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Search Results: 1 - 10 of 223678 matches for " Maria Simone de Menezes Alencar "
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ROTA DE RISCO DA NANOTECNOLOGIA: UMA VIS O GERAL
Leonardo da Silva Sant’Anna,Aldo Pacheco Ferreira,Maria Simone de Menezes Alencar
Revista Uniandrade , 2012,
Abstract: Desenvolvimentos em nanotecnologia continuam a ser produzidos a taxas exponenciais para uma ampla e diversificada gama de aplica es.Neste trabalho foi feito um estudo de prospec o tecnológica em nanotecnologia discutindo a sua evolu o e implica es para a saúde humana e ambiental. Também foi trazido para discuss o às associa es e aplica es benéficas com o desenvolvimento de produtos nanoengenheirados, pendentes em avalia o de risco. Tem-se como meta subsidiaros formuladores de políticas públicas sobre riscos envolvendo nanotecnologia e saúde por ser uma área estratégica na política de Ciência, Tecnologia e Inova o do país. é fundamental que a saúde e o ambiente estejam sempre, direta ou indiretamente, envolvidos em variadas pesquisas para o entendimento das causas de acometimentos e para odesenvolvimento de procedimentos de controle de forma a evita-los, propiciando resultados exequíveis, confiáveis e seguros.
Late Entry into HIV Care: Estimated Impact on AIDS Mortality Rates in Brazil, 2003–2006
Alexandre Grangeiro,Maria Mercedes Escuder,Paulo Rossi Menezes,Rosa Alencar,Euclides Ayres de Castilho
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0014585
Abstract: Worldwide, a high proportion of HIV-infected individuals enter into HIV care late. Here, our objective was to estimate the impact that late entry into HIV care has had on AIDS mortality rates in Brazil.
Characterization of Chemical Constituents of Luffa operculata(Cucurbitaceae)  [PDF]
Cléia Rocha de Sousa Feitosa, Robério Costa da Silva, Raimundo Braz-Filho, Jane Eire Silva Alencar de Menezes, S?nia Maria Costa Siqueira, Francisco José Queiroz Monte
American Journal of Analytical Chemistry (AJAC) , 2011, DOI: 10.4236/ajac.2011.28116
Abstract: A mixture of new ceramides (1, 2, 3, 4 and 5) together with a binary mixture of ceramides with long chain alkyl (6 and 7), triterpenoid (10) and steroids (11 and 12) have been isolated from bark of the fruits and of the stems of Luffa operculata (Cucurbitaceae). The structures were elucidated by comprehensive spectro- scopic analysis including 1H and 13C NMR, DEPT (distortionless enhancement by polarization transfer), COSY (correlated spectroscopy), HMQC (heteronuclear multiple quantum coherence), HMBC (heteronu- clear multiple bond connectivity), IR (infrared), HR-ESI-MS (electrospray ionization-high resolution mass spectra) and LR-MS (low resolution electron ionization mass spectra) experiments. All the ceramides are reported for the first time in Cucurbitaceae and this is the first report of the rare triterpene 10 isolated from Luffa operculata. The ceramides 6 and 7 showed a high acetylcholine esterase inhibitory effect.
Trends in Nanopharmaceutical Patents
Adelaide Antunes,Iolanda Fierro,Rafaela Guerrante,Flavia Mendes,Maria Simone de M. Alencar
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14047016
Abstract: Investment in nanotechnology is now a given constant by governments, research centers and companies in both more developed countries and emerging markets. Due to their characteristics, such as high stability, ability to enable antigen identification on specific cells in the human body and controlling the release of drugs and, therefore, improving therapies, nanoparticles have been the subject of research and patent applications in the pharmaceutical field. According to the Organization for Economic Co-operation and Development (OCDE), patent data can be used as a source of information in order to measure science and technology activities. Thereby, this paper presents an analysis based on patent documents related to nanotechnology in the pharmaceutical sector. As a result, the analysis of patents demonstrate primarily that nanobiotechnology attracts high levels of R&D investments, including nanoparticle-based chemotherapeutic agents/drugs, monoclonal antibody nanoparticle complexes and their role in drug delivery or contrast agents with non-toxic effects.
The surgical treatment of patients with ulcerative colitis from an university hospital at Natal, Brazil
Suelene Suassuna Silvestre de Alencar,Romualdo da Silva Corrêa,Cátia de Fran?a Bezerra,Emanuela Simone Cunha de Menezes
Journal of Coloproctology (Rio de Janeiro) , 2012,
Abstract: INTRODUCTION: Ulcerative colitis (UC) is a chronic inflammatory disease that affects the rectum and colon, involving periods of exacerbation and remission. A considerable number of patients requires surgery during the course of this disease. OBJECTIVE: The purpose of this study is to analyze the profile and therapeutic approach of patients with UC. METHODS: This is a retrospective study that analyzed medical records of patients diagnosed with UC between 1999 and 2010. We selected 45 patients and analyzed the following variables: age, gender, ethnic group, interval between onset of symptoms and diagnosis, extraintestinal manifestations, extent of colonic involvement, disease complications, pharmacological treatment, indication for surgery, time between diagnosis and indication, surgical procedures, early and late complications and pathological results of surgical specimens. Data were analyzed descriptively and compared with other studies. RESULTS: The clinical profile of the patients was consistent with the literature. Nine patients underwent surgical treatment: seven were submitted to proctocolectomy with anastomosis in the ileo-anal pouch and two were submitted to total colectomy; in addition, eight were submitted to ileostomy. Postoperative complications occurred in 55.5% of patients. CONCLUSIONS: The study confirms data from the literature regarding the profile and therapeutic approach of patients with ulcerative colitis. INTRODU O: A retocolite ulcerativa (RCU) é uma doen a inflamatória cr nica que acomete reto e cólon, cursando com períodos de exacerba o e remiss o. Uma parcela considerável de pacientes necessita de procedimento cirúrgico ao longo do curso dessa enfermidade. OBJETIVO: Este estudo objetiva analisar perfil e abordagem terapêutica de portadores de RCU. MéTODOS: Trata-se de estudo retrospectivo realizado por meio da análise de prontuários de pacientes acompanhados com diagnóstico de RCU no período de 1999 a 2010. Foram selecionados 45 pessoas, sendo analisadas as variáveis: idade, sexo, ra a, intervalo entre início dos sintomas e diagnóstico, sintomatologia, manifesta es extraintestinais, extens o do acometimento col nico, complica es da doen a, tratamento medicamentoso, indica o de cirurgia, tempo entre esta e o diagnóstico, procedimentos cirúrgicos, complica es precoces e tardias e resultado anatomopatológico das pe as cirúrgicas. Os dados foram analisados de forma descritiva e comparados com outros estudos. RESULTADOS: O perfil clínico dos pacientes foi condizente com a literatura. Nove foram submetidos a tratamento cirúrgico,
Pré-germina??o de sementes de arroz de sequeiro
Franzin, Simone Medianeira;Menezes, Nilson Lemos de;Garcia, Danton Camacho;Tillmann, Maria Angela André;
Revista Brasileira de Sementes , 2007, DOI: 10.1590/S0101-31222007000100010
Abstract: pre-germination is a technique of seed physiological conditioning of seeds that is based on their controlled hydration, preparing them for germination and the initial development of the seedlings. the objective of this study was to evaluate the effects of the physiological conditioning, through the pre-germination at the temperatures of 20 and 25°c, with subsequent drying of the rice seeds cv. primavera. the seeds were submitted to immersion in water for periods of 8, 16, 24 and 32h, followed by 16, 24, 32 and 40h incubation. at the two temperatures, after conditioning, the germination tests and first count tests were applied. for the temperature of 25°c, in addition, initially, the imbibition curve was determined and, later, the cold test and the length and dried seedling mass tests were applied. at the temperature of 25°c, the treatment of 8 h of immersion and 16h of incubation presented humidity of 30.5%, considered enough for metabolic activation and presenting the best results detected in the vigor tests. it was concluded that the periods of 8 h immersion for16 h of incubation, at the temperature of 25°c and, 16 h of immersion for 24h of incubation, at the temperature of 20°c, are suitable for the pre-germination of upland rice seeds cv. primavera. the drying of the seeds, after the pre-germination, can be accomplished up to 17.0%, without damage to the physiological quality, however, the reduction of the water content to 13.0% annuls the benefits of the treatment, harming the seed vigor.
Situa??o de trabalho dos profissionais da Estratégia Saúde da Família em Ceará-Mirim
Pinto, Erika Simone Galv?o;Menezes, Rejane Maria Paiva de;Villa, Tereza Cristina Scatena;
Revista da Escola de Enfermagem da USP , 2010, DOI: 10.1590/S0080-62342010000300015
Abstract: the purpose of this study was to analyze the work situations experienced by family health strategy (fhs) professionals. this descriptive study was performed in ceará-mirim, rio grande do norte state, in 2007. the population consisted of 190 fhs professionals, in which a questionnaire with closed-questions was applied. the results showed that 83.2% of the professionals consider that knowing the geographical area under their responsibility is a positive aspect that helps performing their activities, while 40.5% consider the number of families that each team has to follow to be a difficulty. regarding work conditions, 93.2% reported the presence of professionals with a public health profile and 86.6% reported there is a lack of equipment and instruments. of professionals who work exclusively with the fhs, 74% are community health agents. the commitment and responsibility to replace the traditional care practices should concern everyone, and there is a need for an interaction between historical, political, social, economic, and cultural factors.
The surgical treatment of patients with ulcerative colitis from an university hospital at Natal, Brazil
Alencar, Suelene Suassuna Silvestre de;Corrêa, Romualdo da Silva;Bezerra, Cátia de Fran?a;Menezes, Emanuela Simone Cunha de;Nascimento, Antonio Luiz do;Costa, Davi Arag?o Alves da;Alencar, Marcelo José Carlos;
Journal of Coloproctology (Rio de Janeiro) , 2012, DOI: 10.1590/S2237-93632012000300010
Abstract: introduction: ulcerative colitis (uc) is a chronic inflammatory disease that affects the rectum and colon, involving periods of exacerbation and remission. a considerable number of patients requires surgery during the course of this disease. objective: the purpose of this study is to analyze the profile and therapeutic approach of patients with uc. methods: this is a retrospective study that analyzed medical records of patients diagnosed with uc between 1999 and 2010. we selected 45 patients and analyzed the following variables: age, gender, ethnic group, interval between onset of symptoms and diagnosis, extraintestinal manifestations, extent of colonic involvement, disease complications, pharmacological treatment, indication for surgery, time between diagnosis and indication, surgical procedures, early and late complications and pathological results of surgical specimens. data were analyzed descriptively and compared with other studies. results: the clinical profile of the patients was consistent with the literature. nine patients underwent surgical treatment: seven were submitted to proctocolectomy with anastomosis in the ileo-anal pouch and two were submitted to total colectomy; in addition, eight were submitted to ileostomy. postoperative complications occurred in 55.5% of patients. conclusions: the study confirms data from the literature regarding the profile and therapeutic approach of patients with ulcerative colitis.
Análise dos fatores de risco ou de prote??o para fluorose dentária em crian?as de 6 a 8 anos em Fortaleza, Brasil
Teixeira,Ana Karine Macedo; Menezes,Léa Maria Bezerra de; Dias,Aldo Angelim; Alencar,Carlos Henrique Morais de; Almeida,Maria Eneide Leit?o de;
Revista Panamericana de Salud Pública , 2010, DOI: 10.1590/S1020-49892010001200003
Abstract: objective: to investigate protection or risk factors for dental fluorosis in permanent teeth of 6 to 8 year-old children in a neighborhood of fortaleza, brazil. methods: this case-control study included 57 controls and 67 children with fluorosis affecting superior and inferior incisors teeth as determined by the dean classification criteria. presence of fluorosis was considered as the dependent variable. data concerning independent variables were obtained through interviews with the parents. fisher's exact test was used to determine associations between fluorosis and the independent variables. odds ratios (or) were calculated to investigate associations and likelihood of fluorosis in the case group, with 95% significance level. results: fluorosis was significantly associated with type of housing (owned, rented or squatted), but not with the source of drinking water or use of fluoridated toothpaste and fluoride supplements. univariate analysis showed that the risk of fluorosis was higher in children who began drinking powdered milk mixed with water before 2 years of age (or = 4.53; ic95%: 1.07-26.74) and in those who did not breastfeed (or = 6.66; ic95%: 1.61-38.62). in the multivariate analysis, only breastfeeding was associated with fluorosis (4.54; ic95%: 1.21-16.66). conclusions: breastfeeding was a protection factor against fluorosis. more specific categorization criteria must be established to investigate relationships between fluorosis and socioeconomic class
Occurrence of Natural Vertical Transmission of Dengue-2 and Dengue-3 Viruses in Aedes aegypti and Aedes albopictus in Fortaleza, Ceará, Brazil
Victor Emanuel Pessoa Martins, Carlos Henrique Alencar, Michel Tott Kamimura, Fernanda Montenegro de Carvalho Araújo, Salvatore Giovanni De Simone, Rosa Fireman Dutra, Maria Izabel Florindo Guedes
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041386
Abstract: Background Aedes aegypti and Aedes albopictus perform an important role in the transmission of the dengue virus to human populations, particularly in the tropical and subtropical regions of the world. Despite a lack of understanding in relation to the maintenance of the dengue virus in nature during interepidemic periods, the vertical transmission of the dengue virus in populations of A. aegypti and A. albopictus appears to be of significance in relation to the urban scenario of Fortaleza. Methods From March 2007 to July 2009 collections of larvae and pupae of Aedes spp were carried out in 40 neighborhoods of Fortaleza. The collections yielded 3,417 (91%) A. aegypti mosquitoes and 336 (9%) A. albopictus mosquitoes. Only pools containing females, randomly chosen, were submitted to the following tests indirect immunofluorescence (virus isolation), RT-PCR/nested-PCR and nucleotide sequencing at the C-prM junction of the dengue virus genome. Results The tests on pool 34 (35 A. albopictus mosquitoes) revealed with presence of DENV-3, pool 35 (50 A. aegypti mosquitoes) was found to be infected with DENV-2, while pool 49 (41 A. albopictus mosquitoes) revealed the simultaneous presence of DENV-2 and DENV-3. Based on the results obtained, there was a minimum infection rate of 0.5 for A. aegypti and 9.4 for A. albopictus. The fragments of 192 bp and 152 bp related to DENV-3, obtained from pools 34 and 49, was registered in GenBank with the access codes HM130699 and JF261696, respectively. Conclusions This study recorded the first natural evidence of the vertical transmission of the dengue virus in populations of A. aegypti and A. albopictus collected in Fortaleza, Ceará State, Brazil, opening a discuss on the epidemiological significance of this mechanism of viral transmission in the local scenario, particularly with respect to the maintenance of these viruses in nature during interepidemic periods.
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