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Search Results: 1 - 10 of 7718 matches for " Maribel; Th?rn "
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Influencia de las vías de inmunización mucosales sobre la protección contra herpes simple tipo 2 con el AFCo1 como adyuvante
Osmir Cabrera,Maribel Cuello,Karolina Thrn,Madelene Lindqvist
Vaccimonitor , 2011,
Abstract: Las vacunas mucosales se han planteado como una estrategia prometedora para inducir protección mucosal.El virus herpes simple tipo 2 es uno de los patógenos más frecuentes en el humano transmitidos por vía sexual.Varios candidatos vacunales contra este patógeno se han evaluado, pero no han sido efectivos, por lo que aún no se cuenta con una vacuna profiláctica ni terapéutica. La gD2 es una glicoproteína recombinante y está reportada como uno de los antígenos de importancia vacunal contra este germen. Contamos con el cocleato derivado del proteoliposoma de Neisseria meningitidis serogrupo B (AFCo1)que ha mostrado capacidades adyuvantes porvarias vías de inmunización. El objetivo de este trabajo fue evaluar la protección inducida en ratones por el AFCo1-gD2, administrada por diferentes vías mucosales. Se utilizaron ratones hembras C57BL6, los cuales fueron inmunizados por vía intranasal (IN), intravaginal (IVag) o intrarrectal (IR) con AFCo1-gD2 o gD2 sola.Se determinó la IgG anti gD2, la proliferación celular específica, la replicación viral en lavado vaginal, los signos de la enfermedad y la protección frente al reto viral. Se obtuvo respuestas significativas de IgG anti gD2 por todas las vías, aunque la IN mostró los valores más elevados. Se observó proliferación celular en células de animalesinmunizados IN e IVag, pero no por vía IR. Se observó la mayor protección (100%) en los animales inmunizados por vía IN. Se concluye que la vía nasal es la más prometedora en la inducción de protección contra este reto viral.
La gD2 coadministrada con el AFCo1 por vía intranasal induce inmunidad protectora contra virus de herpes simple tipo 2 en ratones.
Osmir Cabrera,Maribel Cuello,Karolina Thrn,Josefine Peerson
Vaccimonitor , 2012,
Abstract: La infección por virus herpes simple tipo 2 (VHS-2) continúa siendo un problema de salud mundial. Esta infección es transmitida sexualmente y es la principal causa de úlceras genitales. La prevención de esta enfermedad requiere de la utilización de vacunas mucosales, pues las vacunas parenterales no han sido exitosas. Por otra parte, no existen adyuvantes mucosales, por lo que el desarrollo de estos es esencial para la estrategia de estasvacunas. La administración intranasal (IN) de la glicoproteína D del VHS-2 (gD2), coadministrada con el cocleato (AFCo1+gD2) sería igualmente efectiva con la gD2 incluida (AFCo1-gD2). Se inocularon ratones hembras C57BL/6 por la vía IN con gD2, contenida dentro del cocleato, coadministrada con el cocleato o gD2 sola. Se determinaronlos niveles de IgG anti gD2 en suero y lavado vaginal, así como las subclases de IgG anti gD2 por ELISA. Se determinó la respuesta linfoproliferativa en células de bazo, el perfil de citoquinas Th1/Th2, los signos de la enfermedad y la protección frente al reto viral. Se observaron altos títulos de IgG e IgG2c anti gD2 en el suero de los animales inoculados con la gD2 y el AFCo1 como adyuvante. No se observaron diferencias significativas (p>0,05) entre los grupos que recibieron AFCo1+gD2 y los que recibieron AFCo1-gD2. Se observó un perfil de citoquinas tipo Th1 y un 100% de sobrevida en los grupos que recibieron el AFCo1 como adyuvante de la gD2,mientras que en el grupo que recibió la gD2 sola no se observó protección. Estos resultados indican que la gD2 puede ser utilizada coadministrada con AFCo1 por vía IN como un potencial candidato vacunal contra VHS-2.
Influencia de las vías de inmunización mucosales sobre la protección contra herpes simple tipo 2 con el AFCo1 como adyuvante
Cabrera,Osmir; Cuello,Maribel; Thrn,Karolina; Lindqvist,Madelene; Lastre,Miriam; González,Elizabeth; Zayas,Caridad; Balboa,Julio; Romeo,Belkis; Sarandi,Ali M; Pérez,Oliver;
Vaccimonitor , 2011,
Abstract: mucosal vaccines are a promising strategy to induce mucosal protection. herpes simplex virus type 2 is the commonest pathogens in the human transmitted by exposure at the genital mucosal surfaces. many vaccine candidates against this pathogen have been evaluated; but they have not been effective, and neither a prophylactic nor a therapeutic vaccine has been yet obtained. the gd2 is a recombinant glycoprotein and it is reported as one of the antigens of importance for vaccine against this virus. there is the cochleate (afco1) derived from proteoliposome of neisseria meningitidis serogroup b. this cochleate has shown potentialities as adjuvant for several immunization routes. the objective of this study was to evaluate the protection induced in mice by the afco1-gd2 administered by different mucosal routes. female mice c57bl/6 were used and immunized by: intranasal (in), intravaginal (ivag), or intrarectal (ir) routes with afco1-gd2 or gd2 alone. the anti-gd2 igg and specific cellular proliferation were determined and the viral replication in vaginal wash, the signs of disease and the protection against the viral challenge, were measured too. a significant anti-gd2 igg response was obtained by all routes, although the in route showed the highest values. cellular proliferation was observed in cells of animals immunized in and ivag route; but not by ir route. in addition, a higher protection (100%) in the animals immunized with afco1-gd2 by in route was observed. in conclusion the intranasal is the most promising route in the protection induction against this viral challenge.
Inmunización nasal con AFCo1 induce en ratones respuesta inmune a N. gonorrhoea
Cuello,Maribel; Cabrera,Osmir; Acevedo,Reinaldo; Nu?ez,Niury; del Campo,Judith; Lastre,Miriam; Zayas,Caridad; González,Elizabeth; Balboa,Julio; Romeu,Belkis; Thrn,Karolina; Lindqvist,Madelene; Persson,Jossefine; Harandi,Ali M.; Pérez,Oliver;
Vaccimonitor , 2009,
Abstract: neisseria gonorrhoeae infections are common sexually transmitted diseases. increased antibiotic-resistant of n. gonorrhoeae strains were reported. n. meningitidis is another human restricted bacterium transmitted through mucosa. however, the induction of systemic specific igg antibody against some proteins between the two species is known, but the mucosal immune response to these pathogens is not clear. we hypothesized that n. meningitidis could induce immune response against n. gonorrhoeae. therefore, serogroup b proteoliposome (pl) was transformed into afco1 (adjuvant finlay cochleate 1) and used for nasal immunization of c57bl/6 mice. the specific igg and igg subclasses against both antigens in sera and vaginal extraction were measured by elisa. specific proliferation (3h incorporation) of spleen cells and lymph node recall in vitro with pl or n. gonorrhoeae total antigens was measured. serum and vaginal extraction anti n. meningitidis and n. gonorrhoeae igg as well as the induction of specific igg subclasses were detected. n. gonorrhoeae induces specific proliferation of spleen, cervical lymph node (cln), and mediestinal (meln) cells from immunized mice. in conclusion, afco1 induce anti n. meningitidis immune responses that recognized n. gonorrhoeae antigens in mice.
Men’s Experience of Difficulties during First Year Following Myocardial Infarction—Not Only Fatigue  [PDF]
Pia Alsén, Susanna Thrn, Linnea Nordqvist, Ina Berndtsson
Health (Health) , 2016, DOI: 10.4236/health.2016.815161
Abstract: Recovery from a myocardial infarction (MI) can be a very difficult process and some patients are also stricken by fatigue. The aim of the study was to describe the difficulties experienced by men with fatigue during the first year following their MI. The study was conducted using qualitative content analysis of semi-structured interviews with nine men in working age (mean age: 55 years) with verified fatigue (≥12 of 20 on the Multidimensional Fatigue Scale with a mean of 17) one year after their MI. During the first year after the MI the men suffering from fatigue experienced various difficulties in terms of both themselves and the care received. The analysis generated three themes with difficulties described by the interviewed men. 1) Going through involuntary change: not recognizing their body and the inability to recognize themselves. 2) Lacking individualized care: To be denied satisfactory health care treatment and to be denied respectful treatment. 3) Not being seen in the light of the social context: The MI affects the whole family and caregivers do not pay attention to the family. In order to make both the patient and relatives feel secure and cared for, it is essential that caregivers be aware of the importance of providing individualized care over time with particular attention for the patient’s social context.
Ab initio study of the ferroelectric strain dependence and 180$^\circ$ domain walls in the barium metal fluorides BaMgF$_4$ and BaZnF$_4$
Maribel Nú?ez Valdez,Hendrik Th. Spanke,Nicola A. Spaldin
Physics , 2015,
Abstract: We investigate the strain dependence of the ferroelectric polarization and the structure of the ferroelectric domain walls in the layered perovskite-related barium fluorides, BaMF$_4$ (M=Mg, Zn). The unusual "geometric ferroelectricity" in these materials is driven by the softening of a single polar phonon mode consisting of rotations of the MF$_6$ octahedra accompanied by polar displacements of the Ba cations, and in contrast to conventional ferroelectrics involves minimal electronic rehybridization. We therefore anticipate a different strain dependence of the polarization, and alternative domain wall structures compared with those found in conventional ferroelectric materials. Using first-principles calculations based on density functional theory (DFT) within the general gradient approximation (GGA), we calculate the variation of the crystal structure and the ferroelectric polarization under both compressive and tensile strain. We perform structural relaxations of neutral domain walls between oppositely oriented directions of the ferroelectric polarization and calculate their corresponding energies to determine which are most likely to form. We compare our results to literature values for conventional perovskite oxides to provide a source of comparison for understanding the ferroelectric properties of alternative non-oxide materials such as the barium fluorides.
Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells
Kristofer Thrn, Meri Hovsepyan, Peter Bergsten
Lipids in Health and Disease , 2010, DOI: 10.1186/1476-511x-9-108
Abstract: Insulin-secreting MIN6 cells with reduced levels of SCD1 were established by siRNA mediated knockdown. When fatty acid oxidation was measured, no difference between cells with reduced levels of SCD1 and mock-transfected cells were found. Also, reducing levels of SCD1 did not affect insulin secretion in response to glucose. To investigate how SCD1 knockdown affected cellular mechanisms, differentially regulated proteins were identified by a proteomic approach. Cells with reduced levels of SCD1 had higher levels of ER chaperones and components of the proteasome. The higher amounts did not protect the β-cell from palmitate-induced ER stress and apoptosis. Instead, rise in levels of p-eIF2α and CHOP after palmitate exposure was 2-fold higher in cells with reduced levels of SCD1 compared to mock-transfected cells. Accordingly, apoptosis rose to higher levels after exposure to palmitate in cells with reduced levels of SCD1 compared to mock-transfected cells.In conclusion, reduced levels of SCD1 augment palmitate-induced ER stress and apoptosis in the β-cell, which is an important caveat when considering targeting this enzyme as a treatment of the metabolic syndrome.Stearoyl-CoA desaturases (SCD:s) are a family of endoplasmic reticulum (ER) resident enzymes introducing a Δ9 double-bond in saturated fatty acids, thereby generating their monounsaturated counterparts [1]. In mice, four isoforms of SCD have been characterized, which all catalyze the same reaction but have somewhat different substrate specificities [1]. The physiological role of having multiple isoforms is not fully understood, but the different expression patterns and inducibility indicate exclusive roles for the different isoforms [2]. In humans, only one functional ortholog to mouse SCD has been found [3]. In addition, humans express another SCD isoform, termed hSCD5, which is unique to primates [4]. Much focus has been directed towards the SCD1 isoform, which is ubiquitously expressed in mouse, and the majo
Infant mortality and mortality from arteriosclerotic heart disease
Hans Th. Waaler,Bj?rn Guldvog
Norsk Epidemiologi , 2009,
Abstract: Objective: Design: Setting: Main results: Conclusions: If living conditions in childhood as indicated by infant mortality in a cohort is a valid causative factor for later cardiovascular mortality in the same cohorts, almost 1/2 of the reduction in cardiovascular mortality from 1973-93 in Norway could be explained by this factor.
Almost sure convergence of vertex degree densities in the vertex-splitting model
Sigurdur ?rn Stefánsson,Erik Th?rnblad
Mathematics , 2015,
Abstract: We study the limiting degree distribution of the vertex splitting model introduced in \cite{DDJS:2009}. This is a model of randomly growing ordered trees, where in each time step the tree is separated into two components by splitting a vertex into two, and then inserting an edge between the two new vertices. Under some assumptions on the parameters, related to the growth of the maximal degree of the tree, we prove that the vertex degree densities converge almost surely to constants which satisfy a system of equations. Using this we are also able to strengthen and prove some previously non-rigorous results mentioned in the literature.
Cyclicity degrees of finite groups
Marius T?rn?uceanu,László Tóth
Mathematics , 2014, DOI: 10.1007/s10474-015-0480-2
Abstract: We introduce and study the concept of cyclicity degree of a finite group $G$. This quantity measures the probability of a random subgroup of $G$ to be cyclic. Explicit formulas are obtained for some particular classes of finite groups. An asymptotic formula and several minimality/maximality results on cyclicity degrees are also inferred.
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