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Search Results: 1 - 10 of 182473 matches for " Maria Jo?o; Rebelo "
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Da Classifica??o de Viena para a Nova Classifica??o de Montreal: Caracteriza??o Fenotípica e Evolu??o Clínica da Doen?a de Crohn
Rebelo,Ana; Rosa,Bruno; Moreira,Maria Joo; Cotter,José;
Jornal Português de Gastrenterologia , 2011,
Abstract: montreal classification (mc) succeeded vienna classification (vc) in the characterization of patients with crohn′s disease (cd). in order to evaluate the differences and potential advantages of the first regarding the last one and validate the mc through the longitudinal analysis of the phenotypic variation of this population, 122 crohn′s patients were retrospectively analyzed and classified according to both classifications. the evolution of both subgroups and the need for surgery was analysed. results showed that mc reclassified 6 patients in the criteria age at diagnosis (a), 4 in the criteria location (l) and 18 in the criteria behaviour (b). the disease location (l) remained stable. the behaviour (b) by the vc classification changed at 3 and 5 years. 41,8% of patients underwent major surgery. a higher association between the need for surgery and the group b3 of mc was identified. there were no statistically significant differences between the survival curves and sex, smoking and age at diagnosis. conclusion: the mc is more sensitive in the phenotypic evaluation of behaviour of cd, especially after exclusion of perianal disease from the category penetrating disease. the classification of cd by phenotypic pattern could possibly, in future, be applied to predict its natural history.
Enteroscopia por cápsula na suspeita de doen?a de Crohn: há lugar para o Score de Lewis na prática clínica?
Rosa,Bruno; Moreira,Maria Joo; Rebelo,Ana; Cotter,José;
Jornal Português de Gastrenterologia , 2010,
Abstract: introduction: suspected crohn?s disease (cd) is a common indication for capsule enteroscopy (ce). however, lesions are nonspecific and no gold standard is available for diagnosing cd. lewis score (ls) measures inflammatory activity based on oedematous villous appearance, ulcers and stenoses. aim: to evaluate the role of sl in the diagnosis of cd in clinical practice. methods: thirty patients who underwent ce for suspected cd were included and followed up for at least six months. inflammatory activity was classified in three levels: clinically insignificant (score<135), mild (135≤score≤790) or moderate to severe (score > 790). results: diagnosis of cd was established in 10 patients (33%). clinically significant inflammatory activity (score ≥ 135) had a positive predictive value (vpp) = 75%, negative predictive value (vpn) = 94%, sensitivity (s) = 90% and specificity (e) = 85% for the diagnosis of cd. conclusions: ls seems to be a useful index in the setting of suspected cd, increasing the objectivity of ce findings; it also has a good correlation with the diagnosis established during follow-up.
Enteroscopia por Cápsula na Suspeita da Doen a de Crohn: Há Lugar para o Score de Lewis na Prática Clínica?
Bruno Rosa,Maria Joo Moreira,Ana Rebelo,José Cotter
Jornal Português de Gastrenterologia , 2011,
Abstract:
Enteroscopia por cápsula na suspeita de doen a de Crohn: há lugar para o Score de Lewis na prática clínica? Diagnosis of Crohn’s disease by capsule enteroscopy: is there a role for Lewis Score in clinical practice?
Bruno Rosa,Maria Joo Moreira,Ana Rebelo,José Cotter
Jornal Português de Gastrenterologia , 2010,
Abstract: INTRODU O: A suspeita de Doen a de Crohn (DC) é uma indica o frequente para a realiza o de enteroscopia por cápsula (EC). No entanto, os achados endoscópicos s o inespecíficos e n o existem critérios validados ou um gold-standard para o diagnóstico da doen a. O Score de Lewis (SL) valoriza a presen a de edema vilositário, úlceras e estenoses, permitindo classificar o nível de actividade inflamatória. OBJECTIVOS: Avaliar a utilidade do SL na prática clínica, enquanto contributo para o diagnóstico da DC. MéTODOS: Foram incluídos trinta doentes consecutivos com suspeita de DC, submetidos a EC e com um follow-upmínimo de seis meses. A actividade inflamatória foi classificada em três níveis: n o significativa (score < 135); ligeira (135 ≤ score ≤ 790) ou moderada a severa (score > 790). RESULTADOS: Foi estabelecido o diagnóstico de DC em 10 doentes (33%). A presen a de actividade inflamatória significativa (score ≥ 135), apresentou um Valor Preditivo Positivo (VPP) = 75%, Valor Preditivo Negativo (VPN) = 94%, Sensibilidade (S) = 90% e Especificidade (E) = 85% para o diagnóstico de DC. CONCLUS ES: A utiliza o do SL parece ser um indicador útil na suspeita de DC, permitindo aumentar a objectividade da interpreta o dos achados endoscópicos e apresentando uma boa correla o com o diagnóstico estabelecido durante o follow-up. INTRODUCTION: Suspected Crohn’s Disease (CD) is a common indication for capsule enteroscopy (CE). However, lesions are nonspecific and no gold standard is available for diagnosing CD. Lewis Score (LS) measures inflammatory activity based on oedematous villous appearance, ulcers and stenoses. AIM: To evaluate the role of SL in the diagnosis of CD in clinical practice. METHODS: Thirty patients who underwent CE for suspected CD were included and followed up for at least six months. Inflammatory activity was classified in three levels: clinically insignificant (score<135), mild (135≤score≤790) or moderate to severe (score > 790). RESULTS: Diagnosis of CD was established in 10 patients (33%). Clinically significant inflammatory activity (score ≥ 135) had a Positive Predictive Value (VPP) = 75%, Negative Predictive Value (VPN) = 94%, Sensitivity (S) = 90% and Specificity (E) = 85% for the diagnosis of CD. CONCLUSIONS: LS seems to be a useful index in the setting of suspected CD, increasing the objectivity of CE findings; it also has a good correlation with the diagnosis established during follow-up.
Da Classifica o de Viena para a Nova Classifica o de Montreal: Caracteriza o Fenotípica e Evolu o Clínica da Doen a de Crohn From the Vienna Classification to the New Montreal Classification: Phenotype Characterization and Clinical Evolution of Crohn′s Disease
Ana Rebelo,Bruno Rosa,Maria Joo Moreira,José Cotter
Jornal Português de Gastrenterologia , 2011,
Abstract:
Da Classifica o de Viena para a Nova Classifica o de Montreal: Caracteriza o Fenotípica e Evolu o Clínica da Doen a de Crohn From the Vienna Classification to the New Montreal Classification: Phenotype Characterization and Clinical Evolution of Crohn′s Disease
Ana Rebelo,Bruno Rosa,Maria Joo Moreira,José Cotter
Jornal Português de Gastrenterologia , 2011,
Abstract: A Classifica o de Montreal (CM) sucedeu à de Viena (CV) na caracteriza o dos doentes com Doen a de Crohn (DC). Com o objectivo de avaliar as diferen as e potenciais vantagens da primeira em rela o à última e validar a CM através da análise longitudinal da varia o fenotípica desta popula o, analisaram-se retrospectivamente 122 doentes com DC classificados segundo as CV e CM. Avaliou-se a evolu o dos subgrupos e a necessidade de cirurgia. Nos resultados verificou-se que a CM reclassificou 6 doentes no critério idade de diagnóstico (A), 4 no critério localiza o (L) e 18 no critério comportamento (B). A localiza o (L) da doen a permaneceu estável. O comportamento (B) pela CV modificou-se aos 3 e 5 anos. Foram submetidos a cirurgia major 41,8% dos doentes. Identificou-se uma maior associa o entre a necessidade de cirurgia e o grupo B3 da CM. N o se verificaram diferen as estatisticamente significativas entre as curvas de sobrevivência e as variáveis sexo, tabaco e idade de diagnóstico. CONCLUS O: A CM é mais sensível na avalia o fenotípica do comportamento da doen a, principalmente após a exclus o da doen a perianal da categoria doen a penetrante. A classifica o da DC por padr o fenotípico poderá eventualmente, no futuro, ser aplicada para predizer a sua história natural. Montreal classification (MC) succeeded Vienna classification (VC) in the characterization of patients with Crohn′s disease (CD). In order to evaluate the differences and potential advantages of the first regarding the last one and validate the MC through the longitudinal analysis of the phenotypic variation of this population, 122 Crohn′s patients were retrospectively analyzed and classified according to both classifications. The evolution of both subgroups and the need for surgery was analysed. Results showed that MC reclassified 6 patients in the criteria age at diagnosis (A), 4 in the criteria location (L) and 18 in the criteria behaviour (B). The disease location (L) remained stable. The behaviour (B) by the VC classification changed at 3 and 5 years. 41,8% of patients underwent major surgery. A higher association between the need for surgery and the group B3 of MC was identified. There were no statistically significant differences between the survival curves and sex, smoking and age at diagnosis. Conclusion: The MC is more sensitive in the phenotypic evaluation of behaviour of CD, especially after exclusion of perianal disease from the category penetrating disease. The classification of CD by phenotypic pattern could possibly, in future, be applied to predict its natural his
Cultural heritage policy. The Alto Douro wine region - World Herita-ge Site. Is there an argument for reinforcing the role of the state?
Louren?o, Lina,Rebelo, Joo
PASOS : Revista de Turismo y Patrimonio Cultural , 2006,
Abstract: In this paper we trace the emergence of a specific case of cultural policy: the example chosen is a UNESCO World Heritage site, namely the Alto Douro Wine Region (ADW) a portuguese living and evolving cultural landscape. In order to contextualize the particularities of the means that have been adopted for the management of the ADW, we use Throsby’s (2001) typology of most commonly-used cultural heritage policy instruments. Additionally we draw on the arguments that are frequently used to support public intervention in this sphere. We conclude that ADW’s management policy should: 1) use binding agreements to operational-ize a range of measures that compensate farmers who become providers of cultural products; 2) strengthen education and information so as to promote greater physical access and personal appreciation of the ADW’s cultural goods and services; and 3) formulate an integrated set of social policies able to mitigate the negative socio-demographic trends that characterize the region and its population
Preeclampsia: a bioinformatics approach through protein-protein interaction networks analysis
Eduardo Tejera, Joo Bernardes, Irene Rebelo
BMC Systems Biology , 2012, DOI: 10.1186/1752-0509-6-97
Abstract: We confirmed the well known relationship between preeclampsia and cardiovascular diseases but also identified statistically significant relationships with respect to cancer and aging. Moreover, significant metabolic pathways such as apoptosis, cancer and cytokine-cytokine receptor interaction have also been identified by enrichment analysis. We obtained FLT1, VEGFA, FN1, F2 and PGF genes with the highest scores by hubs analysis; however, we also found other genes as PDIA3, LYN, SH2B2 and NDRG1 with high scores.The applied methodology not only led to the identification of well known genes related to preeclampsia but also to propose new candidates poorly explored or completely unknown in the pathogenesis of preeclampsia, which eventually need to be validated experimentally. Moreover, new possible connections were detected between preeclampsia and other diseases that could open new areas of research. More must be done in this area to resolve the identification of unknown interactions of proteins/genes and also for a better integration of metabolic pathways and diseases.Preeclampsia is a pregnancy related disease associated with hypertension, proteinuria and increased maternal and perinatal morbidity and mortality, without known underlying mechanism and preventive treatment [1,2]. On the other hand, the future health or possible risks of women with previous history of preeclampsia are important areas of investigation. In this direction, it is well known the increased risk of future cardiovascular disease and renal dysfunction, however, other risks are also being discussed [1,3-5]. Owing to the morbidity and mortality of this pregnancy related disease and the possible multifactorial causes involved [1-5], several experimental procedures have been applied by researchers in the last two decades, evidently, generating an elevated number of unprocessed information.Although some bioinformatic analysis has been performed in particular microarray assays [6,7], an extensive data
The euro area ten years after its creation: (Divergent) competitiveness and the optimum currency area theory
Rebelo Joo Barbosa,Alves Henrique Rui
Panoeconomicus , 2011, DOI: 10.2298/pan1105605r
Abstract: As the euro is on its second decade, the European sovereign debt crisis and the ever more evident disparities in competitiveness among member states are prompting many to question whether monetary union is bringing more benefits than costs. The optimum currency area (OCA) theory provides a framework with several criteria for such analysis. In such context, we start by a descriptive analysis of the first twelve euro countries under six criteria, leading to a mixed conclusion on whether the EMU is closer or farther to fulfil them. Then we assess the impact of five OCA criteria on countries’ relative competitiveness. Differences in the growth of unit labour costs, the dissimilarity of trade and the differences in output growth were found to be the most significant. This way, we identify some causes of the divergent competitiveness between some EMU countries that contributed to weaker economic growth in some of them.
O portefólio na forma??o e avalia??o profissional de professores
Silva, Joo;Rebelo, Nicole;Mendes, Patrícia;Candeias, Adelinda;
Educa??o e Pesquisa , 2011, DOI: 10.1590/S1517-97022011000300006
Abstract: the area of teacher education and evaluation is in constant renovation, incapable of encompassing all relevant contents in a complete manner, leaving (dis)satisfied both evaluated and evaluators (that is, teachers). in such complex area, the method of evaluation by portfolio has assumed a vital importance in recent years, regarded as it is as a tool that allows the evaluation of various domains. moreover, it makes it possible to follow the evolution of personal and professional development as a qualitative measure for evaluation, and can also be used to separate excellent teachers from "satisfactory" ones in the process of career progression. portfolios are also used as basis for job interviews and as a means of presentation of the individual in new job situations. in this sense, we investigated the validity and usefulness of this tool for teacher evaluation in the area of professional education, demonstrating its applicability and respective advantages and disadvantages. through a bibliographical survey of several published studies, the importance of the portfolio is highlighted as an instrument for the evaluation of teachers at the beginning of their careers (aiming at their evolution) and its complementarity with respect to other methods. we have, therefore, achieved a more complete evaluation model, more individualized and efficient in the development and evaluation of competences, accessible to all education community, and not restricted to a given period or moment, but valuing the professional life of teachers.
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