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Search Results: 1 - 10 of 436600 matches for " Mary M. Y. Waye "
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The Genetic and Environmental Foundation of the Simple View of Reading in Chinese
Connie Suk-Han Ho, Bonnie Wing-Yin Chow, Simpson Wai-Lap Wong, Mary M. Y. Waye, Dorothy V. M. Bishop
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047872
Abstract: The Simple View of Reading (SVR) in Chinese was examined in a genetically sensitive design. A total of 270 pairs of Chinese twins (190 pairs of monozygotic twins and 80 pairs of same-sex dizygotic twins) were tested on Chinese vocabulary and word reading at the mean age 7.8 years and reading comprehension of sentences and passages one year later. Results of behavior-genetic analyses showed that both vocabulary and word reading had significant independent genetic influences on reading comprehension, and the two factors together accounted for most but not all of the genetic influences on reading comprehension. In addition, sentence comprehension had a stronger genetic correlation with word reading while passage comprehension showed a trend of stronger genetic overlap with vocabulary. These findings suggest that the genetic foundation of the SVR in Chinese is largely supported in that language comprehension and decoding are two core skills for reading comprehension in nonalphabetic as well as alphabetic written languages.
Genetic and Environmental Influences on Chinese Language and Reading Abilities
Bonnie Wing-Yin Chow,Connie Suk-Han Ho,Simpson Wai-Lap Wong,Mary M. Y. Waye,Dorothy V. M. Bishop
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016640
Abstract: This study investigated the etiology of individual differences in Chinese language and reading skills in 312 typically developing Chinese twin pairs aged from 3 to 11 years (228 pairs of monozygotic twins and 84 pairs of dizygotic twins; 166 male pairs and 146 female pairs). Children were individually given tasks of Chinese word reading, receptive vocabulary, phonological memory, tone awareness, syllable and rhyme awareness, rapid automatized naming, morphological awareness and orthographic skills, and Raven's Coloured Progressive Matrices. All analyses controlled for the effects of age. There were moderate to substantial genetic influences on word reading, tone awareness, phonological memory, morphological awareness and rapid automatized naming (estimates ranged from .42 to .73), while shared environment exerted moderate to strong effects on receptive vocabulary, syllable and rhyme awareness and orthographic skills (estimates ranged from .35 to .63). Results were largely unchanged when scores were adjusted for nonverbal reasoning as well as age. Findings of this study are mostly similar to those found for English, a language with very different characteristics, and suggest the universality of genetic and environmental influences across languages.
Anti-Viral Drugs for Human Adenoviruses
Mary Miu Yee Waye,Chor Wing Sing
Pharmaceuticals , 2010, DOI: 10.3390/ph3103343
Abstract: There are many stages in the development of a new drug for viral infection and such processes are even further complicated for adenovirus by the fact that there are at least 51 serotypes, forming six distinct groups (A–F), with different degree of infectivity. This review attempts to address the importance of developing pharmaceuticals for adenovirus and also review recent development in drug discovery for adenovirus, including newer strategies such as microRNA approaches. Different drug screening strategies will also be discussed.
Retrieval of snow Specific Surface Area (SSA) from MODIS data in mountainous regions
A. Mary,M. Dumont,J.-P. Dedieu,Y. Durand
The Cryosphere Discussions , 2012, DOI: 10.5194/tcd-6-1915-2012
Abstract: This study describes a method to retrieve snow specific surface area (SSA) from satellite radiance reasurements in mountainous terrain. It aims at comparing different retrieval methods and at addressing topographic corrections of reflectance, namely slope and aspect of terrain and multiple reflections on neighbouring slopes. We use an iterative algorithm to compute reflectance from radiance of the MODerate resolution Imaging Spectrometer (MODIS) with a comprehensive correction of local illumination with regards to topography. The retrieved SSA is compared to the results of the snowpack model Crocus, fed by driving data from the SAFRAN meteorological analysis, over a large domain in the French Alps. We compared SSA retrievals with and without topographic or anisotropy correction, and with a spherical or non-spherical snow reflectance model. The topographic correction enables SSA to be retrieved in better agreement with those from SAFRAN-Crocus. The root mean square deviation is 10.0 m2 kg 1 and the bias is 0.6 m2 kg 1, over 3829 pixels representing seven different dates and snow conditions. The standard deviation of MODIS retrieved data, larger than the one of SAFRAN-Crocus estimates, is responsible for half this RMSD. It is due to the topographic classes used by SAFRAN-Crocus. In addition, MODIS retrieved data show SSA gradients with elevation and solar exposition, physically consistent and in good agreement with SAFRAN-Crocus.
Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children
Cadmon KP Lim, Connie SH Ho, Crystal HN Chou, Mary MY Waye
Behavioral and Brain Functions , 2011, DOI: 10.1186/1744-9081-7-16
Abstract: Eight single nucleotide polymorphisms (SNPs) were genotyped from three hundred and ninety three individuals from 131 Chinese families with two which have been reported in the literature and six tag SNPs at DYX1C1. Analysis for allelic and haplotypic associations was performed with the UNPHASED program and multiple testing was corrected using false discovery rates. We replicated the previously reported association of rs3743205 in Chinese children with dyslexia (pcorrected = 0.0072). This SNP was also associated with rapid naming, phonological memory and orthographic skills in quantitative trait analysis.Our findings suggest that DYX1C1 is associated with dyslexia in people of Chinese ethnicity in Hong Kong.Developmental dyslexia (DD) is a learning disability that is characterized by difficulties in the acquisition of reading and spelling skills independent of intelligence, motivation or schooling. It is the most common form of learning disability (about 80% of learning disabilities is due to dyslexia) and affects about 5-10% of school children worldwide [1,2]. Studies delineating genetic factors in developmental dyslexia have identified several putative loci (DYX1 - DYX9) and candidate genes (KIAA0319, DYX1C1, DCDC2 and ROBO1) [3]. Recently, associations with the MRPL19/C2ORF3 genes of DYX3 locus, KIAA0319L of DYX8 locus and GRIN2B gene have also been reported [4-6].DYX1C1 is the first candidate susceptibility gene of dyslexia to be identified. A cytogenetic study revealed that two chromosome translocations [t(2;15)(q11;q21) and t(2;15)(q13;q22)] in the DYX1 locus co-segregated with dyslexia [7]. Taipale et al. [8] confirmed these translocations in another dyslexic cohort, and further reported two functional variants -3G/A (rs3743205) and 1249G/T in DYX1C1 associated with dyslexia. Rare variant -3A was proposed to be able to alter the Elk-1 transcription factor binding site and affect translation initiation, while 1249T caused a nucleotide transversion to result in a
Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia
Mary Terry, Alfred I Neugut, Mahesh Mansukhani, Jerome Waye, Noam Harpaz, Hanina Hibshoosh
BMC Cancer , 2003, DOI: 10.1186/1471-2407-3-29
Abstract: We examined p53 status, as measured by protein overexpression, in 157 cases with early colorectal neoplasia selected from three New York City colonoscopy clinics. After collecting paraffin-embedded tissue blocks, immunohistochemistry was performed using an anti-p53 monoclonal mouse IgG2a [BP53-12-1] antibody. We analyzed whether p53 status was different for risk factors for colorectal neoplasia relative to a polyp-free control group (n = 508).p53 overexpression was found in 10.3%, 21.7%, and 34.9%, of adenomatous polyps, CIS, and intramucosal cases, respectively. Over 90% of the tumors with p53 overexpression were located in the distal colon and rectum. Heavy cigarette smoking (30+ years) was associated with cases not overexpressing p53 (OR = 1.8, 95% CI = 1.1–2.9) but not with those cases overexpressing p53 (OR = 1.0, 95% CI = 0.4–2.6). Heavy beer consumption (8+ bottles per week) was associated with cases overexpressing p53 (OR = 4.0, 95% CI = 1.3–12.0) but not with cases without p53 overexpression (OR = 1.6, 95% CI = 0.7–3.7).Our findings that p53 overexpression in early colorectal neoplasia may be positively associated with alcohol intake and inversely associated with cigarette smoking are consistent with those of several studies of p53 expression and invasive cancer, and suggest that there may be relationships of smoking and alcohol with p53 early in the adenoma to carcinoma sequence.The molecular model of genetic changes along the colorectal adenoma-carcinoma sequence, first described by Vogelstein and colleagues, has become the framework for understanding the timing and role multiple mutations and genetic alterations play in carcinogenesis [1]. It is thought that multiple mutations are needed for invasive cancer [1-4]. Although the number of mutations and not their order has been found to be paramount, there are general trends in terms of timing in the sequence. Of more common genes important to colorectal carcinogenesis (e.g., APC, K-ras, and p53), most data
Dimensions of child punishment in two Central American countries: Guatemala and El Salvador
Speizer,Ilene S.; Goodwin,Mary M.; Samandari,Ghazaleh; Kim,Shin Y.; Clyde,Maureen;
Revista Panamericana de Salud Pública , 2008, DOI: 10.1590/S1020-49892008000400004
Abstract: objective: severe physical punishment of children is an important issue in international child health and welfare. this study examines such punishment in guatemala and el salvador. methods: data came from nationally representative surveys of women aged 15-49 and men aged 15-59 residing in guatemala (2002) and el salvador (2002-2003). the surveys included questions about punishment experienced during childhood, with response options ranging from verbal scolding to beating. in guatemala, parents were asked how they disciplined their children; questions allowed them to compare how they were punished in their childhood with how they punished their own children. bivariate and multivariate analyses are presented. results: in guatemala, 35% of women and 46% of men reported being beaten as punishment in childhood; in el salvador, the figures were 42% and 62%, respectively. in both countries, older participants were relatively more likely than younger participants to have been beaten as children. witnessing familial violence was associated with an increased risk of being beaten in childhood. in guatemala, having experienced physical punishment as a child increased the chance that parents would use physical punishment on their own children. multivariate analyses revealed that women who were beaten in childhood were significantly more likely in both countries to be in a violent relationship. conclusions: the use of beating to physically punish children is a common problem in guatemala and el salvador, with generational and intergenerational effects. its negative and lingering effects necessitate the introduction of policies and programs to decrease this behavior.
Vibrational Spectroscopic Studies and Computational Study of 1,2-Diphenyl-4-n-Butyl-3,5-Pyrazolidinedione
C. Yohannan Panicker,M. R. Anoop,P.S.Binil,Sheena Mary Y
International Journal of Industrial Chemistry , 2011,
Abstract: FT-IR and FT-Raman spectra of 1,2-diphenyl-4-n-Butyl-3,5-pyrazolidinedione (Phenylbutazone) were recorded and analyzed. The vibrational wavenumbers were computed using HF/6-31G(d) and B3LYP/6-31G(d) basis sets and compared with experimental data. The first hyperpolarizability, infrared intensities and Raman activities are also reported. The geometrical parameters of the title compound obtained from theoretical calculations are in agreement with that of reported similar derivatives. The first hyperpolarizability is comparable with reported values of similar derivatives and is an attractive molecule for future applications in non-linear optics. The variation in C-N bond lengths suggests an extended π-electron delocalization over the pyrazolidinedione moiety which is responsible for the nonlinearity of the molecule.
FT-IR, FT-Raman and Computational Study of Ethyl Methyl Ketone Semicarbazone
P. S. Binil,M. R. Anoop,Sheena Mary Y.,Hema Tresa Varghese
International Journal of Industrial Chemistry , 2011,
Abstract: FT-IR and FT-Raman spectra of ethyl methyl ketone semicarbazone were recorded and analyzed. The vibrational wavenumbers were computed using HF/6-31G*, B3PW91/6-31G* and B3LYP/6-31G* basis and compared with experimental data. The first hyperpolarizability, infrared intensities and Raman activities are reported. The calculated first hyperpolarizability is comparable with the reported values of similar derivatives and is an attractive object for future studies of non-linear optics. The extended π-electron delocalization over the carbazone moiety is responsible for the nonlinearity of the molecule. The geometrical parameters of the title compound are in agreement with that of similar derivatives. The red shift of the NH stretching wavenumber in the infrared spectrum from the computed wavenumber indicates the weakening of the NH bond resulting in proton transfer to the neighboring oxygen atom.
Colonoscopic Polypectomy
Jerome D. Waye
Diagnostic and Therapeutic Endoscopy , 2000, DOI: 10.1155/dte.6.111
Abstract: Colonoscopic polypectomy is a major advance in the therapy of colon neoplasms. The techniques for safe and efficient polyp removal are described. The uses of a variety of ancillary devices are discussed, including clips, loops, submucosal injection of fluid, and several thermal probes, including the argon plasma coagulator. The location of a lesion may be difficult to ascertain by intracolonic landmarks, but can be more precisely determined by X-ray, magnetic imaging, or intraoperative colonoscopy. Alternatively, it is possible to permanently mark the site of polyp removal with a carbon particle submucosal injection to facilitate subsequent localization either by surgery or interval colonoscopy.
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