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Search Results: 1 - 10 of 311373 matches for " Mark J Minichiello "
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Genome-Wide Associations of Gene Expression Variation in Humans
Barbara E Stranger equal contributor,Matthew S Forrest equal contributor,Andrew G Clark,Mark J Minichiello,Samuel Deutsch,Robert Lyle,Sarah Hunt,Brenda Kahl,Stylianos E Antonarakis,Simon Tavaré,Panagiotis Deloukas ,Emmanouil T Dermitzakis
PLOS Genetics , 2005, DOI: 10.1371/journal.pgen.0010078
Abstract: The exploration of quantitative variation in human populations has become one of the major priorities for medical genetics. The successful identification of variants that contribute to complex traits is highly dependent on reliable assays and genetic maps. We have performed a genome-wide quantitative trait analysis of 630 genes in 60 unrelated Utah residents with ancestry from Northern and Western Europe using the publicly available phase I data of the International HapMap project. The genes are located in regions of the human genome with elevated functional annotation and disease interest including the ENCODE regions spanning 1% of the genome, Chromosome 21 and Chromosome 20q12–13.2. We apply three different methods of multiple test correction, including Bonferroni, false discovery rate, and permutations. For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs) with expression variation in lymphoblastoid cell lines after correcting for multiple tests. Based on our analyses, the signal proximal (cis-) to the genes of interest is more abundant and more stable than distal and trans across statistical methodologies. Our results suggest that regulatory polymorphism is widespread in the human genome and show that the 5-kb (phase I) HapMap has sufficient density to enable linkage disequilibrium mapping in humans. Such studies will significantly enhance our ability to annotate the non-coding part of the genome and interpret functional variation. In addition, we demonstrate that the HapMap cell lines themselves may serve as a useful resource for quantitative measurements at the cellular level.
Genome-Wide Associations of Gene Expression Variation in Humans.
Stranger,Forrest,Clark,Minichiello
PLOS Genetics , 2005,
Abstract: The exploration of quantitative variation in human populations has become one of the major priorities for medical genetics. The successful identification of variants that contribute to complex traits is highly dependent on reliable assays and genetic maps. We have performed a genome-wide quantitative trait analysis of 630 genes in 60 unrelated Utah residents with ancestry from Northern and Western Europe using the publicly available phase I data of the International HapMap project. The genes are located in regions of the human genome with elevated functional annotation and disease interest including the ENCODE regions spanning 1% of the genome, Chromosome 21 and Chromosome 20q12-13.2. We apply three different methods of multiple test correction, including Bonferroni, false discovery rate, and permutations. For the 374 expressed genes, we find many regions with statistically significant association of single nucleotide polymorphisms (SNPs) with expression variation in lymphoblastoid cell lines after correcting for multiple tests. Based on our analyses, the signal proximal (cis-) to the genes of interest is more abundant and more stable than distal and trans across statistical methodologies. Our results suggest that regulatory polymorphism is widespread in the human genome and show that the 5-kb (phase I) HapMap has sufficient density to enable linkage disequilibrium mapping in humans. Such studies will significantly enhance our ability to annotate the non-coding part of the genome and interpret functional variation. In addition, we demonstrate that the HapMap cell lines themselves may serve as a useful resource for quantitative measurements at the cellular level.
Synaptic membrane rafts: traffic lights for local neurotrophin signaling?
Barbara Zonta,Liliana Minichiello
Frontiers in Synaptic Neuroscience , 2013, DOI: 10.3389/fnsyn.2013.00009
Abstract: Lipid rafts, cholesterol and lipid rich microdomains, are believed to play important roles as platforms for the partitioning of transmembrane and synaptic proteins involved in synaptic signaling, plasticity, and maintenance. There is increasing evidence of a physical interaction between post-synaptic densities and post-synaptic lipid rafts. Localization of proteins within lipid rafts is highly regulated, and therefore lipid rafts may function as traffic lights modulating and fine-tuning neuronal signaling. The tyrosine kinase neurotrophin receptors (Trk) and the low-affinity p75 neurotrophin receptor (p75NTR) are enriched in neuronal lipid rafts together with the intermediates of downstream signaling pathways, suggesting a possible role of rafts in neurotrophin signaling. Moreover, neurotrophins and their receptors are involved in the regulation of cholesterol metabolism. Cholesterol is an important component of lipid rafts and its depletion leads to gradual loss of synapses, underscoring the importance of lipid rafts for proper neuronal function. Here, we review and discuss the idea that translocation of neurotrophin receptors in synaptic rafts may account for the selectivity of their transduced signals.
On Some Numbers Related to the Erdös-Szekeres Theorem  [PDF]
Mark J. Nielsen, William Webb
Open Journal of Discrete Mathematics (OJDM) , 2013, DOI: 10.4236/ojdm.2013.33030
Abstract:

A crossing family of segments is a collection of segments each pair of which crosses. Given positive integers j and k,a(j,k) grid is the union of two pairwise-disjoint collections of segments (with j and k members, respectively) such that each segment in the first collection crosses all members of the other. Let c(k) be the least integer such that any planar set of c(k) points in general position generates a crossing family of k segments. Also let #(j,k) be the least integer such that any planar set of #(j,k) points in general position generates a (j,k)-grid. We establish here the facts 9≤c(3)≤16 and #(1,2)=8.


Do Clusters Influence Productivity in China’s Software Industry?  [PDF]
Mark J. Purdy, Xiao Chang
Theoretical Economics Letters (TEL) , 2014, DOI: 10.4236/tel.2014.41005
Abstract:

Based on data from 2007 to 2011 across 29 provinces in China, this paper employs a panel-based econometric model to investigate the impact of clusters (of firms and educational institutions) and R & D investment in driving productivity in China’s software industry. In respect of clusters, our results show that a one percent increase in the density of firm clusters leads to a 0.10 percent increase in productivity; for clusters of educational institutions, a significantly positive impact on productivity in coastal regions has been identified. In terms of R & D investment, a one percent increase in R & D expenditure per R & D worker leads to a 0.22 percent increase in productivity, although the effect is significantly reduced in coastal region. For policymakers, the results of this study shed light on the effectiveness of different levers in narrowing regional productivity gaps. It can also help business leaders make better decisions regarding their innovation activities.

Male sex workers in Córdoba, Argentina: sociodemographic characteristics and sex work experiences
Mari?o,Rodrigo; Minichiello,Victor; Disogra,Carlos;
Revista Panamericana de Salud Pública , 2003, DOI: 10.1590/S1020-49892003000400006
Abstract: objective: to report on the sociodemographic characteristics and work experiences of 31 male sex workers (msws) in the city of córdoba, argentina. methods: information on each of the msws was collected using a questionnaire that covered his personal characteristics and his work background, self-assessed general health status, and use of health and social services. scales were included in order to assess attitudes towards condom use, knowledge about safe sex, perceptions about the risk of getting hiv, individual self-efficacy, and locus of control. the questionnaire also asked each respondent to rank his level of agreement with interactive strategies for gaining client compliance with safe sex practices. results: in terms of their self-identity, out of the 30 msws who answered the question, 10 of them (33.3%) self-identified as heterosexual and 9 (30%) as bisexual. alcohol and drug consumption and unsafe sexual practices were relatively low among the msws. of the 31 msws responding, 21 of them (67.7%) reported that they had been tested for hiv, but only 13 of them (41.9%) said they had been vaccinated for either hepatitis a or hepatitis b. a variety of differences were found between the study's 17 street sex workers (sex workers who offer their services in public places such as streets and parks) and the 14 independent sex workers (sex workers who are self-employed, advertise and manage their own business, and have an exclusive location for their commercial sex work). the street msws were younger and had less formal education. independent msws were economically more settled, had been working longer in the sex industry, and were more comfortable about having sex with men. independent msws were also more likely to report a gay sexual orientation and less likely to report using alcohol, marijuana, or other substances. conclusions: the differences between street msws and independent msws are important since they could influence the negotiating of safer sex practices with
Male sex workers in Córdoba, Argentina: sociodemographic characteristics and sex work experiences
Mari?o Rodrigo,Minichiello Victor,Disogra Carlos
Revista Panamericana de Salud Pública , 2003,
Abstract: OBJECTIVE: To report on the sociodemographic characteristics and work experiences of 31 male sex workers (MSWs) in the city of Córdoba, Argentina. METHODS: Information on each of the MSWs was collected using a questionnaire that covered his personal characteristics and his work background, self-assessed general health status, and use of health and social services. Scales were included in order to assess attitudes towards condom use, knowledge about safe sex, perceptions about the risk of getting HIV, individual self-efficacy, and locus of control. The questionnaire also asked each respondent to rank his level of agreement with interactive strategies for gaining client compliance with safe sex practices. RESULTS: In terms of their self-identity, out of the 30 MSWs who answered the question, 10 of them (33.3%) self-identified as heterosexual and 9 (30%) as bisexual. Alcohol and drug consumption and unsafe sexual practices were relatively low among the MSWs. Of the 31 MSWs responding, 21 of them (67.7%) reported that they had been tested for HIV, but only 13 of them (41.9%) said they had been vaccinated for either hepatitis A or hepatitis B. A variety of differences were found between the study's 17 street sex workers (sex workers who offer their services in public places such as streets and parks) and the 14 independent sex workers (sex workers who are self-employed, advertise and manage their own business, and have an exclusive location for their commercial sex work). The street MSWs were younger and had less formal education. Independent MSWs were economically more settled, had been working longer in the sex industry, and were more comfortable about having sex with men. Independent MSWs were also more likely to report a gay sexual orientation and less likely to report using alcohol, marijuana, or other substances. CONCLUSIONS: The differences between street MSWs and independent MSWs are important since they could influence the negotiating of safer sex practices with clients. Programs aimed at preventing the spread of HIV and other sexually transmitted infections and promoting responsible self-care among MSWs in Córdoba should be introduced. Such programs could increase the proportion of MSWs who know their HIV serostatus and could make MSWs more aware of the risk of different sex acts performed in commercial sex encounters. Given the differences that we found between street MSWs and independent MSWs, specific strategies and educational materials should be developed for those two subgroups within the MSW population.
An efficient algorithm for the calculation of reserves for non-unit linked life policies
Mark Tucker,J. Mark Bull
Computer Science , 2014,
Abstract: The underlying stochastic nature of the requirements for the Solvency II regulations has introduced significant challenges if the required calculations are to be performed correctly, without resorting to excessive approximations, within practical timescales. It is generally acknowledged by practising actuaries within UK life offices that it is currently impossible to correctly fulfil the requirements imposed by Solvency II using existing computational techniques based on commercially available valuation packages. Our work has already shown that it is possible to perform profitability calculations at a far higher rate than is achievable using commercial packages. One of the key factors in achieving these gains is to calculate reserves using recurrence relations that scale linearly with the number of time steps. Here, we present a general vector recurrence relation which can be used for a wide range of non-unit linked policies that are covered by Solvency II; such contracts include annuities, term assurances, and endowments. Our results suggest that by using an optimised parallel implementation of this algorithm, on an affordable hardware platform, it is possible to perform the `brute force' approach to demonstrating solvency in a realistic timescale (of the order of a few hours).
Relief of osteoarthritis with a herbal-amino acid supplement: A randomized double-blind placebo controlled trial  [PDF]
Mark J.S. Miller, Ross Butler
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.324066
Abstract: A redox active medicinal plant and L-leucine mixture (HLM) was investigated in subjects with established osteoarthritis of the knee in a multi-center, rando- m-ized, placebo-controlled, double-blind clinical trial. A total of 96 subjects with osteoarthritis were enrolled and randomized to either placebo (n = 38) or HLM treatment group (n = 38). The HLM group re- ceived a combination of Uncaria tomentosa (300 mg), Boswellia serrata (200 mg), Lepidium meyenii (1000 mg) and L-Leucine (700 mg) given as 3 capsules once a day. The placebo group received matching capsules with carboxymethylcellulose. The treatment period was 8 weeks, with assessments made at days 7, 14, 28 and 56. The primary outcome was reduction in total WOMAC score. VAS pain, tolerability, investigator assessments, use of rescue medication (acetominophen), and safety assessments of vital signs and laboratory assessments were included. Subject randomization was effective for age, gender and disease severity. In the placebo group 32/38 subjects completed the trial and for HLM 35/38. WOMAC scores (pain, stiffness, physical performance and total) steadily declined over the course of the 8 week study in both groups, but the magnitude was significantly greater for HLM (P < 0.05). Total WOMAC was reduced 46.5% for HLM and 25.4 % for placebo. VAS pain was reduced 21.8% in the placebo group (p < 0.002) but the changes were significantly greater (37.8% p < 0.03) with HLM treatment. Investigator’s global assessment rating of good-excellent was 24/35 (69%) for HLM and 14/32 (44%) for placebo (P = 0.05). Rescue medication consumption and tolerability were comparable for HLM and placebo. No safety issues were evident with either group. As expected a placebo effect was observed, nevertheless HLM was clearly more effective in relieving the symptoms of osteoarthritis. This HLM represents a safe and effective new approach to the management of osteoarthritis symptoms.
The Organizational Culture Audit: Countering Cultural Ambiguity in the Service Context  [PDF]
Mark R. Testa, Lori J. Sipe
Open Journal of Leadership (OJL) , 2013, DOI: 10.4236/ojl.2013.22005
Abstract: Development of a compelling organizational culture continues to be an imperative for organizations seeking a competitive advantage. Identifying culture deficiencies or gaps is an important step in creating such a culture. For culture development efforts to be successful, leaders must first know the reality of the current organizational culture, however assessing the organizations’ true culture may be more complicated than it appears. Several theoretical frameworks illustrate how highly committed mangers may have difficulty in this regard. The following study links theory with application providing an action research based model of culture assessment. First, the rationale and conceptual model of cultural analysis is provided based on past research. Next, a five-step model analyzing ten cultural areas is proposed, and recommendations are provided for implementation.
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