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Search Results: 1 - 10 of 1625 matches for " Martina Telecká "
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Selective Sorption of Sb(V) Oxoanion by Composite Sorbents Based on Cerium and Zirconium Hydrous Oxides
Eva Mi?tová,Martina Telecká,Helena Parschová,Luděk Jelínek
Ion Exchange Letters , 2008,
Abstract: Composite sorbents based on hydrous oxides of cerium and zirconium were used for selective removal of Sb(V) oxoanion. The effects of pH, concentration of Sb and accompanying anions in the feed solution and kinetic of the sorption were studied. Both CeO2.nH2O/XAD-7 and ZrO-PAN sorbents showed maximum sorption of Sb(V) oxoanions at pH of 3.5. Sorbent CeO2.nH2O/XAD-7 showed higher removal efficiency than ZrO-PAN. In both cases, increased concentration of sulfates and chlorides in the feed solution caused a decrease of Sb(V) removal
Selective sorption of Sb(III) oxoanion by composite sorbents based on cerium and zirconium hydrous oxides
Eva Mi?tová,Martina Telecká,Helena Parschová,Luděk Jelínek
Ion Exchange Letters , 2009,
Abstract: Composite sorbents based on hydrous oxides of cerium and zirconium were used for selective removal of Sb(III) oxoanion. The effects of pH, concentration of Sb and accompanying anions in the feed solution and kinetic of the sorption were studied. Both CeO2.nH2O/XAD-7 and ZrO-PAN sorbents showed similar sorption capacity at all pH value which was studied. Sorbent CeO2.nH2O/XAD-7 showed higher removal efficiency than ZrO-PAN. In both cases, increased concentration of sulfates and chlorides in the feed solution caused a decrease of Sb(III) removal.
Alternative UV Sensors Based on Color-Changeable Pigments  [PDF]
Martina Vikova, Michal Vik
Advances in Chemical Engineering and Science (ACES) , 2011, DOI: 10.4236/aces.2011.14032
Abstract: Photochromism is a chemical process in which a compound undergoes a reversible change between two states having separate absorption spectra, i.e. different color [1]. In our previous work we have published some solutions of problems of measuring photochromic textile sample by standard commercial spectrophotometric systems [2]. Main problem with measurement of kinetic behavior of photochromic pigments by standard spectrophotometer is relatively long time period between individual measurements (5 s) and impossibility of measuring whole color change during exposure without interruption of illumination of sample during measurement. It means, standard commercial spectrophotometers enable off-line measurement of kinetic behavior during exposure period and quasi on-line measurement during reversion period. Based on this problem, it is only possible to obtain precise data during reversion—decay process and growth process (exposure) is affected by high variability of data. Following this knowledge, we developed original experimenttal system with short time scanning of color change of photochromic samples during growth and decay period of color change. In this study it is presented new view on the relationship between intensity of UV-A radiation and color change half-life t1/2. Via this relation, it is demonstrated the possibility of the flexible textile-based sensors construction in the area of the radiation intensity identification.
Direct Infection and Replication of Naturally Occurring Hepatitis C Virus Genotypes 1, 2, 3 and 4 in Normal Human Hepatocyte Cultures
Martina Buck
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002660
Abstract: Background Hepatitis C virus (HCV) infection afflicts about 170 million individuals worldwide. However, the HCV life cycle is only partially understood because it has not been possible to infect normal human hepatocytes in culture. The current Huh-7 systems use cloned, synthetic HCV RNA expressed in hepatocellular carcinoma cells to produce virions, but these cells cannot be infected with naturally occurring HCV obtained from infected patients. Methodology/Principal Findings Here, we describe a human hepatocyte culture permissible to the direct infection with naturally occurring HCV genotypes 1, 2, 3 and 4 in the blood of HCV-infected patients. The culture system mimics the biology and kinetics of HCV infection in humans, and produces infectious virions that can infect na?ve human hepatocytes. Conclusions/Significance This culture system should complement the existing systems, and may facilitate the understanding of the HCV life cycle, its effects in the natural host cell, the hepatocyte, as well as the development of novel therapeutics and vaccines.
Max Planck announces cuts
Martina Habeck
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20030611-01
Abstract: The announcement vindicates concerns expressed in December 2002, when the German government decided to freeze the budgets of the public research organizations at 2002 levels. Since then, chancellor Gerhard Schr?der has promised a 3% budget increase per year beginning in 2004. But in order to fund its 80 research institutes and 12,000 employees, the MPG needs an annual budget increase of at least 4%."The freeze really hurts," Christina Beck of the MPG told The Scientist, "because it actually means less money, not least because of increased personnel costs due to tariff rises." She added that recruiting a new research director now costs roughly 1.3 times more than in the past. This means funding for only three new directors when four directors retire.The budget freeze came at a time when the MPG was already struggling financially. In the 1990s, it received extra funding to pay for its part in "Aufbau Ost," the rebuilding of eastern Germany. The MPG opened 20 new research institutes in the new L?nder; the last building works were only finished this year, and nine of 57 research director positions at the new institutes in the east still need to be filled. But the extra funding for Aufbau Ost dried up in 2000, and the MPG drew criticism from research minister Edelgard Bulmahn for having taken so much time and having wasted funds in the early 1990s."It is easy to say that we were too slow," countered Beck. "I would say we have been careful and thorough. The MPG is well advised to take its time in choosing directors carefully, if it wants to keep its international reputation for conducting excellent research."In order to continue to be able to afford the best scientists, the MPG decided to adopt a strategy of cuts that wouldn't compromise its reputation. It identified department directors due for retirement by 2007 and then assessed the potential of the research in those departments. "We wondered where we can expect scientific breakthroughs in the next few years," explaine
Swiss computing center opens
Martina Habeck
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20040428-02
Abstract: Inaugurated last Thursday (April 22), the Lausanne-based Vital-IT center is equipped with two HP clusters of 32 production and 8 development servers, based on Intel's Itanium 2 processor. These kinds of clusters allow life scientists to run complicated software 10 to 50 times faster, thereby opening new research avenues, says Christos Ouzounis at the European Bioinformatics Institute. "You can think of problems that you could not think of otherwise if you had a limited computational capacity," he told us.The impact of the new computing power may soon be felt not only by scientists directly associated with Vital-IT, but by researchers worldwide who use the services available through the Swiss Institute of Bioinformatics, such as proteomics tools on the ExPASy (Expert Protein Analysis System) servers.The Vital-IT center also employs four information technology specialists who have access to the full technological know-how of Intel and HP. According to the center's director, Victor Jongeneel, a major aim is to develop software for the life sciences that is more robust and that performs better than the current programs, which are often written by people who are not professional programmers.The new software will run on the Itanium 2 architecture, which has been on the market for 2 years. The technology is particularly suited for large-scale computational problems; however, its uptake has been slow, partly because there is not much software that runs on it."We took a chance in deciding to go for machines that have this chip," concedes Jongeneel. "But rather than going with legacy technology, even though it is very fast right now, we [have gone] with technology that is maybe a little more expensive and with a slightly lower performance right now, with the idea that 5 years from now, we will have gone beyond all the problems associated with it, while other centers will be struggling to keep up."
Compromise reached over German copyright bill
Martina Habeck
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20030411-01
Abstract: The EU directive on digital copyright should have been implemented into national law by the end of last year, but only a few of the 15 member states have done so to date. The intention is to enable scientists to share information for research and teaching purposes while at the same time protecting the interests of copyright owners.But in Germany, the digital copyright bill has angered academic publishers. They fear the new law could make the distribution of unauthorized copies easier than ever before, and may thus have "disastrous consequences" for the publishing trade. In particular, they argue that university libraries could use the new law to save money by digitizing copyrighted work and making it freely available to other libraries."This is all lies and deliberate misinformation," said Ulf Gerder, a spokesperson for the justice ministry. "Paragraph 52a [which sparked off the row] does not even mention libraries.""The right to make digital copies is a pretty harmless issue, and for libraries of no interest whatsoever," agreed Friedrich Gei?elmann, chair of the German Libraries Association. He suspects that the aim of the publishers' campaign is to strengthen their stance and attack alternative publishing models.Indeed, there is a powerful debate in Germany about how to enable scientists to make their work more widely available. The growing open-access movement involves national and international initiatives such as Hamburg University Press, Math-Net, Open Archives Initiative and the Budapest Open Access Initiative. Proponents of open-access publishing models argue that the bill blocks the way to a free information society.Following heated debates in the national press last week, the German Parliament's legal committee decided yesterday to strike a compromise between the opposing sides. The wording of the controversial paragraph 52a will not be changed, but during a transitional period that will end in 2006, its implementation will be under close scrutiny. If the
Tony Hyman wins EMBO Gold Medal
Martina Habeck
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20030805-01
Abstract: "Tony's work has always benefited from his ability to identify, adapt, and adopt new technologies," said Michael Glotzer at the Research Institute of Molecular Pathology in Vienna. "He has been instrumental in developing new ways to study microtubules and microtubule-dependent processes," Glotzer added. For example, Hyman developed a labeling method to determine the orientation of microtubules in the cell. He was also involved in one of the first attempts to visualize the regulation of microtubule dynamics. In addition, he developed an in vitro assay to study the assembly of the mitotic spindle. More recently, he became one of the first investigators to use RNA interference to search for genes involved in cell division.Thanks to this pioneering approach to research, Hyman has had a major impact on his field while relatively young. As a PhD student and as a postdoc, he investigated mechanisms that determine the orientation of cell division during the early stages of development.When Hyman established his first research group at the European Molecular Biology Laboratory (EMBL) in Heidelberg, he met Eric Karsenti, also at the EMBL. "We worked together on the formation of the mitotic spindle in a frog egg system," recalled Karsenti. "Together, we identified a lot of molecules that are involved in the regulation of microtubule dynamics during mitosis."In 1998, at the age of 36, Hyman became director and group leader at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden. He has since devoted much energy to helping to get the new research institute off the ground. Karsenti was sad to see Hyman go - not only because of his scientific input: "He is fantastic fun."Hyman will receive his award at the EMBO New Members Workshop, "Frontiers of Molecular Biology," in Killarney, Ireland, on October 17.
The Use of AlphaScreen Technology in HTS: Current Status
Martina Bielefeld
Current Chemical Genomics , 2008, DOI: 10.2174/1875397300801010002]
Abstract: 2-10 Richard M. Eglen, Terry Reisine, Philippe Roby, Nathalie Rouleau, Chantal Illy, Roger Bossé and Martina Bielefeld Published Date: (25 February, 2008) AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay Screen) is versatile assay technology developed to measuring analytes using a homogenous protocol. This technology is an example of a bead-based proximity assay and was developed from a diagnostic assay technology known as LOCI (Luminescent Oxygen Channeling Assay). Here, singlet oxygen molecules, generated by high energy irradiation of Donor beads, travel over a constrained distance (approx. 200 nm) to Acceptor beads. This results in excitation of a cascading series of chemical reactions, ultimately causing generation of a chemiluminescent signal. In the past decade, a wide variety of applications has been reported, ranging from detection of analytes involved in cell signaling, including protein:protein, protein:peptide, protein:small molecule or peptide:peptide interactions. Numerous homogeneous HTS-optimized assays have been reported using the approach, including generation of second messengers (such as accumulation of cyclic AMP, cyclic GMP, inositol [1, 4, 5] trisphosphate or phosphorylated ERK) from liganded GPCRs or tyrosine kinase receptors, post-translational modification of proteins (such as proteolytic cleavage, phosphorylation, ubiquination and sumoylation) as well as protein-protein and protein-nucleic acid interactions. Recently, the basic AlphaScreen technology was extended in that the chemistry of the Acceptor bead was modified such that emitted light is more intense and spectrally defined, thereby markedly reducing interference from biological fluid matrices (such as trace hemolysis in serum and plasma). In this format, referred to as AlphaLISA, it provides an alternative technology to classical ELISA assays and is suitable for high throughput automated fluid dispensing and detection systems. Collectively, AlphaScreen and AlphaLISA technologies provide a facile assay platform with which one can quantitate complex cellular processes using simple no-wash microtiter plate based assays. They provide the means by which large compound libraries can be screened in a high throughput fashion at a diverse range of therapeutically important targets, often not readily undertaken using other homogeneous assay technologies. This review assesses the current status of the technology in drug discovery, in general, and high throughput screening (HTS), in particular.
Erfahrung und Wissen. Husserls Forschungen zum impliziten Wissen
Martina Pluemacher
Rivista Internazionale di Filosofia e Psicologia , 2012,
Abstract: Experience and Knowledge. Husserl's Investigations on Implicit Knowledge - This paper deals with Husserl’s view of experience. Husserl emphasized the internal connection between action and knowledge; this paper aims to elucidate his analyses of different forms of implicit knowledge, the relevance of implicit knowledge for action, and its role in his conceptualization of experience. Specific attention is given to Husserl’s methods and his understanding of philosophy as a “rigorous science”.
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