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Search Results: 1 - 10 of 13204 matches for " Marta Chagas Monteiro "
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Componentes antiinflamatórios na saliva do Lutzomyia longipalpis, vetor da Leishmania chagasi
Marta Chagas Monteiro
Ambiência , 2005,
Abstract: A inocula o da saliva de vetores na pele do hospedeiro é importante tanto para a alimenta o do inseto quanto para a transmiss o e estabelecimento de várias infec es. Em leishmaniose, vários estudos demonstram que a saliva dos vetores Lutzomyia e Phlebotomus contém substancias com atividades imunossupressoras, imunomodulatórias, vasodilatadoras, anti-plaquetárias e anticoagulantes. Os componentes salivares auxiliam a alimenta o do inseto através do aumento do fluxo sanguíneo, assim como induzem a imunossupress o no hospedeiro, o que é fundamental para o estabelecimento da infec o por Leishmania. Neste trabalho foi observado que a saliva induz a produ o de IL-10, citocina antiinflamatória, n o alterando a produ o de IFN-g , citocina próinflamatória, no foco da inflama o. Além disso, a saliva potencializa o edema induzido por carragenina.
Detec??o de sífilis por ensaios de ELISA e VDRL em doadores de sangue do Hemonúcleo de Guarapuava, Estado do Paraná
Oliveira, Viviane Matoso de;Verdasca, Izabel Cristina;Monteiro, Marta Chagas;
Revista da Sociedade Brasileira de Medicina Tropical , 2008, DOI: 10.1590/S0037-86822008000400023
Abstract: the aim of this study was to evaluate the syphilis seroprevalence among 5,752 blood donors who were attended at the blood center of guarapuava, state of paraná, in 2006. the seropositivity rates were 2.1% for enzyme linked immuno sorbent assay and 0.2% for veneral disease research laboratory, thus showing low prevalence of syphilis among the individuals who came to this blood bank.
Aflatoxinas: um risco a saúde humana e animal / Aflatoxins: a risk animal and human health
Helder Ferreira,Elaine Pittner,Hermes Francisco Sanches,Marta Chagas Monteiro
Ambiência , 2006,
Abstract: O Aspergillus flavus e a subespécie próxima relacionada parasiticus têm sido reconhecidas por muito tempo como contaminadores principais de produtos organicos e inorganicos. A. flavus, um fungo comum do solo, pode infestar uma larga escala de produtos agrícolas. Algumas variedades de A. flavus produzem as aflatoxinas, que s o toxinas neoplásicas capazes de induzir neoplasia hepática em animais de laboratório. O crescimento de A. flavus e a biossíntese da aflatoxina depende da carca a, da umidade, da temperatura, do pH, da aera o e da microflora competindo. As aflatoxinas s o consideradas contaminantes naturais; cuja aproxima o ideal de controle é a preven o do crescimento do fungo e produ o das aflatoxinas nos produtos. As aflatoxinas (B1, B2, G1 e G2) s o metabólitos secundários associados à toxicidade causada por alimenta es em animais. As aflatoxinas s o relatadas como sendo hepatotóxicas, mutagênicas, imunossupressora e neoplásicas. A exposi o as aflatoxinas dietéticas é considerada um fator de risco importante para o desenvolvimento de neoplasia hepatocelular em determinadas regi es do mundo. A indu o de adutos no DNA pela aflatoxina B1 no fígado foi revista extensivamente em uma avalia o quantitativa de fatores de risco a neoplasias por aflatoxinas. As aflatoxinas s o pró-neoplásicas, reagindo com o ácido desoxirribonucléico (DNA), ácido ribonucléico (RNA) e as proteínas. Atualmente, vários avan os científicos têm sido feitos a fim de compreender a toxicologia clínica das aflatoxinas.
Detec??o de casos novos de hanseníase no município de Prudentópolis, PR: uma análise de 1998 a 2005
Sanches, Lucas Augusto Thomé;Pittner, Elaine;Sanches, Hermes Francisco;Monteiro, Marta Chagas;
Revista da Sociedade Brasileira de Medicina Tropical , 2007, DOI: 10.1590/S0037-86822007000500010
Abstract: the aim of this study was to evaluate the detection of new cases of leprosy in prudentópolis, state of paraná, from 1998 to 2005. additionally, we investigated the age group and predominant clinical form of leprosy cases. data were obtained from clinical-epidemiological records of confirmed leprosy cases that were notified in the information system for notifiable diseases, between 1998 and 2005. over this period, 222 leprosy cases were notified, of which 63% presented the multibacillary form, with predominance of the virchow clinical form, thus indicating a process of intense disease transmission. among these leprosy cases, 35% of the patients were at an economically active age (31 to 45 years old). these indicators showed that there was a high level of bacillus circulation in the community, considering that one risk factor for infection by the bacillus mycobacterium leprae is contact with untreated individuals who have the multibacillary form. this is despite the drastic reduction in leprosy prevalence over the last two decades, through the implementation of polychemotherapy and other preventive measures.
Antimicrobial activity of extracts obtained from the seeds of Vatairea guianensis (Aublet)
Cléia Tereza LAMAR?O DA SILVA,Lúcia Carla MENDON?A,Marta CHAGAS MONTEIRO,José Carlos TAVARES CARVALHO
Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas , 2011,
Abstract: Las plantas medicinales son ampliamente utilizados y culturalmente de forma empírica para tratar varias enfermedades en la Amazonía. Aquí, fue estudiado Vatairea guianensis, que se utiliza en la medicina tradicional para tratar infecciones de la piel, como las micosis cutáneas. El presente trabajo se evaluó la actividad in vitro antibacteriana de los extractos hidroetanólico, hexánico, clorofórmico y metanólico, obtenido de las semillas de V. guianensis por el método de microdilución en caldo, para medir su concentración inhibitoria mínima (CIM) y la concentración mínima bactericida (CMB) contra las bacterias Gram-positivas (Staphylococcus aureus y Enterococcus faecalis) y Gram-negativas (Pseudomonas aeruginosa y Salmonella sp.). Todos los extractos mostraron actividad antimicrobiana frente a bacterias Gram-positivas y Gram-negativas, con los CIM que van desde 3,12 ug / ml a 50 ug / mL y CMB que van de 6,25 ug / ml a 100 ug / ml. Por último, estos resultados sobre la actividad antimicrobiana podrían contribuir al estudio de V. guianensis y aumentar el interés médico en este género, que todavía está poco estudiada.
Spatial distribution of enteroparasites among school children from Guarapuava, State of Paraná, Brazil
Buschini, Maria Luisa Tunes;Pittner, Elaine;Czervinski, Tiago;Moraes, Ivonete de Fátima;Moreira, M?nica Monteiro;Sanches, Hermes Francisco;Monteiro, Marta Chagas;
Revista Brasileira de Epidemiologia , 2007, DOI: 10.1590/S1415-790X2007000400015
Abstract: the most common infections in human beings are caused by intestinal parasites. they can lead to a number of harmful effects, which could include, among others, intestinal obstruction, malnutrition, iron deficiency anemia, diarrhea, and poor absorption. in brazil, enteroparasites are one of the main public health issues. the present study aims at analyzing the distribution and frequency of enteroparasite occurrence in 635 children from seven community schools in the city of guarapuava, paraná (pr). in addition, we used similarity and diversity indices to analyze the parasite community. we found 475 samples with at least one parasite showing that 75.27% of children had enteroparasites. a smaller fraction (26.73%) of children harbored several parasites (multiparasitism), especially giardia duodenalis (56%), and ascaris lumbricoides (18%). statistical analysis showed that three (out of seven) children communities had higher similarity in frequency and amount of parasites. our results suggest that the children studied were highly infected by enteroparasites. these levels of infestation could be related to several factors, such as climate, social and economic conditions and characteristics of the parasites.
Clinical Oxidative Stress during Leprosy Multidrug Therapy: Impact of Dapsone Oxidation
Taysa Ribeiro Schalcher, Rosivaldo S. Borges, Michael D. Coleman, Jo?o Batista Júnior, Claudio G. Salgado, Jose Luiz F. Vieira, Pedro R. T. Rom?o, Fabio R. Oliveira, Marta Chagas Monteiro
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0085712
Abstract: This study aims to assess the oxidative stress in leprosy patients under multidrug therapy (MDT; dapsone, clofazimine and rifampicin), evaluating the nitric oxide (NO) concentration, catalase (CAT) and superoxide dismutase (SOD) activities, glutathione (GSH) levels, total antioxidant capacity, lipid peroxidation, and methemoglobin formation. For this, we analyzed 23 leprosy patients and 20 healthy individuals from the Amazon region, Brazil, aged between 20 and 45 years. Blood sampling enabled the evaluation of leprosy patients prior to starting multidrug therapy (called MDT 0) and until the third month of multidrug therapy (MDT 3). With regard to dapsone (DDS) plasma levels, we showed that there was no statistical difference in drug plasma levels between multibacillary (0.518±0.029 μg/mL) and paucibacillary (0.662±0.123 μg/mL) patients. The methemoglobin levels and numbers of Heinz bodies were significantly enhanced after the third MDT-supervised dose, but this treatment did not significantly change the lipid peroxidation and NO levels in these leprosy patients. In addition, CAT activity was significantly reduced in MDT-treated leprosy patients, while GSH content was increased in these patients. However, SOD and Trolox equivalent antioxidant capacity levels were similar in patients with and without treatment. These data suggest that MDT can reduce the activity of some antioxidant enzyme and influence ROS accumulation, which may induce hematological changes, such as methemoglobinemia in patients with leprosy. We also explored some redox mechanisms associated with DDS and its main oxidative metabolite DDS-NHOH and we explored the possible binding of DDS to the active site of CYP2C19 with the aid of molecular modeling software.
Modernidade pedagógica e modelos de forma??o docente
CARVALHO, MARTA MARIA CHAGAS DE;
S?o Paulo em Perspectiva , 2000, DOI: 10.1590/S0102-88392000000100013
Abstract: o artigo objetiva discernir, na prolifera??o dos discursos que, no brasil, a partir do final do século xix e nas primeiras quatro décadas do século xx, buscaram legitimar-se como saber pedagógico de tipo novo, moderno, experimental e científico, estilos distintos de organiza??o do campo dos saberes representados como necessários à prática docente. compreendendo o impresso destinado ao uso de professores como dispositivo de constitui??o desse campo, distingue dois modelos de forma??o docente inscritos na configura??o material de revistas, livros e cole??es que circularam no período: a "caixa de utensílios" e a "biblioteca".
Pedagogia da Escola Nova e usos do impresso: itinerário de uma investiga o
Marta Maria Chagas de Carvalho
Educa??o : Revista do Centro de Educa??o UFSM , 2005,
Abstract: O objetivo deste artigo é analisar a dissemina o do chamado "escolanovismo" no Brasil. é examinado o modo pelo qual o impresso funcionou como dispositivo de configura o do campo da pedagogia e de conforma o das práticas escolares. Recusando-se automatizar o ideário escolanovista das práticas em que se inscreveu e dos dispositivos que o fizeram circular, a investiga o situou-se no domínio de uma história material da circula o do impresso e de suas apropria es. Palavras-chave: Escola Nova. Impresso. Pedagogia.
Testes de for?a e resistência muscular: confiabilidade e predi??o de uma repeti??o máxima - Revis?o e novas evidências
Pereira, Marta Inez Rodrigues;Gomes, Paulo Sergio Chagas;
Revista Brasileira de Medicina do Esporte , 2003, DOI: 10.1590/S1517-86922003000500007
Abstract: intra-tester reliability is fundamental in determining the quality of data collected in research. few controlled studies have reported the reliability of strength tests and, in spite of most published studies reporting it to be good (0.79 to 0.99), differences between test and retest are observed to be statistically significant. thus, for research purposes, it is suggested that values should be taken from a second test, at least, so that changes in strength may be attributed to treatment effect and not simply to adaptation to the test protocol. the relationships between maximum strength tests and submaximal tests or anthropometric variables have been investigated in order to predict maximal strength without submitting subjects to a maximal load test, so as to avoid the risk of injury. maximal load, or a percentage of it, is commonly used to better prescribe training. prediction of one repetition maximum (1rm) from submaximal tests seems to be good (in general, correlation coefficients > 0.90), although studies have mostly failed to cross-validate prediction equations. thus, care should be taken especially in relation to specificity of the population, of the exercise, and performance technique when developing and applying these equations. anthropometric variables have not proven to be good predictors of 1rm. the number of repetitions for a given % of 1rm is different for different exercises, so is the load for a given number of repetitions maximum (nrm) when performed at different velocities. exercise prescription based, indifferently, on number of repetitions or %1rm should be carefully considered.
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