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Search Results: 1 - 10 of 231429 matches for " Martin L?uter "
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Fast and Robust Linear Motion Deblurring
Martin Welk,Patrik Raudaschl,Thomas Schwarzbauer,Martin Erler,Martin Luter
Computer Science , 2012, DOI: 10.1007/s11760-013-0563-x
Abstract: We investigate efficient algorithmic realisations for robust deconvolution of grey-value images with known space-invariant point-spread function, with emphasis on 1D motion blur scenarios. The goal is to make deconvolution suitable as preprocessing step in automated image processing environments with tight time constraints. Candidate deconvolution methods are selected for their restoration quality, robustness and efficiency. Evaluation of restoration quality and robustness on synthetic and real-world test images leads us to focus on a combination of Wiener filtering with few iterations of robust and regularised Richardson-Lucy deconvolution. We discuss algorithmic optimisations for specific scenarios. In the case of uniform linear motion blur in coordinate direction, it is possible to achieve real-time performance (less than 50 ms) in single-threaded CPU computation on images of $256\times256$ pixels. For more general space-invariant blur settings, still favourable computation times are obtained. Exemplary parallel implementations demonstrate that the proposed method also achieves real-time performance for general 1D motion blurs in a multi-threaded CPU setting, and for general 2D blurs on a GPU.
Some Notes on Blinded Sample Size Re-Estimation
Ekkehard Glimm,Jürgen Luter
Statistics , 2013,
Abstract: This note investigates a number of scenarios in which unadjusted testing following a blinded sample size re-estimation leads to type I error violations. For superiority testing, this occurs in certain small-sample borderline cases. We discuss a number of alternative approaches that keep the type I error rate. The paper also gives a reason why the type I error inflation in the superiority context might have been missed in previous publications and investigates why it is more marked in case of non-inferiority testing.
A Note on Two Theorems of C. Dong and J. Wang Concerning Combinatorial Identities
Arnold R. Kr?uter
Modern Applied Science , 2009, DOI: 10.5539/mas.v2n5p50
Abstract: In a recent paper C. Dong and J. Wang rederived three classical combinatorial identities by applying a special Vandermonde determinant. Two of their results, however, turn out to be incorrectly stated. This note presents counterexamples along with revised versions of the results mentioned.
SOME REMARKS ABOUT A SIMULATION STUDY FOR A LATENT CLASS MODEL UNDER SPARSENESS
Adalberto González Debén*, Hannelore Liero**, Jesús E. Sánchez García*, Henning Luter**
Revista Investigación Operacional , 2010,
Abstract: A theoretical study is accomplished in this paper in order to explain some simulation results exposed in the paper “Sobre la estimación de los parámetros del modelo de clases latentes en condiciones de raleza” (About the parameter estimation of the latent class model under sparseness ) (González, Sánchez & Hernández, 2002). The main tool is the application of results concerning asymptotic normality of the maximum likelihood estimators
Massive Transcriptional Perturbation in Subgroups of Diffuse Large B-Cell Lymphomas
Maciej Rosolowski, Jürgen Luter, Dmitriy Abramov, Hans G. Drexler, Michael Hummel, Wolfram Klapper, Roderick A.F. MacLeod, Shoji Pellissery, Friedemann Horn, Reiner Siebert, Markus Loeffler
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076287
Abstract: Based on the assumption that molecular mechanisms involved in cancerogenesis are characterized by groups of coordinately expressed genes, we developed and validated a novel method for analyzing transcriptional data called Correlated Gene Set Analysis (CGSA). Using 50 extracted gene sets we identified three different profiles of tumors in a cohort of 364 Diffuse large B-cell (DLBCL) and related mature aggressive B-cell lymphomas other than Burkitt lymphoma. The first profile had high level of expression of genes related to proliferation whereas the second profile exhibited a stromal and immune response phenotype. These two profiles were characterized by a large scale gene activation affecting genes which were recently shown to be epigenetically regulated, and which were enriched in oxidative phosphorylation, energy metabolism and nucleoside biosynthesis. The third and novel profile showed only low global gene activation similar to that found in normal B cells but not cell lines. Our study indicates novel levels of complexity of DLBCL with low or high large scale gene activation related to metabolism and biosynthesis and, within the group of highly activated DLBCLs, differential behavior leading to either a proliferative or a stromal and immune response phenotype.
Is occupational exposure to solvents associated with an increased risk for developing systemic scleroderma?
Birgitta Kütting, Wolfgang Uter, Hans Drexler
Journal of Occupational Medicine and Toxicology , 2006, DOI: 10.1186/1745-6673-1-15
Abstract: A standardised questionnaire was published in two journals subscribed by members of two different support groups and all members were asked to complete the questionnaire and to return it anonymously. The subjects were not informed on the scientific hypotheses, nor did they know who of them belonged to the case group (scleroderma) or to the control group (multiple sclerosis).175 questionnaires could be included in the statistical analysis. As expected, a female predominance was in our collective. In the male subpopulation, the occupational exposure to solvents was higher in the case group than in the control-group (70% versus 45.8%).Based only on the male subgroup, a tendency for an association between occupational exposure to solvents and the risk to develop systemic sclerosis was found.According to our experience in this case-control-study exposure misclassification, qualitative or quantitative, was an eminent problem. Within such a setting, it is generally very difficult to establish an exact dose-response relationship due to incomplete, imprecise or missing data concerning duration of exposure, frequency of use and kind of solvent. Additionally, a well-known problem in studies based on self-reported questionnaires is the so-called volunteer bias. Unfortunately, but similar to other studies assessing epidemiologic factors in such a rare disease, our study was of limited power, especially in the subgroups defined by gender.Systemic sclerosis is a rare multisystem disease with a reported incidence of 2 to 12 cases per million people per year [1]. The disease is characterized by microvascular alteration and massive deposition of collagen affecting connective tissue in many parts of the body, especially skin, oesophagus, lungs, gastrointestinal tract, kidney, heart and other internal organs [2]. The aetiology of systemic sclerosis still remains unclear. Data of epidemiological studies suggest a complex interaction of genetic, hormonal and environmental factors in the
Secondary prevention of allergic symptoms in a dairy farmer by use of a milking robot
Gintautas Korinth, Horst Broding, Wolfgang Uter, Hans Drexler
Clinical and Molecular Allergy , 2005, DOI: 10.1186/1476-7961-3-8
Abstract: In a 37-year-old female farmer daily asthmatic complaints appeared, associated with cow dust-derived allergen exposure by milking with a conventional device. Respiratory symptoms increased during a period of 12 years. Allergic bronchial asthma was diagnosed, caused by sensitization against cow dust-derived allergens, as demonstrated by positive skin prick test and by detection of IgE antibodies. In a separate specific inhalation challenge test using a 10% extract of cow dust-derived allergens a 330% increase of airway resistance was detected. To enable further dairy farming, a milking robot was installed in 1999, i.e., an automatic milking system. The novel milking technique reduced the daily exposure from over 2 hours to approximately 10 min. The clinical course after the installation of the milking robot was favourable, with less frequent allergic and asthmatic symptoms. Furthermore, asthma medication could be reduced. Improvement was noted also in terms of lung-function and decreased total serum IgE.The case presented and the evidence from the literature indicates that the strategy of exposure minimization to allergens at workplaces can be an effective alternative to total elimination. In farmers with cow dust allergy a milking robot is an appropriate technical measure to minimize allergen-exposure.Allergic asthma ranks in Germany among frequent occurred occupational diseases. Cow hair allergy in Finland is one of the most frequent reasons for the development of occupational asthma [1], but epidemiologically in Germany still insufficiently explored. The prevalence of respiratory complaints in Finnish farmers with cow husbandry is 27% for rhinitis respectively 12% for asthma in consequence of occupational exposure [2,3]. Until now there is only limited insight into the risk factors with regard to this disease. The prevention of sensitization in stock farming to cow hair and epithelial allergens including lipocalins is often difficult due to intense exposure, with
The ORF1 Protein Encoded by LINE-1: Structure and Function During L1 Retrotransposition
Sandra L. Martin
Journal of Biomedicine and Biotechnology , 2006, DOI: 10.1155/jbb/2006/45621
Abstract: LINE-1 or L1 is an autonomous non-LTR retrotransposon in mammals. Retrotransposition requires the function of the two L1-encoded polypeptides, ORF1p and ORF2p. Early recognition of regions of homology between the predicted amino acid sequence of ORF2 and known endonuclease and reverse transcriptase enzymes led to testable hypotheses regarding the function of ORF2p in retrotransposition. As predicted, ORF2p has been demonstrated to have both endonuclease and reverse transcriptase activities. In contrast, no homologs of known function have contributed to our understanding of the function of ORF1p during retrotransposition. Nevertheless, significant advances have been made such that we now know that ORF1p is a high-affinity RNA-binding protein that forms a ribonucleoprotein particle together with L1 RNA. Furthermore, ORF1p is a nucleic acid chaperone and this nucleic acid chaperone activity is required for L1 retrotransposition.
Distribution of warm water alpheoid shrimp (Crustacea, Caridea) on the continental shelf of eastern South America between 23 and 35o Lat. S
Christoffersen, Martin L;
Boletim do Instituto Oceanográfico , 1982, DOI: 10.1590/S0373-55241982000100007
Abstract: the southern boundaries of tozeuma serratum a. milne edwards, salmoneus ortmanni (rankin) and processa profunda manning & chace, previously known only from the northwestern atlantic, have been extended to s?o paulo, paraná and uruguay, respectively. latreutes parvulus (stimpson), previously not known beyond s?o paulo has been found to as far south as the province of buenos aires. a systematic account of these four species is furnished, based mainly on material collected by the r/v "prof. w. besnard". the 16 species of alpheoidea whose southern boundaries occur in warm-temperate shelf waters of eastern south america belong to two distinct faunal assemblages: (1) tropical species - alpheus floridanus kingsley, a. intrinsecus bate, a. normanni kingsley, salmoneus ortmanni (rankin) synalpheus longicarpus (herrick), ogyrides alphaerostris (kingsley) (= o. occidentalis(ortmann)), exhippolysmata oplophoroides (holthuis), latreutes parvalus (stimpson), processa bermudensis (rankin) and p. hemphilli manning & chace - which are largely restricted to coastal and inshore shelf waters less than 50 m deep; and (2) subtropical species - alpheus pouang chris toffersen, a. puapeba christoffersen, merhippolyte americana holthuis, tozeuma serratum a. milne edwards, processa guyanae. holthuis and p. profunda manning & chace - which are largely restricted to the outer portion of the continental shelf within the studied area. considering the temperature and distributional data available for each species, it is suggested that the poleward boundaries of o. alphaerostris are set by maximum summer temperatures of about 20oc required for the reproduction of the species, while the poleward boundaries of most of the tropical and subtropical species are set by minimum winter temperatures critical for their survival: about 15oc for a. floridanus, about 11oc for e. oplophoroides, about 9oc for a. pouang, l. parvulus, p. guyanae., p. guyanae and p. hemphilli, and p. profunda and about 8oc for a. pu
Distribution of warm water alpheoid shrimp (crustacea, caridea) on the continental shelf of eastern south america between 23 and 35o lat. S
Christoffersen, Martin L;
Brazilian Journal of Oceanography , 1982, DOI: 10.1590/S1679-87591982000100007
Abstract: the southern boundaries of tozeuma serratum a. milne edwards, salmoneus ortmanni (rankin) and processa profunda manning & chace, previously known only from the northwestern atlantic, have been extended to s?o paulo, paraná and uruguay, respectively. latreutes parvulus (stimpson), previously not known beyond s?o paulo has been found to as far south as the province of buenos aires. a systematic account of these four species is furnished, based mainly on material collected by the r/v "prof. w. besnard". the 16 species of alpheoidea whose southern boundaries occur in warm-temperate shelf waters of eastern south america belong to two distinct faunal assemblages: (1) tropical species - alpheus floridanus kingsley, a. intrinsecus bate, a. normanni kingsley, salmoneus ortmanni (rankin) synalpheus longicarpus (herrick), ogyrides alphaerostris (kingsley) (= o. occidentalis(ortmann)), exhippolysmata oplophoroides (holthuis), latreutes parvalus (stimpson), processa bermudensis (rankin) and p. hemphilli manning & chace - which are largely restricted to coastal and inshore shelf waters less than 50 m deep; and (2) subtropical species - alpheus pouang chris toffersen, a. puapeba christoffersen, merhippolyte americana holthuis, tozeuma serratum a. milne edwards, processa guyanae. holthuis and p. profunda manning & chace - which are largely restricted to the outer portion of the continental shelf within the studied area. considering the temperature and distributional data available for each species, it is suggested that the poleward boundaries of o. alphaerostris are set by maximum summer temperatures of about 20oc required for the reproduction of the species, while the poleward boundaries of most of the tropical and subtropical species are set by minimum winter temperatures critical for their survival: about 15oc for a. floridanus, about 11oc for e. oplophoroides, about 9oc for a. pouang, l. parvulus, p. guyanae., p. guyanae and p. hemphilli, and p. profunda and about 8oc for a. pu
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