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Search Results: 1 - 10 of 190084 matches for " Maricel G. Kann "
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Chapter 4: Protein Interactions and Disease
Mileidy W. Gonzalez,Maricel G. Kann
PLOS Computational Biology , 2012, DOI: 10.1371/journal.pcbi.1002819
Abstract: Proteins do not function in isolation; it is their interactions with one another and also with other molecules (e.g. DNA, RNA) that mediate metabolic and signaling pathways, cellular processes, and organismal systems. Due to their central role in biological function, protein interactions also control the mechanisms leading to healthy and diseased states in organisms. Diseases are often caused by mutations affecting the binding interface or leading to biochemically dysfunctional allosteric changes in proteins. Therefore, protein interaction networks can elucidate the molecular basis of disease, which in turn can inform methods for prevention, diagnosis, and treatment. In this chapter, we will describe the computational approaches to predict and map networks of protein interactions and briefly review the experimental methods to detect protein interactions. We will describe the application of protein interaction networks as a translational approach to the study of human disease and evaluate the challenges faced by these approaches.
Transcriptional Interactions During Smallpox Infection and Identification of Early Infection Biomarkers
Willy A. Valdivia-Granda,Maricel G. Kann,Jose Malaga
Quantitative Biology , 2006,
Abstract: Smallpox is a deadly disease that can be intentionally reintroduced into the human population as a bioweapon. While host gene expression microarray profiling can be used to detect infection, the analysis of this information using unsupervised and supervised classification techniques can produce contradictory results. Here, we present a novel computational approach to incorporate molecular genome annotation features that are key for identifying early infection biomarkers (EIB). Our analysis identified 58 EIBs expressed in peripheral blood mononuclear cells (PBMCs) collected from 21 cynomolgus macaques (Macaca fascicularis) infected with two variola strains via aerosol and intravenous exposure. The level of expression of these EIBs was correlated with disease progression and severity. No overlap between the EIBs co-expression and protein interaction data reported in public databases was found. This suggests that a pathogen-specific re-organization of the gene expression and protein interaction networks occurs during infection. To identify potential genome-wide protein interactions between variola and humans, we performed a protein domain analysis of all smallpox and human proteins. We found that only 55 of the 161 protein domains in smallpox are also present in the human genome. These co-occurring domains are mostly represented in proteins involved in blood coagulation, complement activation, angiogenesis, inflammation, and hormone transport. Several of these proteins are within the EIBs category and suggest potential new targets for the development of therapeutic countermeasures.
INCA-CE: a Central European initiative in nowcasting severe weather and its applications
A. Kann, G. Pistotnik,B. Bica
Advances in Science and Research (ASR) , 2012, DOI: 10.5194/asr-8-67-2012
Abstract: The INCA-CE (Integrated Nowcasting through Comprehensive Analysis – Central Europe) project aims at implementing a transnational weather information system as well as applications for different socio-economic sectors to reduce risks of major economic damage and loss of life caused by severe weather. Civil protection and also stakeholders from economic sectors are in a growing need of accurate and reliable short-term weather forecasts. Within INCA-CE, a state-of-the art nowcasting system (INCA) is implemented at weather services throughout the European Union's CE (Central Europe) Programme Area, providing analyses and short term forecasts to the aforementioned end-users. In a coherent approach, the INCA (Integrated Nowcasting through Comprehensive Analysis) system will be adapted for implementation and use in a number of partner countries. Within transregional working groups, the gap between short-term weather information and its downstream activities in hydrological disaster management, civil protection and road management will be bridged and best practice management and measure plans will be produced. A web-based platform for outreach to related socio-economic sectors will initiate and foster a dialogue between weather services and further stakeholders like tourism or the insurance sector, flood authorities for disaster management, and the construction industry for cost-efficient scheduling and planning. Furthermore, the project will produce a compact guideline for policy makers on how to combine structural development aspects with these new features. In the present paper, an outline of the project implementation, a short overview about the INCA system and two case studies on precipitation nowcasts will be given. Moreover, directions for further developments both within the INCA system and the INCA-CE project will be pointed out.
Recent Applications of Polymer Supported Organometallic Catalysts in Organic Synthesis
Nina Kann
Molecules , 2010, DOI: 10.3390/molecules15096306
Abstract: Recent developments concerning the application of polymer supported organometallic reagents in solid phase synthesis are reviewed, with a special focus on methodology for carbon-carbon formation. Examples of reactions that are covered include the classical Suzuki, Sonogashira and Heck coupings, but also aryl amination, epoxide opening, rearrangements, metathesis and cyclopropanation. Applications in the field of asymmetric synthesis are also discussed.
On the skill of various ensemble spread estimators for probabilistic short range wind forecasting
A. Kann
Advances in Science and Research (ASR) , 2012, DOI: 10.5194/asr-8-115-2012
Abstract: A variety of applications ranging from civil protection associated with severe weather to economical interests are heavily dependent on meteorological information. For example, a precise planning of the energy supply with a high share of renewables requires detailed meteorological information on high temporal and spatial resolution. With respect to wind power, detailed analyses and forecasts of wind speed are of crucial interest for the energy management. Although the applicability and the current skill of state-of-the-art probabilistic short range forecasts has increased during the last years, ensemble systems still show systematic deficiencies which limit its practical use. This paper presents methods to improve the ensemble skill of 10-m wind speed forecasts by combining deterministic information from a nowcasting system on very high horizontal resolution with uncertainty estimates from a limited area ensemble system. It is shown for a one month validation period that a statistical post-processing procedure (a modified non-homogeneous Gaussian regression) adds further skill to the probabilistic forecasts, especially beyond the nowcasting range after +6 h.
Wachstumshormontherapie alternder M nner in der Anti-Aging-Medizin - Sinn oder Unsinn?
Kann PH
Blickpunkt der Mann , 2003,
Abstract: Nach den Kriterien der evidenzbasierten Medizin ist die Substitution mit Wachstumshormon bei Vorliegen einer organisch verursachten Hypophysenvorderlappeninsuffizienz eine in bezug auf Wirksamkeit, klinische Effektivit t und Sicherheit gut belegte therapeutische Ma nahme. Andere Indikationen im Erwachsenenalter, wie der Einsatz von Wachstumshormonen in der Anti-Aging-Medizin, sind derzeit mit wissenschaftlichen Erkenntnissen nicht zu begründen. Weder die m glichen Nutzen, noch die Risikoprofile sind gekl rt.
Evaluación de la respuesta de isotipos de inmunoglobulina especifica a Leishmania en leishmaniasis tegumentaria Americana
Labrada, Maricel;Weigle, Kristen;Valderrama, Liliana;Saravia, Nancy G.;
Memórias do Instituto Oswaldo Cruz , 1989, DOI: 10.1590/S0074-02761989000300018
Abstract: leishmania-specific immunoglobulin subclass response was evaluated in 133 patients infected with leishmania braziliensis. the indirect immunofluorescent antibody test (ifat) was employed with amastigotes of l. mexicana amazonensis as antigen. among the 133 sera obtained at consultation fo rdiagnosis of active lesions, igm was detected in 54 following absorption with staphylococcus aureus cowan strain i, and in 5 sera prior to absorption. igm reactive with leishmania antigen was only found in sera from patients whose lesions had envolved over past two months or less. leishmania-specific igg was detected in all sera prior to absorption. sera obtained at the time of recurrence of after complete healing of lesions presented only specific igc. the combined use of the montenegro skin test and specific igm increased the sensitivity of immunodiagnostic methods in patients with lesions of less than 2 months duration. normal control volunteers were negative for specific igm and unreactive to montenegro skin testin. among 16 patients with non-leishmanial lesion, 3 with sporotrichosis showed igg reactive with leishmania; none, including 4 with lesions of less than two months duration, showed specific igm. we conclude that in patients infected with l. brasiliensis the presence of specific igg and igm is associated with the time of lesion evolution and the primary or recurrent nature of the lesions. in addition, the combined use of igm titer and montenegro reactivity is of potential utility in the diagnosis of early lesions.
O desenvolvimento da enfermagem na América Latina: uma vis?o estratégica
Manfredi, Maricel;
Revista Latino-Americana de Enfermagem , 1993, DOI: 10.1590/S0104-11691993000100004
Abstract: nursing in latin america is facing a number of serious challanges significantly effecting contributions its personnel con make to the health of the people they serve. this article presents an overview of nursing as an important component of the health system in latin america through the prospective and orientation provided by strategic planning. the author, following an analysis of the nursing in the region, identifies several problems and then creates a vision for the future. the article looks at the possibilities of developing and implementing projects and action plans to address the priority problems. it sees strategic thinking as a possible means for nursing to reflect on and maximize its contribution and presence in the solution of the health problems in the current decade and into the next century.
The ‘Dys-Appearing’ Body in Doris Lessing’s The Diary of a Good Neighbour and Margaret Forster’s Have the Men Had Enough?
Maricel Oró-Piqueras
Societies , 2012, DOI: 10.3390/soc2040270
Abstract: If the old body is usually read as a synonym of fragility and upcoming illness, even though not the case for most elderly citizens, the reality is that the longer we live, the increased probability of being affected by different illnesses cannot be eluded or denied. In Doris Lessing’s The Diary of a Good Neighbour and Margaret Forster’s Have the Men Had Enough? the reader is invited to participate in the day-to-day routines of two aged female protagonists, as well as to empathize with their inner feelings as they go through their last life stage. In fact, their ‘dys-appearing’ bodies, marked by their respective terminal illnesses, force these characters to grow closer to those around them and to accept the help of their families and friends, despite their desire to keep their free will and independence until the very end. The analysis of the two novels within the framework of ageing studies aims to show the contradictions existing between a growing ageing society and the negative cultural connotations of old age in Western society and the need to revise them.
Maricel Julve
Revista de la Sociedad Espa?ola de Enfermería Nefrológica , 2007,
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