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Search Results: 1 - 10 of 492909 matches for " Martínez-García Pedro "
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Two new cases of anti-Ca (anti-ARHGAP26/GRAF) autoantibody-associated cerebellar ataxia
Jarius Sven,Martínez-García Pedro,Hernandez Adelaida León,Brase Jan Christoph
Journal of Neuroinflammation , 2013, DOI: 10.1186/1742-2094-10-7
Abstract: Recently, we discovered a novel serum and cerebrospinal fluid (CSF) autoantibody (anti-Ca) to Purkinje cells in a patient with autoimmune cerebellar ataxia (ACA) and identified the RhoGTPase-activating protein 26 (ARHGAP26; alternative designations include GTPase regulator associated with focal adhesion kinase pp125, GRAF, and oligophrenin-1-like protein, OPHN1L) as the target antigen. Here, we report on two new cases of ARHGAP26 autoantibody-positive ACA that were first diagnosed after publication of the index case study. While the index patient developed ACA following an episode of respiratory infection with still no evidence for malignancy 52 months after onset, neurological symptoms heralded ovarian cancer in one of the patients described here. Our finding of anti-Ca/anti-ARHGAP26 antibodies in two additional patients supports a role of autoimmunity against ARHGAP26 in the pathogenesis of ACA. Moreover, the finding of ovarian cancer in one of our patients suggests that anti-Ca/anti-ARHGAP26-positive ACA might be of paraneoplastic aetiology in some cases. In conclusion, testing for anti-Ca/anti-ARHGAP26 should be included in the diagnostic work-up of patients with ACA, and an underlying tumour should be considered in patients presenting with anti-Ca/ARHGAP26 antibody-positive ACA.
Health Systems as Complex Systems  [PDF]
Mireya Martínez-García, Enrique Hernández-Lemus
American Journal of Operations Research (AJOR) , 2013, DOI: 10.4236/ajor.2013.31A011

Health systems are paradigmatic examples of human organizations that blend a multitude of different professional and disciplinary features within a critically performance environment. Communication failure and defective processes in health systems have a tremendous impact in society, both in the financial and human aspects. Traditionally, health systems have been regarded as linear hierarchic structures. However, recent developments in the sciences of complexity point out to health systems as complex entities governed by non-linear interaction laws, self-organization and emergent phenomena. In this work we review some aspects of complexity behind health systems and how they can be applied to improve the performance of healthcare organizations.

Martínez-García,Juan Diego;
International Law , 2012,
Abstract: on the 2nd of february 2009 the european union enacted the directive 2008/101/ec, which amended directive 2003/87/ec, to include aviation activities in the scheme for greenhouse gas emission allowance trading within the community. the purpose of this paper is to define whether this unilateral measure constitutes a breach of international law.
Carbonización cadavérica Cadaverous Carbonization
P. Martínez-García
Cuadernos de Medicina Forense , 2006,
Embolismo de cristales de colesterol secundario a trombolisis: a propósito de un caso A case of embolism caused by cholesterol crystals secondary to thrombolysis
P. Martínez-García
Cuadernos de Medicina Forense , 2006,
Testing theories in barred spiral galaxies
Eric E. Martínez-García
Physics , 2011, DOI: 10.1088/0004-637X/744/2/92
Abstract: According to one version of the recently proposed "manifold" theory that explains the origin of spirals and rings in relation to chaotic orbits, galaxies with stronger bars should have a higher spiral arms pitch angle when compared to galaxies with weaker bars. A sub-sample of barred-spiral galaxies in the Ohio State University Bright Galaxy Survey, was used to analyze the spiral arms pitch angle. These were compared with bar strengths taken from the literature. It was found that the galaxies in which the spiral arms maintain a logarithmic shape for more than 70$\degr$ seem to corroborate the predicted trend.
Statistical Analysis of Natural Water Conductivity Data Behavior in Two Wells: Seismic Coastal Border Limits of Guerrero-Oaxaca States, Mexico  [PDF]
Fidel Martínez-García
Open Access Library Journal (OALib Journal) , 2017, DOI: 10.4236/oalib.1103900
In this document, with the purpose of strengthening more in the knowledge of the previous events on the earthquakes, the possible connection between natural voltage and electromagnetic energy emanating from the inner layers of the Earth and the seismic activity in the Mexican seismic coastal border, is evaluated, through an indirect estimation of the statistical analysis of natural water conductivity data (μS/cm) and the seismic activity occurred in the same period within continental and marine environment, monitored intensively from February 2 to April 15, 2015 and from May 11 to July 17, 2015 in two ordinary man-made wells. A total 128,469 water conductivity data with a sampling frequency of 45 seconds, confronted with 950 earthquakes occurred in the same periods to distance range of 50, 100, 150, 200, 250, 300, 350 and 400 kilometers far away from a conductivity sensor, are analyzed. As results, in the range of 50 kilometers round the conductivity sensor, the study area applied demonstrates to be a location where the major quantity of earthquakes and most atypical conductivity variations occurred. The influence of the local environment on the behavior of the conductivity data is debated according to the geographical position of the conductivity sensor. Within the continental environment, the range of 0 to 50 km showed the most important statistical significance, revealing to have the most number of earthquakes, with higher values and more intensity, particularly when the trend of conductivity data is descending. Within the marine environment, a very similar connection between the conductivity data behavior and seismic activity occurred was observed.
Application of Genomic and Quantitative Genetic Tools to Identify Candidate Resistance Genes for Brown Rot Resistance in Peach
Pedro J. Martínez-García, Dan E. Parfitt, Richard M. Bostock, Jonathan Fresnedo-Ramírez, Alejandra Vazquez-Lobo, Ebenezer A. Ogundiwin, Thomas M. Gradziel, Carlos H. Crisosto
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0078634
Abstract: The availability of a complete peach genome assembly and three different peach genome sequences created by our group provide new opportunities for application of genomic data and can improve the power of the classical Quantitative Trait Loci (QTL) approaches to identify candidate genes for peach disease resistance. Brown rot caused by Monilinia spp., is the most important fungal disease of stone fruits worldwide. Improved levels of peach fruit rot resistance have been identified in some cultivars and advanced selections developed in the UC Davis and USDA breeding programs. Whole genome sequencing of the Pop-DF parents lead to discovery of high-quality SNP markers for QTL genome scanning in this experimental population. Pop-DF created by crossing a brown rot moderately resistant cultivar ‘Dr. Davis’ and a brown rot resistant introgression line, ‘F8,1–42’, derived from an initial almond × peach interspecific hybrid, was evaluated for brown rot resistance in fruit of harvest maturity over three seasons. Using the SNP linkage map of Pop-DF and phenotypic data collected with inoculated fruit, a genome scan for QTL identified several SNP markers associated with brown rot resistance. Two of these QTLs were placed on linkage group 1, covering a large (physical) region on chromosome 1. The genome scan for QTL and SNP effects predicted several candidate genes associated with disease resistance responses in other host-pathogen systems. Two potential candidate genes, ppa011763m and ppa026453m, may be the genes primarily responsible for M. fructicola recognition in peach, activating both PAMP-triggered immunity (PTI) and effector-triggered immunity (ETI) responses. Our results provide a foundation for further genetic dissection, marker assisted breeding for brown rot resistance, and development of peach cultivars resistant to brown rot.
El impacto de la detección de disfunción endotelial en la aterosclerosis: estudio mediante tomografía por emisión de positrones
Alexánderson-Rosas, Erick;Calleja-Torres, Rodrigo;Martínez-García, Alfonso;Lamothe-Molina, Pedro Alberto;Ochoa-López, Juan Manuel;Meléndez, Gabriela;Kimura-Hayama, Eric;Meave-González, Aloha;
Archivos de cardiología de México , 2010,
Abstract: the endothelium plays an important role in the regulation of the intracellular fluid, vascular permeability, and modulation of vascular focal tone and angiogenesis. endothelial dysfunction is manifested by the loss of the endothelium ability to modulate physiology changes in its vascular bed, and actually it is considered a prognostic marker of coronary artery disease. the relevance of assessing endothelial dysfunction relies in that it has been observed in different pathologies like dm, dyslipidemia, hypertension, tabaquism and in immunologic diseases like antiphospholipid syndrome and systemic lupus. pet is a non invasive method that allows the absolute quantification of myocardial blood flow during rest, stress and adrenergic stimulation, which allows to asses endothelial function. therefore pet is a useful diagnostic technique to identify patients with endothelial dysfunction, and in the assessment of its response to administered therapy, allowing an optimal control and prevention of secondary adverse events of these diseases.
Contusión figurada en precipitación
Sibón Olano,A.; Martínez-García,P.;
Cuadernos de Medicina Forense , 2003, DOI: 10.4321/S1135-76062003000300006
Abstract: we present a case of precipitation from great height in which some figured bruises that reproduce the drawing of the pavement are highlighted. a combination of bruise and laceration that imitates the same figure stands ont on the forearm. the elasticity of the skin resists the traumatism with more effectiveness than the internal organs, for which reason, as in most of these events, the disproportion of the internal lesions in relation to the external ones predominates. likewise, the lesions found in the autopsy are described, and the etiology, incidence and frequency of lesions in the lateral precipitation of the body are discussed.
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