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Search Results: 1 - 10 of 220108 matches for " Mariana da Cunha Lopes de Lima "
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-DTPA Study to Validate an Experimental Model of Ureteral Obstruction in Rabbits: Preliminary Results
Marcelo Lopes de Lima,Rodolfo Bertti,Juliano César Moro,Fábio Coltro Neto,Ricardo Miyaoka,Adriano Fregonesi,Mariana da Cunha Lopes de Lima,Celso Darío Ramos
Advances in Urology , 2013, DOI: 10.1155/2013/929620
Abstract: Objective. To create a ureteral obstruction experimental model that can be proved through -DTPA renal scintigraphy and histopathological studies, without causing total renal function loss. Materials and Methods. Ten New Zealand white rabbits were submitted to a surgical experiment to create a model of unilateral obstruction to urinary flow. Surgery procedure provided unilateral ureteral obstruction (left kidney) to urinary flow and posteriorly was evaluated by -DTPA renal scintigraphy and histopathological study. -DTPA renal study was performed to detect and quantify signs of obstruction and to evaluate renal function. Statistical analysis was performed through the Student -test with a significance level of . Results. Nine of the ten rabbits presented left renal unit obstruction and one nonobstructive on the -DTPA and histopathological studies. All the right renal units, which were not submitted to surgical procedure, were nonobstructed by the studies. There was a general agreement between scintigraphy and histopathological results in both groups. Conclusion. The experimental model promoted the creation of ureteral obstruction in rabbits, confirmed by nuclear medicine scintigraphy and histopathology, and could be used in further studies to better understand urinary obstruction. 1. Introduction Pelvi-ureteric junction (PUJ) obstruction is one of the most frequent congenital anomalies of the urinary tract system. It is associated with pain, hydronephrosis, urinary tract infections, and eventually loss of renal function [1, 2]. It affects around 40% to 60% of all newborns with hydronephrosis [3], two times more common in males, and may be bilateral in 5% to 15% of cases [1, 4]. PUJ obstruction may be caused by intrinsic factors, like aperistaltic ureteral segment, obstructive fold mucosa, ureteral polyp, or ureteral stenosis [5]. Among extrinsic factors stands inferior renal polar vessel crossing anteriorly the PUJ [6]. Treatment varies from clinical observation to surgery. There are some surgical modalities available to correct the PUJ obstruction, differing from the open pyeloplasty to the latest in technology such as robotic assisted surgeries and endourological procedures [7–9]. Currently scientific literature is short in ureteral obstruction models that accurately reproduce the clinical and microscopic features of this infirmity [10–12]. The creation of a standardized experimental model that would be able to cause obstructive disturbance without leading to renal function loss would provide information capable of enhancing not only the diagnosis but
Estimation of absolute renal uptake with technetium-99m dimercaptosuccinic acid: direct comparison with the radioactivity of nephrectomy specimens
Lima, Mariana da Cunha Lopes de;Ramos, Celso Darío;Brunetto, Sérgio Quirino;Lima, Marcelo Lopes de;Ferreira, Ubirajara;Etchebehere, Elba Cristina Sá Camargo;Santos, Allan de Oliveira;Netto Júnior, Nelson Rodrigues;Camargo, Edwaldo Eduardo;
Sao Paulo Medical Journal , 2008, DOI: 10.1590/S1516-31802008000300003
Abstract: context and objective: studies using radionuclides are the most appropriate method for estimating renal function. dimercaptosuccinic acid chelate labeled with technetium-99m (99mtc-dmsa) is the radiopharmaceutical of choice for high-resolution imaging of the renal cortex and estimation of the functional renal mass. the aim of this study was to evaluate a simplified method for determining the absolute renal uptake (aru) of 99mtc-dmsa prior to nephrectomy, using the radioactivity counts of nephrectomy specimens as the gold standard. design and setting: prospective study at the division of nuclear medicine, department of radiology, universidade estadual de campinas. methods: seventeen patients (12 females; range 22-82 years old; mean age 50.8 years old) underwent nephrectomy for various reasons. renal scintigraphy was performed three to four hours after intravenous administration of a mean dose of 188.7 mbq (5.1 mci) of 99mtc-dmsa, which was done six to 24 hours before surgery. the in vivo renal uptake of 99mtc-dmsa was determined using the radioactivity of the syringe before the injection (measured using a dose calibrator) and the images of the syringe and kidneys, obtained from a scintillation camera. after surgery, the reference value for renal uptake of 99mtc-dmsa was determined by measuring the radioactivity of the nephrectomy specimen using the same dose calibrator. results: the aru measurements were very similar to those obtained using the reference method, as determined by linear regression (r-squared = 0.96). conclusion: aru estimation using the proposed method before nephrectomy seems to be accurate and feasible for routine use.
Functional electrical stimulation improves brain perfusion in cranial trauma patients
Amorim, Bárbara Juarez;Santos, Allan de Oliveira;Oberg, Telma Dagmar;Romanato, Juliana;Anjos, Dalton A.;Lima, Mariana da Cunha Lopes de;Ramos, Celso Darío;Honorato, Donizete Cesar;Camargo, Edwaldo Eduardo;Etchebehere, Elba Cristina de Sá Camargo;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000500020
Abstract: objective: demonstrate brain perfusion changes due to neuronal activation after functional electrical stimulation (fes). method: it was studied 14 patients with hemiplegia who were submitted to a program with fes during fourteen weeks. brain perfusion spect was performed before and after fes therapy. these patients were further separated into 2 groups according to the hemiplegia cause: cranial trauma and major vascular insults. all spect images were analyzed using spm. results: there was a significant statistical difference between the two groups related to patient's ages and extent of hypoperfusion in the spect. patients with cranial trauma had a reduction in the hypoperfused area and patients with major vascular insult had an increase in the hypoperfused area after fes therapy. conclusion: fes therapy can result in brain perfusion improvement in patients with brain lesions due to cranial trauma but probably not in patients with major vascular insults with large infarct area.
Low sensitivity of three-phase bone scintigraphy for the diagnosis of repetitive strain injury
Amorim, Bárbara Juarez;Etchebehere, Elba Cristina Sá de Camargo;Torre, Graciella Dalla;Lima, Mariana da Cunha Lopes de;Santos, Allan de Oliveira;Ramos, Celso Darío;Gonzalez, Luiz Ricardo;Oliveira, José Inácio;Camargo, Edwaldo Eduardo;
Sao Paulo Medical Journal , 2006, DOI: 10.1590/S1516-31802006000300007
Abstract: context and objective: the diagnosis of repetitive strain injury (rsi) is subjective and solely based on clinical signs and physical examination. the aim of this paper was to assess the usefulness of three-phase bone scintigraphy (tpbs) in diagnosing rsi. design and setting: prospective study at the division of nuclear medicine, department of radiology, school of medical sciences, universidade estadual de campinas (unicamp). methods: seventy-three patients (mean age 31.2 years; 47 males) with clinical suspicion of rsi in the upper limbs were studied. a total of 127 joints with suspicion of rsi were studied. the shoulders, elbows and wrists were analyzed semi-quantitatively, using the shafts of the humeri and ulnae as references. the results were compared with a control group of 40 normal individuals. the patients? signs and symptoms were used as the "gold standard" for calculating the probabilities. results: from visual analysis, abnormalities were observed in the flow phase for four joints, in the blood pool phase for 11 joints and in the delayed images for 26 joints. visual analysis of the joints of the control group did not show any abnormalities. semi-quantitative analysis showed that most of the patients? joint ratios were normal. the exceptions were the wrists of patients with left-sided rsi (p = 0.0216). however, the sensitivity (9%) and accuracy (41%) were very low. conclusion: tpbs with semi-quantitative analysis has very low sensitivity and accuracy in the detection of rsi abnormalities in the upper limbs.
Brain SPECT in mesial temporal lobe epilepsy: comparison between visual analysis and SPM
Amorim, Bárbara Juarez;Ramos, Celso Darío;Santos, Allan Oliveira dos;Lima, Mariana da Cunha Lopes de;Min, Li Li;Camargo, Edwaldo Eduardo;Cendes, Fernando;Etchebehere, Elba Cristina Sá de Camargo;
Arquivos de Neuro-Psiquiatria , 2010, DOI: 10.1590/S0004-282X2010000200001
Abstract: objective: to compare the accuracy of spm and visual analysis of brain spect in patients with mesial temporal lobe epilepsy (mtle). method: interictal and ictal spects of 22 patients with mtle were performed. visual analysis were performed in interictal (visual(inter)) and ictal (visual(ictal/inter)) studies. spm analysis consisted of comparing interictal (spm(inter)) and ictal spects (spm(ictal)) of each patient to control group and by comparing perfusion of temporal lobes in ictal and interictal studies among themselves (spm(ictal/inter)). results: for detection of the epileptogenic focus, the sensitivities were as follows: visual(inter)=68%; visual(ictal/inter)=100%; spm(inter)=45%; spm(ictal)=64% and spm(ictal/inter)=77%. spm was able to detect more areas of hyperperfusion and hypoperfusion. conclusion: spm did not improve the sensitivity to detect epileptogenic focus. however, spm detected different regions of hypoperfusion and hyperperfusion and is therefore a helpful tool for better understand pathophysiology of seizures in mtle.
Estudo comparativo do nível de qualidade de vida entre sujeitos acondroplásicos e n?o-acondroplásicos
Cervan, Mariana Pereira;Silva, Márcia Cristina Pires da;Lima, Rodrigo Lopes de Oliveira;Costa, Roberto Fernandes da;
Jornal Brasileiro de Psiquiatria , 2008, DOI: 10.1590/S0047-20852008000200004
Abstract: achondroplasia is characterized as an autosomal dominant genetic disturbance which affects the endochondral ossification which is a common cause of dwarfism syndrome. among the characteristics the most common are the short stature and disproportional trunk/limbs. thus, the achondroplasic subjects can face themselves inferior and not satisfied with their physical appearance, influencing, among other factors, the quality of life of this population. objective: to compare the quality of life level between achondroplasic and non-achondroplasic subjects. methods: study with 21 achondroplasics in which, nine were men and 13 women, paired by age and gender to 21 non-achondroplasic subjects. the quality of life level was estimated by whoqol-bref questionnaire. results: in the comparison between achondroplasic and non-achondroplasic females we verified that in physical domain achondroplasic women presented mean score significantly lower than non-achondroplasic. in the comparison between genders, achondroplasic females presented mean score significantly lower than achondroplasic males in psychological domain. conclusion: in this study, the quality of life didn't present any difference between groups, however, in physical and psychological domains, achondroplasic women demonstrated less satisfaction to their condition.
Gallium-67 imaging in a patient with paracoccidioidomycosis: a case report
TEIXEIRA Ana Beatriz Marinho de Jesus,ETCHEBEHERE Elba Cristina Sá de Camargo,LIMA Mariana Cunha Lopes de,SANTOS Allan de Oliveira
Revista do Instituto de Medicina Tropical de S?o Paulo , 2000,
Abstract: A 26 year-old female was admitted with abdominal pain, fever and weight loss. The clinical and laboratory investigations led to the diagnosis of paracoccidioidomycosis. Gallium-67 whole body images correlated well with the clinical course of the disease and with the patient's prognosis.
Pré-condicionamento isquêmico em diferentes tempos e seu efeito na transloca o bacteriana induzida por isquemia e reperfus o intestinal em ratos Ischemic preconditioning in different times and its effect on bacterial translocation induced by intestinal ischemia and reperfusion in rats
Aldo da Cunha Medeiros,Irami Araújo-Filho,Mariana Lima T?rres,Caroline de Vasconcelos Sá
Revista do Colégio Brasileiro de Cirurgi?es , 2013,
Abstract: OBJETIVO: avaliar os efeitos de diferentes tempos de pré-condicionamento isquêmico(PCI) intestinal sobre a transloca o bacteriana (TB). MéTODOS: Trinta ratos Wistar pesando 280±27g foram alocados em cinco grupos. No grupo IR (n=6), foi realizada laparotomia e a artéria mesentérica superior foi ocluída por microclampe atraumático por 30 minutos. Nos quatro grupos com pré-condicionamento (n=6 cada), antes dos 30 minutos de isquemia-reperfus o (I/R) os ratos foram submetidos a PCI de dois, cinco, dez e 15 minutos e, em seguida, ao mesmo tempo de reperfus o. Vinte e quatro horas após, para avaliar se os tempos de pré-condicionamento influenciam o aparecimento de transloca o bacteriana, amostras de linfonodos mesentéricos, fígado e ba o foram coletadas em condi es estéreis, para quantifica o de unidades formadoras de col nias bacterianas por grama de tecido (UFC/g). Sangue foi coletado para dosagem de citocinas. RESULTADOS: No grupo I/R, o total de UFC/g em linfonodos mesentéricos, ba o, fígado, bem como, a dosagem sérica de TNF-a, IL-1b e IL-6 foram significativamente maiores do que nos demais grupos (p<0,05). Pré-condicionamento de 15 minutos atenuou significativamente a BT e as citocinas séricas, comparando com os outros tempos de pré-condicionamento (p<0,05). CONCLUS O: Nossos dados sugerem o pré-condicionamento como fator-chave para reduzir transloca o bacteriana em I/R intestinal. Numa escala de dois a 15 minutos, o melhor tempo de pré-condicionamento isquêmico para a atenua o da transloca o bacteriana foi 15 minutos. OBJECTIVE: To evaluate the effects of different times of ischemic preconditioning (IPC) on intestinal bacterial translocation (BT). METHODS: Thirty Wistar rats weighing 280 ± 27g were divided into five groups. In the IR group (n = 6), laparotomy was performed and the superior mesenteric artery was occluded by an atraumatic microclamp for 30 minutes. In the four preconditioning groups (n = 6 each) before the 30 minutes of ischemia-reperfusion (I/R) rats underwent IPC for two, five, ten and 15 minutes, followed by the same time of reperfusion. In order to assess whether the time of preconditioning influenced the onset of bacterial translocation, samples of mesenteric lymph nodes, liver and spleen were collected in sterile conditions twenty-four hours after the procedures for quantification of bacterial colony forming units per gram of tissue (CFU/g). Blood was collected for measurement of cytokines. RESULTS: In the I/R group, the total CFU/g in mesenteric lymph nodes, spleen, liver, as well as the serum TNF-á, IL-1a and IL-6 were sig
Gallium-67 imaging in a patient with paracoccidioidomycosis: a case report
TEIXEIRA, Ana Beatriz Marinho de Jesus;ETCHEBEHERE, Elba Cristina Sá de Camargo;LIMA, Mariana Cunha Lopes de;SANTOS, Allan de Oliveira;PIRES, Bruno Cunha;VALEN?A JR., José Telmo;RAMOS, Celso Darío;CAMARGO, Edwaldo E.;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2000, DOI: 10.1590/S0036-46652000000300011
Abstract: a 26 year-old female was admitted with abdominal pain, fever and weight loss. the clinical and laboratory investigations led to the diagnosis of paracoccidioidomycosis. gallium-67 whole body images correlated well with the clinical course of the disease and with the patient's prognosis.
Treatment of bone pain secondary to metastases using samarium-153-EDTMP
Etchebehere, Elba Cristina Sá de Camargo;Pereira Neto, Carlos Araújo Cunha;Lima, Mariana Cunha Lopes de;Santos, Allan de Oliveira;Ramos, Celso Darío;Silva, Cleide Maria;Camargo, Edwaldo Eduardo;
Sao Paulo Medical Journal , 2004, DOI: 10.1590/S1516-31802004000500006
Abstract: context: more than 50% of patients with prostate, breast or lung cancer will develop painful bone metastases. the purpose of treating bone metastases is to relieve pain, reduce the use of steroids and to maintain motion. objective: to evaluate the use of samarium-153-edtmp (153sm-edtmp) for the treatment of bone pain secondary to metastases that is refractory to clinical management. type of study: retrospective. setting: division of nuclear medicine, universidade estadual de campinas (unicamp). methods: fifty-eight patients were studied (34 males) with mean age 62 years; 31 patients had prostate cancer, 20 had breast cancer, three had lung cancer, one had lung hemangioendothelioma, one had parathyroid adenocarcinoma, one had osteosarcoma and one had an unknown primary tumor. all patients had multiple bone metastases demonstrated by bone scintigraphy using 99mtc-mdp,and were treated with 153sm-edtmp. response to treatment was graded as good (pain reduction of 50-100%), intermediate (25-49%) and poor (0-24%). results: all patients showed good uptake of 153sm-edtmp by bone metastases. among the patients with prostate cancer, intermediate or good response to therapy occurred in 80.6% (25 patients) and poor response in 19.4% (6). among the patients with breast cancer, 85% (17) showed intermediate or good response to therapy while 15% (3) showed poor response. all three patients with lung cancer showed poor response to treatment. the lung hemangioendothelioma and unknown primary lesion patients showed intermediate response to treatment; the osteosarcoma and parathyroid adenocarcinoma patients showed good response to treatment. no significant myelotoxicity occurred. discussion: pain control is important for improving the quality of life of patients with advanced cancers. the mechanism by which pain is relieved with the use of radionuclides is still not yet completely understood, however, the treatment is simple and provides a low risk of mielotoxicity. conclusion: treatmen
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