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Search Results: 1 - 10 of 321903 matches for " Martin J. Jones "
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Rydberg atoms with a reduced sensitivity to dc and low-frequency electric fields
L. A. Jones,J. D. Carter,J. D. D. Martin
Physics , 2013, DOI: 10.1103/PhysRevA.87.023423
Abstract: A non-resonant microwave dressing field at 38.465 GHz was used to eliminate the static electric dipole moment difference between the $49s_{1/2}$ and $48s_{1/2}$ Rydberg states of $^{87}$Rb in dc fields of approximately 1 V/cm. The reduced susceptibility to electric field fluctuations was measured using 2-photon microwave spectroscopy. An anomalous spectral doublet is attributed to polarization ellipticity in the dressing field. The demonstrated ability to inhibit static dipole moment differences --- while retaining sensitivity to high frequency fields --- is applicable to sensors and/or quantum devices using Rydberg atoms.
The information sources and journals consulted or read by UK paediatricians to inform their clinical practice and those which they consider important: a questionnaire survey
Teresa H Jones, Steve Hanney, Martin J Buxton
BMC Pediatrics , 2007, DOI: 10.1186/1471-2431-7-1
Abstract: We enquired, by questionnaire survey, about the information sources and academic journals that UK medical paediatric specialists generally consulted, attended or read and considered important to their clinical practice.The same three information sources – professional meetings & conferences, peer-reviewed journals and medical colleagues – were, overall, the most consulted or attended and ranked the most important. No one information source was found to be of greatest importance to all groups of paediatricians. Journals were widely read by all groups, but the proportion ranking them first in importance as an information source ranged from 10% to 46%. The number of journals read varied between the groups, but Archives of Disease in Childhood and BMJ were the most read journals in all groups. Six out of the seven journals previously identified as containing best paediatric evidence are the most widely read overall by UK paediatricians, however, only the two most prominent are widely read by those based in the community.No one information source is dominant, therefore a variety of approaches to Continuing Professional Development and the dissemination of research findings to paediatricians should be used. Journals are an important information source. A small number of key ones can be identified and such analysis could provide valuable additional input into the evaluation of clinical research outputs.If medicine is to be evidence-based then health research findings need to be implemented appropriately in the clinical setting. However, there is an ever-expanding wealth of biomedical knowledge to be assimilated and used by clinicians [1,2]. The range of potentially available information sources is large and even for one of them, peer-reviewed journals, the choice within a specialty is enormous.A review of the information sources used and favoured by clinicians from many different medical specialties, as well as some nursing groups, found results varied from one study to an
The journals of importance to UK clinicians: a questionnaire survey of surgeons
Teresa H Jones, Steve Hanney, Martin J Buxton
BMC Medical Informatics and Decision Making , 2006, DOI: 10.1186/1472-6947-6-24
Abstract: A questionnaire survey sent to 2,660 UK surgeons asked which information sources they considered to be important and which peer-reviewed journals they read, and perceived as important, to inform their clinical practice. Comparisons were made with numbers of UK NHS-funded surgery publications, journal impact factors and other similar surveys.Peer-reviewed journals were considered to be the second most important information source for UK surgeons. A mode of four journals read was found with academics reading more than non-academics. Two journals, the BMJ and the Annals of the Royal College of Surgeons of England, are prominent across all sub-specialties and others within sub-specialties. The British Journal of Surgery plays a key role within three sub-specialties. UK journals are generally preferred and readership patterns are influenced by membership journals. Some of the journals viewed by surgeons as being most important, for example the Annals of the Royal College of Surgeons of England, do not have high impact factors.Combining the findings from this study with comparable studies highlights the importance of national journals and of membership journals. Our study also illustrates the complexity of the link between the impact factors of journals and the importance of the journals to clinicians. This analysis potentially provides an additional basis on which to assess the role of different journals, and the published output from research.The increasing importance of evidence-based practice in medicine highlights the desirability of clinical practitioners keeping in touch with clinical research. The growing volume of information is available in many different forms, but Schein et al[1] found that the traditional, peer-reviewed journals were the information source considered most important by American surgeons. Many groups have an interest in knowing about the perceived importance and readership of the various journals, including researchers, the users of research an
We are not all Egyptian
Martin Jones
Forced Migration Review , 2012,
Abstract: For many refugees in Egypt the weeks of the revolution were marked byisolation, fear and brutality. In the aftermath of the revolution, the promise of greater freedom has not yet been extended to refugees.
Intraspecific competition in the speckled wood butterfly Pararge aegeria: Effect of rearing density and gender on larval life history
Melanie Gibbs,Lesley A. Lace,Martin J. Jones,Allen J. Moore
Journal of Insect Science , 2004,
Abstract: In insects, the outcome of intraspecific competition for food during development depends primarily upon larval density and larval sex, but effects will also depend on the particular trait under consideration and the species under study. Experimental manipulations of larval densities of a Madeiran population of the speckled wood butterfly Pararge aegeria confirmed that intraspecific competition affected growth. As densities increased P. aegeria adults were smaller and larval development periods were longer. Sexes responded differently to rearing density. Females were more adversely affected by high density than males, resulting in females having smaller masses at pupation. Survivorship was significantly higher for larvae reared at low densities. No density effect on adult sex ratios was observed. Intraspecific competition during the larval stage would appear to carry a higher cost for females than males. This may confer double disadvantage since females are dependent on their larval derived resources for reproduction as they have little opportunity to accumulate additional resources as adults. This suggests that shortages of larval food could affect fecundity directly. Males, however, may be able to compensate for a small size by feeding as adults and/or by altering their mate location tactics.
KiWi: A Scalable Subspace Clustering Algorithm for Gene Expression Analysis
Obi L. Griffith,Byron J. Gao,Mikhail Bilenky,Yuliya Prichyna,Martin Ester,Steven J. M. Jones
Computer Science , 2009,
Abstract: Subspace clustering has gained increasing popularity in the analysis of gene expression data. Among subspace cluster models, the recently introduced order-preserving sub-matrix (OPSM) has demonstrated high promise. An OPSM, essentially a pattern-based subspace cluster, is a subset of rows and columns in a data matrix for which all the rows induce the same linear ordering of columns. Existing OPSM discovery methods do not scale well to increasingly large expression datasets. In particular, twig clusters having few genes and many experiments incur explosive computational costs and are completely pruned off by existing methods. However, it is of particular interest to determine small groups of genes that are tightly coregulated across many conditions. In this paper, we present KiWi, an OPSM subspace clustering algorithm that is scalable to massive datasets, capable of discovering twig clusters and identifying negative as well as positive correlations. We extensively validate KiWi using relevant biological datasets and show that KiWi correctly assigns redundant probes to the same cluster, groups experiments with common clinical annotations, differentiates real promoter sequences from negative control sequences, and shows good association with cis-regulatory motif predictions.
Differential effects of Mycobacterium bovis - derived polar and apolar lipid fractions on bovine innate immune cells
Chris Pirson, Gareth J Jones, Sabine Steinbach, Gurdyal Besra, H Martin Vordermeier
Veterinary Research , 2012, DOI: 10.1186/1297-9716-43-54
Abstract:
The serious mental illness health improvement profile [HIP]: study protocol for a cluster randomised controlled trial
Jacquie White, Richard J Gray, Louise Swift, Garry R Barton, Martin Jones
Trials , 2011, DOI: 10.1186/1745-6215-12-167
Abstract: A single blind parallel group cluster randomised controlled trial with secondary economic analysis and process observation. Unit of randomisation: mental health nurses [MHNs] working in adult community mental health teams across two NHS Trusts. Subjects: Patients over 18 years with a diagnosis of schizophrenia, schizoaffective or bipolar disorder on the caseload of participating MHNs. Primary objective: To determine the effects of the HIP programme on patients' physical wellbeing assessed by the physical component score of the Medical Outcome Study (MOS) 36 Item Short Form Health Survey version 2 [SF-36v2]. Secondary objectives: To determine the effects of the HIP programme on: cost effectiveness, mental wellbeing, cardiovascular risk, physical health care attitudes and knowledge of MHNs and to determine the acceptability of the HIP Programme in the NHS. Consented nurses (and patients) will be randomised to receive the HIP Programme or treatment as usual. Outcomes will be measured at baseline and 12 months with a process observation after 12 months to include evaluation of patients' and professionals' experience and observation of any effect on care plans and primary-secondary care interface communication. Outcomes will be analysed on an intention-to-treat (ITT) basis.The results of the trial and process observation will provide information about the effectiveness of the HIP Programme in supporting MHNs to address physical comorbidity in serious mental illness. Given the current unacceptable prevalence of physical comorbidity and mortality in the serious mental illness population, it is hoped the HIP trial will provide a timely contribution to evidence on organisation and delivery of care for patients, clinicians and policy makers.ISRCTN: ISRCTN41137900Improving the physical health of people with serious mental illness [SMI] (people with a diagnosis of schizophrenia, schizoaffective or bipolar disorder) is an important public health challenge[1,2]. Comorbid physical
Genomic sequence of a mutant strain of Caenorhabditis elegans with an altered recombination pattern
Ann M Rose, Nigel J O'Neil, Mikhail Bilenky, Yaron S Butterfield, Nawar Malhis, Stephane Flibotte, Martin R Jones, Marco Marra, David L Baillie, Steven JM Jones
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-131
Abstract: Using Illumina sequencing and MAQ software, 83% of the base pair sequence reads were aligned to the reference genome available at Wormbase, providing a 21-fold coverage of the genome. Using the software programs MAQ and Slider, we observed 1124 base pair differences between Rec-1 and the reference genome in Wormbase (WS190), and 441 between the mutagenized Rec-1 (BC313) and the wild-type N2 strain (VC2010). The most frequent base-substitution was G:C to A:T, 141 for the entire genome most of which were on chromosomes I or X, 55 and 31 respectively. With this data removed, no obvious pattern in the distribution of the base differences along the chromosomes was apparent. No major chromosomal rearrangements were observed, but additional insertions of transposable elements were detected. There are 11 extra copies of Tc1, and 8 of Tc2 in the Rec-1 genome, most likely the remains of past high-hopper activity in a progenitor strain.Our analysis of high-throughput sequencing was able to detect regions of direct repeat sequences, deletions, insertions of transposable elements, and base pair differences. A subset of sequence alterations affecting coding regions were confirmed by an independent approach using oligo array comparative genome hybridization. The major phenotype of the Rec-1 strain is an alteration in the preferred position of the meiotic recombination event with no other significant phenotypic consequences. In this study, we observed no evidence of a mutator effect at the nucleotide level attributable to the Rec-1 mutation.Caenorhabditis elegans is an animal model widely used in biomedical and biological research. C. elegans was the first animal to have its genome completely sequenced [1] and the compiled and annotated sequence is available at WormBase http://www.wormbase.org webcite. The ready availability of genomic sequence information along with an extensive body of knowledge about gene function in this species provides an exceptional opportunity to examine th
Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation
Andrew E Teschendorff, Allison Jones, Heidi Fiegl, Alexandra Sargent, Joanna J Zhuang, Henry C Kitchener, Martin Widschwendter
Genome Medicine , 2012, DOI: 10.1186/gm323
Abstract: We analyzed DNA methylation (DNAm) profiles of over 27,000 CpGs in cytologically normal cells of the uterine cervix from 152 women in a prospective nested case-control study. We used statistics based on differential variability to identify CpGs associated with the risk of transformation and a novel statistical algorithm called EVORA (Epigenetic Variable Outliers for Risk prediction Analysis) to make predictions.We observed many CpGs that were differentially variable between women who developed a non-invasive cervical neoplasia within 3 years of sample collection and those that remained disease-free. These CpGs exhibited heterogeneous outlier methylation profiles and overlapped strongly with CpGs undergoing age-associated DNA methylation changes in normal tissue. Using EVORA, we demonstrate that the risk of cervical neoplasia can be predicted in blind test sets (AUC = 0.66 (0.58 to 0.75)), and that assessment of DNAm variability allows more reliable identification of risk-associated CpGs than statistics based on differences in mean methylation levels. In independent data, EVORA showed high sensitivity and specificity to detect pre-invasive neoplasia and cervical cancer (AUC = 0.93 (0.86 to 1) and AUC = 1, respectively).We demonstrate that the risk of neoplastic transformation can be predicted from DNA methylation profiles in the morphologically normal cell of origin of an epithelial cancer. Having profiled only 0.1% of CpGs in the human genome, studies of wider coverage are likely to yield improved predictive and diagnostic models with the accuracy needed for clinical application.The ARTISTIC trial is registered with the International Standard Randomised Controlled Trial Number ISRCTN25417821.It has been proposed that epigenetic variation may contribute to the risk of complex genetic diseases like cancer and that differential exposure to environmental risk factors may underlie much of this variation [1,2]. Consistent with this view, a recent study has shown that regi
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