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Search Results: 1 - 10 of 71090 matches for " Maria Muccioli "
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Dendritic Cells The Tumor Microenvironment and the Challenges for an Effective Antitumor Vaccination
Fabian Benencia,Leslee Sprague,John McGinty,Michelle Pate,Maria Muccioli
Journal of Biomedicine and Biotechnology , 2012, DOI: 10.1155/2012/425476
Abstract: Many clinical trials have been carried out or are in progress to assess the therapeutic potential of dendritic-cell- (DC-) based vaccines on cancer patients, and recently the first DC-based vaccine for human cancer was approved by the FDA. Herewith, we describe the general characteristics of DCs and different strategies to generate effective antitumor DC vaccines. In recent years, the relevance of the tumor microenvironment in the progression of cancer has been highlighted. It has been shown that the tumor microenvironment is capable of inactivating various components of the immune system responsible for tumor clearance. In particular, the effect of the tumor microenvironment on antigen-presenting cells, such as DCs, does not only render these immune cells unable to induce specific immune responses, but also turns them into promoters of tumor growth. We also describe strategies likely to increase the efficacy of DC vaccines by reprogramming the immunosuppressive nature of the tumor microenvironment.
Uveítes anteriores associadas a doen?as sistêmicas
Dimantas, Maria Angélica Pav?o;Lowder, Careen;Muccioli, Cristina;
Arquivos Brasileiros de Oftalmologia , 2003, DOI: 10.1590/S0004-27492003000200023
Abstract: anterior uveitis describes a disease predominantly limited to the anterior segment of the eye. conjunctival hyperemia, anterior chamber cell and flare, keratic precipitates, and iris abnormalities including posterior synechiae characterize the inflammation. this article discusses clinical aspects of the systemic diseases that cause anterior uveitis with review of the literature.
Uveítes anteriores associadas a doen as sistêmicas
Dimantas Maria Angélica Pav?o,Lowder Careen,Muccioli Cristina
Arquivos Brasileiros de Oftalmologia , 2003,
Abstract: As uveítes anteriores s o caracterizadas pela inflama o preponderante do segmento anterior do olho. Hiperemia conjuntival, rea o de camara anterior com células e "flare", precipitados ceráticos e sinéquias posteriores s o sinais que comp em o quadro inflamatório. Aspectos clínicos de algumas doen as sistêmicas envolvidas na etiologia das uveítes anteriores ser o abordados neste artigo.
Toll-Like Receptors as Novel Therapeutic Targets for Ovarian Cancer
Maria Muccioli,Leslee Sprague,Harika Nandigam,Michelle Pate
ISRN Oncology , 2012, DOI: 10.5402/2012/642141
Toll-Like Receptors as Novel Therapeutic Targets for Ovarian Cancer
Maria Muccioli,Leslee Sprague,Harika Nandigam,Michelle Pate,Fabian Benencia
ISRN Oncology , 2012, DOI: 10.5402/2012/642141
Abstract: Ovarian cancer (OC) is an aggressive disease that affects approximately 1 in 70 women and has a poor prognosis (<50%, 5-year survival rate), in part because it is often diagnosed at a late stage. There are three main types of OC: neoplasms of surface epithelial, germ cell, or stromal origin, with surface epithelial tumors comprising about 80% of all OCs. In addition to improving diagnostics, it is necessary to develop more effective treatments for epithelial-origin OC. Here, we describe the paradoxical roles of toll-like receptor (TLR) signaling in the progression of cancer and discuss how its modulation may result in decreased tumor growth and metastasis via the attenuation of proangiogenic cytokines and potentiation of proapoptotic factors. In particular, it has been found that TLR activity can behave like a “double-edged sword”, as its signaling pathways have been implicated as having both tumor-suppressive and tumor-promoting effects. With particular emphasis on OC, we discuss the need to consider the signaling details of TLRs and associated proteins in the multiple cell types present in the tumor milieu to achieve safe and effective design of TLR-based cancer therapies. 1. Ovarian Cancer Disease Characteristics Ovarian cancer (OC) is characterized by malignant transformation of ovarian epithelial, stromal, or germ line cells. It affects approximately 1 in 70 women and has a poor prognosis (<50%, 5-year survival rate) [1]. Early-stage OC presents no obvious symptoms in the majority of patients, and no effective screening method is available at the current time. As a result, OC is most commonly diagnosed at stage III or stage IV. In later stages, metastasis often occurs, which can involve the peritoneal surface and adjacent organs, lymph nodes, lungs, and liver, among other sites. For these patients, the outcome is poor, with an on average 20% long-term survival rate [1]. OC can develop as a result of genetic risk factors, such as mutations in BRCA1 and BRCA2 genes. However, less than 10% of OCs arise as a result of genetic predisposition. Other nongenetic causes, such as chronic inflammation can result in OC development as well [1]. It has been shown that a higher number of pregnancies and oral contraceptive use correlates to decreased OC risk, suggesting that limited ovulation creates an environment that is less conducive to neoplasm development. The most common tools used today in diagnostics include measurement of CA-125 levels in the serum, pelvic ultrasonography, and biopstic and histochemical analysis. The downfall of the screening methodology
O Comitê de ética em Pesquisa (CEP) e as publica es científicas
Muccioli Cristina
Arquivos Brasileiros de Oftalmologia , 2004,
Σ τυρο Φιλοπ τωρ πικαλο μενο (Aristot., EN, VII, 4, 1148a, 34ss.)
Tekmēria , 1998,
Abstract: No Abstracts
Neovasculariza??o retiniana secundária a obstru??o vascular em retinocoroidite por toxoplasmose em paciente HIV positivo: relato de caso
Ewert, Vania;Finamor, Luciana Peixoto;Dimantas, Maria Angélica;Muccioli, Cristina;
Arquivos Brasileiros de Oftalmologia , 2004, DOI: 10.1590/S0004-27492004000400019
Abstract: to present a case of an hiv-infected patient, who presented with active chorioretinal inflammatory lesion suggestive of toxoplasmosis, that during the specific treatment developed a retinal vascular occlusion, and adjacent neovascularization. 35-year-old aids patient that, presented with toxoplasmic retinochoroiditis and after 4 weeks of the specific therapy (pyrimethamine and sulfadiazine) developed a vascular occlusion and retinal neovascularization that healed without the need for phototocoagulation or other adjunctive therapy. this case demonstrates that acute toxoplasmic retinochoroiditis that develops vascular complications may present a good result with the specific treatment without the need for adjunctive therapy.
Glaucoma persistente secundário à inje??o subtenoniana posterior de acetato de triancinolona (Kenalog?): relato de casos
Finamor, Luciana Peixoto;Dimantas, Maria Angélica P.;Campos, Vania Ewert de;Muccioli, Cristina;
Arquivos Brasileiros de Oftalmologia , 2003, DOI: 10.1590/S0004-27492003000200019
Abstract: purpose: to describe 3 cases of children submitted to posterior subtenon steroid injection (pssi) of triamcinolone acetonide (kenalog? 40mg) for the treatment of intermediate uveitis, with development of refractory glaucoma. methods: case report. results: three children with the diagnosis of intermediate uveitis were treated with pssi of triamcinolone for the control of a chronic vitreous inflammation and/or cystoid macular edema. after treatment they developed refractory glaucoma and were submitted to surgery, for removal of the steroid deposit and/or filtering surgery to control the intraocular pressure (iop). conclusion: the use of pssi can represent a high risk for development of secondary glaucoma, with difficult control in children. surgery to remove the remaining steroid may control iop, but in some cases filtering surgery may be necessary.
Retinite por citomegalovírus em pacientes pediátricos infectados pelo vírus da imunodeficiência humana em tratamento com "highly active antiretrovirus therapy"
Dimantas, Maria Angélica;Finamor, Luciana Peixoto;Ewert, Vania;Nakanami, Célia;Muccioli, Cristina;
Revista da Associa??o Médica Brasileira , 2004, DOI: 10.1590/S0104-42302004000300042
Abstract: background: to describe three cases of cytomegalovirus retinitis occurring in hiv-infected children taking protease inhibitors combined with transcriptase inhibitors (haart). methods: three cases of hiv-infected children taking highly active antiretrovirus therapy (haart) underwent an ocular examination at a university referral center - unifesp. results: the average age was 6 years (10 months to 13 years old), and all of them were c3 (cdc - atlanta - eua 1994). median cd4 cell count and plasma hiv rna were 67 cells/mm3 (43 - 98 cells/ mm3) and 190.000 copies/ml (53.600 - 460.000 copies/ml). the three patients presented haart failure and all of them were treated with anti-cmv agents without success. conclusion: the unprecedented benefits resulting from highly active antiretroviral therapy (haart) have been well described. however, treatment failure has become increasingly complex, because of the aggressive forms of opportunistic diseases like cmv retinitis, despite anti-cmv agents. prompt diagnosis and treatment are essential to minimize the risk of long-term loss of vision for these infected children.
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