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Search Results: 1 - 10 of 9554 matches for " Marlene Isabel; Songane "
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A single dose of live-attenuated 638 Vibrio cholerae oral vaccine is safe and immunogenic in adult volunteers in Mozambique
García,Hilda María; Thompson,Ricardo; Valera,Rodrigo; Fando,Rafael; Fumane,Jo?o; Jani,Ilesh; Mirabal,Mayelín; Armesto,Marlene Isabel; Songane,Mario; Luis,Sonia; Nzualo,Ana María; Celeste,Judite; Viegas,Sofía; Samo Gudo,Eduardo; Melembe,Amélia; Bila,Dulce; Cemá,Cynthia; Mabumo,Carolina; García,Luis; Cedré,Bárbara; A?o,Gemma; Martínez,Juan Carlos; Mandarioti,Aleyda; Lugones,Juan; González,Domingo; Baró,Morelia; Hernández,Jonathan; Talavera,Arturo; Solis,Rosa Lidia; Sierra,Gustavo; Barberá,Ramón; Domínguez,Francisco; Gutiérrez,Carlos; Campa,Concepción; Garrido,Ivo; Menéndez,Jorge;
Vaccimonitor , 2011,
Abstract: a placebo-controlled randomized, double-blind, clinical trial was carried out to assess the safety, reactogenicity, and immunogenicity of the lyophilized vaccine candidate against cholera derived from the live attenuated 638 vibrio cholerae o1 el tor ogawa strain. one hundred and twenty presumably healthy female and male adult volunteers aged between 18 and 50 years were included. they were from maputo, mozambique a cholera endemic area, where, in addition, human immunodeficiency virus (hiv) seroprevalence is from 20 to 30%. a dose of 2 x 10 9 colony forming units (cfu) was given to 80 subjects and other 40 received only vaccine lyoprotectors as a placebo control. out-patient follow-up of adverse events was carried out during the following 30 days after vaccination. the immune response was evaluated by the estimation of seroconversion rate and the geometric mean titer (gmt) of vibriocidal antibodies in the sera from volunteers that was collected previously, and at days 14 and 21 after immunization. no serious adverse events were reported. the adverse events found in the vaccine group were similar to those of the placebo groups. they were independent from the detection of antibodies against hiv-1, hiv-2, hepatitis (h) a; hc and hepatitis b surface antigen. the presence of helminthes did not modify the incidence of adverse events. the 638 vaccine strain was isolated in 37 (46.25%) vaccinated volunteer's feces. the peak of the gmt of vibriocidal antibodies in the vaccine group was 9056 versus 39 in the placebo group at 14 days with a total seroconversion of 97.4% at 21 days. the 638 vaccine candidate is safe and immunogenic in a cholera endemic region.
Infecciones por Strongyloides stercoralis en Chile
Mercado,Rubén; Jercic,María Isabel; Ueta,Marlene T;
Boletín chileno de parasitología , 2001, DOI: 10.4067/S0365-94022001000200007
Abstract: a limited epidemiological information on strongyloides stercoralis infection excists in chile. in 1983 a mentally retarded 53-year-old man died by disseminated strongyloidiosis associated with malabsortion syndrome, this case constitutes the first histopathological confirmation of the parasitose in chile. later on, cases have been described in hospitalized patients in mental institutions from the central part of the country, where the frequency of infection registered in studies carried out in the psyquiatric hospital of putaendo in 1985 and 1987-1989 were 11.6% and 7.0%. in 1992 an outbreak of strongyloidiasis that affected 13 out of 55 children in a nutritional recuperation center in the north extreme of chile was reported. in 2000 four cases were detected in a group of 20 hospitalized mental affected patients with elevated eosinophilia. sensitive methods for detecting larvae in stool samples and seroepidemiological surveys would permit determine the importance of this human heminthic infection in chile.
Altera??es fetais induzidas pelo uso de antiinflamatórios durante a gesta??o
Fonseca, Cláudia Sampaio;Viloria, Marlene Isabel Vargas;Repetti, Leandro;
Ciência Rural , 2002, DOI: 10.1590/S0103-84782002000300027
Abstract: in general, all effects of the antiinflammatory drugs are related to the inhibition of the arachidonic acid and inhibition of prostaglandins and tromboxans production. two types of ciclo-oxygenasis (cox) exist, which are cox-1 and cox-2. cox-1 is a constitutional enzyme expressed in many sites, including platelets, and is involved in tecidual homeostasis. on the other hand, cox-2 is induced in inflammatory cells when they are activated, and it is considered as being the enzyme that produces the mediators of the inflammation. the action of antiinflammatory drugs is related to the inhibition of cox-2 and is probable that their undesirable effects are due mainly to the inhibition of cox-1. maternal treatments with nsaids have been frequently associated, with the vasoconstriction of the fetal ductus arteriosus, lung arterial hypertension and inhibition of platelet aggregation. alterations in hemostasis are some of the collateral effects produced by the indiscriminate use of nsaids, which induce to an unbalance in the prostaglandins and tromboxans liberation, that are reflected in the adhesiveness and platelet aggregation. the haemostatic alterations observed in neonates, caused by salicilates?s ingestion by the mother, are due to inhibition of the platelet aggregation and the decrease of the activity of the factor xii related to the clotting. studies in mice revealed that corticoids?s use during the gestation can lead to abnormalities in fetal development, because of the alterations in the cellular differentiation.
Altera es fetais induzidas pelo uso de antiinflamatórios durante a gesta o
Fonseca Cláudia Sampaio,Viloria Marlene Isabel Vargas,Repetti Leandro
Ciência Rural , 2002,
Abstract: Em geral, todos os efeitos dos antiinflamatórios est o relacionados com a inibi o da ciclo-oxigenase (COX) do ácido araquid nico e, portanto, inibi o da produ o de prostaglandinas e tromboxanos. Existem dois tipos de COX, quais sejam COX-1 e COX-2. A COX-1 é uma enzima constitucional expressa em muitos tecidos, incluindo plaquetas sangüíneas, e está envolvida na homeostase tecidual. Por outro lado, a COX-2 é induzida em células inflamatórias quando elas s o ativadas, sendo considerada a enzima que produz os mediadores da inflama o da classe dos prostanóides. A a o dos antiinflamatórios está relacionada à inibi o da COX-2 e é provável que seus efeitos indesejados se devam principalmente à inibi o da COX-1. Tratamentos maternos com antiinflamatórios n o esteroidais (AINEs) têm sido associados, com freqüência, à vasoconstri o do ducto arterioso fetal, hipertens o arterial pulmonar e inibi o da agrega o plaquetária. Altera es na hemostasia s o alguns dos efeitos colaterais produzidos pelo uso incontrolado dos AINEs, os quais induzem a um desequilíbrio na libera o de prostaglandinas e tromboxanos, que se reflete na adesividade e agrega o plaquetária. As altera es hemostáticas observadas em neonatos, decorrentes do uso de salicilatos pela m e, ocorrem devido à inibi o da agrega o plaquetária e à diminui o da atividade do fator XII relacionado à coagula o sangüínea. Estudos em camundongos revelaram que o uso de corticóides durante a gesta o pode levar a anormalidades no desenvolvimento fetal, por altera es na diferencia o celular.
Infecciones por Strongyloides stercoralis en Chile Strongyloides stercoralis infections in Chile
Rubén Mercado,María Isabel Jercic,Marlene T Ueta
Boletín chileno de parasitología , 2001,
Abstract: A limited epidemiological information on Strongyloides stercoralis infection excists in Chile. In 1983 a mentally retarded 53-year-old man died by disseminated strongyloidiosis associated with malabsortion syndrome, this case constitutes the first histopathological confirmation of the parasitose in Chile. Later on, cases have been described in hospitalized patients in mental institutions from the central part of the country, where the frequency of infection registered in studies carried out in the Psyquiatric Hospital of Putaendo in 1985 and 1987-1989 were 11.6% and 7.0%. In 1992 an outbreak of strongyloidiasis that affected 13 out of 55 children in a nutritional recuperation center in the north extreme of Chile was reported. In 2000 four cases were detected in a group of 20 hospitalized mental affected patients with elevated eosinophilia. Sensitive methods for detecting larvae in stool samples and seroepidemiological surveys would permit determine the importance of this human heminthic infection in Chile.
Non-Vitamin K Antagonist Oral Anticoagulants: Redefining the Role of the Nurse to Improve Patient Care  [PDF]
Marlene Robinson
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.512121
Abstract: Thromboembolic disorders and their associated long-term complications place a burden on patients, healthcare systems and society. Non-vitamin K antagonist (VKA) oral anticoagulants (OACs), including rivaroxaban, dabigatran, apixaban and edoxaban, are effective for the prevention of stroke in patients with non-valvular atrial fibrillation and for the treatment and secondary prevention of venous thromboembolism. The increasing uptake of the non-VKA OACs in primary care lessens the burden of care and allows for an easier transition of treatment from hospital to home. This transformation in terms of patient management has resulted in the need to empower nurses working in this field to endorse management strategies with a focus on patient education and long-term management (i.e. assessment of compliance, scheduling follow-up visits). Management of both venous thromboembolism and stroke prevention in patients with non-valvular atrial fibrillation requires a multidisciplinary team approach and, looking to the future, nurses are likely to have a key role at the heart of the thrombosis team. This review aims to provide nurses with the confidence to manage patients with thromboembolic disorders, and highlights the importance of responsible non-VKA OAC use and the impact that this can have on improving patient care and outcomes.
Terapêutica fotodinamica com ácido delta-aminolevulínico e luz de diodos em ceratoses actínicas
Ritter, Clarice Gabardo;Kuhl, Isabel Cristina Palma;Lenhardt, Carolina;Weissbluth, Marlene Laks;Bakos, Renato Marchiori;
Anais Brasileiros de Dermatologia , 2010, DOI: 10.1590/S0365-05962010000500007
Abstract: background: photodynamic therapy is a form of treatment in which a photosensitizing substance is applied to tissue and activated by a light source at a specific wavelength, thus selectively destroying cells. new light sources are being evaluated for use in the treatment of actinic keratoses. objectives: to evaluate the efficacy of photodynamic therapy with delta-aminolevulinic acid using a light emitting diode device as a light source in the treatment of actinic keratoses of the face and upper limbs. methods: eighteen patients with actinic keratoses of the face or upper limbs received an application of a 20% delta-aminolevulinic acid cream and were submitted to diode light irradiation at a wavelength of 630 nm. results: a total of 328 actinic keratoses were treated, obtaining complete cure in 210 (64.0%) after 24 weeks. lesions situated on the back of the hands were clinically cured in 49.2% of cases compared to 81.4% in the cases of lesions in other areas. there was no record of any severe adverse effects and patient satisfaction with the results was high. conclusion: photodynamic therapy with a diode light emitting source proved effective and well-tolerated for the treatment of actinic keratoses, with results similar to those reported in the literature with other light sources.
Copépodos Notodiaptomus sp. Kiefer (Crustacea, Calanoida) naturalmente infectados com metacestódeos no reservatório do Juqueri, S?o Paulo, Brasil
Madi, Rubens Riscala;Ueta, Marlene Tiduko;Frezza, Tarsila Ferraz;Müller, Maria Isabel;Simionatto, Karen Bazan;
Biota Neotropica , 2011, DOI: 10.1590/S1676-06032011000200018
Abstract: the aim of this work was to identify the components of zooplankton that act as intermediate hosts of cestodes. one hundred and ninety four copepods of the suborder calanoida, 317 copepods of the suborder cyclopoida and 4240 cladocerans were collected in the juqueri reservoir, in the state of s?o paulo, from january to august, 2003. only copepods calanoida of the genus notodiaptomus sp. kiefer were found to be infected and contained two distinct forms of metacestodes. the metacestodes, denominated met 1 (order proteocephalidea) and met 2 (order cyclophyllidea), had the following rates of prevalence and mean intensities of infection: met 1 - 2.06% and 64 larvae/copepod and met 2 - 0.52% and one larvae/copepod. the positive copepods were collected at the margins of the reservoir during the day. this finding suggest that parasitism may lead to a change in the behavior of the copepods and make them more susceptible to predation in shallow water.
Eletroterapia no processo de repara??o da superfície articular de coelhos
Souza, Tayse Domingues de;Del Carlo, Ricardo Junqueira;Viloria, Marlene Isabel Vargas;
Ciência Rural , 2001, DOI: 10.1590/S0103-84782001000500013
Abstract: the effects of postooperative electrotherapy in the repair of full-thickness osteochondral defects in the troclear groove of 36 adult rabbits were evaluated histologically. in the control group, granulation tissue was present two weeks post-operatively (po); hyaline cartilage was observed at four and at seven weeks po; subchondral bone regeneration was limited to the deeper portions of the defects at seven weeks po. in group i (stimulated daily), granulation tissue presented abundant vascularization at two weeks po and the repair tissue remained undifferentiated superficially, with formation of new subchondral bone up to the level of the original osteochondral junction, at seven weeks po. the animals in group ii (stimulated every other day), responded in two ways: through repair with hyaline cartilage, with reduced osteogenesis, similar to control group; or undifferentiated tissue, with an intense osteogenesis, as in group i. the postoperative electrical stimulation inhibited the tissue differentiation into hialine cartilage. on the other hand, endochondral ossification was accelerated, with complete regeneration of subchondral bone, in treated animals. in view of the importance of the subchondral bone for the integrity of the repair tissue, electrical stimulation is benefic in the initial fase (four weeks) of osteochondral defects repair.
Avalia??o histológica do processo de repara??o da superfície articular de coelhos
Souza, Tayse Domingues de;Del Carlo, Ricardo Junqueira;Viloria, Marlene Isabel Vargas;
Ciência Rural , 2000, DOI: 10.1590/S0103-84782000000300011
Abstract: the repairing process in the articular surface was evaluated microscopically in an osteochondral gap produced in the left troclear groove of 12 adult rabbits. it was observed that the granulation tissue wich initially filled this gap had diferentiated into hyaline cartilage by 4 weeks after surgery, presenting parcial reconstitution of subchondral bone excised at seven weeks following surgery. in some animals, cleft formation was observed between the repair tissue and adjacent bone, always where bone remodeling did not occured. in animals wich the bottom and lateral edges of the defect were formed by lamelar subchondral bone with few blood vessels, bone remodeling was not observed, having no attachment of the repair tissue to the adjacent bone. the results show the importance of complete removal of the lamelar subcondral bone during the surgical procedures in the articular surface, in order to allow better blood supply from the subjacent cancellous bone, better bone remodeling, and attachment of the repair tissue to the bottom of the defect.
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