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Search Results: 1 - 10 of 26390 matches for " Martin-Comin "
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Hank?s balanced salt solution: an alternative resuspension medium to label autologous leukocytes. Experience in inflammatory bowel disease
Martin-Comin, Joseph;Cardoso, Valbert Nascimento;Plaza, Pedro;Roca, Manoel;
Brazilian Archives of Biology and Technology , 2002, DOI: 10.1590/S1516-89132002000500006
Abstract: in this work hank's balanced salt solution (hbss) has been used, as resuspension medium, instead of leukocyte poor plasma (lpp) to label autologous white blood cells in 28 patients with suspicion af active inflammatory bowel disease.labelled cells were reinjected and anterior and caudo-craneal views were obtained at 30 min, 2 h and 6 h p.i. regions of interest were outlined on liver, spleen, lung, bone marrow (spine), background and lesions and the organ/background activity ratios were calculated in all scans. patients were classified into 2 groups: group 1: lpp, 30 patients and groups 2: hbss, 28 patients. labelling efficiency was higher in hbbs group (89.0 ± 3.2 %) than in the lpp group (6.5 ± 6.3%). organ/background activity ratios were similar in both groups. concerning diagnostic accuracy was similar at 30 min and 2 h but the false positive rate increased at 6 h p.i. in the hbss group. hbss seems to be a valid alternative as resuspension medium in the labeling of autologous leukocytes but leukocyte poor plasma seem to induce less leukocyte damage. based on these results, in our center hbss is the currently used medium to label leukocytes.
Comparación del Citrato de Galio-67, de los Leucocitos marcados con Exametazina-Tecnecio-99M y de la Inmunoglobulina G marcada con DTPA-INDIO-111 en el diagnóstico de infecciones óseas y articulares.
de Lima Ramos, Paulo Alberto.,Martin-Comin, Josep.,Roca, Manel.,Ricart, Yvone.
Alasbimn Journal , 2000,
Abstract: El objetivo de este estudio ha sido comparar la capacidad de la gammagrafia con citrato de Gálio-67 (67Ga), de los leucocitos marcados con Tc-99m (99mTc-leucocitos) y de la inmunoglobulina G marcada con In-111 (111In-IgG) en el diagnóstico de infecciones óseas y articulares. Han sido estudiados 56 pacientes. En todos ellos se indicó una gammagrafia ósea (99mTc-MDP). Los pacientes han sido aleatoriamente asignados para estudios con 67Ga (Grupo 1 - 22 pacientes) o con la administración simultánea de 99mTc-leucocitos y con 111In-IgG.(Grupo 2 - 34 pacientes).Para los grupos 1 y 2 han sido confirmadas 12/26 y 11/34 lesiones sépticas respectivamente. La gammagrafia con 67Ga mostró 6 verdadero-positivos, 9 verdadero-negativos, 5 falso-positivos y 6 falso-negativos. Con los 99mTc-leucocitos, los resultados han sido 8, 18, 5 y 3, respectivamente. Con la 111In-IgG, 7, 17, 6 y 4, respectivamente. La sensibilidad, especificidad y precisión han sido respectivamente del 50%, 64,3% y 57,7% para el 67Ga, 72,7%, 78,2% y 76,4% para los 99mTc-leucocitos y 63,6%, 73,9% y 70,6% para la 111In-IgG.En este estudio, la gammagrafia con los leucocitos marcados presentó mayor precisión que con 67Ga y con 111In-IgG en el diagnóstico de infecciones óseas y articulares. Sin embargo, en el diagnóstico de infecciones en prótesis articulares los resultados han sido menos fiables.The aim of this study was to compare the ability of 67-Gallium citrate (67Ga), 99m-Tc labelled leucocytes (99mTc-WBC) and 111-In-labelled immunoglobulin G (111In-IgG) scintigraphy in bone and joint infections diagnosis. Fifty-six patients were studied. For all patients a bone scan using 99mTc-MDP was indicated. The patients were randomized allocated for 67Ga (Group 1 - 22 patients) or simmultaneous administration 99mTc-labelled leucocytes and 111In-IgG.(Group 2 - 34 patients) study.For the groups 1 and 2 were confirmated respectively 12/26 y 11/34 septic lesions. The 67Ga scintigraphy showed 6 true-positive, 9 true-negative, 5 false-positive and 6 false-negative. With 99mTc-WBC, the respective values were 8, 18, 5 and 3. With 111In-IgG, the figures were 7, 17, 6 and 4, respectively. The sensitivity, specificity and accuracy were 50%, 64,3% and 57,7% respectively for the 67Ga, 72,7%, 78,2% and 76,4% respectively for 99mTc-WBC and 63,6%, 73,9% and 70,6% respectively for 111In-IgG.In this study, the labelled leucocytes scintigraphy showed more accurate than 67Ga and 111In-IgG scans for the diagnosis of bone and joint infections. However, the obtained results were less reliable for the diagnosis of occult sepsis in
Hank?s balanced salt solution: an alternative resuspension medium to label autologous leukocytes. Experience in inflammatory bowel disease
Martin-Comin Joseph,Cardoso Valbert Nascimento,Plaza Pedro,Roca Manoel
Brazilian Archives of Biology and Technology , 2002,
Abstract: In this work Hank's balanced salt solution (HBSS) has been used, as resuspension medium, instead of leukocyte poor plasma (LPP) to label autologous white blood cells in 28 patients with suspicion af active inflammatory bowel disease.Labelled cells were reinjected and anterior and caudo-craneal views were obtained at 30 min, 2 h and 6 h p.i. Regions of interest were outlined on liver, spleen, lung, bone marrow (spine), background and lesions and the organ/background activity ratios were calculated in all scans. Patients were classified into 2 groups: Group 1: LPP, 30 patients and Groups 2: HBSS, 28 patients. Labelling efficiency was higher in HBBS group (89.0 ± 3.2 %) than in the LPP group (6.5 ± 6.3%). Organ/background activity ratios were similar in both groups. Concerning diagnostic accuracy was similar at 30 min and 2 h but the false positive rate increased at 6 h p.i. in the HBSS group. HBSS seems to be a valid alternative as resuspension medium in the labeling of autologous leukocytes but leukocyte poor plasma seem to induce less leukocyte damage. Based on these results, in our center HBSS is the currently used medium to label leukocytes.
Technetium-99m ceftizoxime kit preparation
Diniz, Simone Odília Fernandes;Siqueira, Cristiano Ferrari;Nelson, David Lee;Martin-Comin, Josep;Cardoso, Valbert Nascimento;
Brazilian Archives of Biology and Technology , 2005, DOI: 10.1590/S1516-89132005000700014
Abstract: the aim of this work was to prepare a kit of 99mtc-ceftizoxime (99mtc-cft), with stability and biological activity preserved, able to identify a septic focus (e. coli) in the experimental infection model in rats. the preparation of the cft kit involved the use of lyophilized solutions containing the antibiotic ceftizoxime and the sodium dithionite reducing agent (6.0 mg/ml). after lyophilization, the kit was reconstituted with 1.0 ml of sodium 99mtc-pertechnetate solution (na99mtco4-) with an activity of 370 mbq. the solution was boiled for 10 min and filtered through a cellulose ester filter. the labeling efficiency was on the order of 92%, remaining stable for six hours and the kit remained stable for two months. the biological activity of the 99mtc-cft was evaluated by diffusion in agar impregnated with e.coli and s. aureus. seven wistar rats, weighing from 200 to 250 g, were used for the development of the septic focus. after 24 hours from the induction of the infectious site (e.coli), the animals were anesthetized and 0.1 ml of 99mtc-cft (37 mbq) was injected into the tail veins of the animals. the images were obtained with a gamma camera one, two and six hours after injection and the regions of interest (rois) were calculated. the diameters of the inhibition halos for 99mtc-cft were 27.16 ± 0.23 and 27.17 ± 0.20 for s.aureus and e.coli, respectively, while those for the unlabeled cft were 30.4 ± 0.33 and 29.43 ± 0.26, respectively. the results for the biodistribution of 99mtc-cft in infected animals furnished a ratio of 1.97 ± 0.31, 2.10 ± 0.42 and 2.01 ± 0.42 for cpm-target/cpm-no target for the one, two and six-hour periods, respectively. the images showed a clear uptake of labeled antibiotic (99mtc-cft) by the infectious site during the experiment. the results attest to the viability of producing a kit with 99mtechnetium-labeled ceftizoxime for the investigation of infectious processes.
Leukocyte-technetium-99m uptake in Crohn’s disease: Does it show subclinical disease?
Luciene G Mota, Luiz GV Coelho, Carlos JR Simal, Maria LA Ferrari, Clodomiro Toledo, Josep Martin-Comin, Simone OF Diniz, Valbert N Cardoso
World Journal of Gastroenterology , 2010,
Abstract: AIM: To evaluate inflammatory activity in patients with Crohn’s disease (CD) using technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) granulocyte scintigraphy.METHODS: Twenty patients (7 male and 13 female) with CD and five healthy volunteers were selected for 99mTc-HMPAO granulocyte scintigraphy. The Crohn’s Disease Activity Index (CDAI), blood tests and C-reactive protein (CRP) of each patient were performed 7 d before the scintigraphic images. The leukocytes were labeled according to the International Society of Radiolabeled Blood Elements (ISORBE) consensus protocol and the scintigraphic images, including single photon emission computed tomography, were obtained 30 min and 2 h after injection of the radiolabeled leukocytes.RESULTS: The labeling yield of the leukocytes with the lipophilic complex 99mTc-HMPAO was 55.0% ± 10%. Six of the 20 patients (30%) presented congruent results for the three parameters investigated (CDAI, Scintigraphic Index and CRP). On the other hand, 14 patients (70%) did not show congruent results. There was no significant correlation between the indices analyzed according to the Spearman test (P > 0.05, n = 20).CONCLUSION: The results suggest that 99mTc-HMPAO-labeled leukocyte scintigraphy could be important for determining inflammatory activity in CD even in the absence of clinical symptoms.
Factors associated with the non detection of the sentinel node in breast cancer
Guirao, Sara;Benítez Segura, Ana;Bajén, Maria Tereza;Brulles, Ynonet Ricart;Salvado, Jaume Mora;Vilardell, Ana Domenech;Rodriguez Gassen, Alba;Engronyat, Manel Roca;Puchal A?e, Rafael;Martin-Comin, Josep;
Brazilian Archives of Biology and Technology , 2005, DOI: 10.1590/S1516-89132005000700026
Abstract: the aim of the work was to analyse the potential influence of different factors on the surgical detection of sentinel lymph node in breast cancer. the procedure has been performed in 704 patients. in 43 out of the 704 cases, the sn was not detected, 24 were palpable and 19 had no palpable tumors. lymphoscitigraphy was done in 2 h p.i. of 37-55 mbq of 99mtc-nanocolloid. the day before surgery in palpable tumours and 4 h previous to surgery in non-palpable tumours, surgical detection was performed using a gammaprobe. the following factors were analysed: patient age, tumour size, breast quadrant tumour localization, scintigraphic visualizatio,n and the palpation of the tumour. results: patient age was significantly (p<0.001) higher in the patients in whom sn was not detected. scintigraphic visualization was significantly (p<0.05) lower in the patients in whom sn was not detected. there were no significant differences concerning the other parameters analysed. conclusion: patient age and scintigraphic visualization are parameters that directly influence the detection of sentinel node in breast cancer.
Globalización y dependencia: los nuevos impasses del desarrollo brasile o
Alexandre COMIN
América Latina Hoy , 2009,
Abstract: RESUMEN: Empezando por un análisis del patrón de industrialización brasile o y las causas de su fracaso a partir de los 80 en un contexto de ideología neoliberal, el autor analiza los nuevos parámetros de la política industrial de los a os 90. A la luz del nuevo contexto de estabilización y de integración regional, se observan los diferentes impactos que esta estrategia tiene sobre la estructura productiva. ABSTRACT: Begining with an analysis of the brazilean industrialization pattern and the causes of its failure form the eighties in a context of neoliberal ideology, the author analyzes the new parameters of the industrial policies in the nineties. In this new context of stabilization and regional integration, it is observed the different impacts thar this strategy has over the productive structure.
Energy Structure of Optimal Positional Strategies in Mean Payoff Games
Carlo Comin
Computer Science , 2015,
Abstract: This work studies structural aspects concerning optimal positional strategies in Mean Payoff Games, it is a contribution to understanding the relationship between optimal positional strategies in MPGs and small energy-progress measures in reweighted energy games. In particular, it is observed an energy decomposition theorem which describes the whole space of all optimal positional strategies in terms of so-called extremal small energy-progress measures. This points out what we called the "energy structure" of the space of all optimal positional strategies in MPGs, as it allows for a disjoint-set decomposition (of that space) which is expressed in terms of small energy-progress measures in reweighted energy games.
(Extended Version) Algebraic Characterization of the Class of Languages recognized by Measure Only Quantum Automata
Carlo Comin
Computer Science , 2013,
Abstract: We study a model of one-way quantum automaton where only measurement operations are allowed ($\mon$). We give an algebraic characterization of $\lmo(\Sigma)$, showing that the syntactic monoids of the languages in $\lmo(\Sigma)$ are exactly the $J$-trivial literally idempotent syntactic monoids, where $J$ is the Green's relation determined by two-sided ideals. We also prove that $\lmo(\Sigma)$ coincides with the literal variety of literally idempotent piecewise testable regular languages. This allows us to prove the existence of a polynomial time algorithm for deciding whether a regular language belongs to $\lmo(\Sigma)$ and to discuss definability issues in terms of the existential first-order logic $\Sigma_1[<]$ and the linear temporal logic without the next operator LTLWN.
O Brasil homossexual em retrato: articula es entre direitos humanos, literatura e arte
Fabio Scorsolini-Comin
Paidéia (Ribeir?o Preto) , 2011, DOI: 10.1590/s0103-863x2011000300017
Abstract:
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