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Search Results: 1 - 10 of 85381 matches for " Maria-Cristina Keightley "
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Mediator Subunit 12 Is Required for Neutrophil Development in Zebrafish
Maria-Cristina Keightley, Judith E. Layton, John W. Hayman, Joan K. Heath, Graham J. Lieschke
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023845
Abstract: Hematopoiesis requires the spatiotemporal organization of regulatory factors to successfully orchestrate diverse lineage specificity from stem and progenitor cells. Med12 is a regulatory component of the large Mediator complex that enables contact between the general RNA polymerase II transcriptional machinery and enhancer bound regulatory factors. We have identified a new zebrafish med12 allele, syr, with a single missense mutation causing a valine to aspartic acid change at position 1046. Syr shows defects in hematopoiesis, which predominantly affect the myeloid lineage. Syr has identified a hematopoietic cell-specific requirement for Med12, suggesting a new role for this transcriptional regulator.
Disinfection of swimming pools with chlorine and derivatives: formation of organochlorinated and organobrominated compounds and exposure of pool personnel and swimmers  [PDF]
Maria-Cristina Aprea, Bruno Banchi, Liana Lunghini, Massimo Pagliantini, Antonio Peruzzi, Gianfranco Sciarra
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.22011
Abstract: Chlorination of pool water leads to the forma-tion of many by-products, chloroform usually being the most abundant. The paper reports the results of a study evaluating exposure of bath-ers and pool employees to trihalomethanes (chloroform, bromodichloromethane, dibromo-chloromethane, bromoform) in four indoor swimming pools with chlorinated water. Chlo-roform concentrations in environmental air samples when the pool was in use (about 9 h), in the range 1-182 μg/m3, were greater near the pool than in the change rooms, passageways and offices. Chloroform concentrations in per-sonal air samples of pool employees were in the range 18-138 μg/m3. Urinary concentrations of chloroform averaged (geometric means) 0.123 and 0.165 μg/l and 0.404 and 0.342 μg/l prior and at the end of exposure during in water and out of water activities, respectively. The significant increase in urinary excretion of chloroform confirms that the source of the contaminant was pool water. Absorption of chloroform, estimated from airborne and water concentrations, was significantly correlated with delta chloroform (after/before exposure) and urinary concentra-tions of chloroform at the end of exposure. As chloroform is a toxic and possibly carcinogenic substance, these observations pose a problem principally for the general population of pool users.
Mercury Determination in Fish Samples by Chronopotentiometric Stripping Analysis Using Gold Electrodes Prepared from Recordable CDs
Maria-Cristina Radulescu,Andrei Florin Danet
Sensors , 2008, DOI: 10.3390/s8117157
Abstract: A simple method for manufacturing gold working electrodes for chronopotentiometric stripping measurements from recordable CD-R’s is described. These gold electrodes are much cheaper than commercially available ones. The electrochemical behavior of such an electrode and the working parameters for mercury determination by chronopotentiometric stripping analysis were studied. Detection limit was 0.30 μg Hg/L and determination limit was 1.0 μg Hg/L for a deposition time of 600 s. Using the developed working electrodes it was possible to determine the total mercury in fish samples. A method for fish sample digestion was developed by using a mixture of fuming nitric acid and both concentrated sulfuric and hydrochloric acids. The recovery degree for a known amount of mercury introduced in the sample before digestion was 95.3% (n=4).
Expression and function of beta1 integrins on human eosinophils
Seminario, Maria-Cristina;Bochner, Bruce S;
Memórias do Instituto Oswaldo Cruz , 1997, DOI: 10.1590/S0074-02761997000800021
Abstract: eosinophils preferentially accumulate at sites of chronic allergic diseases such as bronchial asthma. the mechanisms by which selective eosinophil migration occurs are not fully understood. however, interactions of cell-surface adhesion molecules on the eosinophil with molecular counterligands on endothelial and epithelial cells, and on extracellular matrix proteins, are likely to be critical during the recruitment process. one possible mechanism for selective eosinophil recruitment involves the a4b 1 (vla-4) integrin which is not expressed on neutrophils. correlations have been found between infiltration of eosinophils and endothelial expression of vcam-1, the ligand for vla-4, in the lungs of asthmatic individuals as well as in late phase reactions in the lungs, nose and skin. epithelial and endothelial cells respond to the th2-type cytokines il-4 and il-13 with selective de novo expression of vcam-1, consistent with the possible role of vcam-1/vla-4 interactions in eosinophil influx during allergic inflammation. both b 1 and b 2 integrins on eosinophils exist in a state of partial activation. for example, eosinophils can be maximally activated for adhesion to vcam-1 or fibronectin after exposure to b 1 integrin-activating antibodies or divalent cations, conditions that do not necessarily affect the total cell surface expression of b 1 integrins. in contrast, cytokines like il-5 prevent b 1 integrin activation while promoting b 2 integrin function. furthermore, ligation of integrins can regulate the effector functions of the cell. for example, eosinophil adhesion via b 1 and/or b 2 integrins has been shown to alter a variety of functional responses including degranulation and apoptosis. thus, integrins appear to be important in mediating eosinophil migration and activation in allergic inflammation. strategies that interfere with these processes may prove to be useful for treatment of allergic diseases.
Expression and function of b1 integrins on human eosinophils
Seminario Maria-Cristina,Bochner Bruce S
Memórias do Instituto Oswaldo Cruz , 1997,
Abstract: Eosinophils preferentially accumulate at sites of chronic allergic diseases such as bronchial asthma. The mechanisms by which selective eosinophil migration occurs are not fully understood. However, interactions of cell-surface adhesion molecules on the eosinophil with molecular counterligands on endothelial and epithelial cells, and on extracellular matrix proteins, are likely to be critical during the recruitment process. One possible mechanism for selective eosinophil recruitment involves the alpha4beta 1 (VLA-4) integrin which is not expressed on neutrophils. Correlations have been found between infiltration of eosinophils and endothelial expression of VCAM-1, the ligand for VLA-4, in the lungs of asthmatic individuals as well as in late phase reactions in the lungs, nose and skin. Epithelial and endothelial cells respond to the Th2-type cytokines IL-4 and IL-13 with selective de novo expression of VCAM-1, consistent with the possible role of VCAM-1/VLA-4 interactions in eosinophil influx during allergic inflammation. Both beta 1 and beta 2 integrins on eosinophils exist in a state of partial activation. For example, eosinophils can be maximally activated for adhesion to VCAM-1 or fibronectin after exposure to beta 1 integrin-activating antibodies or divalent cations, conditions that do not necessarily affect the total cell surface expression of beta 1 integrins. In contrast, cytokines like IL-5 prevent beta 1 integrin activation while promoting beta 2 integrin function. Furthermore, ligation of integrins can regulate the effector functions of the cell. For example, eosinophil adhesion via beta 1 and/or beta 2 integrins has been shown to alter a variety of functional responses including degranulation and apoptosis. Thus, integrins appear to be important in mediating eosinophil migration and activation in allergic inflammation. Strategies that interfere with these processes may prove to be useful for treatment of allergic diseases.
Northern Rock: The Crisis of a UK Mortgage Lender
Maria-Cristina UNGUREANU,Vasile COCRIS
Review of Economic and Business Studies (REBS) , 2008,
Abstract: The global market liquidity squeeze for securities that initiated in 2007 has increased pressure among banks to sell, pushed down prices, and impacted the market for interbank loans, leading to a funding gap at Northern Rock, Britain’s fifth largest mortgage bank. This paper presents an analysis of the events that lead to the collapse of Northern Rock in the second half of 2007 and its rescue by the UK Government towards the end of the same year and the beginning of 2008. The paper presents the implications and banking reforms proposed by the UK financial authorities.
Analysis of Unemployment in Romania During 2007-2011
Maria-Cristina Stefan,Valentin Radu
International Journal of Academic Research in Business and Social Sciences , 2013,
Abstract: The main purpose of this paper is to make an analysis of unemployment in Romania, as market labor imbalance between 2007 and 2011. The necessity of the work is given by the complex evolution of unemployment phenomenon depending on a multiplicity of economic and social factors. Strategies for combating unemployment and stimulate employment must be build upon the main objective established in the market labor of Romania: development of human resources and increase it competitiveness on labor market, by assuring equal opportunities for lifelong learning and developing a new labor market.
NORTHERN ROCK: THE CRISIS OF A UK MORTGAGE LENDER
Maria-Cristina UNGUREANU,Vasile COCRI?
Scientific Annals of the Alexandru Ioan Cuza University of Iasi : Economic Sciences Series , 2008,
Abstract: The global market liquidity squeeze for securities that initiated in 2007 has increased pressure among banks to sell, pushed down prices, and impacted the market for interbank loans, leading to a funding gap at Northern Rock, Britain’s fifth largest mortgage bank. This paper presents an analysis of the events that lead to the collapse of Northern Rock in the second half of 2007 and its rescue by the UK Government towards the end of the same year and the beginning of 2008. The paper presents the implications and banking reforms proposed by the UK financial authorities.
Clinical and therapeutic implications of psychiatric comorbidity in high functioning autism/Asperger syndrome: An Italian study  [PDF]
Silvia Giovinazzo, Sara Marciano, Grazia Giana, Paolo Curatolo, Maria-Cristina Porfirio
Open Journal of Psychiatry (OJPsych) , 2013, DOI: 10.4236/ojpsych.2013.33034
Abstract: The present study describes the occurrence of psychiatric comorbid disorders in a cohort of 86 high functioning autism (HFA)/Asperger syndrome (AS) patients, examined at Child Neurology and Psychiatry Unit of Tor Vergata University. 38 patients out of 86 (44.2%) presented one or more psychiatric comorbidities, such as mood disorders, Attention Deficit/Hyperactivity Disorder (ADHD), Tourette syndrome (TS), anxiety disorders, including obsessive-compulsive disorder (OCD), and psychotic symptoms. We compared our sample with the evidences from the scientific literature on psychiatric comorbidity in ASD patient, in particular in HFA/AS. In this paper we focus on the high frequency of comorbid psychiatric disorders in HFA/AS patients, such as mood disorders, Attention Deficit/Hyperactivity Disorder (ADHD), Tourette syndrome (TS), anxiety disorders, including obsessive-compulsive disorder (OCD), and psychosis, including schizophrenia. We analyzed rates of all psichiatric comorbidities diagnosed in a sample of HFA/AS subjects and we compared findings from our study with the evidences from the scientific literature on psychiatric comorbidity in ASD patients, in particular HFA/AS. We point out that comorbid psychiatric symptoms can be hardly diagnosed, because they could present atipically in ASDs then in general population. Furthermore, they could be masked by ASD core symptoms.
Synthesis of Bis-ureas from Bis(o-nitrophenyl) Carbonate
Maria-Cristina Turoczi,Monika Simon,Valentin Badea,Carol Csunderlik
Molecules , 2008, DOI: 10.3390/molecules13123192
Abstract: A general method for the preparation of bis-ureas from bis(o-nitrophenyl) carbonate has been developed. Directional urea synthesis is achieved by sequential amine addition to bis(o-nitrophenyl) carbonate in two steps: in the first step bis(o-nitrophenyl) carbonate is reacted with benzylamine to form benzyl-o-nitrophenyl carbamate; in the second step the carbamate is reacted with a variety of diamines in toluene to yield bis-ureas.
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