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Search Results: 1 - 10 of 6275 matches for " Marian Christoph Neidert "
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Reduction of Thromboembolic Events in Meningioma Surgery: A Cohort Study of 724 Consecutive Patients
Christian Valentin Eisenring, Marian Christoph Neidert, Daniel Sabanés Bové, Leonhard Held, Johannes Sarnthein, Niklaus Krayenbühl
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079170
Abstract: Background Meningiomas are associated with the highest postoperative rate of venous thromboembolic events (VTE) among all intracranial tumors. The aim of this study is to compare two entirely different VTE prophylaxis regimens in 724 consecutive patients undergoing meningioma surgery. Methods Two cohorts at a single institution treated with different regimens to prevent VTE were reviewed retrospectively. Cohort A (n = 482; 314 females, mean age 57 years, range: 11–87 years) received our institutional regimen during the years 1999–2006, consisting of low-molecular-weight heparin (LMWH) and compression stockings. For cohort B (n = 242; 163 females, mean age 56.8 years, range: 16–90 years), during the years 2008–2010, the management included intraoperative 10°–20° leg elevation with intermittent pneumatic compression (IPC), heparin and LMWH administration. We compared the incidence of the endpoints pulmonary embolism (PE), deep venous thrombosis (DVT), hemorrhage and death, taking into account several known associated risk factors. Results For all endpoints, we observed a more favorable outcome with the new regimen. The difference in incidence of PEs (cohort A: 38/482, 8%; cohort B: 6/242, 2.5%) reached statistical significance (p = 0.002). In general, patients with skull base meningiomas had a higher risk for PE (OR 2.77). Regarding VTE prophylaxis, an adjusted subgroup analysis suggests that the new regimen is particularly beneficial for patients with skull base meningiomas. Conclusions We recommend perioperative prophylaxis using a management composed of intraoperative leg-elevation, IPC, early heparin administration and LMWH to reduce the risk for PE.
Meteorological Influences on the Incidence of Aneurysmal Subarachnoid Hemorrhage – A Single Center Study of 511 Patients
Marian Christoph Neidert, Michael Sprenger, Heini Wernli, Jan-Karl Burkhardt, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Christoph Michael Woernle
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081621
Abstract: Objective To assess the potential meteorological influence on the incidence of aneurysmal subarachnoid hemorrhage (SAH). Previous studies used inhomogeneous patient groups, insufficient study periods or inappropriate statistics. Patients and Methods We analyzed 511 SAH admissions between 2004 and 2012 for which aneurysmal rupture occurred within the Zurich region. The hourly meteorological parameters considered are: surface pressure, 2-m temperature, relative humidity and wind gusts, sunshine, and precipitation. For all parameters we investigate three complementary statistical measures: i) the time evolution from 5 days before to 5 days after the SAH occurrence; ii) the deviation from the 10-year monthly mean; and iii) the change relative to the parameter's value two days before SAH occurrence. The statistical significance of the results is determined using a Monte Carlo simulation combined with a re-sampling technique (1000×). Results Regarding the meteorological parameters considered, no statistically significant signal could be found. The distributions of deviations relative to the climatology and of the changes during the two days prior to SAH events agree with the distributions for the randomly chosen days. The analysis was repeated separately for winter and summer to exclude compensating effects between the seasons. Conclusion By using high-quality meteorological data analyzed with a sophisticated and robust statistical method no clearly identifiable meteorological influence for the SAH events considered can be found. Further studies on the influence of the investigated parameters on SAH incidence seem redundant.
Ferromagnetic Dissection in a Rat Glioma Model  [PDF]
Sina Tok, Marian C. Neidert, Momen Sharab, I-Mei Siu, Jeanine P. Reyes, Vanessa Charubhumi, Robert T. Wicks, Charles Eberhart, George I. Jallo, Betty M. Tyler
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.67067
Abstract: Background: We compared cutting and coagulation of a novel ferromagnetic tool (FMwand) with modalities currently used in the clinical setting. Methods: 24 F344 rats with 9L gliosarcoma flank tumours were randomized into 2 groups (n = 12): 1) Five parallel incisions were made into the tumor of each rat using monopolar electrosurgery (MES) cut mode, MES coagulation (coag) mode, FMwand, carbon dioxide (CO2) laser and cold scalpel. 2) Two parallel incisions were made comparing the MES and the FMwand, both with resecting loop tips. The study was then repeated by a second surgeon. The surgeons applied a grading scale (1 = worst, 5 = best) based on their observations. Results: Average scores for FMwand were superior in ease of tissue dissection (3.58), distortion upon tissues (3.67), and smoke production (2.87). CO2 laser led in effectiveness of hemostasis (4.32). MES cut mode had the highest scores for ease of cleaning of tip (3.17) and speed of dissection (3.92). The FMwand loop device led in all attributes except for ease of cleaning. Conclusions: The FMwand outperformed CO2 laser significantly in ease and speed. It was superior compared to MES cut mode for hemostasis and superior compared to coag mode in ease and speed, distortion upon tissues and smoke production. The FMwand loop was significantly better compared to MES loop for hemostasis, distortion, ease and speed. The FMwand was shown to be safe and effective for hemostatic soft tissue cutting and coagulation.
Gesetzliche Statik und wissenschaftliche Dynamik in der Reproduktionsmedizin
Neidert R
Journal für Reproduktionsmedizin und Endokrinologie , 2004,
Abstract: Der Autor stellt die stürmische Entwicklung der Reproduktionsmedizin seit 25 Jahren der weitgehenden Statik des seit 1991 geltenden Embryonenschutzgesetzes (ESchG) gegenüber, was dessen zunehmende Reformbedürftigkeit zeigt. In der "aufgeheizten" Bioethik-Kontroverse der letzten Jahre ist das EschG mitunter zum "Vorzeigegesetz" absoluten Embryonenschutzes mi deutet worden. Der Aufsatz will deshalb die wichtigsten Grunds tze einer exakten Auslegung dieser Strafrechtsnormen aufzeigen, insbesondere das Bestimmtheitsgebot der Verfassung. Au erdem hebt er eine doppelte Beschr nkung des Embryonenschutzes in diesem Gesetz hervor: Geltung nur für die künstliche Befruchtung in vitro bis zur Nidation, für den Regelfall natürlicher Zeugung in vivo überhaupt nicht; nach der Einnistung setzen die §§ 218 ff. des Strafgesetzbuches (StGB) ein. Ausgehend von den dringlichen Forderungen der Fachgesellschaften an den Gesetzgeber in deren Positionspapier vom Jahr 2001, prüft der Verfasser, inwieweit hierfür bei einer Auslegung mit der gebotenen Restriktion eine nderung des ESchG notwendig ist. Das Absterbenlassen überz hliger Embryonen bei IVF und die Pr implantationsdiagnostik (PID) h lt er schon heute nicht für strafbar, im Gegensatz zur Eizellspende. Zu der zentralen Forderung der deutschen Reproduktionsmediziner – den internationalen Standard des Ein-Embryo-Transfers nach Blastozystenselektion praktizieren zu dürfen – h lt er zwar die l ngere Kultivierungszeit für zul ssig, nicht aber, von vornherein mehr Eizellen zu befruchten, als nach Auswahl der besten Embryos übertragen werden sollen. Diesbezüglich ist das Gesetz nach seiner Auffassung zu strikt formuliert, um die erwünschte Auslegung (etwa von Frommel) abzusichern. Im notwendigen Kontext des Gesetzes zeigt der Autor, wie das schrittweise veraltende ESchG im Interpretations- und Bewertungszusammenhang eines "zunehmenden Lebensrechtes" Ungeborener zwischen Zeugung und Geburt steht. Das Erreichen der intrauterinen Lebensf higkeit des Fetus ist für ihn der Punkt, an dem die medizinisch-soziale Indikation befristet werden mü te. Wenn Regierung und Bundestag auch in dieser Wahlperiode nicht wenigstens eine Dringlichkeitsnovelle zum ESchG vorlegen, wird man dessen Auslegungsspielraum – so der rechtspolitische Ausblick – noch st rker auch gegen herrschende Meinungen auszuloten haben.
Investigating quantum transport with an initial value representation of the semiclassical propagator
Christoph-Marian Goletz,Frank Grossmann,Steven Tomsovic
Physics , 2009, DOI: 10.1103/PhysRevE.80.031101
Abstract: Quantized systems whose underlying classical dynamics possess an elaborate mixture of regular and chaotic motion can exhibit rather subtle long-time quantum transport phenomena. In a short wavelength regime where semiclassical theories are most relevant, such transport phenomena, being quintessentially interference based, are difficult to understand with the system's specific long-time classical dynamics. Fortunately, semiclassical methods applied to wave packet propagation can provide a natural approach to understanding the connections, even though they are known to break down progressively as time increases. This is due to the fact that some long-time transport properties can be deduced from intermediate-time behavior. Thus, these methods need only retain validity and be carried out on much shorter time scales than the transport phenomena themselves in order to be valuable. The initial value representation of the semiclassical propagator of Herman and Kluk [M. F. Herman and E. Kluk, Chem. Phys. 91, 27 (1984)] is heavily used in a number of molecular and atomic physics contexts, and is of interest here. It is known to be increasingly challenging to implement as the underlying classical chaos strengthens, and we ask whether it is possible to implement it well enough to extract the kind of intermediate time information that reflects wave packet localization at long times. Using a system of two coupled quartic oscillators, we focus on the localizing effects of transport barriers formed by stable and unstable manifolds in the chaotic sea and show that these effects can be captured with the Herman-Kluk propagator.
Evaluating a Student MIS in the Tertiary Education Sector: Addressing Functional-Operational Misalignment through Continuous Participative Evaluation  [PDF]
Marian Carcary
Journal of Service Science and Management (JSSM) , 2010, DOI: 10.4236/jssm.2010.31004
Abstract: The Information and Communications Technology (ICT) evaluation literature spans several decades. ICT evaluation approaches range from objective and positivistic to subjective and interpretive. While positivistic approaches have dominated the past, there is increasing recognition of the value of interpretivist methods and the need for ongoing project evaluation. Formative continuous participative evaluation (CPE) offers several benefits in terms of project control, enhanced stakeholder relationships and benefit realisation; nonetheless this is often ignored in practice. There is a paucity of ICT evaluation within the Higher Education sector. The 14 Irish Institutes of Technology (IoTs) recently underwent an extensive transformation of their ICT systems, through a nationwide implementation of a suite of integrated IS. This research study, centred on the evaluation of the Student MIS implementation was interpretive in nature; case studies were conducted in five IoTs. This paper focuses specifically on one issue uncovered through the research i.e. the misalignment between the Student MIS and the IoTs requirements. The paper proposes a set of guidelines for addressing this issue through focusing on the theoretical underpinnings of CPE and its importance for organisational learning and benefit realisation.
Cancer Status: Mocb and tPSA Prostate Cancer Markers  [PDF]
Marian Surma
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.36144
Abstract: On the basis of the results of magneto-optical studies and their comparison with the outcome of medical tests magneto-optical MOCB and tPSA serum markers of cancer/recovered patient are presented. Status of the cancer serum donor is recognized as presence of the laevorotatory optical active molecules of (-)p density in serum while status of the recovered donor is recognized as quantitative domination of the dextrorotatory (+)p molecules in serum. These molecular information carriers (-)p and (+)p are recorded by the magneto-optical circular birefringence MOCB effect in B2 magnetic field. The laevo/dextrorotatory carriers are enantiomers in the case of (-)p = (+)p relations fulfilled for any individual cancer and the same recovered patient. The positive predictive value PPV of MOCB results is 100%.
Enantiomers Present in Serum Carry Cancer and/or Recovery Status Information  [PDF]
Marian Surma
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.56071
Abstract:

Human blood serum of cancer, cancer-recovered and healthy patients contains laevorotatory and dextrorotatory B2 active molecules. The laevorotatory B2 active carriers in patient serum carry information on the cancer status while the dextrorotatory B2 active carriers carry information on the recovered and/or healthy patient status. Their magneto-optical characteristic is analysed by the B2 Magneto Optical Circular Birefringence. By applying the MOCB experimental technique, it is possible to differentiate between the cancer and non-cancer patients. The paper introduces a purely molecular physics approach for description of the cancer/recovered and also non-cancer patients status.

“To Understand Russia”? Question about Russia as a Philosophical Problem  [PDF]
Marian Broda
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.44063
Abstract: The aim of this article is to identify and explain the cognitive possibilities which—for the sake of analysis of the questions about Russia and the efforts to “understand Russia”, for centuries central to the Russian intellectual and cultural tradition—are offered by the post-Kantian philosophical perspective. The fundamental research method is the analysis of texts in which representative members of the Russian philosophical and broader intelectual-cultural tradition undertake selfcoqnitive attempts, asking questions about Russia. The analyses which I have undertaken, show that in the post-Kantian theoretical perspective it is possible to strive for recognition of the basic assumptions, structures, properties and conditions of the sense-making processes, which are invisible for such a subject, which is directly involved in a specific cognitive relation. It is then possible and required to determine which forms and structures can appear—and why—within those basic assumptions or conditions as important—from the perspective of subject, object or axiology—the recognition of factors, conditions and limits of heterogenization of the basic structural and substantial solutions, the recurring relations of senses and the types of their specifications, and the scope and methods of permitted self-problematization. In conclusion, I wish to state that the questions about Russia are, therefore, truly questions of their authors about themselves and their way of understanding the world.
Influência da limpeza prévia por sputtering na nitreta??o por plasma de a?os inoxidáveis
Reis, R. F. dos;Neidert, R.;
Matéria (Rio de Janeiro) , 2011, DOI: 10.1590/S1517-70762011000200004
Abstract: samples of iso 5832-1 stainless steel were nitrided for 2h in a gas mixture of 50% vol. n2 and 50% vol. h2 at a temperature of 420 oc. before plasma treatment, the samples were cleaned by cathodic sputtering, in the reactor, using different parameters. the following analytical techniques were used: optical microscopy (om) and microhardness. the results showed that the use of a cleaning step by sputtering prior to processing can promote significant changes in the results obtained by plasma nitriding. it was also found that the use of hydrogen as a sputtering agent causes no change in the results compared to a processing performed without this cleanup step.
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