Publish in OALib Journal
APC: Only $99
The new field of mitochondrial filamentation and its first potential
applications are just getting underway (1-7), following a series of pilot experiments
in our laboratory over the past few decades (8-14). I should like to give a
brief overview of the role that some new methods are playing in this emerging
area of physiological bioenergetics, supported by a few references to our
contributions as I scarcely have the faculties now to understand other specific
contributions. This new field is brimming with promises for medicine, science
and society, in general. I cannot and must not be concrete or comprehensive,
because I honestly feel that it is now that matters are really beginning to
take off, assisted by the most appropriate international capabilities.
The contribution of the author’s groups on the control
of energy metabolism of cancer cells has been concisely reviewed. It is
proposed that Otto Warburg’s “respiratory defect” of tumoral cells resides in
an alteration of the recurrent filamentation cycle of mitochondria. These give
those organelles an affinity lower for ADP than the affinity of the tumor cell
isoenzyme of pyruvate kinase. These two findings may explain the essentials of
the intimate mechanism of the aerobic glycolysis of cancer cells.
Essential bibliography, with therein references included,
is presented owing to the contribution of the author groups to Mitochondrial
Filamentation, which is a new emerging field of physiological energy metabolism.
These studies provide the first seed concept for trials to extend the metabolic
life, for a few days, in low order laboratory mammals killed by electrocution,
as a first type of accidental death. It is proposed, essentially, to cool out
the corpses very soon after death at 12oC-14oC and take advantage of the effect
super magnetism to counteract the force of gravity to install a net recurrent
cycle of oxygen consumption and oxygen production by filamented mitochondria in
all the organism tissues. Once the cause of death had been corrected adequately,
it is possible to try the reanimation to experience the full life of the corpse
with highly sophisticated methodology.
The title of this little assay coins three new words: Pre-Chelates, Post-Adducts and Implexes.
These, very daring new excursions into the scientific English language,
come from the developments of Quelamycin and Sodium L-Thioproline, through our
different group studies arriving to cancer reversal by a dual strategy. It is
enough to read all our published materials, cites and related papers, dealing
more or less with the chemistry and possible mechanism of action of these compounds,
to gather somewhat what signified our monomeric-triferric-doxorubicine, as possibly
one of the first Pre-Chelates and our Sodium L-Thioproline, probably as one of
the first Post-Adducts. Both molecules come to the human patients with cancer
blood from the exterior. After this indication, it will be proposed a seed
concept of a new type of molecules, the “Implexes” in which the metals will be
embraced instead of being linked.
I present herewith a concise historic account of our development of the new technique for cancer therapy: Reversal of Cancer by Dual Strategy. This new method is based on the possible correction of the mitochondrial filamentation defect of tumors plus minor cytotoxicity addressed to the anoxic and fagocitic tumor’s redoubts, using the administration of the anticancer agents with a chrono-therapeutic emphasis on the patient’s mobility. Such methods probably will reach patients in the near future with the collaboration of private clinical trials mainly at least in the USA, Europe and Japan. Only the more essential references of this effort are provided.