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Search Results: 1 - 10 of 71054 matches for " Maria Spadea "
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STUDIO PRELIMINARE SULLE OSCILLAZIONI LIBERE DEL LAGO DI IDRO
MARIA CECILIA SPADEA
Annals of Geophysics , 1953, DOI: 10.4401/ag-5765
Abstract: .
Report on public health actions and vaccination strategies to monitor measles epidemic in Local Health Unit A in Rome, Italy
Antonietta Spadea,Simonetta Casini,Anna Maria D’Amici,Emanuele Di Cosimo
Italian Journal of Public Health , 2012, DOI: 10.2427/5627
Abstract: : Background: between May 2010 and october 2011 the unit of Preventive Medicine for the developmental ages of district IV, Health unit aSL rM/a, received 136 measles case notifications from the unit of Epidemiology and Prophylaxis of Infectious diseases. Methods: in accordance with the infectious diseases monitoring protocol, we introduced a series of preventive measures, such as monitoring subjects in contact with measles-infected patients, recommend- ing the administration of two Measles Mumps and rubella (MMr) doses four weeks apart, and informing paediatricians, families and school teachers about the measles epidemic. Results: all the activities above led to an increased number of MMr doses administered and a significant improvement of measles immunization coverage among residents of the district IV health unit of rome. concerning MMr 1, in a sample cohort consisting of children ≤24 months, the immunization coverage increased from 77% on the 31/12/09 to 88% on the 31/12/11. Instead, for MMr 2, in a cohort of children ≤6 years, the same ratio improved from 51% on the 31/12/09 to 65% on the 31/12/11. Discussion: the results indicate a material increase in the immunization coverage once our public health actions and vaccination strategies had been implemented among young residents of district IV aSL rM/a...
Severe Macular Edema in Patients with Juvenile Idiopathic Arthritis-Related Uveitis
Maria Pia Paroli,Claudia Fabiani,Giovanni Spinucci,Irene Abicca,Alfredo Sapia,Leopoldo Spadea
Case Reports in Ophthalmological Medicine , 2013, DOI: 10.1155/2013/803989
Abstract: Purpose. To report the onset of severe macular edema in adolescent female patients affected by juvenile idiopathic arthritis (JIA). Methods. Four female patients affected by JIA-related chronic anterior uveitis (CAU), complicated by severe macular edema, were retrospectively analyzed. Macular area was evaluated by fluorescein angiography and optical coherence tomography (OCT). Results. CAU was bilateral in three patients. Mean age of uveitis and arthritis onset was, respectively, years and years. All patients underwent cataract extraction surgery. Despite ocular inflammation being controlled by topical/systemic therapy, during adolescence (mean age of appearance/diagnosis: years) patients developed severe unilateral macular edema. OCT revealed massive macular thickening (range from 550?μm to 1214?μm). Conclusions. Macular edema appeared in female adolescent patients in eyes with long-dating CAU submitted to cataract surgery. In such patients, in presence of age-related microvascular changes due to the enhancer effect of sex hormones, cataract extraction should be a factor triggering the retinal complication. 1. Introduction Eye involvement in juvenile idiopathic arthritis (JIA) is frequent: typically the uveitis is a chronic, bilateral, and nongranulomatous anterior uveitis with insidious and asymptomatic course. Macular edema is one of the most sight-threatening complications, ranging from 3% to 47% [1]. It is reported that macular edema is the cause of legal blindness in 8% of children affected by active uveitis [1]. Pathophysiology of inflammatory macular edema is still unclear. The major cause might be the breakdown of the inner blood-retinal barrier. Microvascular factors are involved and probably enhanced by inflammatory factors and by sex hormones. In our study, we describe four peculiar cases of severe macular edema which appeared during adolescence in JIA female patients affected by chronic anterior uveitis (CAU) from infancy, in which uveitis was under control for a long time. 2. Material and Methods The clinical history of four patients affected by JIA-related uveitis presenting highly severe macular??edema was retrospectively analyzed. Fluorescein angiography (FA) and optical coherence??tomography (OCT) examination were also performed to determine qualitatively and quantitatively??the entity of macular involvement. This study was conducted according to the principles of the??Helsinki Declaration and good clinical practices. The following data were collected??for each patient: age at first visit, age at onset of uveitis, age at onset of
Intra-fraction setup variability: IR optical localization vs. X-ray imaging in a hypofractionated patient population
Maria Spadea, Barbara Tagaste, Marco Riboldi, Eleonora Preve, Daniela Alterio, Gaia Piperno, Cristina Garibaldi, Roberto Orecchia, Antonio Pedotti, Guido Baroni
Radiation Oncology , 2011, DOI: 10.1186/1748-717x-6-38
Abstract: We analyzed data coming from 87 patients treated with hypo-fractionated radiotherapy at cranial and extra-cranial sites. Patient setup was realized through the ExacTrac X-ray 6D system (BrainLAB, Germany), consisting of 2 infrared TV cameras for external fiducial localization and X-ray imaging in double projection for image registration. Before irradiation, patients were pre-aligned relying on optical marker localization. Patient position was refined through the automatic matching of X-ray images to digitally reconstructed radiographs, providing 6 corrective parameters that were automatically applied using a robotic couch. Infrared patient localization and X-ray imaging were performed at the end of treatment, thus providing independent measures of intra-fraction motion.According to optical measurements, the size of intra-fraction motion was (median ± quartile) 0.3 ± 0.3 mm, 0.6 ± 0.6 mm, 0.7 ± 0.6 mm for cranial, abdominal and lung patients, respectively. X-ray image registration estimated larger intra-fraction motion, equal to 0.9 ± 0.8 mm, 1.3 ± 1.2 mm, 1.8 ± 2.2 mm, correspondingly.Optical tracking highlighted negligible intra-fraction motion at both cranial and extra-cranial sites. The larger motion detected by X-ray image registration showed significant inter-patient variability, in contrast to infrared optical tracking measurement. Infrared localization is put forward as the optimal strategy to monitor intra-fraction motion, featuring robustness, flexibility and less invasivity with respect to X-ray based techniques.Over the last few years, the development of Image Guided Radiation Therapy (IGRT) technologies has resulted in the design and realization of systems allowing precise patient setup and monitoring at each therapy fraction [1-3]. The rationale is related to dose escalation and hypo-fractionated protocols, which require the precise localization of the target throughout the treatment. Morphological changes, tumor shrinkage and organ motion effects lead
Simultaneous topography-guided PRK followed by corneal collagen cross-linking after lamellar keratoplasty for keratoconus
Spadea L, Paroli M
Clinical Ophthalmology , 2012, DOI: http://dx.doi.org/10.2147/OPTH.S37280
Abstract: ltaneous topography-guided PRK followed by corneal collagen cross-linking after lamellar keratoplasty for keratoconus Original Research (1430) Total Article Views Authors: Spadea L, Paroli M Published Date November 2012 Volume 2012:6 Pages 1793 - 1800 DOI: http://dx.doi.org/10.2147/OPTH.S37280 Received: 23 August 2012 Accepted: 27 September 2012 Published: 02 November 2012 Leopoldo Spadea,1 Marino Paroli2 1University of L’Aquila, Department of Biotechnological and Applied Clinical Sciences, Eye Clinic, L’Aquila, 2La Sapienza University, Department of Biotechnology and Medical-Surgical Sciences, Latina, Italy Background: The purpose of this paper is to report the results of using combined treatment of customized excimer laser-assisted photorefractive keratectomy (PRK) and prophylactic corneal collagen crosslinking (CXL) for residual refractive error in a group of patients who had previously undergone lamellar keratoplasty for keratoconus. Methods: The study included 14 eyes from 14 patients who had originally been treated for keratoconus in one eye by excimer laser-assisted lamellar keratoplasty (ELLK), and subsequently presented with residual ametropia (-6.11 D ± 2.48, range -2.50 to -9.50). After a mean 40.1 ± 12.4 months since ELLK they underwent combined simultaneous corneal regularization treatment with topographically guided transepithelial excimer laser PRK (central corneal regularization) and corneal CXL induced by riboflavin-ultraviolet A. Results: After a mean 15 ± 6.5 (range 6–24) months, all eyes gained at least one Snellen line of uncorrected distance visual acuity (range 1–10). No patient lost lines of corrected distance visual acuity, and four patients gained three lines of corrected distance visual acuity. Mean manifest refractive spherical equivalent was -0.79 ± 2.09 (range +1 to -3.0) D, and topographic keratometric astigmatism was 5.02 ± 2.93 (range 0.8–8.9) D. All the corneas remained clear (haze < 1). Conclusion: The combination of customized PRK and corneal CXL provided safe and effective results in the management of corneal regularization for refractive purposes after ELLK for keratoconus.
Laser refractive surgery in diabetic patients: a review of the literature
Spadea L, Paroli MP
Clinical Ophthalmology , 2012, DOI: http://dx.doi.org/10.2147/OPTH.S37384
Abstract: ser refractive surgery in diabetic patients: a review of the literature Review (1564) Total Article Views Authors: Spadea L, Paroli MP Published Date November 2012 Volume 2012:6 Pages 1775 - 1783 DOI: http://dx.doi.org/10.2147/OPTH.S37384 Received: 27 August 2012 Accepted: 13 September 2012 Published: 02 November 2012 Leopoldo Spadea,1 Maria Pia Paroli2 1University of L’Aquila, Department of Biotechnological and Applied Clinical Sciences, Eye Clinic, L’Aquila, 2University of Rome “La Sapienza”, Department of Surgical Sciences, Eye Clinic, Rome, Italy Background: The purpose of this study was to evaluate the current recommendations regarding laser refractive surgery in patients with diabetes mellitus and to assess whether these patients make appropriate candidates for laser vision correction. Methods: A literature search was conducted to identify current research on the ocular complications of diabetes and original publications on laser refractive surgery in diabetic patients. Results: Diabetes was associated with several ocular complications. Initially the US Food and Drug Administration listed these complications as justification to advise against refractive surgery in patients with diabetes. However, recent studies on laser in situ keratomileusis in diabetic patients indicate that this procedure may be safe in diabetic patients with very well controlled systemic disease and no ocular manifestations. Conclusion: Laser refractive surgery may be performed safely in a very selected group of patients with diabetes.
Transepithelial corneal collagen cross-linking in ultrathin keratoconic corneas
Spadea L, Mencucci R
Clinical Ophthalmology , 2012, DOI: http://dx.doi.org/10.2147/OPTH.S37335
Abstract: ansepithelial corneal collagen cross-linking in ultrathin keratoconic corneas Original Research (1633) Total Article Views Authors: Spadea L, Mencucci R Published Date November 2012 Volume 2012:6 Pages 1785 - 1792 DOI: http://dx.doi.org/10.2147/OPTH.S37335 Received: 24 August 2012 Accepted: 13 September 2012 Published: 02 November 2012 Leopoldo Spadea,1 Rita Mencucci2 1University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, Eye Clinic, L'Aquila, 2University of Florence, Department of Oto-Neuro-Ophthalmological Surgical Sciences, Eye Clinic, Florence, Italy Background: The purpose of this paper was to report the results of transepithelial corneal collagen cross-linking (CXL) with modified riboflavin and ultraviolet A irradiation in patients affected by keratoconus, each with thinnest pachymetry values of less than 400 μm (with epithelium) and not treatable using standard de-epithelialization techniques. Methods: Sixteen patients affected by progressive keratoconus with thinnest pachymetry values ranging from 331 μm to 389 μm underwent transepithelial CXL in one eye using a riboflavin 0.1% solution in 15% Dextran T500 containing ethylenediamine tetra-acetic acid 0.01% and trometamol to enhance epithelial penetration. The patients underwent complete ophthalmological examination, including endothelial cell density measurements and computerized videokeratography, before CXL and at one day, one week, and one, 6, and 12 months thereafter. Results: Epithelial healing was complete in all patients after one day of use of a soft bandage contact lens. No side effects or damage to the limbal region was observed during the follow-up period. All patients showed slightly improved uncorrected and spectacle-corrected visual acuity; keratometric astigmatism showed reductions (up to 5.3 D) and apical ectasia power decreased (Kmax values reduced up to 4.3 D). Endothelial cell density was unchanged. Conclusion: Application of transepithelial CXL using riboflavin with substances added to enhance epithelial permeability was safe, seemed to be moderately effective in keratoconic eyes with ultrathin corneas, and applications of the procedure could be extended to patients with advanced keratoconus.
Laser refractive surgery in diabetic patients: a review of the literature
Spadea L,Paroli MP
Clinical Ophthalmology , 2012,
Abstract: Leopoldo Spadea,1 Maria Pia Paroli21University of L’Aquila, Department of Biotechnological and Applied Clinical Sciences, Eye Clinic, L’Aquila, 2University of Rome “La Sapienza”, Department of Surgical Sciences, Eye Clinic, Rome, ItalyBackground: The purpose of this study was to evaluate the current recommendations regarding laser refractive surgery in patients with diabetes mellitus and to assess whether these patients make appropriate candidates for laser vision correction.Methods: A literature search was conducted to identify current research on the ocular complications of diabetes and original publications on laser refractive surgery in diabetic patients.Results: Diabetes was associated with several ocular complications. Initially the US Food and Drug Administration listed these complications as justification to advise against refractive surgery in patients with diabetes. However, recent studies on laser in situ keratomileusis in diabetic patients indicate that this procedure may be safe in diabetic patients with very well controlled systemic disease and no ocular manifestations.Conclusion: Laser refractive surgery may be performed safely in a very selected group of patients with diabetes.Keywords: diabetes, laser in situ keratomileusis, photorefractive keratectomy, refractive surgery
Transepithelial corneal collagen cross-linking in ultrathin keratoconic corneas
Spadea L,Mencucci R
Clinical Ophthalmology , 2012,
Abstract: Leopoldo Spadea,1 Rita Mencucci21University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, Eye Clinic, L'Aquila, 2University of Florence, Department of Oto-Neuro-Ophthalmological Surgical Sciences, Eye Clinic, Florence, ItalyBackground: The purpose of this paper was to report the results of transepithelial corneal collagen cross-linking (CXL) with modified riboflavin and ultraviolet A irradiation in patients affected by keratoconus, each with thinnest pachymetry values of less than 400 μm (with epithelium) and not treatable using standard de-epithelialization techniques.Methods: Sixteen patients affected by progressive keratoconus with thinnest pachymetry values ranging from 331 μm to 389 μm underwent transepithelial CXL in one eye using a riboflavin 0.1% solution in 15% Dextran T500 containing ethylenediamine tetra-acetic acid 0.01% and trometamol to enhance epithelial penetration. The patients underwent complete ophthalmological examination, including endothelial cell density measurements and computerized videokeratography, before CXL and at one day, one week, and one, 6, and 12 months thereafter.Results: Epithelial healing was complete in all patients after one day of use of a soft bandage contact lens. No side effects or damage to the limbal region was observed during the follow-up period. All patients showed slightly improved uncorrected and spectacle-corrected visual acuity; keratometric astigmatism showed reductions (up to 5.3 D) and apical ectasia power decreased (Kmax values reduced up to 4.3 D). Endothelial cell density was unchanged.Conclusion: Application of transepithelial CXL using riboflavin with substances added to enhance epithelial permeability was safe, seemed to be moderately effective in keratoconic eyes with ultrathin corneas, and applications of the procedure could be extended to patients with advanced keratoconus.Keywords: keratoconus, pachymetry, topography, transepithelial corneal collagen cross-linking, thin cornea
Simultaneous topography-guided PRK followed by corneal collagen cross-linking after lamellar keratoplasty for keratoconus
Spadea L,Paroli M
Clinical Ophthalmology , 2012,
Abstract: Leopoldo Spadea,1 Marino Paroli21University of L’Aquila, Department of Biotechnological and Applied Clinical Sciences, Eye Clinic, L’Aquila, 2La Sapienza University, Department of Biotechnology and Medical-Surgical Sciences, Latina, ItalyBackground: The purpose of this paper is to report the results of using combined treatment of customized excimer laser-assisted photorefractive keratectomy (PRK) and prophylactic corneal collagen crosslinking (CXL) for residual refractive error in a group of patients who had previously undergone lamellar keratoplasty for keratoconus.Methods: The study included 14 eyes from 14 patients who had originally been treated for keratoconus in one eye by excimer laser-assisted lamellar keratoplasty (ELLK), and subsequently presented with residual ametropia (-6.11 D ± 2.48, range -2.50 to -9.50). After a mean 40.1 ± 12.4 months since ELLK they underwent combined simultaneous corneal regularization treatment with topographically guided transepithelial excimer laser PRK (central corneal regularization) and corneal CXL induced by riboflavin-ultraviolet A.Results: After a mean 15 ± 6.5 (range 6–24) months, all eyes gained at least one Snellen line of uncorrected distance visual acuity (range 1–10). No patient lost lines of corrected distance visual acuity, and four patients gained three lines of corrected distance visual acuity. Mean manifest refractive spherical equivalent was -0.79 ± 2.09 (range +1 to -3.0) D, and topographic keratometric astigmatism was 5.02 ± 2.93 (range 0.8–8.9) D. All the corneas remained clear (haze < 1).Conclusion: The combination of customized PRK and corneal CXL provided safe and effective results in the management of corneal regularization for refractive purposes after ELLK for keratoconus.Keywords: corneal collagen crosslinking, excimer laser-assisted lamellar keratoplasty, photorefractive keratectomy
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