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Search Results: 1 - 10 of 71121 matches for " Maria Rosaria Capobianchi "
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HDV-RNA and HBsAg Evolution during peg-IFN Treatment in Three HBV-HDV-HCV-HIV Coinfected Patients  [PDF]
Anna Rosa Garbuglia, Daniele Lapa, Angela Testa, Maria Rosaria Capobianchi, Ubaldo Visco-Comandini
World Journal of AIDS (WJA) , 2012, DOI: 10.4236/wja.2012.24039
Abstract: Background: Patients coinfected with HBV, HDV, HCV and HIV are usually excluded from clinical trials. Data on pegylated interferon treatment in this setting are limited, with predictive factors for HDV virologic success being unknown. Objectives: In this study we analyzed the time course of HDV viral load and HBsAg in HBV-HDV-HCV-HIV patients, who underwent pegylated alfa-2a interferon (peg-IFN) therapy for HDV infection between 2005 and 2009, with different virologic outcomes (no response, relapse or sustained response). Methods: Three patients were selected for virologic analysis, since complete clinical and laboratory data and stored residual blood samples, collected before/during/after peg-IFN treatment were available. Plasma samples were retrospectively analyzed for HDV-RNA detection and quantitative HBsAg determination. Results: All patients were HCV-Ab positive, persistently HCV-RNA negative, and received a peg-IFN treatment curse (180 mcg/week) for 12 to 18 months. HIV and HBV viral loads remained undetectable due to underlying Tenofovir/Emtricitabine (TDF/FTC) treatment. Low baseline HDV-RNA and HBsAg levels were both observed in the patient with sustained viral response. A HDV-RNA decline greater than 2log10 at month 6 was observed in two of the three patients, both with compensated liver cirrhosis, achieving a viral clearance at the end of treatment. Conclusions: Although performed in few patients, this study suggests that a decline of HDV-RNA during treatment and low baseline quantitative HBsAg may be associated to HDV virologic response to peg-IFN in HIV-infected subjects, independently of fibrosis stage. If confirmed on larger patient number, these data may help to select those HDV-infected patients with a reliable chance to respond to prolonged peg-IFN treatment and suggest the importance of quantitative HBsAg monitoring in this setting.
IFN-Alpha Receptor-1 Upregulation in PBMC from HCV Na?ve Patients Carrying CC Genotype. Possible Role of IFN-Lambda
Eleonora Lalle, Licia Bordi, Claudia Caglioti, Anna Rosa Garbuglia, Concetta Castilletti, Chiara Taibi, Francesca Cristofari, Maria Rosaria Capobianchi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093434
Abstract: Background and Aims IL-28B gene polymorphisms predict better therapeutic response and spontaneous clearance of HCV. Moreover, higher expression of IFN-lambda has been reported in patients with the rs12979860 CC favourable genotype. The study aim was to establish possible relationships between IL-28B rs12979860 genotypes and expression of IFN-alpha receptor-1 (IFNAR-1) in na?ve HCV patients, and to explore the possible role of IFN-lambda. Methods IFNAR-1 mRNA levels were measured in PBMC from na?ve patients with chronic hepatitis C with different IL-28 genotypes. The ability of IFN-lambda to up-regulate the expression of IFNAR-1 was established in PBMC from healthy donors carrying different IL-28B genotypes. Results Lower IFNAR-1 mRNA levels were observed in PBMC from HCV-infected na?ve patients as compared to healthy donors. In healthy donors, IFNAR-1 mRNA levels were independent from IL-28B genotype, while in HCV patients, an increasing gradient was observed in TT vs CT vs CC carriers. In the latter group, a direct correlation between IFNAR-1 and endogenous IL-28B expression was observed. Moreover, IFN-lambda up-regulated IFNAR-1 expression in normal PBMC in a time-and dose-dependent manner, with a more effective response in CC vs TT carriers. Conclusion Endogenous levels of IFN-lambda may be responsible for partial restoration of IFNAR-1 expression in HCV patients with favourable IL-28 genotype. This, in turn, may confer to CC carriers a response advantage to either endogenous or exogenous IFN-alpha, representing the biological basis for the observed association between CC genotype and favourable outcome of either natural infection (clearance vs chronicization) or IFN therapy.
Interferon-α Improves Phosphoantigen-Induced Vγ9Vδ2 T-Cells Interferon-γ Production during Chronic HCV Infection
Eleonora Cimini, Cécile Bonnafous, Veronica Bordoni, Eleonora Lalle, Helene Sicard, Alessandra Sacchi, Giulia Berno, Cristiana Gioia, Gianpiero D’Offizi, Ubaldo Visco Comandini, Chrysoula Vlassi, Maria Rosaria Capobianchi, Federico Martini, Chiara Agrati
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037014
Abstract: In chronic HCV infection, treatment failure and defective host immune response highly demand improved therapy strategies. Vγ9Vδ2 T-cells may inhibit HCV replication in vitro through IFN-γ release after Phosphoantigen (PhAg) stimulation. The aim of our work was to analyze Vγ9Vδ2 T-cell functionality during chronic HCV infection, studying the role of IFN-α on their function capability. IFN-γ production by Vγ9Vδ2 T-cells was analyzed in vitro in 24 HCV-infected patients and 35 healthy donors (HD) after PhAg stimulation with or without IFN-α. The effect of in vivo PhAg/IFN-α administration on plasma IFN-γ levels was analyzed in M. fascicularis monkeys. A quantitative analysis of IFN-γ mRNA level and stability in Vγ9Vδ2 T-cells was also evaluated. During chronic HCV infection, Vγ9Vδ2 T-cells showed an effector/activated phenotype and were significantly impaired in IFN-γ production. Interestingly, IFN-α was able to improve their IFN-γ response to PhAg both in vitro in HD and HCV-infected patients, and in vivo in Macaca fascicularis primates. Finally, IFN-α increased IFN-γ-mRNA transcription and stability in PhAg-activated Vγ9Vδ2 T-cells. Altogether our results show a functional impairment of Vγ9Vδ2 T-cells during chronic HCV infection that can be partially restored by using IFN-α. A study aimed to evaluate the antiviral impact of PhAg/IFN-α combination may provide new insight in designing possible combined strategies to improve HCV infection treatment outcome.
Large Human Outbreak of West Nile Virus Infection in North-Eastern Italy in 2012
Luisa Barzon,Monia Pacenti,Elisa Franchin,Silvana Pagni,Enrico Lavezzo,Laura Squarzon,Thomas Martello,Francesca Russo,Loredana Nicoletti,Giovanni Rezza,Concetta Castilletti,Maria Rosaria Capobianchi,Pasquale Salcuni,Margherita Cattai,Riccardo Cusinato,Giorgio Palù
Viruses , 2013, DOI: 10.3390/v5112825
Abstract: Human cases of West Nile virus (WNV) disease have been reported in Italy since 2008. So far, most cases have been identified in north-eastern Italy, where, in 2012, the largest outbreak of WNV infection ever recorded in Italy occurred. Most cases of the 2012 outbreak were identified in the Veneto region, where a special surveillance plan for West Nile fever was in place. In this outbreak, 25 cases of West Nile neuroinvasive disease and 17 cases of fever were confirmed. In addition, 14 WNV RNA-positive blood donors were identified by screening of blood and organ donations and two cases of asymptomatic infection were diagnosed by active surveillance of subjects at risk of WNV exposure. Two cases of death due to WNND were reported. Molecular testing demonstrated the presence of WNV lineage 1 in all WNV RNA-positive patients and, in 15 cases, infection by the novel Livenza strain was ascertained. Surveillance in other Italian regions notified one case of neuroinvasive disease in the south of Italy and two cases in Sardinia. Integrated surveillance for WNV infection remains a public health priority in Italy and vector control activities have been strengthened in areas of WNV circulation.
Semilinear Venttsel’ Problems in Fractal Domains  [PDF]
Maria Rosaria Lancia, Paola Vernole
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.512175
Abstract: We study a semilinear parabolic problem with a semilinear dynamical boundary condition in an irregular domain with fractal boundary. Local existence, uniqueness and regularity results for the mild solution, are established via a semigroup approach. A sufficient condition on the initial datum for global existence is given.
The Genotypic False Positive Rate Determined by V3 Population Sequencing Can Predict the Burden of HIV-1 CXCR4-using Species Detected by Pyrosequencing
Valentina Svicher, Valeria Cento, Gabriella Rozera, Isabella Abbate, Maria Mercedes Santoro, Daniele Armenia, Lavinia Fabeni, Alessandro Bruselles, Alessandra Latini, Guido Palamara, Valeria Micheli, Giuliano Rizzardini, Caterina Gori, Federica Forbici, Giuseppe Ippolito, Massimo Andreoni, Andrea Antinori, Francesca Ceccherini-Silberstein, Maria Rosaria Capobianchi, Carlo Federico Perno
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053603
Abstract: Objective The false-positive rate (FPR) is a percentage-score provided by Geno2Pheno-algorithm indicating the likelihood that a V3-sequence is falsely predicted as CXCR4-using. We evaluated the correlation between FPR obtained by V3 population-sequencing and the burden of CXCR4-using variants detected by V3 ultra-deep sequencing (UDPS) and Enhanced-Sensitivity Trofile assay (ESTA). Methods 54 HIV-1 B-subtype infected-patients (all maraviroc-na?ve), with viremia >10,000copies/ml, were analyzed. HIV-tropism was assessed by V3 population-sequencing, UDPS (considering variants with >0.5% prevalence), and ESTA. Results By UDPS, CCR5-using variants were detected in 53/54 patients, irrespective of FPR values, and their intra-patient prevalence progressively increased by increasing the FPR obtained by V3 population-sequencing (rho = 0.75, p = 5.0e-8). Conversely, the intra-patient prevalence of CXCR4-using variants in the 54 patients analyzed progressively decreased by increasing the FPR (rho = ?0.61; p = 9.3e-6). Indeed, no CXCR4-using variants were detected in 13/13 patients with FPR>60. They were present in 7/18 (38.8%) patients with FPR 20–60 (intra-patient prevalence range: 2.1%–18.4%), in 5/7 (71.4%) with FPR 10–20, in 4/6 (66.7%) with FPR 5–10, and in 10/10(100%) with FPR<5 (intra-patient prevalence range: 12.1%–98.1%). Conclusions FPR by V3 population-sequencing can predict the burden of CXCR4-using variants. This information can be used to optimize the management of tropism determination in clinical practice. Due to its low cost and short turnaround time, V3 population-sequencing may represent the most feasible test for HIV-1 tropism determination. More sensitive methodologies (as UDPS) might be useful when V3 population-sequencing provides a FPR >20 (particularly in the range 20–60), allowing a more careful identification of patients harboring CXCR4-using variants.
Asymmetric Friedel-Crafts Alkylation of Indole with Chalcones Catalyzed by Chiral Phosphoric Acids
Arrigo Scettri,Rosaria Villano,Maria Rosaria Acocella
Molecules , 2009, DOI: 10.3390/molecules14083030
Abstract: The reaction of indole with chalcones, to give Michael-type adducts, was found to occur with good efficiency (up to 98% yield) and moderate enantioselectivity (up to 52% e.e.) in the presence of a chiral BINOL-based phosphoric acid. Furthermore, the alkylation products can be obtained in much higher e.e.s after one only crystallization.
Eleonora de Fonseca Pimentel: morire per la rivoluzione
Maria Rosaria Pelizzari
Storia delle Donne , 2009,
Abstract: Eleonora de Fonseca Pimentel, poetess, scholar of jurisprudence, natural and mathematical sciences, at first, was an enthusiastic supporter of Ferdinand IV of Burbon’s enlightened politics reforms. After the French Revolution and the radical change of Neapolitan government policy, much more illiberal and repressive, she was an active protagonist of 1799’ Revolution and founded the “Neapolitan Republic”. Editor of Monitore napoletano , she was a free, courageous, journalist, committed in changing of “Neapolitan plebs” into “Civil people”. At fall of Republic, she showed herself fearless in meeting the death on the scaffold. Up to the Eighties of XXth century, her final sacrifice has been represented by Virile woman’ image, as a praise for meaning an extraordinary, and intellectually like a man, woman. Today writers represent Eleanor like a “Modern heroin”, far by nineteenth-century Virile woman’s characters. Intellectual virtues do not seem to be sexed any longer: they belong to men and to women at the same time.
Profili di tutela della libertà religiosa nelle Costituzioni dei Paesi della riva sud del Mediterraneo e nelle Dichiarazioni arabo-islamiche sui Diritti dell’Uomo
Maria Rosaria Piccinni
Stato, Chiese e Pluralismo Confessionale , 2011,
Abstract: Il contributo è stato segnalato dal Prof. Gaetano Dammacco. SOMMARIO: 1. Religione e diritto nell’esperienza islamica. I confini della Shari’a – 2. Diritti dell’uomo, diritti della comunità e diritti di Dio nella concezione musulmana. Il dibattito nel contesto culturale arabo-islamico – 3. Le Costituzioni dei Paesi a maggioranza islamica: l’importanza del riferimento religioso – 4. Principio di non discriminazione e libertà delle confessioni religiose nel sistema arabo-islamico – 5. La Dichiarazione Islamica Universale dei diritti dell’uomo e la Dichiarazione del Cairo dei diritti dell’uomo nell’Islam – 6. La Carta araba dei diritti dell’uomo. Prospettive di laicità e di ecumenismo dal testo del 1994 a quello del 2004 – 7. L’attualizzazione della Carta: osservazioni sulla conformità effettiva agli standards dei documenti internazionali.
Parabolic transmission problems across irregular layers PARABOLIC TRANSMISSION PROBLEMS ACROSS IRREGULAR LAYERS
Maria Rosaria Lancia
Le Matematiche , 2007,
Abstract: We study second order transmission problems across either a fractal surface or across the corresponding pre-fractal surface. Existence uniqueness and regularity results for the strict solution in both cases are proved. The asymptotic behaviour of the solutions of the approximating problems is also investigated. We study second order transmission problems across either a fractal surface or across the corresponding pre-fractal surface. Existence uniqueness and regularity results for the strict solution in both cases are proved. The asymptotic behaviour of the solutions of the approximating problems is also investigated.
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