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Search Results: 1 - 10 of 71180 matches for " Maria Papadimitriou "
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Stemness Gene Profiles of Circulating Tumor Cells  [PDF]
Panagiotis Apostolou, Maria Papadimitriou, Ioannis Papasotiriou
Journal of Cancer Therapy (JCT) , 2017, DOI: 10.4236/jct.2017.82013
Abstract: Circulating tumor cells (CTCs) are a population of tumor-derived cells that detach from the primary tumor and initiate metastasis. However, the mechanisms of this process are still unknown. This phenomenon renders CTCs as a valuable resource for prognosis and diagnosis of cancer. The involvement of stemness transcription factors and markers, such as NANOG, OCT3/4, CD34, NESTIN, and SOX2, in metastasis initiation has been studied recently because their abnormally elevated expression in cancer cells may be highly important in understanding tumor initiation. This study analyzed the genetic profiles of the above genes in CTCs derived from patients with different types of cancer. Blood samples were randomly collected from 71 cancer patients with various cancer types. CTCs were isolated using enrichment protocols and RNA was extracted. RT-qPCR was performed in triplicate using ACTB as the reference gene. The statistical analysis was performed among the ΔCts of the samples using parametric and non-parametric methods. The molecular analysis revealed that the expression of each gene was different than the others. When each type of cancer was analyzed separately, the gene expression profile was not always the same. It is noteworthy that, in all cases, the gene expression of NESTIN differed from that of transcription factors. According to the above data, gene expression profiles might be used as a potential biomarker or constitute a gene signature.
Linearity Comparison of Three Colorimetric Cytotoxicity Assays  [PDF]
Maria Papadimitriou, Eleana Hatzidaki, Ioannis Papasotiriou
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.107047
Abstract: Cell viability assays, including techniques to assess the proliferation of cancer cell lines, constitute a rapid, inexpensive and sensitive screening method to pre-clinically evaluate the activity of a potential drug or substance. This study investigates and compares seeding densities and linearity of three such methods: MTT ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide), SRB (sulforhodamine B) and CVE (crystal violet elution) assays. SRB and CVE are staining assays for proteins, while MTT measures the mitochondrial activity of living cells. Assays were performed on five cancer cell lines, A375, PC3, DU145, HCT116 and COR-L105, and the coefficient of determination (R2) was employed to determine fit into a linear regression model. The results show that CVE is the most linear assay at fixed time points. SRB at 515 nm is better for measurements over time. Seeding densities between 9000 and 12,000 were the optimum. However, seeding densities and doubling times should be taken into consideration when designing an experiment.
Level of Knowledge of specialist cardiologists and anesthesiologists in Basic and Advanced Life Support
Maria Vachla,Dimitris Barouxis,Evagelos Kotsiomitis,Lila Papadimitriou Lila
To Vima tou Asklipiou , 2013,
Abstract: Health professionals often witness in-hospital episodes of cardiac arrest. The quality of the Cardiopulmonary Resuscitation (CPR) depends on the level of theoretical background and practical skills. Purpose: The aim of the present study was to investigate the level of theoretical knowledge of skilled cardiologists and anesthesiologists in the Basic and Advanced Life Support (BLS/ ALS). Material - method: In this study, sample included 240 cardiologists and anesthesiologists, chosen randomly from employers of 17 General Public Hospitals of Athens. For data collection, a questionnaire with 16 theoretical questions was designed, based on the guidelines of the European Resuscitation Council (ERC) 2005. Significance level was set at p=≤0,05. The analysis was performed with the Statistical Package IBM SPSS Statistics 19. Results: No statistically significant difference was observed between specialists cardiologists and anesthesiologists in overall performance in theoretical knowledge on the BLS and ALS. Additionally, no statistical significance was observed between the two separate groups of theoretical background. Statistically significant difference was observed among those who had participated in a training seminar in BLS and ALS and those who had not participated (p<0,001). Also, there was statistical significance between the follow-up seminar in BLS/ ALS and specialty for the right answer to the question "which is the right ratio of chest compressions and ventilation", (p<0,001). Conclusions: The level of background knowledge of specialist cardiologists and anesthesiologists in the algorithms of BLS and ALS seem to correlate to the attendance of a training course.
Induced delusional disorder: a case report of Folie A' Famille
Katsigiannopoylos Konstantinos,Pazarlis Pandelis,Zambioglou Georgios,Papadimitriou Maria
Annals of General Psychiatry , 2006, DOI: 10.1186/1744-859x-5-s1-s276
A critical evaluation of antipsychotics; towards the next generation?
Papadimitriou George
Annals of General Psychiatry , 2006, DOI: 10.1186/1744-859x-5-s1-s24
Upsilon Production at CDF
Vaia Papadimitriou
Physics , 1995,
Abstract: We report on measurements of the Upsilon(1S), Upsilon(2S) and Upsilon(3S) differential and integrated cross sections in pp(bar) collisions at sqrt(s)=1.8 TeV. The three resonances were reconstructed through the decay Upsilon-->mu(+)mu(-). The cross section measurements are compared to theoretical models of direct bottomonium production.
Luminosity determination at the Tevatron
Vaia Papadimitriou
Physics , 2011,
Abstract: In this paper we discuss the luminosity determination at the Tevatron. We discuss luminosity measurements by the machine as well as by using the luminosity detectors of the CDF and D0 experiments. We discuss the uncertainties of the measurements, the effort to maximize the initial and integrated luminosity, the challenges and the lessons learned.
Holographic Renormalization of general dilaton-axion gravity
Ioannis Papadimitriou
Physics , 2011, DOI: 10.1007/JHEP08(2011)119
Abstract: We consider a very general dilaton-axion system coupled to Einstein-Hilbert gravity in arbitrary dimension and we carry out holographic renormalization for any dimension up to and including five dimensions. This is achieved by developing a new systematic algorithm for iteratively solving the radial Hamilton-Jacobi equation in a derivative expansion. The boundary term derived is valid not only for asymptotically AdS backgrounds, but also for more general asymptotics, including non-conformal branes and Improved Holographic QCD. In the second half of the paper, we apply the general result to Improved Holographic QCD with arbitrary dilaton potential. In particular, we derive the generalized Fefferman-Graham asymptotic expansions and provide a proof of the holographic Ward identities.
Calculation of expectation values of operators in the Complex Scaling method
G. Papadimitriou
Physics , 2015,
Abstract: The complex scaling method (CSM) provides with a way to obtain resonance parameters of particle unstable states by rotating the coordinates and momenta of the original Hamiltonian. It is convenient to use an L$^2$ integrable basis to resolve the complex rotated or complex scaled Hamiltonian H$_{\theta}$, with $\theta$ being the angle of rotation in the complex energy plane. Within the CSM, resonance and scattering solutions do not exhibit an outgoing or scattering wave asymptotic behavior, but rather have decaying asymptotics. One of the consequences is that, expectation values of operators in a resonance or scattering complex scaled solution are calculated by complex rotating the operators. In this work we are exploring applications of the CSM on calculations of expectation values of quantum mechanical operators by retrieving the Gamow asymptotic character of the decaying state and calculating hence the expectation value using the unrotated operator. The test cases involve a schematic two-body Gaussian model and also applications using realistic interactions.
Bs, Bc and b-baryons
Vaia Papadimitriou
Physics , 2005, DOI: 10.1063/1.2173585
Abstract: We present the latest measurements on masses, lifetimes and branching fractions for the B_s and B_c mesons as well as for b-baryons. For the B_s meson we discuss as well the latest results on mixing. These results were produced by the CDF and D0 experiments at Fermilab or by earlier LEP and PEPII experiments.
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