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Search Results: 1 - 10 of 2496 matches for " Marwa Taha Mostafa Sarg "
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Efficient Utilization of 6-Aminouracil to Synthesize Fused and Related Heterocyclic Compounds and Their Evaluation as Prostate Cytotoxic Agents with Cathepsin B Inhibition  [PDF]
Marwa Taha Mostafa Sarg, Shereen Said El-Shaer
Open Journal of Medicinal Chemistry (OJMC) , 2014, DOI: 10.4236/ojmc.2014.42003
Abstract:
6-aminouracil 1 was utilized to introduce different heterocyclic rings at C-6 position through various synthetic strategies. The synthesized compounds bear rings that are either directly attached to the uracil back bone as in compounds 6, 12a-c and 15, or attached through an amino bridge as compounds 3a-c, 5a, b, 7a, b, 9 and 10, or through an imino bridge as compound 18. Also, compounds 4, 8, 11a-c, 14, 16 and 17 bearing biologically active side chains were synthesized. In addition to, compounds 13, 19, 20, 21 and 22 bear fused rings to the uracil backbone. All synthesized compounds were evaluated for their anticancer activity against prostate PC3 cell line using in-vitro sulforhodamine-B (SRB) method, from which compounds 3a, c, 4, 5a, b, 6, 7a, b, 11a-c, 12a, b, 17 and 20 were the most active. These active compounds were further evaluated for their ability to inhibit cathepsin B enzyme by using enzyme-linked immunosorbent assay, which revealed that compounds 5a, b, 7a, 11a, 12a and 17 exhibited more than 50% inhibition of cathepsin B. Among which the phenyl thiourea derivative 17 was the most active exhibiting 82.3% inhibition, while the reference doxorubicin exerted 18.7% inhibition.
Utility of 2-Methyl-quinazolin-4(3H)-one in the Synthesis of Heterocyclic Compounds with Anticancer Activity  [PDF]
Aisha Youssif Hassan Helali, Marwa Taha Mostafa Sarg, Makarem Mohamed Said Koraa, Mona Said Fathy El-Zoghbi
Open Journal of Medicinal Chemistry (OJMC) , 2014, DOI: 10.4236/ojmc.2014.41002
Abstract:
Quinolino[2,1-b]quinazolines 3 and 4, pyrrolo[2,1-b]quinazoline 5 and various substituted 2-(4-chlorostyryl)quinazoline derivatives including: 4-amino derivative 8, 4-hydrazino derivative 9, thiourea derivative 10, thiosemicarbazide derivative 19, 4-benzylidene hydrazinyl derivative 21, 4-amino thiazolidene derivatives 11, 12, 13, 22, imidazoquinazolines 15, 16, quinazolinium chloride 14, triazino[4,3-c]quinazolines 17, 18, tetrazino[1,6-c]quinazoline 20, 4-amino azetidinyl derivative 23, triazolo[4,3-c]quinazoline 24, 4-amino substituted quinazolines 25, 26, 27, 29 and quinazolino quinazoline 28 were synthesized through different chemical reactions. The obtained compounds were evaluated for their in vitro antitumor activity against HEPG2 and MCF-7 cell lines compared to the reference drug (doxorubicin). Compounds 18, 19, 20, 23 and 24 were found to be the most active against both cell lines exhibiting IC50 values ranging from 10.82 - 29.46 μM/L and 7.09 - 31.85 μM/L against Hep-G2 and MCF-7 cell lines, respectively, in addition to docking study of these five compounds against thymidylate synthase and dihydrofolate reductase enzymes active sites.
Supra-Tentorial Cortical Ependymoma in an Adult: Case Report and Review of the Literature  [PDF]
Shaymaa Al Umran, Mahmoud Taha, Marwa Abdulkader
Open Journal of Modern Neurosurgery (OJMN) , 2018, DOI: 10.4236/ojmn.2018.84032
Abstract: Supratentorial cortical ependymoma is a rare primary brain tumor in adults. Only 50 cases are reported in the literature including pediatric and adult patients. We report a 30-year-old male with sensory-type seizures who was found to have a right posterior frontal cortical lesion with large cystic component. The lesion was resected completely and histopathology and immunohistochemistry examinations confirmed anaplastic ependymoma WHO grade III. The patient received radiotherapy treatment post-surgery, and he was tumor free one year after treatment.
Human Cytomegalovirus Infection Enhances NF-κB/p65 Signaling in Inflammatory Breast Cancer Patients
Mohamed El-Shinawi, Hossam Taha Mohamed, Eslam A. El-Ghonaimy, Marwa Tantawy, Amal Younis, Robert J. Schneider, Mona Mostafa Mohamed
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055755
Abstract: Human Cytomegalovirus (HCMV) is an endemic herpes virus that re-emerges in cancer patients enhancing oncogenic potential. Recent studies have shown that HCMV infection is associated with certain types of cancer morbidity such as glioblastoma. Although HCMV has been detected in breast cancer tissues, its role, if any, in the etiology of specific forms of breast cancer has not been investigated. In the present study we investigated the presence of HCMV infection in inflammatory breast cancer (IBC), a rapidly progressing form of breast cancer characterized by specific molecular signature. We screened for anti-CMV IgG antibodies in peripheral blood of 49 non-IBC invasive ductal carcinoma (IDC) and 28 IBC patients. In addition, we screened for HCMV-DNA in postsurgical cancer and non-cancer breast tissues of non-IBC and IBC patients. We also tested whether HCMV infection can modulate the expression and activation of transcriptional factor NF-κB/p65, a hallmark of IBC. Our results reveal that IBC patients are characterized by a statistically significant increase in HCMV IgG antibody titers compared to non-IBC patients. HCMV-DNA was significantly detected in cancer tissues than in the adjacent non-carcinoma tissues of IBC and IDC, and IBC cancer tissues were significantly more infected with HCMV-DNA compared to IDC. Further, HCMV sequence analysis detected different HCMV strains in IBC patients tissues, but not in the IDC specimens. Moreover, HCMV-infected IBC cancer tissues were found to be enhanced in NF-κB/p65 signaling compared to non-IBC patients. The present results demonstrated a correlation between HCMV infection and IBC. Etiology and causality of HCMV infection with IBC now needs to be rigorously examined.
Recent Techniques in Management of Lumbosacral Region Tumours: A Prospective Comparative Study  [PDF]
Mostafa Abd Elsamea, Mohamed Shaaban, Ahmed Taha
Open Journal of Modern Neurosurgery (OJMN) , 2018, DOI: 10.4236/ojmn.2018.82020
Abstract:

Background: The lumbosacral plexus consists of the ventral rami from the L2 to S3 nerve roots, with some additions from the L1 and S4 nerve roots as well. The standard treatment for spinal cord compression is urgent surgically decompressive laminectomy over the affected level with resection as much as possible of the exposed tumor to relieve the cord compression. We aim to correlate the impact of preoperative clinical picture, duration of symptoms, and the pathological nature of the lumbo-sacral spine tumors on the outcome of comparative study different modalities of management. Patients and Methods: During the period between 2015 and 2017, thirty cases were studied and surgically managed in Al-Azhar University Hospital, Damietta. Cases were selected for surgery if they were diagnosed as having a symptomatizing lumbosacral lesion. Results: Thirty patients were included in the current study; the commonest lesion in this study was ependymoma eight patients (27%), astrocytoma six patients (20%), and meningioma five patients (17%). Nerve sheath tumor comprised five cases (17%) with the hemangioblastomas three cases (10%), epidermoid one case (3%), and ependymoma of the filum terminale two cases (6%). The mean age of the included patients was 38.96 ± 15.42. The mean duration of lesions was 13.66 ± 10.93. They were 15 male patients (50%), and 15 female patients (50%), with male: female ratio 1:1. The mean duration of symptoms ranged for 1:60 months. The most common presenting manifestations were sensory followed by motor and sphinctric disturbance. Complications occurred in 8 patients (23%), and the most common was postoperative CSF leak. 19 out of 30 cases were surgically totally resected (63%), while 11 cases (37%) were grossly totally resected. Conclusions: Ependymoma and meningioma have more favorable outcome compared to other spinal tumors. Accurate and rapid diagnosis prior to surgery also associated with good outcome.

Dysexecutive Performance of Elderly Patients with Chronic Hepatitis C Virus Infection  [PDF]
Tomader Taha Abdel Rahman, Marwa Abdel Azeem Abdel Guaad, Ahmad Kamel Mortagy
Advances in Aging Research (AAR) , 2014, DOI: 10.4236/aar.2014.34037
Abstract:

Chronic infection with hepatitis C virus (HCV) is one of the most important causes of chronic liver disease, which can progress to cirrhosis and hepatocellular carcinoma (HCC). It is well established that advanced forms of the disease are accompanied by overt and global cognitive deficits (hepatic encephalopathy) but now there is a growing evidence that the alterations in cerebral function in patients with chronic HCV infection may appear long before the development of severe liver cirrhosis, it has been hypothesized that it is related to a direct effect of HCV on the brain; or the neurotoxic effect of HCV-related systemic inflammation. The purpose of the study was to assess the possible existence of executive dysfunction in chronic HCV infected patients. One hundred elderly patients aged 60 years and above agreed to participate in this study; 50 patients were HCV positive (cases) and 50 patients were HCV negative (controls). All participants were subjected to the following: diagnosis of HCV by detection of HCV antibodies using ELISA technique, non-invasive assessment of liver condition, and evaluation of executive functions using 5 neuropsychological tests. The study showed that there was a significant difference between cases and controls regarding 2 executive function tests related to the phonological loop component of working memory among HCV positive patients. The study concluded that chronic HCV infection is accompanied by dysexecutive performance.

Volumetric Assessment of Corticospinal Tract Infiltration by Astrocytoma Using Diffusion Tensor Tractography  [PDF]
Marwa Adel Shaaban, Taha Kamel Alloush, Mohamed Hamdy Ibrahim, Ahmed Abd el bar, Sherif Hashim Morad
Open Journal of Medical Imaging (OJMI) , 2014, DOI: 10.4236/ojmi.2014.42009
Abstract:
Objectives: The aim of the study is to assess volumetric Corticospinal Tract infiltration by Astro-cytoma using Diffusion Tensor Tractography. Material and Methods: Preoperative, anatomic (T1- and T2-weighted) and diffusion tensor MRI were performed in 9 patients with supratentorial gliomas (WHO grade II and III). The tumors were manually segmented from the T1- and T2-weighted MRI, and their volume calculated. A three-dimensional tractography was performed in each case. A second segmentation and volume measurement was performed on the tumor regions intersecting adjacent white matter fiber tracts. Results: We identified that white matter tracts were infiltrated by 6 Astrocytoma tumors. The median tumor volume (±standard deviation) in our patient population was 33 ± 26.82 ml. The median tumor volume (±standard deviation) infiltrating white matter fiber tracts was 4.15 ± 9.23 ml. The median fraction of tumor volume infiltrating white matter fiber tracts was 26.3% ± 10.1%. Conclusions: Diffusion tensor MR Tractography is a reliable preoperative assessment tool since it detects extensive white matter infiltration by Astrocytoma irrespective of brain tumors volume. Recommendations: Prospective large population studies are required to clarify how infiltration relates to tumor location.
Green Synthesis of New Tetra Schiff Bases and Bis-Azo Bis-Schiff Bases Derived from 2,6-Diaminopyridine as Promising Photosensitizers  [PDF]
Nihad I. Taha, Nashwan O. Tapabashi, Marwa N. El-Subeyhi
International Journal of Organic Chemistry (IJOC) , 2018, DOI: 10.4236/ijoc.2018.83023
Abstract: Nine new tetra Schiff bases (M2 - M9) were prepared in moderate yields via the condensation of different aromatic amines and bis-Schiff base (M1) in microwave synthesizer. Also five new azo-Schiff bases (M16 - M20) were prepared by the condensation of (M1) with the azo-salicylaldehyde (M11 - M15) using the same method. The green synthesis by microwave irradiation was chosen as route due to its novelty, cleanliness, efficiency, time and solvent saving properties compared with the conventional methods which lack these advantages; such as time consume and wasting environment polluting organic solvents to achieve the same efficiency in synthesis. The prepared compounds which are believed by us to be competent as photosensitizers in photochemical systems were identified by IR and NMR spectroscopy besides elemental analysis.
Lumbar Disc Herniation in Pediatric  [PDF]
Mostafa Abd Elsamea, Mohamed Shaban, Ahmed Taha, Samer Elshora
Open Journal of Modern Neurosurgery (OJMN) , 2018, DOI: 10.4236/ojmn.2018.82019
Abstract: Lumbar disc herniation is a common complaint among adults with degenerated lumbar intervertebral discs, however its incidence in childhood and adolescence is abundant. Findings recommended that pediatric lumbar disc herniation is dissimilar in numerous way from that in adults. It was confirmed that pediatric patients respond to conventional management less than adults, also the consequence of the operation continued to be acceptable for at least 10 years after the first surgery even though it seems to decline somewhat. This retrospective study was undertaken to determine the clinical outcome and the feature of lumbar disc prolapse in pediatric patients. 12 patients younger than 18 years were operated for lumbar disc prolapse in the period from 2012-2016. Patients preoperative data and radiological imaging, operative and postoperative follow up were reviewed. 12 patients were included in this study, 10 were male and 2 females, the average age was 15 years (ranging between 12 - 18 years). The average duration of the symptoms was 11 months. The average follow up was 14 months. All patients had a sciatica prior to surgery, 35% had motor deficit, and 60% had parasthesia. Conservative treatment failed in all patients. After surgery and follow up, improvement occurs in about 80% of patients, ranging from excellent to good, and 20% of patients with fair outcome. According to Pain Visual Analogue Scale, leg pain reduced from 90 - 30 and back pain from 80 - 35. Conclusion: Pediatric lumbar disc herniation is an uncommon object leading to hospitalization. About 0.1% - 0.2% of children and adolescence surgery for lumbar disc herniation in pediatric does not lead to chronic back pain or interfere with physical activity and is related to the excellent short consequence.
Silent Cerebral Infarctions in Type II Diabetes Mellitus Patients; Could Brain MRI Be a Routine Investigation?  [PDF]
Mohamed Hamdy Ibrahim, Taha Kamel Alloush, Marwa Adel Shaaban, Mohammed Khalid Abdul Rahim, Mohammad Ahmad M. Saad
Open Journal of Medical Imaging (OJMI) , 2014, DOI: 10.4236/ojmi.2014.43016
Abstract:
Objective: To study the prevalence of silent cerebral infarction in Type II diabetes mellitus. Patients and Methods: The study was a prospective on 80 patients recruited from neurology, endocrine outpatient clinics. Patients were type II diabetics as described by the American Diabetes Association, 2011 criteria. All patients underwent full metabolic profiles to diagnose diabetes mellitus and MRI brain scans to detect cerebral infarction. Results: Silent cerebral infarctions were detected in 60% of patients (48/80 patients) predominately along periventricular white matter area and subcortical areas (Basal ganglia, Thalamus). Conclusion: Asymptomatic Type II diabetes mellitus patients could have vascular cerebral changes without neurological symptoms. MRI brain scans could be recommended as routine diagnosis (if possible) for early cerebral infarct detection in type II diabetic patients.
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