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Search Results: 1 - 10 of 31 matches for " MaryBeth Shwayder "
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P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN)
Ann E. Walts,Juan Lechago,Bing Hu,MaryBeth Shwayder
Clinical Medicine : Pathology , 2008,
Abstract: Background: Significant variation is reported in the diagnosis of HPV-associated AIN. We previously observed that bandlike positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade AIN. This study was undertaken to determine if addition of p16 and Ki67 immunostaining would reduce inter- and intraobserver variability in diagnosis and grading of AIN.Design: H&E stained slides of 60 anal biopsies were reviewed by three pathologists and consensus diagnoses were achieved: 25 negative, 12 low (condyloma and/or AIN I) and 23 high (9 AIN II and 14 AIN III) grade lesions. The H&E stained slides were diagnosed independently by three additional (“participant”) pathologists. Several weeks later they re-examined these slides in conjunction with corresponding p16 and Ki67 immunostains.Results: Addition of p16 and Ki67 immunostains reduced intra- and interobserver variability, improved concurrence with consensus diagnoses and reduced two-step differences in diagnosis. Negative and high grade AIN diagnoses showed the most improvement in concurrence levels.Conclusion: Addition of p16 and Ki67 immunostains is helpful in the diagnosis and grading of AIN.
P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN)
Ann E. Walts, Juan Lechago, Bing Hu, MaryBeth Shwayder, Lynn Sandweiss and Shikha Bose
Clinical Medicine Insights: Pathology , 2012,
Abstract: Background: Significant variation is reported in the diagnosis of HPV-associated AIN. We previously observed that bandlike positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade AIN. This study was undertaken to determine if addition of p16 and Ki67 immunostaining would reduce inter- and intraobserver variability in diagnosis and grading of AIN. Design: H&E stained slides of 60 anal biopsies were reviewed by three pathologists and consensus diagnoses were achieved: 25 negative, 12 low (condyloma and/or AIN I) and 23 high (9 AIN II and 14 AIN III) grade lesions. The H&E stained slides were diagnosed independently by three additional (“participant”) pathologists. Several weeks later they re-examined these slides in conjunction with corresponding p16 and Ki67 immunostains. Results: Addition of p16 and Ki67 immunostains reduced intra- and interobserver variability, improved concurrence with consensus diagnoses and reduced two-step differences in diagnosis. Negative and high grade AIN diagnoses showed the most improvement in concurrence levels. Conclusion: Addition of p16 and Ki67 immunostains is helpful in the diagnosis and grading of AIN.
Engineering education in the wake of hurricane Katrina
Marybeth Lima
Journal of Biological Engineering , 2007, DOI: 10.1186/1754-1611-1-6
Abstract: Hurricane Katrina struck the gulf coast on August 29, 2005. This natural disaster catastrophically affected the U.S. gulf states and negatively impacted the entire country. My place of residence, Baton Rouge, Louisiana, survived hurricane Katrina with serious but non-catastrophic damage because the edge of the 40 mile wide eye of the storm passed 90 miles to the east of the city.I experienced many events analytically and from an engineering perspective, for example, the doubling of our city population, traffic gridlock, loss of communication (two days), loss of power (three days), and a gas shortage (none for five days, shortage for five weeks). Volunteering in the aftermath of Katrina provided many more experiences that were primarily emotional. I volunteered at the University of New Orleans satellite office that was established on the Louisiana State University (LSU) campus just after the hurricane. Employees were supposed to call in with contact information and their evacuation location; about half the calls I fielded were from relatives of the employees who were trying to ensure that their loved ones were okay. On the rare occasions that a loved one's relative had already contacted us, I could inform the caller that the person was safe, but I wasn't allowed to provide the person's phone number for liability reasons.School classrooms and boy and girl scout troops from all over the country sent school supplies for displaced children; while unpacking these supplies, our public school distribution team read heartfelt words of hope and kindness that frequently brought us to tears.The LSU AgCenter livestock barn, the Parker Coliseum, was turned into a holding area for pets evacuated from the storm. Of all my experiences, the wall of animals seeking people was the most poignant. While staring at approximately 150 Polaroid pictures of animals replete with their names and tags and the words OWNER MISSING printed on every photograph, I realized that I never would have con
Contextos comunitários favoráveis ao bem-estar
Shinn,Marybeth;
Análise Psicológica , 2007,
Abstract: this chapter identifies "context minimization error" as the tendency to ignore the impact of enduring neighbourhood and community contexts on human behaviour. the error has adverse consequences for understanding psychological processes and efforts at social change. the chapter describes a series of theoretical models of how neighbourhoods and community settings are associated with various aspects of human welfare and reviews evidence of associations of context with health, psychological distress, risk behaviours, psychological attitudes, and child development. it suggests that many psychological processes may play out differently in different contexts and that contextual factors interact with socio-cultural characteristics of individuals in predicting outcomes. people, in turn, can shape community contexts. a more sophisticated understanding of the effects of contexts depends on more sophisticated approaches to assessing them.
The Challenge of Copyright in the Digital Age
Marybeth Peters
La Propiedad Inmaterial , 2006,
Abstract: The author explains how the revolution in the way new technology can reproduce, disseminate, and store digital information, including copyrighted works, is truly a double-edged sword for authors and right-holders. The challenge of copyright in the digital age is to preserve the author’s and right-holder’s incentive to create new works and use new technologies to distribute them to users and consumers in the face of a huge competitive threat from the illicit use of technology by infringers. Finally, the author warns about the debate that new technologies often prompt about whether the set of exclusive rights granted to authors and right-holders should be modified, either with new or broadened rights or new or broadened exemptions, to continue to serve the purpose of copyright.
Hana Cervinkova, Playing Soldiers in Bohemia: An Ethnography of NATO Membership. Prague Studies in Sociocultural Anthropology 4, 2006, 161 pages.
Marybeth Peterson Ulrich
Journal of Power Institutions in Post-Soviet Societies , 2007,
Abstract: Hana Cervinkova’s ethnographic portrait of the Czech military in its “post-socialist” moment is a fascinating contribution to the literature on post-communist transitions. Not merely concerned with the provision of several anthropological descriptions of disappearing cultures, such as the obsolescent enlisted ranks and Air Force technicians expert in the mechanics of moth-balled Soviet aircraft, Cervinkova is determined to link the military’s post-socialist story to the Czech state’s own fort...
Pilot Scale Mill Characterization and Evaluation of Rice Bran Oil Concentration of Jazzman Rice  [PDF]
Rebecca Schramm, Grant Gonzalez, Nicole Walker, Marybeth Lima
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.612189
Abstract: The demand for aromatic rice has increased in the United States during the last two decades. Jazzman, the first US-bred jasmine-type rice variety, was released by the Louisiana State University (LSU) AgCenter Rice Research Station in 2008 to compete for a market share of jasmine-type rice. Jazzman, a long grain aromatic rice variety, was developed from a cross between Ahrent and an unreleased aromatic Chinese rice line 96a-8. In pre-release field tests and laboratory scale evaluation, Jazzman rice yield and milling quality compared favorably with two high-yielding and good-milling non-aromatic long grain varieties, Cypress and Cheniere. Pilot scale evaluation of Jazzman for milling quality supported laboratory scale evaluation while providing additional data for milling optimization. Pilot scale milling uses larger rice samples than laboratory scale testing and employs a continuous process instead of the batch process used at laboratory scale. As a result, pilot scale milling offers more comprehensive information regarding the milling yield and quality of rice varieties as they are considered for industrial scale release. Another consideration for new rice varieties involves their potential for value-added processing, in which waste streams during processing can be used to create valuable products. The oil from rice bran is one such product. The objective of this study was to use pilot scale milling to determine the potential of Jazzman for industrial scale release, including its potential for value-added processing. Results showed that bran was easily removed during milling; the head rice recovery ranged from 66% to 74% as a function of milling flow rate. Water polishing had little effect on head rice recovery, but improved the final degree of milling (DOM) to a commercially acceptable level of 87 - 90. Additionally, rice bran oil concentration decreased as pilot scale flow rate increased, indicating that oil was concentrated in the outer bran layer of Jazzman. Pilot scale milling shows that Jazzman is a high-yielding and good-milling aromatic long grain rice variety.
Rate of Improvement following Volar Plate Open Reduction and Internal Fixation of Distal Radius Fractures
Chris Dillingham,MaryBeth Horodyski,Aimee M. Struk,Thomas Wright
Advances in Orthopedics , 2011, DOI: 10.4061/2011/565642
Abstract: Purpose. To determine recovery timeline of unstable distal radius fractures treated by open reduction and internal fixation with a locking volar plate. Methods. Data was collected prospectively on a consecutive series of twenty-seven patients during routine post-operative visits at 2 and 6 weeks, and 3, 6, 12 and 24 months. Range of motion measures and grip strength for both wrists were recorded. Results. Greatest gains were made within the first 3 months after surgery. Supination and pronation returned more quickly than flexion or extension, with supination and pronation both at 92% of the uninjured wrist at 3 months. Only flexion improved significantly between 3 and 6 months. All wrist motions showed some improvement until 1 year. Grip strength returned to 94% of the uninjured wrist by 12 months. Conclusions. Range of motion improvement will be greatest between 2 weeks and 3 months, with improvement continuing until 12 months. Grip strength should return to near normal by one year. Function and pain will improve, but not return to normal by the end of 12 months. Clinical Relevance. These results provide the surgeon with information that can be shared with patients on the anticipated timeline for normal recovery of function and strength.
Transposon Excision from an Atypical Site: A Mechanism of Evolution of Novel Transposable Elements
Marybeth Langer, Lynn F. Sniderhan, Ueli Grossniklaus, Animesh Ray
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000965
Abstract: The role of transposable elements in sculpting the genome is well appreciated but remains poorly understood. Some organisms, such as humans, do not have active transposons; however, transposable elements were presumably active in their ancestral genomes. Of specific interest is whether the DNA surrounding the sites of transposon excision become recombinogenic, thus bringing about homologous recombination. Previous studies in maize and Drosophila have provided conflicting evidence on whether transposon excision is correlated with homologous recombination. Here we take advantage of an atypical Dissociation (Ds) element, a maize transposon that can be mobilized by the Ac transposase gene in Arabidopsis thaliana, to address questions on the mechanism of Ds excision. This atypical Ds element contains an adjacent 598 base pairs (bp) inverted repeat; the element was allowed to excise by the introduction of an unlinked Ac transposase source through mating. Footprints at the excision site suggest a micro-homology mediated non-homologous end joining reminiscent of V(D)J recombination involving the formation of intra-helix 3′ to 5′ trans-esterification as an intermediate, a mechanism consistent with previous observations in maize, Antirrhinum and in certain insects. The proposed mechanism suggests that the broken chromosome at the excision site should not allow recombinational interaction with the homologous chromosome, and that the linked inverted repeat should also be mobilizable. To test the first prediction, we measured recombination of flanking chromosomal arms selected for the excision of Ds. In congruence with the model, Ds excision did not influence crossover recombination. Furthermore, evidence for correlated movement of the adjacent inverted repeat sequence is presented; its origin and movement suggest a novel mechanism for the evolution of repeated elements. Taken together these results suggest that the movement of transposable elements themselves may not directly influence linkage. Possibility remains, however, for novel repeated DNA sequences produced as a consequence of transposon movement to influence crossover in subsequent generations.
Fractionation of the rice bran layer and quantification of vitamin E, oryzanol, protein, and rice bran saccharide
Rebecca Schramm, Alicia Abadie, Na Hua, Zhimin Xu, Marybeth Lima
Journal of Biological Engineering , 2007, DOI: 10.1186/1754-1611-1-9
Abstract: The importance of rice to the world population's dietary requirement is evident from its presence in the diet of a quarter of the world's people [1]. Rice processing or milling produces several streams of material, including husks, milled rice, and bran. In the United States, rice bran material is considered a by-product of the milling process and is most commonly used in animal feed or as a food ingredient due to its high nutritional content [2].As interest in value-added processing research grows, attempts are being made to increase the value of agricultural crop by-products, including rice bran, by increasing their pharmaceutical or nutraceutical potential. While rice bran has traditionally been utilized for pet food products [3], there is growing interest in the wide array of potentially human-health enhancing compounds found in rice bran. Rice bran is a good source of antioxidants including vitamin E and oryzanol, high quality oil and protein, and cholesterol-lowering waxes and anti-tumor compounds like rice bran saccharide [4-6]. Value-added processing to obtain these phytochemicals has the potential to be an important way of improving human health while increasing economic rates of return.In the unsaponifiable portion of rice bran oil, two groups of antioxidant compounds were identified as tocotrienols and gamma (γ)-oryzanol [7]. Tocotrienols, which are members of the vitamin E family, and γ-oryzanol, have been studied for potential health benefits [7]. Epidemiological studies have shown that antioxidants reduce oxidative damage to bimolecular structures that play a role in the prevention of chronic diseases. Antioxidants may help slow the onset of diabetes and Alzheimer's disease, and appear to play a role in the prevention of heart disease and cancer [8]. Tocotrienols have been shown to address free radicals in cell membranes and help in the prevention of coronary artery disease; γ-oryzanol (oryzanol) has been shown to lower blood cholesterol and to reduce
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