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Search Results: 1 - 10 of 5501 matches for " Markus Lanthaler "
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Seamless Integration of RESTful Services into the Web of Data
Markus Lanthaler,Christian Gütl
Advances in Multimedia , 2012, DOI: 10.1155/2012/586542
Abstract: We live in an era of ever-increasing abundance of data. To cope with the information overload we suffer from every single day, more sophisticated methods are required to access, manipulate, and analyze these humongous amounts of data. By embracing the heterogeneity, which is unavoidable at such a scale, and accepting the fact that the data quality and meaning are fuzzy, more adaptable, flexible, and extensible systems can be built. RESTful services combined with Semantic Web technologies could prove to be a viable path to achieve that. Their combination allows data integration on an unprecedented scale and solves some of the problems Web developers are continuously struggling with. This paper introduces a novel approach to create machine-readable descriptions for RESTful services as a first step towards this ambitious goal. It also shows how these descriptions along with an algorithm to translate SPARQL queries to HTTP requests can be used to integrate RESTful services into a global read-write Web of Data. 1. Introduction We live in an era where exabytes of data are produced every single year; never before in human history had we to deal with such an abundance of information. To cope with this information overload, more sophisticated methods are required to access, manipulate, and analyze these humongous amounts of data. Service-oriented architectures (SOAs) built on Web services were a first attempt to address this issue, but the utopian promise of uniform service interface standards, metadata, and universal service registries, in the form of SOAP, WSDL, and UDDI has proven elusive. This and other centralized, registry-based approaches were overwhelmed by the Web’s rate of growth and the lack of a universally accepted classification scheme. In consequence, the usage of SOAP-based services is mainly limited to company-internal systems and to the integration of legacy systems. In practice, however, such a clear and crisp definition of data is rare. Today’s systems integrate data from many sources. The data quality and meaning are fuzzy and the schema, if present, are likely to vary across the different sources. In very large and loosely coupled systems, such as the Internet, the gained adaptability, flexibility, and extensibility, in a transition away from strict and formal typing to simple name/value pairs or triples, outweighs the resulting loss off “correctness.” Thus, it is not surprising that RESTful services, and there especially the ones using the lightweight JavaScript Object Notation (JSON) [1] as the serialization format, are increasingly
Computation of measure-valued solutions for the incompressible Euler equations
Samuel Lanthaler,Siddhartha Mishra
Mathematics , 2014,
Abstract: We combine the spectral (viscosity) method and ensemble averaging to propose an algorithm that computes admissible measure valued solutions of the incompressible Euler equations. The resulting approximate young measures are proved to converge (with increasing numerical resolution) to a measure valued solution. We present numerical experiments demonstrating the robustness and efficiency of the proposed algorithm, as well as the appropriateness of measure valued solutions as a solution framework for the Euler equations. Furthermore, we report an extensive computational study of the two dimensional vortex sheet, which indicates that the computed measure valued solution is non-atomic and implies possible non-uniqueness of weak solutions constructed by Delort.
Unusual Differential Diagnosis of Upper Abdominal Pain
Lanthaler Monika,Grissmann Thomas,Schwentner Lukas,Nehoda Hermann
Diagnostic and Therapeutic Endoscopy , 2009, DOI: 10.1155/2009/817052
Abstract: We here present an interesting unusual case of upper abdominal pain. The patient was a 38-year-old man, who was admitted to our hospital complaining of right upper quadrant pain caused by a toothpick that perforated the anterior gastric wall and penetrated segment I of the liver. After endoscopic removal and an initially uneventful course, computed tomography revealed a perigastric abscess that was treated by repeated gastroscopic rinsing via an endoscopically placed catheter. After another three uneventful weeks, a liver abscess with minor tendency to constrict the portal vein was diagnosed, and a segment I liver resection together with abscess drainage was performed. The peculiarity of this case is the rarity of toothpick ingestion and gastric perforation in a young and healthy white Caucasian followed by development of a liver abscess after primary uneventful endoscopic removal. In light of this case, gastric perforation due to ingested foreign bodies such as toothpicks can be considered a rare cause of upper abdominal pain.
On the Ontology of Structural Realism  [PDF]
Markus Fischer
Open Journal of Political Science (OJPS) , 2019, DOI: 10.4236/ojps.2019.91008
Abstract: Due to its systemic approach, structural realism (or neorealism) can be subsumed under methodological holism, which takes social phenomena to be wholes that cannot be reduced to their parts. The wholes posited by structural realism are the state and the international structure. Recent developments in the philosophy of social science suggest that methodological holism ought to be limited to causal explanation and complemented by ontological individualism, which requires an account of how social wholes derive from individuals. Structural realism lacks such an account because it takes the state as an empirical given, mistaking for a fact what is really a concept in need of deductive derivation from individuals. To bring the theory methodologically up to date, this essay undertakes such a derivation of the state from individuals, proceeding in the deductive manner of political theory. It thus provides structural realism with a methodologically valid ontology, which, in turn, enables the theory to better defend itself against liberal and constructivist critics who reduce the state to a transient phenomenon.
Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae
Mikko Arvas, Tiina Pakula, Karin Lanthaler, Markku Saloheimo, Mari Valkonen, Tapani Suortti, Geoff Robson, Merja Penttil?
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-32
Abstract: Chemostat cultures of T. reesei expressing human tissue plasminogen activator (tPA) and batch bioreactor cultures treated with dithiothreitol (DTT) to prevent correct protein folding were analysed with cDNA subtraction and cDNA-amplified fragment length polymorphism (AFLP) experiments. ESTs corresponding to 457 unique genes putatively induced under secretion stress were isolated and the expression pattern of 60 genes was confirmed by Northern analysis. Expression of these genes was also studied in a strain over-expressing inositol-requiring enzyme 1 (IREI) protein, a sensor for the UPR pathway. To compare the data with that of S. cerevisiae, published transcriptome profiling data on various stress responses in S. cerevisiae was reanalysed. The genes up-regulated in response to secretion stress included a large number of secretion related genes in both organisms. In addition, analysis of T. reesei revealed up regulation of the cpc1 transcription factor gene and nucleosomal genes. The induction of the cpcA and histone gene H4 were shown to be induced also in cultures of Aspergillus nidulans treated with DTT.Analysis of the genes induced under secretion stress has revealed novel features in the stress response in T. reesei and in filamentous fungi. We have demonstrated that in addition to the previously rather well characterised induction of genes for many ER proteins or secretion related proteins also other types of responses exist.In eukaryotic cells after translocation to the endoplasmic reticulum (ER), the folding of secreted proteins is supported and controlled by chaperones, glycosylation enzymes and oxidoreductases. The correctly folded proteins are transported to the Golgi compartment where further modification of the proteins takes place and the proteins are thereafter secreted out of the cell. Accumulation of unfolded, misfolded or otherwise inefficiently secreted proteins or other impairing of secretion can cause stress to cells, i.e. secretion stress. Secre
Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast
Karin Lanthaler, Elizabeth Bilsland, Paul D Dobson, Harry J Moss, P?nar Pir, Douglas B Kell, Stephen G Oliver
BMC Biology , 2011, DOI: 10.1186/1741-7007-9-70
Abstract: To answer this, we have constructed a chemical genomics platform built upon the yeast gene deletion collection, using competition experiments in batch fermenters and robotic automation of cytotoxicity screens, including protection by 'natural' substrates. Using these, we tested 26 different drugs and identified the carriers required for 18 of the drugs to gain entry into yeast cells.As well as providing a useful platform technology, these results further substantiate the notion that the cellular uptake of pharmaceutical drugs normally occurs via carrier-mediated transport and indicates that establishing the identity and tissue distribution of such carriers should be a major consideration in the design of safe and effective drugs.Of the many reasons for the attrition of candidate drugs during the development process, toxicity or lack of efficacy in vivo are among the most frequent [1,2]. Excessive concentration in particular tissues can be the cause of the former, while failure to reach targets can contribute to the latter. The steady-state tissue distributions of drugs are determined by the rates of their uptake and efflux. While the role of carriers as mediators of drug efflux is well appreciated, uptake was, until recently, considered to be almost entirely a process of passive diffusion through the lipid part of the membrane and therefore largely determined by drug lipophilicity, with carrier uptake considered exceptional [3]. It is now increasingly recognized that drug uptake is predominantly carrier-mediated [4-7]. The missing information required to understand the tissue distributions of drugs is thus represented by the specificities and location of uptake carriers. Although there are any number of specific examples [6], the first task is to establish general methods for determining which of the known carriers are most responsible for the cellular uptake of particular drugs, as a prelude to establishing the tissue distributions of the relevant carriers.Saccharo
Discretisation of stochastic control problems for continuous time dynamics with delay
Markus Fischer,Markus Reiss
Mathematics , 2006,
Abstract: As a main step in the numerical solution of control problems in continuous time, the controlled process is approximated by sequences of controlled Markov chains, thus discretising time and space. A new feature in this context is to allow for delay in the dynamics. The existence of an optimal strategy with respect to the cost functional can be guaranteed in the class of relaxed controls. Weak convergence of the approximating extended Markov chains to the original process together with convergence of the associated optimal strategies is established.
Spectral covolatility estimation from noisy observations using local weights
Markus Bibinger,Markus Rei?
Statistics , 2011,
Abstract: We propose localized spectral estimators for the quadratic covariation and the spot covolatility of diffusion processes which are observed discretely with additive observation noise. The eligibility of this approach to lead to an appropriate estimation for time-varying volatilities stems from an asymptotic equivalence of the underlying statistical model to a white noise model with correlation and volatility processes being constant over small intervals. The asymptotic equivalence of the continuous-time and the discrete-time experiments are proved by a construction with linear interpolation in one direction and local means for the other. The new estimator outperforms earlier nonparametric approaches in the considered model. We investigate its finite sample size characteristics in simulations and draw a comparison between the various proposed methods.
The Influence of Surface Energy on the Washing Quality of Filter Cakes  [PDF]
Markus Wilkens, Urs A. Peuker
Advances in Chemical Engineering and Science (ACES) , 2011, DOI: 10.4236/aces.2011.14036
Abstract: The washing of filter cakes, especially the displacement washing, represents an important aspect in science researches and industrial applications. A lot of ongoing researches are focussed on impurities, which are dissolved in the mother liquid (e.g. sodium chloride) and washed out with the identical pure liquid without impurities. The project flushing focuses on systems with two chemically different liquids. The main aim is to exchange an organic solvent by water. This article focuses on the adsorption effects during a washing process with solid systems of different wetting behaviours.
Not All Shrivels Are Created Equal—Morpho-Anatomical and Compositional Characteristics Differ among Different Shrivel Types That Develop during Ripening of Grape (Vitis vinifera L.) Berries  [PDF]
Bhaskar Rao Bondada, Markus Keller
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.37105
Abstract: An understanding of physiological disorders associated with ripening of fruits triggered by abiotic stress relies on anatomical and physico-chemical analyses, as it provide insights into their origin and probable causes. The objective of this study was to analyze different ripening disorders of grape (Vitis vinifera L.) berries by dissecting their morpho-anatomy, shriveling nature, and composition. Four well-defined disorders—sunburn, prolonged dehydration (PD), late-season bunch stem necrosis (LBSN), and berry shrivel (BS) were analyzed in field-grown grapevines of the cultivar Cabernet Sauvignon. Early bunch stem necrosis (EBSN) that occurred before ripening was also included in the study. Unlike healthy spherical berries, the pericarp of disordered berries except for sunburn shriveled causing concomitant reductions in fresh weight and volume. The exocarp of PD berries developed well-ordered indentations as distinct from the wrinkles in LBSN berries, whereas BS berries were flaccid with numerous skin folds. The epicuticular wax occurred as upright platelets in all shrivel forms excluding the sun-exposed hemisphere of sunburned berries. A chlorophyllous inflorescence framework persisted in all shrivel forms but in LBSN, wherein the necrotic regions developed tylosis. Unlike the translucent mesocarp of healthy, sunburned, and PD berries, the mesocarp was collapsed in BS and LBSN berries, nevertheless all had well-developed seeds. The composition of healthy berries was optimal, whereas the disordered berries were compositionally distinct from each other, which as a whole differed from the healthy berries. The BS berries had the lowest sugar content, and although sugar concentration was higher in LBSN, sunburned and PD berries, sugar amount per berry was highest in the healthy berries, the same was true for hexoses. Healthy and BS berries exhibited highest amounts of tartaric acid followed by sunburn and PD berries, whereas the LBSN berries had the lowest values. Conversely, healthy and PD berries had the highest amounts of malic acid followed by LBSN, sunburn and BS berries, which collectively displayed similar amounts. The PD berries exhibited the highest calcium content followed by LBSN, healthy, and finally BS and sunburned berries. A linear relationship existed between potassium (K) and pH of the berries. The PD berries had the highest amounts of K followed by healthy, sunburn, LBSN, and BS berries. Overall, the results reported here provided combined morpho-anatomical and compositional analyses of different shrivel types that occurred during
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