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Search Results: 1 - 10 of 2031 matches for " Marianne Pons "
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Cigarette Smoke-Related Hydroquinone Dysregulates MCP-1, VEGF and PEDF Expression in Retinal Pigment Epithelium in Vitro and in Vivo
Marianne Pons,Maria E. Marin-Casta?o
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016722
Abstract: Age-related macular degeneration (AMD) is the leading cause of legal blindness in the elderly population. Debris (termed drusen) below the retinal pigment epithelium (RPE) have been recognized as a risk factor for dry AMD and its progression to wet AMD, which is characterized by choroidal neovascularization (CNV). The underlying mechanism of how drusen might elicit CNV remains undefined. Cigarette smoking, oxidative damage to the RPE and inflammation are postulated to be involved in the pathophysiology of the disease. To better understand the cellular mechanism(s) linking oxidative stress and inflammation to AMD, we examined the expression of pro-inflammatory monocyte chemoattractant protein-1 (MCP-1), pro-angiogenic vascular endothelial growth factor (VEGF) and anti-angiogenic pigment epithelial derived factor (PEDF) in RPE from smoker patients with AMD. We also evaluated the effects of hydroquinone (HQ), a major pro-oxidant in cigarette smoke on MCP-1, VEGF and PEDF expression in cultured ARPE-19 cells and RPE/choroids from C57BL/6 mice.
Leadership Ideas—A Study with Prospective Nursing Leaders  [PDF]
Marianne Frilund
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.55054
Abstract: Introduction: The study is based on P. Kostenbaums theory about leadership as greatness. His theory distinguishes four interdependent leadership “orientations”: ethics, vision, courage and reality. People with qualities have developed greatness and wisdom in their mind, as well as competence to act ethically. The leadership research has shaped a leadership figure that can be described as a picture of a hero. Aim: The aim of this paper is to find out the idea of leadership based on earlier research and analyse their relevancy for nursing-management. Method: The study is a qualitative study based on earlier studies with focus on the basic idea of leadership with relevancy for nursing management and leadership. Sex students, from a master degree program in Finland, collected data based on earlier research. Findings and Interpretation: The ideas of leadership consist of three basic ideas: leadership as greatness, leadership as interactions and relations, and leadership based on the idea of shared leadership. Discussion: The prospects for leading others are to master the balance between the degree of freedom and control, to build trust, and to provide directives and control until confidence. To lead without “meeting” makes that the employers never give desired results. The purposes of the ideas of leadership are to create trust, confidence and understanding of where the other person is located. Being seen and being confirmed is fundamental to pace an individual and create opportunities to lead within nursing care.
Mapping Trajectories of Attention to Drug Related Issues in Estonian Main Dailies  [PDF]
Marianne Paimre
Advances in Journalism and Communication (AJC) , 2015, DOI: 10.4236/ajc.2015.32005
Abstract: Illicit drugs have been a burning social issue in Estonia over the last fifteen years. Estonia has taken the lead in Europe with regard to drug-related deaths and prevalence of HIV among injecting drug users. Experimental drug use among Estonian students is more widespread than the European average. It is important to study press coverage, because according to agenda setting theory, the media plays an important role in influencing the salience of social issues on the public agenda. The aim of this article is to map fluctuations in attention received from Estonian two major dailies to different drug related issues during the last 25 years. The author focuses on issues highlighted in national and international drug reports such as drug addiction, drug related crime, spread of HIV among addicts, drug-induced deaths, drug problem in schools etc. Content analysis of almost 1000 press articles reflecting drug problems in Estonia was carried out from 1990 to 2014. The study revealed that since 1995, attention received from the major newspapers to drug related crime has been high and quite stable compared to other drug issues. Press interest with regard to problem drug use and HIV was notice a bleat the turn of the millennium and in the beginning of the new century, but almost lost by 2014. More intense periods of coverage were triggered by specific events. Only a few articles have reflected drug induced death despite the fact that Estonia is the undisputed leader in the EU regarding this indicator. This reflects that the coverage was not been in line with the drug situation in Estonia. It seems that the attention of the press depends rather on newsworthiness of the issue and the agenda setting processes.
Multicultural Working Teams and Safety Awareness: How Effective Leadership Can Motivate Safety Behaviour  [PDF]
Marianne Starren
Psychology (PSYCH) , 2016, DOI: 10.4236/psych.2016.77102
Abstract: This empirical study focuses on the diversity of cultural values and leadership preferences in multicultural working teams and how this interaction makes it difficult to guarantee and motivate safety at the workfloor. It is often hypothesized that when employees from different national identities have to work together in one team, their different cultural backgrounds make a common mental state of safety awareness very complex. In managing this diversity of cultural values, the role of leadership style could be crucial. The results show that a cultural value as uncertainty avoidance clearly has its influence on safety awareness and that this outcome is mediated by the motivating leadership style.
Asymmetrical Genesis by Remanufacture of Antielectrons  [PDF]
Dirk J. Pons, Arion D. Pons, Aiden J. Pons
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.517193
Abstract: Problem: The asymmetrical genesis problem concerns why the universe should have an abundance of matter over antimatter. Purpose: This paper shows how the baryogenesis and leptogenesis asymmetries may both be resolved. Approach: Design methods were used to develop a conceptual mechanics for the remanufacturing processes that transform particles in the decay processes. This was based on the structures for the photon, electron, antielectron, proton and antineutrino as previously identified as logical necessities for the beta decay process, and represented as a non-local hidden-variable design with discrete fields. Findings: The solution is given in terms of a mechanics that defines the transformation of discrete field structures in particles. The genesis problem is shown to be solvable. The mechanics describes pair production of an electron and antielectron from two initial photons, and subsequent remanufacture of the antielectron into a proton. It is predicted that two antineutrinos would be emitted, which are testable and falsifiable. The theory identifies that the role of the antineutrinos is to remove the antimatter handed field structures. The original electron and proton may bond to form a simple hydrogen atom, or combine via electron capture to form a neutron and hence heavier nuclides. The subsequent preponderance of the matter pathways in the genesis production sequence is also addressed and is explained as domain warfare between the matter and antimatter species. Originality: The concept of remanufacture of antielectrons into protons, with emission of antineutrinos, is novel. Extensions of the theory explain the nuclides. Consequently the theory explains from pair production up to nuclear structure, which is also original.
Energy Conversion Mechanics for Photon Emission per Non-Local Hidden-Variable Theory  [PDF]
Dirk J. Pons, Arion D. Pons, Aiden J. Pons
Journal of Modern Physics (JMP) , 2016, DOI: 10.4236/jmp.2016.710094
Abstract: Problem-Energy conversion processes in optical phenomena are incompletely explained by wave theory or quantum mechanics. There is a need for ontologically rich explanations at the level of individual particles. Purpose: This paper reports on the application of a non-local hidden-variable solution called the Cordus theory to this problem. The method is directed to the systematic development of a conceptual framework of proposed causal mechanisms. Findings: It has long been known that the bonding commitments of the electron affect its energy behaviour but the mechanisms for this have been elusive. We show how the degree of bonding constraint on the electron determines how it processes excess energy. A key concept is that the span and frequency of the electron are inversely proportional. This explains why energy changes cause positional distress for the electron. Natural explanations are given for multiple emission phenomena: Absorbance; Saturation; Beer-Lambert law; Colour; Quantum energy states; Directional emission; Photoelectric effect; Emission of polarised photons from crystals; Refraction effects; Reflection; Transparency; Birefringence; Cherenkov radiation; Bremsstrahlung and Synchrotron radiation; Phase change at reflection; Force impulse at reflection and radiation pressure; Simulated emission (Laser). Originality: The paper elucidates a mechanism for how the electron responds to combinations of bonding constraint and pumped energy. The crucial insight is that the electron size and position(s) are coupled attributes of its frequency and energy, where the coupling is achieved via physical substructures. The theory is able to provide a logically coherent explanation for a wide variety of energy conversion phenomena.
Entropy at the Level of Individual Particles: Analysis of Maxwell’s Agent with a Hidden-Variable Theory  [PDF]
Dirk J. Pons, Arion D. Pons, Aiden J. Pons
Journal of Modern Physics (JMP) , 2016, DOI: 10.4236/jmp.2016.710113
Abstract: Problem: Maxwell’s Agent (MA) is a thought experiment about whether the second Law is violated at smaller scales. This is a complex problem because the scale dependencies are unclear for perfect gas assumptions, quantum coherence, thermalisation, and contextual measurement. Purpose: The MA is explored from a non-local hidden-variable (NLHV) perspective. Approach: The Cordus theory, a specific NLHV solution, was applied at macroscopic to fundamental scales. Physical realism requires the Agent be included in the analysis. Findings: The primary function is sorting, i.e. a one-time separation of species by some attribute. The thermodynamic MA situation is merely a special case for reducing disorder (entropy). A one-time extraction of energy is possible. This requires input energy, hence the device only has thermodynamic leverage and is not a perpetual motion device. Inefficiencies arise from thermalisation causing short mean free path of Brownian motion, perfect gases having minimal interaction with the gate, ambiguity about spatial location arising from quantum superposition, contextual measurement interfering with the particle velocity, and bremsstrahlung hysteresis losses occurring when the Agent operates. Implications: Entropy is a group property at the bulk level, not a characteristic of the individual particle, and can be reversed at an energy cost at the particle level. Originality: The explanation spans multiple levels from macroscopic down to fundamental, which is unusual. Achieving an explanation from the NLHV sector is novel. The theory accommodates superposition, irreversibility, entropy, contextual measurement, coherence-discord transition, and Brownian motion.
A Physical Basis for Entanglement in a Non-Local Hidden Variable Theory  [PDF]
Dirk J. Pons, Arion D. Pons, Aiden J. Pons
Journal of Modern Physics (JMP) , 2017, DOI: 10.4236/jmp.2017.88082
Abstract: Problem: Superposition and entanglement are coherent effects, which can be quantified by quantum mechanics (QM), but lack descriptive explanations. They are typically analysed with inequality methods, and the results favour QM and reject physical realism and hidden-variable solutions. In particular, Colbeck & Renner (2011) showed that no extension of quantum theory can exist with better predictive power than quantum mechanics itself. Purpose: The purpose here is to critically evaluate from a conceptual and philosophical perspective the ontological underpinnings of the inequality approach. The current work is speculative in nature as it is based on a conjectured non-local hidden-variable (NLHV) design for particles, and does not yet have a mathematical formalism. Nonetheless this is worth attempting for the philosophical questions it poses about the nature of reality, and the pointers it gives to possible future directions in fundamental physics. Findings: The premises of the C & R proof (that particles are points, that locality exists, that quantum theory is correct) are inconsistent, hence invalidate its conclusion. We also show that superposition and entanglement may be qualitatively explained if particles were to have the internal structure proposed by the Cordus NLHV theory. Originality: The ability to explain superposition and entanglement conceptually in terms of physical realism is relevant because it rebuts the claim that it is impossible that such a hidden-variable theory could exist. This is significant because previously it has been believed that these phenomena are explainable by QM only.
Effect of Matter Distribution on Relativistic Time Dilation  [PDF]
Dirk J. Pons, Arion D. Pons, Aiden J. Pons
Journal of Modern Physics (JMP) , 2018, DOI: 10.4236/jmp.2018.93035
Abstract: Context: Derivations for the relativity formulations for the Lorentz are conventionally based on continuum mechanics. Purpose: This paper derives the formulations from a particle perspective. Approach: A non-local hidden-variable (NLHV) approach is adopted, based on the specific particle structures of the Cordus Theory. Findings: The Lorentz and relativistic Doppler formulations are shown to be derivable from a NLHV particle perspective. Unexpectedly, the equations contain an additional term relating to the difference in the distribution of matter (fabric density) between situations. For a homogenous fabric, which is the assumption of general relativity, the conventional formulations are recovered. Originality: The novel contribution is deriving the relativistic formulation from a NLHV theory. Also novel is the identification of the fabric density as a term in the Lorentz. Implications: It is predicted that inertial frames of reference are only situationally equivalent in the special case where they also have the same fabric density. We find against the cosmological principle with its assumption of homogeneity. The resulting situational theory of relativity has further implications for interpreting gravitational interactions at the galactic scale and larger.
Jornades d'estudi sobre Baltasar Porcel
Damià Pons i Pons
Llengua & Literatura , 2008, DOI: 10.2436/l&l.vi.1229
Abstract:
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