}$
Hiroshi Tanida,Daiki Tanaka,Masafumi Sera,Chikako Moriyoshi,Yoshihiro Kuroiwa,Tomoaki Takesaka,Takashi Nishioka,Harukazu Kato,Masahiro Matsumura
Physics , 2010,
Abstract: We studied the transport properties of CeRu_2Al_10 single crystals. All the transport properties show largely anisotropic behaviors below T_0. Those along the a- and c-axes show similar behaviors, but are different from those along the b-axis. This suggests that the system could be viewed as a two-dimensional system. The results of the thermal conductivity and thermoelectric power could be explained by assuming the singlet ground state below T_0. However, the ground state is not simple but has some kind of structure within a spin gap.
Possible Long-Range Order with Singlet Ground State in CeRu2Al10
Hiroshi Tanida,Daiki Tanaka,Masafumi Sera,Chikako Moriyoshi,Yoshihiro Kuroiwa,Tomoaki Takesaka,Takashi Nishioka,Harukazu Kato,Masahiro Matsumura
Physics , 2010, DOI: 10.1143/JPSJ.79.043708
Abstract: We investigate the thermal and transport properties of CexLa1-xRu2Al10 to clarify the origin of the recently discovered mysterious phase below T0=27 K in CeRu2Al10 where a large magnetic entropy is released, however, the existence of an internal magnetic field is ruled out by 27Al-NQR measurement. We find that T0 decreases with decreasing x and disappears at x~0.45. T0 of CeRu2Al10 is suppressed down to 26 K under H=14.5 T along the a-axis. These results clearly indicate that the transition has a magnetic origin and is ascribed to the interaction between Ce ions. Considering the results of specific heat, magnetic susceptibility, thermal expansion, and electrical resistivity and also 27Al NQR, we propose that the transition originates from the singlet pair formation between Ce ions. Although its properties in a Ce dilute region is basically understood by the impurity Kondo effect, CeRu2Al10 shows a Kondo-semiconductor-like behavior. The phase transition at T0 may be characterized as a new type of phase transition that appears during the crossover from the dilute Kondo to the Kondo semiconductor.
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