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Search Results: 1 - 10 of 2069 matches for " Masahiko Kimura "
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EMI-Specific Performance Integrity of OS Migration (Teleportation) Over a Wireless Channel Such as WLAN
Yusuke Kimura,Masahiko Sano,Perambur S. Neelakanta
Advanced Computational Techniques in Electromagnetics , 2012, DOI: 10.5899/2012/acte-00120
Abstract: The performance aspects of OS migration implemented in a wireless LAN (WLAN) environment is investigated taking into account of underlying physical-layer based constraints due to EMI/RFI implications in the indoor operations. Specifically, the interfering effects of coexisting IEEE 802.11 devices on OS migration are analyzed {it via} spectrum spill-over effects and host-to-interferer separation. Basic models are presented thereof and computed results are furnished and discussed. While generic studies, for example, on wireless coexistence between IEEE 802.11 and IEEE 802.15.4 devices prevail, no such efforts {it per se} exist on the topic of WLAN supporting OS migration {it vis-à-vis} associated EMI/RFI related impairments in the teleportation. As such, this study can be regarded as a novel attempt.
Antitumor Effects and Acute Oral Toxicity Studies of a Plant Extract Mixture Containing Rhus verniciflua and Some Other Herbs  [PDF]
Wataru Hiruma, Kohei Suruga, Kazunari Kadokura, Tsuyoshi Tomita, Ayaka Miyata, Yoshihiro Sekino, Masahiko Kimura, Nobuo Yamaguchi, Yasuhiro Komatsu, C. A. Tony Buffington, Nobufumi Ono
Open Journal of Immunology (OJI) , 2015, DOI: 10.4236/oji.2015.51005
Abstract: A novel antitumor agent was developed from six kinds of herbs containing Rhus verniciflua (Rv-PEM01). The components were traditionally established for each formula for traditional medicine. The formula was designed to affect antitumor effect as well as maintain host immune functions. First, we investigated the antiproliferative activities of Rv-PEM01 on human and canine tumor cell lines in vitro, and on antitumor effects using BALB/cAJcl-nu/nu mice in vivo. Acute oral toxicity of Rv-PEM01 was also investigated in vivo in ddY mice. Rv-PEM01 exhibited antiproliferative activities against PC-3 (IC50: 0.328 ± 0.081 mg/ml), A549 (IC50: 0.520 ± 0.070 mg/ml), D-17 (IC50: 0.124 ± 0.037 mg/ml) and MRC-5 (IC50: 0.505 ± 0.058 mg/ml) cells. Luteolin 7-β-D-glucopyranoside and apigenin 7-β-D-glucopyranoside were identified as the main active compounds in Rv-PEM01 by HPLC analysis. The single dose toxicity study of Rv-PEM01 did not result in any deaths or abnor-malities in daily behavior, body weight gain, or anatomical observations at necropsy. Thus, so we could not calculate the 50% lethal dose (LD50) in mice, but it would be higher than 5.0 g/kg. Treat- ment with Rv-PEM01 at a dose of 2.5 g/kg tended to show antitumor activities on mice bearing Colon26 tumors compared with the control group. It was concluded that the formula was a safe antitumor agent with no side effects on mouse physiological function as judged by survival and organ weight.
Quantitative Evaluation of Compliance with Recommendation for Sulfonylurea Dose Co-Administered with DPP-4 Inhibitors in Japan
Tomomi Kimura,Kazuhito Shiosakai,Yasuaki Takeda,Shinji Takahashi,Masahiko Kobayashi,Motonobu Sakaguchi
Pharmaceutics , 2012, DOI: 10.3390/pharmaceutics4030479
Abstract: After the launch of dipeptidyl peptidase-4 (DPP-4), a new oral hypoglycemic drug (OHD), in December 2009, severe hypoglycemia cases were reported in Japan. Although the definite cause was unknown, co-administration with sulfonylureas (SU) was suspected as one of the potential risk factors. The Japan Association for Diabetes Education and Care (JADEC) released a recommendation in April 2010 to lower the dose of three major SUs (glimepiride, glibenclamide, and gliclazide) when adding a DPP-4 inhibitor. To evaluate the effectiveness of this risk minimization action along with labeling changes, dispensing records for 114,263 patients prescribed OHDs between December 2008 and December 2010 were identified in the Nihon-Chouzai pharmacy claims database. The adherence to the recommended dosing of SU co-prescribed with DPP-4 inhibitors increased from 46.3% before to 63.8% after the JADEC recommendation ( p < 0.01 by time-series analysis), while no change was found in those for SU monotherapy and SU with other OHD co-prescriptions. The adherence was significantly worse for those receiving a glibenclamide prescription. The JADEC recommendation, along with labeling changes, appeared to have a favorable effect on the risk minimization action in Japan. In these instances, a pharmacy claims database can be a useful tool to evaluate risk minimization actions.
Establishment of a new human osteosarcoma cell line, UTOS-1: cytogenetic characterization by array comparative genomic hybridization
Taketoshi Yasuda, Masahiko Kanamori, Shigeharu Nogami, Takeshi Hori, Takeshi Oya, Kayo Suzuki, Tomoatsu Kimura
Journal of Experimental & Clinical Cancer Research , 2009, DOI: 10.1186/1756-9966-28-26
Abstract: Osteosarcoma (OS) is the most common malignant bone tumor in adolescents and young adults, and is characterized by proliferation of tumor cells which produce osteoid or immature bone matrix. Despite recent advances in multimodality treatment consisting of aggressive adjuvant chemotherapy and wide local excision, pulmonary metastasis occurs in approximately 40 to 50% of patients with OS and remains a major cause of fatal outcome [1-3].There have been several reports describing xenotransplantation models of human OS [4-7], but characterization of human OS at the molecular cytogenetic level has been limited [8,9]. We describe the establishment and characterization of a new human OS cell line, designated as UTOS-1, derived from a conventional osteoblastic OS. In addition, we analyze chromosomal aberrations and DNA copy number changes in UTOS-1 by array comparative genomic hybridization (aCGH).An 18-year-old Japanese man noticed swelling and pain of the left shoulder for 2 months. Radiographs showed a periosteal reaction and an osteosclerotic change in the proximal metaphysis of the left humerus. An open biopsy of this humeral tumor confirmed that it was conventional osteoblastic OS (Figure 1). Immunohistochemically, most of the tumor cells were strongly positive for vimentin, alkaline phosphatase (ALP), osteopontin (OP), and osteocalcin (OC). Despite intensive chemotherapy, the patient died of lung metastasis 2 months after open biopsy. The present study was conducted after a human experimentation review by our ethics committee.To determine the tumorigenicity of the UTOS-1 cell line in vivo, 1 × 108 cells were washed, suspended in phosphate-buffered saline (PBS), and injected subcutaneously into the leg of 4-week-old male SCID mice (CB-17/Icrscid; Clea Japan Incorporation, Osaka, Japan). Also, tumor growth in vivo was measured by calculating tumor volume based on the measurement of 2 perpendicular diameters using a caliper [10]. The volume was estimated using the follow
Relationships between Cytokine Profiles and Signaling Pathways (IκB Kinase and p38 MAPK) in Parainfluenza Virus-Infected Lung Fibroblasts
Masakazu Yoshizumi,Hirokazu Kimura,Yoshimichi Okayama,Atsuyoshi Nishina,Masahiro Noda,Hiroyuki Tsukagoshi,Kunihisa Kozawa,Masahiko Kurabayashi
Frontiers in Microbiology , 2010, DOI: 10.3389/fmicb.2010.00124
Abstract: Respiratory viruses such as parainfluenza virus (PIV) in individuals with certain genetic predispositions in early life are associated with the induction of wheezing, which can progress to the development of asthma. It has been suggested that aberrant production of various cytokines due to viral infection are associated with virus-induced asthma. However, the mechanisms of how respiratory viruses induce and exacerbate asthma have yet to be clarified. To examine cytokine responses to PIV infection, we assessed 27 cytokine levels released from PIV-infected human fetal lung fibroblasts. In addition, we examined relationships between these cytokine responses and signaling pathways (IκB kinase and p38 MAPK) in PIV-infected cells. At 24 h after infection, PIV-infected cells significantly released a number of cytokines, namely, proinflammatory cytokines [interleukins (IL)-1β, IL-6, and tumor necrosis factor-α], anti-inflammatory cytokine (IL-1ra), Th1 cytokines (interferon-γ, and IL-2), Th2 cytokines (IL-4, IL-5, and IL-10), granulopoiesis-inducing cytokines (granulocyte colony-stimulating factor and granulocyte–macrophage colony-stimulating factor), neutrophil recruitment-inducing cytokines (IL-8 and interferon-inducible protein-10), and eosinophil recruitment-inducing cytokines (eotaxin and regulated on activation normal T-cell expressed and secreted). PIV infection enhanced phosphorylation of both IκB and p38 MAPK, but not Akt, in the cells. Signaling pathway inhibitors, BMS-345541 (a specific IκB kinase inhibitor) and SB203580 (a specific p38 MAPK inhibitor), significantly suppressed release of these cytokines from PIV-infected cells. The results indicate that PIV infection induces aberrant production and release of various cytokines through IκB kinase and p38 MAPK pathways in human lung fibroblasts. Overproduction and imbalance of these cytokines may be partially associated with the pathophysiology of virus-induced asthma.
Myxoid Liposarcoma-Associated EWSR1-DDIT3 Selectively Represses Osteoblastic and Chondrocytic Transcription in Multipotent Mesenchymal Cells
Kayo Suzuki, Yoshito Matsui, Mami Higashimoto, Yoshiharu Kawaguchi, Shoji Seki, Hiraku Motomura, Takeshi Hori, Yasuhito Yahara, Masahiko Kanamori, Tomoatsu Kimura
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0036682
Abstract: Background Liposarcomas are the most common class of soft tissue sarcomas, and myxoid liposarcoma is the second most common liposarcoma. EWSR1-DDIT3 is a chimeric fusion protein generated by the myxoid liposarcoma-specific chromosomal translocation t(12;22)(q13;q12). Current studies indicate that multipotent mesenchymal cells are the origin of sarcomas. The mechanism whereby EWSR1-DDIT3 contributes to the phenotypic selection of target cells during oncogenic transformation remains to be elucidated. Methodology/Principal Findings Reporter assays showed that the EWSR1-DDIT3 myxoid liposarcoma fusion protein, but not its wild-type counterparts EWSR1 and DDIT3, selectively repressed the transcriptional activity of cell lineage-specific marker genes in multipotent mesenchymal C3H10T1/2 cells. Specifically, the osteoblastic marker Opn promoter and chondrocytic marker Col11a2 promoter were repressed, while the adipocytic marker Ppar-γ2 promoter was not affected. Mutation analyses, transient ChIP assays, and treatment of cells with trichostatin A (a potent inhibitor of histone deacetylases) or 5-Aza-2′-deoxycytidine (a methylation-resistant cytosine homolog) revealed the possible molecular mechanisms underlying the above-mentioned selective transcriptional repression. The first is a genetic action of the EWSR1-DDIT3 fusion protein, which results in binding to the functional C/EBP site within Opn and Col11a2 promoters through interaction of its DNA-binding domain and subsequent interference with endogenous C/EBPβ function. Another possible mechanism is an epigenetic action of EWSR1-DDIT3, which enhances histone deacetylation, DNA methylation, and histone H3K9 trimethylation at the transcriptional repression site. We hypothesize that EWSR1-DDIT3-mediated transcriptional regulation may modulate the target cell lineage through target gene-specific genetic and epigenetic conversions. Conclusions/Significance This study elucidates the molecular mechanisms underlying EWSR1-DDIT3 fusion protein-mediated phenotypic selection of putative target multipotent mesenchymal cells during myxoid liposarcoma development. A better understanding of this process is fundamental to the elucidation of possible direct lineage reprogramming in oncogenic sarcoma transformation mediated by fusion proteins.
Factors Influencing the Development of “Purpose in Life”and Its Relationship to Coping with Mental Stress  [PDF]
Riichiro Ishida, Masahiko Okada
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.21005
Abstract: Factors influencing the development of purpose in life (PIL) were examined. Methods: We recruited 67 healthy students of Niigata University (34 males and 33 females, 18-35 years of age). PIL and approval motivation (AM), and memories of experiences (IME) were measured using the PIL test, Martin-Larsen Approval Motivation Scale (MLAM), and the Early Life and Youth Experiences Inventory. Confusion, heart rate, systolic blood pressure, and thumb-tip temperature were measured before and during “Evaluating-Integrating Words Task (EIWT).” Results: In the Profile of Mood States (POMS) tests, changes in the confusion scores were significantly higher in the weak PIL compared to the firm PIL group. The scores were significantly higher for the firm AM compared to the weak AM group. Changes in heart rate were significantly higher in the weak PIL compared to the firm PIL group. IME scores for memories of the beauty of nature, empathetic listening from parents and teachers were positively or negatively correlated with PIL test scores or MLAM scores for life stages: infancy, junior high school, and university. Conclusion: PIL and AM seemed to grow through the experiences of the beauty of nature and empathic understanding by parents and teachers during various developmental stages. Purpose in life had greater influence on emotional response and the autonomic nervous system response during psychological stress compared to approval motivation
The Function of Roots of Tea Plant (Camellia sinensis) Cultured by a Novel Form of Hydroponics and Soil Acidification  [PDF]
Kieko Saito, Masahiko Ikeda
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.35078
Abstract: A novel form of hydroponic culture was employed to explore the physiological function of roots of a tea plant (Camellia sinensis). The pH of the nutrient solution with an actively growing tea plant decreased during cultivation. Furthermore, no oxalic acid, tartaric acid, malic acid or citric acid, all possible factors in acidification, was detected in the nutrient solution of a growing plant. A proton pump inhibitor suppressed the acidification of the solution. Soil acidification might have been accelerated with a proton released from ammoniacal nitrogen preferentially for the growth, suggesting the specific mechanism of tea plant as a functional food.
A case of very late stent thrombosis after sirolimus-eluting stent implantation in a patient with provoked severe coronary spasm  [PDF]
Shigenori Ito, Masahiko Inomata
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.34A002
Abstract: A 73-year-old male patient suffered from very late stent thrombosis occurred 6 years after sirolimuseluting stent (SES) implantation in the ostial and proximal left anterior descending coronary artery (LAD). He presented emergently with cardiogenic shock and emergent coronary angiography showed thombus in the ostial stent and in the ostial left circumflex artery. Optical coherence tomography found delayed healing on the ostial stent. Acetylcholine provocation test had also shown severe provoked coronary spasm in all coronary arteries 28 months after SES implantation which suggested the association of severe coronary endothelial dysfunction as a potential mechanism of very late stent thrombosis.
Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients
Masahiro Mishina,Kiichi Ishiwata,Mika Naganawa,Yuichi Kimura,Shin Kitamura,Masahiko Suzuki,Masaya Hashimoto,Kenji Ishibashi,Keiichi Oda,Muneyuki Sakata,Makoto Hamamoto,Shiro Kobayashi,Yasuo Katayama,Kenji Ishii
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017338
Abstract: Adenosine A2A receptors (A2ARs) are thought to interact negatively with the dopamine D2 receptor (D2R), so selective A2AR antagonists have attracted attention as novel treatments for Parkinson's disease (PD). However, no information about the receptor in living patients with PD is available. The purpose of this study was to investigate the relationship between A2ARs and the dopaminergic system in the striata of drug-na?ve PD patients and PD patients with dyskinesia, and alteration of these receptors after antiparkinsonian therapy. We measured binding ability of striatal A2ARs using positron emission tomography (PET) with [7-methyl-11C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trime?thylxanthine([11C]TMSX) in nine drug-na?ve patients with PD, seven PD patients with mild dyskinesia and six elderly control subjects using PET. The patients and eight normal control subjects were also examined for binding ability of dopamine transporters and D2Rs. Seven of the drug-na?ve patients underwent a second series of PET scans following therapy. We found that the distribution volume ratio of A2ARs in the putamen were larger in the dyskinesic patients than in the control subjects (p<0.05, Tukey-Kramer post hoc test). In the drug-na?ve patients, the binding ability of the A2ARs in the putamen, but not in the head of caudate nucleus, was significantly lower on the more affected side than on the less affected side (p<0.05, paired t-test). In addition, the A2ARs were significantly increased after antiparkinsonian therapy in the bilateral putamen of the drug-na?ve patients (p<0.05, paired t-test) but not in the bilateral head of caudate nucleus. Our study demonstrated that the A2ARs in the putamen were increased in the PD patients with dyskinesia, and also suggest that the A2ARs in the putamen compensate for the asymmetrical decrease of dopamine in drug-na?ve PD patients and that antiparkinsonian therapy increases the A2ARs in the putamen. The A2ARs may play an important role in regulation of parkinsonism in PD.
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