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Search Results: 1 - 10 of 5795 matches for " Martelli Junior "
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Choroid plexus carcinoma: case report = Carcinoma de plexo coroide: relato de caso
Gon?alves, Eduardo,Bonan, Paulo Ferreti,Martelli Junior, Hercílio
Scientia Medica , 2012,
Abstract: Objetivos: Descrever um caso de carcinoma do plexo coroide no qual os sinais e sintomas iniciais foram relacionadas ao trato respiratório superior, ao contrário da sintomatologia clássica da doen a reportada na literatura. Descri o do caso: Um menino de dois anos e oito meses de idade foi internado por insuficiência respiratória aguda. O paciente foi tratado com antibióticos para suspeita de crupe, sem sucesso, e após oito dias mostrou sintomatologia neurológica, que levou a uma investiga o e ao diagnóstico de carcinoma do plexo coroide. A ressec o foi contra-indicada devido à extens o do tumor e envolvimento de áreas vitais. Conclus es: A evolu o rápida do carcinoma do plexo coroide neste caso mostra a necessidade da suspeita precoce de distúrbios do sistema nervoso central. Este caso pode alertar os pediatras para a necessidade de considerar a presen a de um tumor cerebral levando a les o do nervo vago em casos de dificuldade respiratória resistente ao tratamento. Aims: To describe a case of choroid plexus carcinoma which initial signs and symptoms were related to the upper respiratory tract, contrary to the classic symptomatology of this disease reported in the literature. Case description: A two years and eight months old boy was admitted due to acute respiratory failure. He was treated with antibiotics for suspected croup without success. After two weeks he presented neurological manifestations that led to investigation and diagnosis of choroid plexus carcinoma. Resection was contraindicated due to extension of the tumor and involvement of vital areas. Conclusions: The rapid evolution of choroid plexus carcinoma in this case points to the need for early suspicion of central nervous system disorders. This case may alert pediatricians to the need to consider the presence of a brain tumor causing injury to the vagus nerve in cases of respiratory distress resistant to treatment.
Les?es múltiplas n?o neoplásicas na tomografia computadorizada do cranio
Colli, Benedicto Oscar;Martelli, Nelson;Assirati Junior, Jo?o Alberto;Machado, Hélio Rubens;
Arquivos de Neuro-Psiquiatria , 1986, DOI: 10.1590/S0004-282X1986000200007
Abstract: multiple intracranial lesions observed in the computerized tomography ever cause worry due to the possibility of neoplastic etiology, although granulomatous diseases (parasitic or not) and vascular diseases can produce this type of lesions. five patients with clinical picture that sugested expansive intracranial masses and that had multiple lesions in the computerized tomography that sugested neoplastic diseases are presented. in all patients the clinical evolution and/or other complementary diagnostic tests showed the non neoplastic etiology of the lesions. in three patients the lesions were due to parasitic diseases (intracranial tuberculomas in one case and neurocysticercosis in two cases) and in the other two cases the lesions were due to vascular disturbs (cerebral infarcts). the knowledge of the several diseases that can cause multiple intracranial lesions as seen in the computerized tomography allows to direct the etiologic diagnostic that is essential to introduce the correct treatment avoiding irradiation of non neoplastic lesions and unnecessary surgical procedures. in our country, granulomatous parasitic diseases, mainly neurocysticercosis, tuberculosis and fungal diseases must be considered in the differential diagnosis of multiple intracranial lesions observed in the computerized tomography, together with cerebral infarcts and neoplasms.
Cyclosporin A-induced gingival overgrowth is not associated with myofibroblast transdifferentiation
Sobral, Lays Martin;Kellermann, Michele Gassen;Graner, Edgard;Martelli-Junior, Hercilio;Coletta, Ricardo Della;
Brazilian Oral Research , 2010, DOI: 10.1590/S1806-83242010000200010
Abstract: cyclosporin a (cya) induces gingival overgrowth via its stimulatory effects on expression of transforming growth factor-beta1 (tgf-β1) and collagen. it is not known whether cya has a direct effect on gingival fibroblasts or induces its effect indirectly via stimulation of myofibroblast transdifferentiation. the present study was undertaken to examine the in vivo and in vitro effect of cya on myofibroblast transdifferentiation. rats were treated for 60 days with a daily subcutaneous injection of cya, and the gingival overgrowth tissue was analyzed by immunohistochemistry. in vitro, fibroblasts from normal gingiva (ng) were cultured in the presence of different concentrations of cya, and subjected to semi-quantitative reverse transcriptase-polymerase chain reaction and western blot. although cya treatment stimulated tgf-β1 expression by ng fibroblasts, it lacked to induce expression and production of isoform α of smooth muscle actin (α-sma), the specific myofibroblast marker. the expression levels of connective tissue growth factor (ctgf), which has been considered a key molecule to promote the transdifferentiation of myofibroblasts via tgf-β1 activation, were unaffected by cya. our results demonstrate that cya-induced gingival overgrowth is not associated with activation of myofibroblast transdifferentiation, since cya is not capable to increase ctgf expression.
Compara??o microscópica e proliferativa de fibroblastos gengivais de pacientes com gengiva normal e com fibromatose gengival hereditária
MARTELLI-JUNIOR, Hercílio;BOLZANI, Glaucia;GRANER, Edgard;BOZZO, Louren?o;COLETTA, Ricardo Della;
Pesquisa Odontológica Brasileira , 2000, DOI: 10.1590/S1517-74912000000200006
Abstract: hereditary gingival fibromatosis (hgf) is a rare oral condition, clinically manifested through a generalized and fibrotic enlargement of the gingiva, which may present as an isolated clinical finding or in association with other features, as part of a syndrome. the biological mechanisms involved in hgf are unknown, and the results of cell-culture studies are controversial. to elucidate the phenotypic and proliferative characteristics of hgf fibroblasts, we isolated 4 cell lines of gingival fibroblasts from members of the same family with hgf, and compared with gingival fibroblasts from 4 healthy patients (ng). hgf and ng fibroblasts, in subconfluent culture densities, showed typical morphological characteristics, such as spindle form with a central spherical nucleus and long cytoplasmatic prolongations, but in saturation density, hgf cells were shorter than control cells. the nucleus/cytoplasm relation was always smaller in all hgf cell lines, suggesting that the cellular reduction is derived from reduction or compaction of the cytoplasm and not of the nucleus. the proliferation rate was higher in fibroblasts from hgf than in the ones from ng. these results suggest that differences in the morphology and proliferation of hgf fibroblasts may be associated with the biological events involved in the pathogenesis of gingival overgrowth in hgf patients.
Compara o microscópica e proliferativa de fibroblastos gengivais de pacientes com gengiva normal e com fibromatose gengival hereditária
MARTELLI-JUNIOR Hercílio,BOLZANI Glaucia,GRANER Edgard,BOZZO Louren?o
Pesquisa Odontológica Brasileira , 2000,
Abstract: Fibromatose gengival hereditária (FGH) é uma condi o bucal rara clinicamente manifestada por um aumento gengival generalizado e fibrótico, podendo apresentar-se de forma isolada ou associada a outras altera es, como parte de síndromes. Os mecanismos biológicos envolvidos na FGH s o desconhecidos, e os resultados de estudos de cultura celulares s o controversos. Para elucidar as características fenotípicas dos fibroblastos de FGH, nós isolamos quatro linhagens celulares de fibroblastos de FGH de indivíduos de uma mesma família e comparamos as características morfológicas e proliferativas com fibroblastos provenientes de pacientes com gengiva clinicamente normal (GN). Fibroblastos de GN e FGH em condi es de subconfluência celular apresentaram típicas características morfológicas, como formato fusiforme, núcleo central e longos prolongamentos citoplasmáticos, mas em condi es de satura o da densidade celular, os fibroblastos de FGH apresentaram dimens es menores que as células controle. A rela o núcleo/citoplasma foi sempre menor para todas as linhagens celulares de fibroblastos de FGH, sugerindo que a redu o celular, é proveniente de uma redu o ou compacta o citoplasmática e n o nuclear. A capacidade proliferativa de fibroblastos de FGH foi maior que a de fibroblastos de GN. Estes resultados sugerem que diferen as morfológicas e proliferativas dos fibroblastos de FGH podem estar associadas aos eventos biológicos envolvidos na etiopatogenia do aumento gengival observado em pacientes com FGH.
Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000-2005
Martelli-Junior, Hercílio;Porto, Letícia Vieto;Martelli, Daniella Reis Barbosa;Bonan, Paulo Rogério Ferreti;Freitas, Amanda Beatriz;Coletta, Ricardo Della;
Brazilian Oral Research , 2007, DOI: 10.1590/S1806-83242007000400006
Abstract: the aim of the present study was to analyze the prevalence of nonsyndromic oral clefts in children receiving treatment at the center for the rehabilitation of craniofacial anomalies, josé do rosário vellano university, alfenas, mg, brazil. all the data for the epidemiological study was retrieved from the files of 126 pediatric patients with oral clefts without any additional malformation, who came to the center for treatment between 2000 and 2005. a predominance of clefts was observed in caucasians, and the ratio of male to female was 1.3. males were 2.57 times more affected by cleft lip and palate (clp) than females. clp with a prevalence of 39.68% and isolated cleft lip (cl) with a prevalence of 38.09% were the most common anomalies, followed by isolated cleft palate (cp; 22.23%). complete and unilateral clp (26.19%) presented the highest prevalence, followed by incomplete and unilateral cl (23.81%). the present study presents the experience of a reference hospital in the state of minas gerais; however, the real prevalence of oral clefts in brazil is still unknown. our findings differ from those of a few previous brazilian reports because they suggest similar prevalences of clp and cl, and a higher prevalence of clp in caucasian males.
Pesquisadores do CNPq na área de medicina: compara??o das áreas de atua??o
Martelli-Junior, Hercílio;Martelli, Daniella Reis Barbosa;Quirino, Isabel Gomes;Oliveira, Maria Christina Lopes Araujo;Lima, Leonardo Santos;Oliveira, Eduardo Araujo de;
Revista da Associa??o Médica Brasileira , 2010, DOI: 10.1590/S0104-42302010000400024
Abstract: objective: this study evaluated the profile and scientific production of researchers in medicine who have a scholarship from the " conselho nacional de desenvolvimento científico e tecnológico" . methods: the "lattes" curriculum of 411 researchers in medicine with active scholarships during the years of 2006 to 2008 were included in the analysis. variables of interest were: gender; affiliation; scientific production, and supervision of undergraduate masters and doctorate students.. results: there was a male predominance (68%) and of scholarship level 2 (55.7%). four states of brazil are responsible for 90% of the researchers (sp, rj, rs, and mg). eight institutions account for about 80% of researchers, especially usp (30.7%) and unifesp (17%). the study identified 30 areas of expertise for researchers. in relation to scientific production, the median was 4.13 articles published per year (interquartile range, iq, 2.9 - 5.8). the median adjusted for articles published in the database web of science was 2.23 per year (iq, 1.4 - 3.2). the most productive areas of indexed articles were the areas of neurosciences (3.16, iq, 1.8 - 4.7) and psychiatry (2.92, iq, 1.73 - 4.5). conclusion: researchers in medicine are concentrated in the southeast. this study has disclosed an increase in scientific output by most researchers in the last five years. effective strategies to qualitatively improve the scientific output may possibly be enhanced by knowledge of the profile of researchers in medicine.
Subarachnoid hemorrhage after aneurysm surgery
Carlotti Junior, Carlos Gilberto;Martelli, Nelson;Assirati Junior, Jo?o Alberto;Machado, Hélio Rubens;Santos, Antonio Carlos dos;Colli, Benedicto Oscar;
Arquivos de Neuro-Psiquiatria , 1996, DOI: 10.1590/S0004-282X1996000200001
Abstract: the surgical treatment of intracranial aneurysms by clipping is recognized as effective and definitive. however some cases that suffered a new subarachnoid hemorrhage (sah) some time after they were submitted to aneurysm clipping have raised doubts about the concept of "cure"after this treatment. eleven patients previously submitted to aneurysm clipping who presented a new sah were analyzed. the time elapsed from surgery to sah varied from 3 to 10 years. after sah four patients had a poor outcome. the new episode of sah occurred due to intrinsic factors of the cerebral vasculature: 1. a weak point of the vessel wall near the previous aneurysm, 2. a weak point of another vessel far from the previous aneurysm, 3. a previous infundibular dilation of the posterior communicating artery; and due to technical problems: 1. aneurysm not identified during the previous treatment, 2. aneurysm deliberately left untreated, 3. persistence of the aneurysm due to inappropriate surgery, 4. persistency of part of the aneurysm neck after clipping and 5. slipping of the clip from the neck of the aneurysm. the measures to prevent new sah after surgery start with adequate preoperative angiographic studies, a careful inspection of the position of the clip and emptying of the aneurysm. early angiography studies may reveal a persistent neck and later ones may reveal newly developed aneurysms. in conclusion, sah after aneurysm clipping is a late and severe phenomenon and the concept of "cure" after this surgery should be interpreted with caution.
Gli spazi marginali di un personaggio bizzarro: l’adattamento del romanzo Totò il buono Marginal Spaces of an Eccentric Character: the Adaptation of the Novel Totò il buono
Matteo Martelli
Between , 2012,
Abstract: Il saggio propone uno studio del romanzo di Cesare Zavattini, Totò il buono, e della riscrittura filmica Miracolo a Milano (firmata da Zavattini stesso e Vittorio De Sica) attraverso l’analisi della figura del protagonista, Totò, personaggio eccentrico e buono. In maniera particolare, a partire dalla presenza in entrambi i testi di spazi di marginalità culturale dai quali si costruiscono le qualità bizzarre del personaggio, il saggio descrive come il lavoro d’adattamento rielabori le formulazioni del romanzo attraverso l’introduzione di un punto di vista della tradizione, estetica e antropologica, del grottesco e del realismo popolare, integrando e spostando al tempo stesso il precedente stato di marginalità da uno spazio asociale alla valorizzazione, sul piano immaginario, di un’utopia comunitaria. The study suggests an analysis of the adaptation of character by the novel of Cesare Zavattini Totò il buono to Vittorio De Sica’s film Miracolo a Milano, and focuses on representation of goodness, as eccentric quality that the texts connect with the fictional word of Totò. Particularly if both works show the character linked at marginal spaces in relation at culture of destination, their suggestions are not equivalent. The essay illustrates how adaptation reworks the idea of novel (where marginality is connected with nature and asocial space) by the point of view of grotesque to clime its utopia and valorize popular and folkloric culture according with neorealist interpretation of Zavattini.
Consumers’ perception of farm animal welfare: an Italian and European perspective
Giovanna Martelli
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2009.s1.31
Abstract: The results of some recent European and Italian surveys on consumer perception of farm animal welfare are shown and discussed. Special attention is paid to consumers’ opinions about animal welfare attributes, differences among species (and across countries) in terms of animal welfare perception, “animal-friendly” labels and willingness of purchasers to pay more for food (eggs) deriving from animals raised under higher welfare conditions. From a general standpoint, consumers’ perception and knowledge of animal welfare varies among European countries and it is mainly affected by their economic and educational level. Among animal welfare attributes, a strong preference is given to the availability of spaces, and, in the case of Italian respondents, also to the absence of movement restrictions (chains or tethers). Laying hens (44%), followed by broilers (42%) and pigs (28%) are the categories/species for which rearing conditions in the EU are judged to need the highest improvement in terms of welfare. Italian consumers appear less concerned about swine welfare (17%) than other Europeans. It is noteworthy that 12% of EU respondents states that all farmed animals need more welfare and/or protection. With respect to labels on food packaging, claims for animal welfare often fall within wider schemes for quality assurance and, with the exception of eggs and organic goods, in many countries the possibility of identifying animal friendly products and the knowledge of the specific legislation on farm animal protection are still limited. According to the Community Action Plan on the Protection and Welfare of Animals 2006-2010, the establishment of an EU label for animal welfare, based on standardised scientific indicators, is an option to be explored which could promote the consumption of products elaborated under high welfare standards thus facilitating the choice of consumers. The readiness of consumers to pay more for a higher animal welfare level has been investigated with respect to hen eggs. On the whole, and with deep differences among countries, results indicate that the majority of consumers (57%) are willing to pay more for eggs sourced from animal-friendly systems; however, the increase in price has, in general, a limited extent (5-10%). The perception of a link between food quality, food safety and animal welfare can favourably affect the welfare level of farmed animals.
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