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Search Results: 1 - 10 of 7501 matches for " Marta Muzio "
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Marta Muzio,Eleonora Fonte,Federico Caligaris-Cappio
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity
Federica Riva,Eduardo Bonavita,Elisa Barbati,Marta Muzio,Alberto Mantovani,Cecilia Garlanda
Frontiers in Immunology , 2012, DOI: 10.3389/fimmu.2012.00322
Abstract: Interleukin-1R like receptors (ILRs) and Toll Like Receptors (TLRs) are key receptors of innate immunity, inflammation, and orientation of the adaptive response. They belong to a superfamily characterized by the presence of a conserved intracellular domain, the Toll/IL-1R (TIR) domain, which is involved in the activation of a signaling cascade leading to activation of transcription factors associated to inflammation. The activation of inflammatory responses and immunity by ILRs or TLRs signaling is potentially detrimental for the host in acute and chronic conditions and is tightly regulated at different levels by receptor antagonists, decoy receptors or signaling molecules, and miRNAs. Recent evidence suggests that the ILRs family member TIR8 (also known as SIGIRR) is a regulatory protein acting intracellularly to inhibit ILRs and TLRs signaling. In particular, current evidence suggests that TIR8/SIGIRR dampens TLRs-mediated activation and inhibits signaling receptor complexes of IL-1 family members associated with Th1 (IL-18), Th2 (IL-33), and Th17 (IL-1) differentiation. Studies with Tir8/Sigirr-deficient mice showed that the ability to dampen signaling from ILRs and TLRs family members makes TIR8/SIGIRR a key regulator of inflammation. Here, we summarize our current understanding of the structure and function of TIR8/SIGIRR, focusing on its role in different pathological conditions, ranging from infectious and sterile inflammation, to autoimmunity and cancer-related inflammation.
The Struggle against "Urban Renewal" in Manhattan's Upper West Side and the Emergence of El Comité
Rose Muzio
Centro Journal , 2009,
Abstract: Through an examination of the contentious housing campaign known as "Operation Move-In" in Manhattan's Upper West Side in 1970, this essay demonstrates the partial effectiveness of protests against "urban renewal" that used disruptive tactics, persuasive mobilizing frames, and mainstream allies to elicit concessions from elites. The movement's participants reduced the immediate impact of New York City's displacement policies by squatting in buildings earmarked for destruction and negotiating a higher percentage of units for low-income tenants in high-rise developments. Further, it analyzes the formation and politicization of El Comité, one of the main organizations of the Puerto Rican Left in the 1970s, illustrating how a radical political perspective developed organically among predominantly working-class Puerto Rican activists, rather than as a product of a priori ideology. Among the multiple factors that contributed to political consciousness and activism in the period were the intersecting experiences of national identity, race, and class of Puerto Ricans in New York City.
Indicadores de contaminación biológica asociados a la erosión hídrica en una cuenca de Pampa Ondulada Argentina
Chagas,Celio I.; Morettón,Juan; Santanatoglia,Oscar J.; Paz,Marta; Muzio,Humberto; De Siervi,Marcelo; Castiglioni,Mario;
Ciencia del suelo , 2006,
Abstract: agriculture activities use 70% of the world water resources, partly for animal production and particularly cattle feeding. there is an outstanding risk of biological contamination associated with this kind of production because animal feces and urine containing pathogens can be transported to surface waterways through runoff. the present investigation was carried out in the tala basin belonging to the rolling pampa region in which intense runoff and erosion processes are widespread. in this basin there are extensive cattle feeding farms which are located close to the natural waterways, in bottomlands with hydrohalomorphic soils. there is also an increasing surface devoted to feedlots and intensive swine and poultry productions. the main use of the surface waters from the river and tributaries is direct cattle drinking. the aim of the present work was to analyze through biological indicators, the potential contamination of runoff water and sediments accumulated in lowlands devoted to cattle production and to determinate their human or animal origin. the waters showed concentration of biological indicators belonging to faecal streptococci and enterococci which can be related to animal but no to human contamination processes. a close relationship was observed between total coliforms and erosion borne sediment concentration in the studied area. thus, the capacity of these sediments for carrying bacteria potentially harmful for animal health like salmonella spp. was confirmed. the runoff, erosion and biological contamination processes proved to be related in the studied basin.
Nevoid basal cell carcinoma syndrome (Gorlin syndrome)
Lorenzo Lo Muzio
Orphanet Journal of Rare Diseases , 2008, DOI: 10.1186/1750-1172-3-32
Abstract: The estimated prevalence varies from 1/57,000 to 1/256,000, with a male-to-female ratio of 1:1.Main clinical manifestations include multiple basal cell carcinomas (BCCs), odontogenic keratocysts of the jaws, hyperkeratosis of palms and soles, skeletal abnormalities, intracranial ectopic calcifications, and facial dysmorphism (macrocephaly, cleft lip/palate and severe eye anomalies). Intellectual deficit is present in up to 5% of cases. BCCs (varying clinically from flesh-colored papules to ulcerating plaques and in diameter from 1 to 10 mm) are most commonly located on the face, back and chest. The number of BBCs varies from a few to several thousand. Recurrent jaw cysts occur in 90% of patients. Skeletal abnormalities (affecting the shape of the ribs, vertebral column bones, and the skull) are frequent. Ocular, genitourinary and cardiovascular disorders may occur. About 5–10% of NBCCS patients develop the brain malignancy medulloblastoma, which may be a potential cause of early death.NBCCS is caused by mutations in the PTCH1 gene and is transmitted as an autosomal dominant trait with complete penetrance and variable expressivity.Clinical diagnosis relies on specific criteria. Gene mutation analysis confirms the diagnosis. Genetic counseling is mandatory. Antenatal diagnosis is feasible by means of ultrasound scans and analysis of DNA extracted from fetal cells (obtained by amniocentesis or chorionic villus sampling). Main differential diagnoses include Bazex syndrome, trichoepithelioma papulosum multiplex and Torre's syndrome (Muir-Torre's syndrome).Management requires a multidisciplinary approach. Keratocysts are treated by surgical removal. Surgery for BBCs is indicated when the number of lesions is limited; other treatments include laser ablation, photodynamic therapy and topical chemotherapy. Radiotherapy should be avoided. Vitamin A analogs may play a preventive role against development of new BCCs.Life expectancy in NBCCS is not significantly altered but morb
Propuesta de un dise o teórico-metodológico para la intervención familiar en salud comunitaria
Patricia Arés Muzio
Revista Interamericana de Psicología , 2000,
Aprendizaje instrumental en anfibios
Rubén N. Muzio
Revista Latinoamericana de Psicología , 1999,
Abstract: Este trabajo presenta una revisión de los estudios realizados acerca de los mecanismos de aprendizaje en anfibios. Se conoce muy poco acerca de los procesos de aprendizaje en anfibios, y aún menos respecto de las relaciones cerebro-aprendizaje. Recientemente hemos comenzado el estudio sistemático del aprendizaje instrumental en el sapo Bufo arenarum dentro de un marco comparativo. Se observaron diversos fenómenos de aprendizaje comunes a una amplia variedad de vertebrados, tales como la adquisición bajo condiciones de entrenamiento masivo y espaciado, la extinción, la recuperación espontánea, el efecto subsiguiente al refuerzo, y el efecto en al adquisición de la magnitud del reforzamiento. Además, comenzamos el análisis de los efectos sobre el aprendizaje de las lesiones del pallium medial (estructura postulada como homóloga al hipocampo de los mamíferos). La lesión del paIlium medial no tuvo efectos sobre el desempe o ni sobre la tasa de captación de agua durante la adquisición. Pero retardó significativamente la extinción de la respuesta instrumental en un corredor recto. Estos datos sugieren que el palli um medial de los sapos juega un papel en la inhibición de respuestas previamente aprendidas. Los resultados de nuestros estudios en el sapo Bufo arenarum aportan datos origi na1es a la limitada información disponible sobre aprendizaje en anfibios.
Theism and the Meaning of Life
Muzio, Gianluca di
Ars Disputandi : the Online Journal for Philosophy of Religion , 2006,
Abstract: Theists are inclined to assert that human life would be meaningless if there was no personal immortality and God did not exist. The present paper aims to evaluate the truth of this claim. The author first explores the conception of meaning that is at the roots of the theistic position. After pointing out some difficulties with it, the author shows that, on a plausible alternative interpretation of what it is for an activity to have meaning, human life would fully qualify as meaningful even if it were not inscribed in a universal divine plan.
Charles Flaherty (1937-2004)
Rubén N. Muzio,Alba E. Mustaca
Revista Latinoamericana de Psicología , 2005,
Investigation of the Role of Electrogenerated N-Heterocyclic Carbene in the Staudinger Synthesis in Ionic Liquid  [PDF]
Marta Feroci
International Journal of Organic Chemistry (IJOC) , 2011, DOI: 10.4236/ijoc.2011.14028
Abstract: Electrogenerated N-heterocyclic carbene (NHC), obtained by cathodic reduction of Bmim-BF4, behaves as organocatalyst and base in the Staudinger synthesis from an acyl chloride and a deactivated imine in ionic liquid to yield ?-lactams. The effect of many parameters (temperature, amount of electricity, substituents, presence of an external base) has been evaluated and a tentative mechanism for the Staudinger synthesis in a very polar medium like the ionic liquid reported. The yields of isolated ?-lactams are good, starting from non-electrophilic imines, and predominantly trans lactams are obtained with a good diastereomeric ratio.
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