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Search Results: 1 - 10 of 8731 matches for " Marie-Veronique LeLann "
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Estimación de Estados Funcionales en Procesos Complejos con Base en Agrupamiento Difuso Estimation of Functional States in Complex Processes Based on Fuzzy Clustering
Henry O Sarmiento,Claudia V Isaza,Tatiana Kempowsky-Hamon,Marie-Veronique LeLann
Información Tecnológica , 2013,
Abstract: Este artículo presenta una metodología para predecir estados funcionales en procesos complejos a partir de la estimación de grados de pertenencia difusos. La propuesta integra una medida estática como es el resultado de un clasificador difuso entrenado con los datos históricos del proceso y un algoritmo de estimación basado en la teoría de Markov para eventos discretos. La propuesta, que puede ser integrada a un sistema de monitoreo de sistemas complejos, comprende dos etapas: una etapa de entrenamiento fuera de línea para definir el clasificador difuso y el estimador; y una etapa en línea donde se realizan la clasificación de la situación actual del proceso y la estimación del estado funcional para el siguiente tiempo de muestreo. La propuesta desarrollada para la estimación de estados funcionales permite utilizar cualquier método de agrupamiento difuso que suministre la información base que requiere la metodología. La metodología fue probada con éxito en un sistema de monitoreo para una línea de transmisión de energía y en el monitoreo de un sistema de caldera. This paper presents a methodology to predict functional states in complex processes from the estimation of fuzzy membership degrees. The proposal integrates a static measure, such as the result of a fuzzy classifier trained with historical process data, and an estimation algorithm based on Markov theory for discrete events. The proposal, which can be integrated to the monitoring of complex systems, provides two stages: an off-line training stage to define the fuzzy classifier and the estimator; and an online stage where the classification of the current process situation and the estimation of the next functional state are performed. The proposal for the estimation of functional states allows using any fuzzy clustering method that provides the information required by the methodology. The proposed methodology was successfully tested on a monitoring system for a power transmission line and in the monitoring of a boiler system.
Linked Heritage: a collaborative terminology management platform for a network of multilingual thesauri and controlled vocabularies Linked Heritage: a collaborative terminology management platform for a network of multilingual thesauri and controlled vocabularies
Marie-Veronique Leroi
JLIS.it , 2013, DOI: 10.4403/jlis.it-5471
Abstract: Terminology and multilingualism have been one of the main focuses of the Athena Project. Linked Heritage as a legacy of this project also deals with terminology and bring theory to practice applying the recommendations given in the Athena Project. Linked Heritage as a direct follow-up of these recommendations on terminology and multilingualism is currently working on the development of a Terminology Management Platform (TMP). This platform will allow any cultural institution to register, SKOSify and manage its terminology in a collaborative way. This Terminology Management Platform will provide a network of multilingual and cross-domain terminologies. Terminology and multilingualism have been one of the main focuses of the Athena Project. Linked Heritage as a legacy of this project also deals with terminology and bring theory to practice applying the recommendations given in the Athena Project. Linked Heritage as a direct follow-up of these recommendations on terminology and multilingualism is currently working on the development of a Terminology Management Platform (TMP). This platform will allow any cultural institution to register, SKOSify and manage its terminology in a collaborative way. This Terminology Management Platform will provide a network of multilingual and cross-domain terminologies.
PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1
Chong Kiat Goo, Hwee Ying Lim, Qin Shi Ho, Heng-Phon Too, Marie-Veronique Clement, Kim Ping Wong
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045806
Abstract: Akt, a serine/threonine kinase has been shown to stimulate glycolysis in cancer cells but its role in mitochondrial respiration is unknown. Using PTEN-knockout mouse embryonic fibroblasts (MEFPTEN?/?) with hyper-activated Akt as a cell model, we observed a higher respiratory capacity in MEFPTEN?/? compared to the wildtype (MEFWT). The respiratory phenotype observed in MEFPTEN?/? was reproduced in MEFWT by gene silencing of PTEN which substantiated its role in regulating mitochondrial function. The increased activities of the respiratory complexes (RCs) I, III and IV were retained in the same relative proportions as those present in MEFWT, alluding to a possible co-ordinated regulation by PTEN/Akt. Using LY294002 (a PI3K inhibitor) and Akt inhibitor IV, we showed that the regulation of enzyme activities and protein expressions of the RCs was dependent on PI3K/Akt. There was insignificant difference in the protein expressions of mitochondrial transcription factor: peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and its downstream targets, the nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (mtTFA) between MEFPTEN?/? and MEFWT. Similarly, mRNA levels of the same subunits of the RCs detected in Western blots were not significantly different between MEFPTEN?/? and MEFWT suggesting that the regulation by Akt on mitochondrial function was probably not via gene transcription. On the other hand, a decrease of total 4E-BP1 with a higher expression of its phosphorylated form relative to total 4E-BP1 was found in MEFPTEN?/?, which inferred that the regulation of mitochondrial respiratory activities by Akt was in part through this protein translation pathway. Notably, gene silencing of 4E-BP1 up-regulated the protein expressions of all RCs and the action of 4E-BP1 appeared to be specific to these mitochondrial proteins. In conclusion, PTEN inactivation bestowed a bioenergetic advantage to the cells by up-regulating mitochondrial respiratory capacity through the 4E-BP1-mediated protein translation pathway.
Impacts of Environmental Management on the Quality of Traditional Well Water in the Soubré Region (South-West of C?te d’Ivoire)  [PDF]
Ohou-Yao Marie Jeanne Adela?de, Ouattara Leygnima Yaya, Yapo Ossey Bernard, Mambo Veronique
Journal of Water Resource and Protection (JWARP) , 2017, DOI: 10.4236/jwarp.2017.913102
Abstract: Water supply is a global problem. A study was conducted on twelve (12) traditional wells water in Daba Dagnogo and Gnipi 2 to determine their physico-chemical quality. Two sampling campaigns (dry season and rainy season), were performed on 16 physical and chemical parameters. The results show that the water is acidic with an average pH of 6.41 ± 0.4; moderately mineralized with an average conductivity of 731.14 ± 611.98 μS·cm-1; moderately saline with an average rate of 1.56 ± 1.22. The average temperature of 28.07 ± 0.86°C is above the norm for all wells. All major ions are consistent with WHO standards except calcium and potassium. 41.67% of wells exceed the standard ammonium ion whose average was 1.43 ± 2.79 mg·L-1 nitrate and 100% with an average of 492.42 ± 434.02 mg·L-1. The ion concentrations are highest in the urban area and are higher in the dry season. The quality of the water sampled wells deteriorated. Several factors affect the degradation, namely the shallow wells, their proximity to toilet, the lack of sanitation and poor management of household waste. It will carry out a campaign to educate people to protect the immediate environment of the water points, avoiding the deposit of garbage and to provide the appropriate wells lids.
Metabolic Activity and mRNA Levels of Human Cardiac CYP450s Involved in Drug Metabolism
Veronique Michaud,Martin Frappier,Marie-Christine Dumas,Jacques Turgeon
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015666
Abstract: Tissue-specific expression of CYP450s can regulate the intracellular concentration of drugs and explain inter-subject variability in drug action. The overall objective of our study was to determine in a large cohort of samples, mRNA levels and CYP450 activity expressed in the human heart.
Microcirculatory alterations induced by sedation in intensive care patients. Effects of midazolam alone and in association with sufentanil
Veronique Lamblin, Raphael Favory, Marie Boulo, Daniel Mathieu
Critical Care , 2006, DOI: 10.1186/cc5128
Abstract: Ten non-septic patients under controlled ventilation requiring sedation for therapeutic purposes were enrolled in a prospective observational study conducted in an ICU of a university hospital. Sedation was conducted in two successive steps: first, each patient received midazolam (0.1 mg/kg per hour after a bolus of 0.05 mg/kg, then adapted to reach a Ramsay score of between 3 and 5). Second, after one hour, sufentanil was added (0.1 μg/kg per hour after a bolus of 0.1 μg/kg). Arterial pressure, heart rate, cardiac output determined by transthoracic impedance, transcutaneous oxygen (tcPO2) and carbon dioxide (tcPCO2) pressures, and microcirculatory blood flow determined by laser Doppler flowmetry at rest and during a reactive hyperaemia challenge were measured before sedation (NS period), one hour after midazolam infusion (H period), and one hour after midazolam-sufentanil infusion (HS period).Arterial pressure decreased in both sedation periods, but heart rate, cardiac output, tcPO2, and tcPCO2 remained unchanged. In both sedation periods, microcirculatory changes occurred with an increase in cutaneous blood flow at rest (H period: 207 ± 25 perfusion units [PU] and HS period: 205 ± 25 PU versus NS period: 150 ± 22 PU, p < 0.05), decreased response to ischaemia (variation of blood flow to peak: H period: 97 ± 16 PU and HS period: 73 ± 9 PU versus NS period: 141 ± 14 PU, p < 0.05), and attenuation of vasomotion.Sedation with midazolam or a combination of midazolam and sufentanil induces a deterioration of vasomotion and microvascular response to ischaemia, raising the question of whether this effect may further alter tissue perfusion when already compromised, as in septic patients.Because of its role in blood-tissue exchanges, the microcirculation is a fundamental element of the vascular network [1,2]. It has been long to recognise. It was only recently recognised that numerous pathologic conditions like arteriosclerosis, arterial hypertension, or diabetes alter the
Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-κB/IκB pathway
Marie-Eve St-Germain, Veronique Gagnon, Sophie Parent, Eric Asselin
Molecular Cancer , 2004, DOI: 10.1186/1476-4598-3-7
Abstract: Three different human endometrial cancer cell lines known to have wild type PTEN (HEC 1-A) or a mutated inactive PTEN protein (RL 95-2 and Ishikawa) were used for these studies. Expression IκB and Phospho-IκB were evaluated by Western analysis. The presence of IκB phosphorylation was found in all cell lines studied. There was no difference between cell lines in term of NF-κB abundance. Inhibition of PI 3-K with Wortmannin and LY294002 blocked IκB phosphorylation, reduced NF-κB nuclear activity, reduced COX-2 expression and induced apoptosis. Transfection studies with a dominant negative Akt vector blocked IκB phosphorylation and reduced COX-2 expression. On the opposite, constitutively active Akt transfections resulted in the induction of IκB phosphorylation and up-regulation of COX-2.These results demonstrate that Akt signals through NF-κB/IκB pathway to induce COX-2 expression in mutated PTEN endometrial cancer cells.The phosphoinositide 3-kinase (PI 3-kinase) pathway has been implicated in the activation of the proinflammatory transcription factor nuclear factor κB (NF-κB) [1-3]. It has been demonstrated that both the regulatory and the catalytic subunit of phosphatidylinositol 3-kinase (PI 3-K) play a role in NF-κB activation by the tyrosine phosphorylation-dependent pathway [3]. The NF-κB transcription factor is a pleiotropic activator that participates in the induction of a wide variety of cellular genes [4]. In addition to its role in inflammation and immune response, NF-κB has also been implicated in the suppression of apoptosis [5], cellular survival, transformation, and oncogenesis [6]. Predominantly a heterodimeric complex of two polypeptides (p65/RelA and p50), NF-κB lies dormant in the cytoplasm through the binding IκB inhibitory proteins. When phosphorylated on serine 32 and serine 36, IκBα is targeted and degraded by ubiquitin/26 S proteasome pathway liberating the NF-κB heterodimer so that it may translocate to the nucleus and bind DNA. NF-κB binds t
Temporal and Spatial Variations of Nitrate Levels in Traditional Water-Supply Wells in the Area of Buyo, Cote d`Ivoire
Marie-Jeanne A. Ohou,Veronique Mambo,Bernard O. Yapo,M. Arsene Seka
Journal of Applied Sciences , 2008,
Abstract: In this study, water nitrate concentration, pH, temperature, conductivity, turbidity and Total Dissolved Solids (TDS) were monitored in 34 water-supply wells, located in the three main districts (Buyo cité, Tchemasso and Buyo provisoire) of the city of Buyo (C te d`Ivoire, West Africa) and in two villages (Gbili and Logbozoa) around. Each water-supply well was sampled in September and October 2004 and every other month from January 2005 to November 2005. Other variables like depth of the wells and precipitations were also considered over the same period. The nitrate concentrations in the 34 wells ranged from 1.83 to 412 mg L-1. Most contaminated wells were found in the district Buyo cité and in the two villages. All wells at Buyo cité, 8 out of 10 at Gbili and 4 out of 10 at Logbozoa, exceeded at least once the WHO limit (50 mg NO3– L-1) for drinking water, indicating that populations are at risk in the study area. In contrast, none of the wells reached the WHO limit in Tchemasso and in Buyo provisoire. Pit latrines, inappropriate waste disposal and insufficient well maintenance were suspected to be responsible for the high nitrate concentrations in well water within the study area. It has been found that each contaminated well had a nitrate source in its close environment that permanently released nitrate in the well water, the recharge water exerting a dilution effect. An appropriately designed education programme directed to the populations should allow improving and protecting well water quality in the study area. The principal component analysis of the data revealed that nitrate, temperature, TDS and conductivity are higher in shallow wells than in deep wells.
An Evaluation of West and Central African Ports to Serve as a Hub on the Gulf of Guinea Container Ports Range  [PDF]
Balla Nguele Veronique, Youfang Huang
Open Journal of Applied Sciences (OJAppS) , 2019, DOI: 10.4236/ojapps.2019.94024
Abstract: The level of competitions among ports keep increasing as port worldwide keep upgrading and expanding their port infrastructures so as to capture the greater share of the market. Every continent phases these competitions. This phenomenon is more prominent in developed countries where ports do not only compete among regional ports but also compete with other ports within the same country such as in America, some European countries and part of Asia like in China. However, the situation is a bit different when it comes to African ports. Most African ports have poor infrastructures and limited technological investments and so port competitions in the African continent cannot be compared with that of the western ports. Despite these setbacks, there is a significant amount of competition among these African ports, especially on a regional basis. The aim of this paper is to determine which port can serve as a hub port between the West and Central African ports along the Gulf of Guinea. The method that will be used to evaluate these ports will be a port indexing method. This method considers different indices for port evaluation to determine the most suitable port. The port of Tema appeared as the most suitable port to serve as a hub port.
Non-thermal right-handed sneutrino dark matter and the Omega_DM/Omega_b problem
Page, Veronique
High Energy Physics - Phenomenology , 2007, DOI: 10.1088/1126-6708/2007/04/021
Abstract: We argue that the superpartner of the Dirac right-handed neutrino is a prime candidate for dark matter created from a 'mattergenesis' mechanism. We show that due to the smallness of the Yukawa couplings, a right-handed sneutrino density created in the early Universe would not be erased by annihilations, which remain out of thermal equilibrium. It would also not be drowned by a later, additional production of right-handed sneutrinos, as the relic density of the non-thermal right-handed sneutrinos is found to be generally negligible compared to the observed dark matter density. Mild constraints on sneutrino masses and trilinear SUSY-breaking couplings are obtained. Possible mattergenesis scenarios are also mentioned
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