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Search Results: 1 - 10 of 182495 matches for " Maria Jo?o; Cotter "
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Da Classifica??o de Viena para a Nova Classifica??o de Montreal: Caracteriza??o Fenotípica e Evolu??o Clínica da Doen?a de Crohn
Rebelo,Ana; Rosa,Bruno; Moreira,Maria Joo; Cotter,José;
Jornal Português de Gastrenterologia , 2011,
Abstract: montreal classification (mc) succeeded vienna classification (vc) in the characterization of patients with crohn′s disease (cd). in order to evaluate the differences and potential advantages of the first regarding the last one and validate the mc through the longitudinal analysis of the phenotypic variation of this population, 122 crohn′s patients were retrospectively analyzed and classified according to both classifications. the evolution of both subgroups and the need for surgery was analysed. results showed that mc reclassified 6 patients in the criteria age at diagnosis (a), 4 in the criteria location (l) and 18 in the criteria behaviour (b). the disease location (l) remained stable. the behaviour (b) by the vc classification changed at 3 and 5 years. 41,8% of patients underwent major surgery. a higher association between the need for surgery and the group b3 of mc was identified. there were no statistically significant differences between the survival curves and sex, smoking and age at diagnosis. conclusion: the mc is more sensitive in the phenotypic evaluation of behaviour of cd, especially after exclusion of perianal disease from the category penetrating disease. the classification of cd by phenotypic pattern could possibly, in future, be applied to predict its natural history.
Enteroscopia por cápsula na suspeita de doen?a de Crohn: há lugar para o Score de Lewis na prática clínica?
Rosa,Bruno; Moreira,Maria Joo; Rebelo,Ana; Cotter,José;
Jornal Português de Gastrenterologia , 2010,
Abstract: introduction: suspected crohn?s disease (cd) is a common indication for capsule enteroscopy (ce). however, lesions are nonspecific and no gold standard is available for diagnosing cd. lewis score (ls) measures inflammatory activity based on oedematous villous appearance, ulcers and stenoses. aim: to evaluate the role of sl in the diagnosis of cd in clinical practice. methods: thirty patients who underwent ce for suspected cd were included and followed up for at least six months. inflammatory activity was classified in three levels: clinically insignificant (score<135), mild (135≤score≤790) or moderate to severe (score > 790). results: diagnosis of cd was established in 10 patients (33%). clinically significant inflammatory activity (score ≥ 135) had a positive predictive value (vpp) = 75%, negative predictive value (vpn) = 94%, sensitivity (s) = 90% and specificity (e) = 85% for the diagnosis of cd. conclusions: ls seems to be a useful index in the setting of suspected cd, increasing the objectivity of ce findings; it also has a good correlation with the diagnosis established during follow-up.
Enteroscopia por Cápsula na Suspeita da Doen a de Crohn: Há Lugar para o Score de Lewis na Prática Clínica?
Bruno Rosa,Maria Joo Moreira,Ana Rebelo,José Cotter
Jornal Português de Gastrenterologia , 2011,
Abstract:
Enteroscopia por cápsula na suspeita de doen a de Crohn: há lugar para o Score de Lewis na prática clínica? Diagnosis of Crohn’s disease by capsule enteroscopy: is there a role for Lewis Score in clinical practice?
Bruno Rosa,Maria Joo Moreira,Ana Rebelo,José Cotter
Jornal Português de Gastrenterologia , 2010,
Abstract: INTRODU O: A suspeita de Doen a de Crohn (DC) é uma indica o frequente para a realiza o de enteroscopia por cápsula (EC). No entanto, os achados endoscópicos s o inespecíficos e n o existem critérios validados ou um gold-standard para o diagnóstico da doen a. O Score de Lewis (SL) valoriza a presen a de edema vilositário, úlceras e estenoses, permitindo classificar o nível de actividade inflamatória. OBJECTIVOS: Avaliar a utilidade do SL na prática clínica, enquanto contributo para o diagnóstico da DC. MéTODOS: Foram incluídos trinta doentes consecutivos com suspeita de DC, submetidos a EC e com um follow-upmínimo de seis meses. A actividade inflamatória foi classificada em três níveis: n o significativa (score < 135); ligeira (135 ≤ score ≤ 790) ou moderada a severa (score > 790). RESULTADOS: Foi estabelecido o diagnóstico de DC em 10 doentes (33%). A presen a de actividade inflamatória significativa (score ≥ 135), apresentou um Valor Preditivo Positivo (VPP) = 75%, Valor Preditivo Negativo (VPN) = 94%, Sensibilidade (S) = 90% e Especificidade (E) = 85% para o diagnóstico de DC. CONCLUS ES: A utiliza o do SL parece ser um indicador útil na suspeita de DC, permitindo aumentar a objectividade da interpreta o dos achados endoscópicos e apresentando uma boa correla o com o diagnóstico estabelecido durante o follow-up. INTRODUCTION: Suspected Crohn’s Disease (CD) is a common indication for capsule enteroscopy (CE). However, lesions are nonspecific and no gold standard is available for diagnosing CD. Lewis Score (LS) measures inflammatory activity based on oedematous villous appearance, ulcers and stenoses. AIM: To evaluate the role of SL in the diagnosis of CD in clinical practice. METHODS: Thirty patients who underwent CE for suspected CD were included and followed up for at least six months. Inflammatory activity was classified in three levels: clinically insignificant (score<135), mild (135≤score≤790) or moderate to severe (score > 790). RESULTS: Diagnosis of CD was established in 10 patients (33%). Clinically significant inflammatory activity (score ≥ 135) had a Positive Predictive Value (VPP) = 75%, Negative Predictive Value (VPN) = 94%, Sensitivity (S) = 90% and Specificity (E) = 85% for the diagnosis of CD. CONCLUSIONS: LS seems to be a useful index in the setting of suspected CD, increasing the objectivity of CE findings; it also has a good correlation with the diagnosis established during follow-up.
Da Classifica o de Viena para a Nova Classifica o de Montreal: Caracteriza o Fenotípica e Evolu o Clínica da Doen a de Crohn From the Vienna Classification to the New Montreal Classification: Phenotype Characterization and Clinical Evolution of Crohn′s Disease
Ana Rebelo,Bruno Rosa,Maria Joo Moreira,José Cotter
Jornal Português de Gastrenterologia , 2011,
Abstract:
Da Classifica o de Viena para a Nova Classifica o de Montreal: Caracteriza o Fenotípica e Evolu o Clínica da Doen a de Crohn From the Vienna Classification to the New Montreal Classification: Phenotype Characterization and Clinical Evolution of Crohn′s Disease
Ana Rebelo,Bruno Rosa,Maria Joo Moreira,José Cotter
Jornal Português de Gastrenterologia , 2011,
Abstract: A Classifica o de Montreal (CM) sucedeu à de Viena (CV) na caracteriza o dos doentes com Doen a de Crohn (DC). Com o objectivo de avaliar as diferen as e potenciais vantagens da primeira em rela o à última e validar a CM através da análise longitudinal da varia o fenotípica desta popula o, analisaram-se retrospectivamente 122 doentes com DC classificados segundo as CV e CM. Avaliou-se a evolu o dos subgrupos e a necessidade de cirurgia. Nos resultados verificou-se que a CM reclassificou 6 doentes no critério idade de diagnóstico (A), 4 no critério localiza o (L) e 18 no critério comportamento (B). A localiza o (L) da doen a permaneceu estável. O comportamento (B) pela CV modificou-se aos 3 e 5 anos. Foram submetidos a cirurgia major 41,8% dos doentes. Identificou-se uma maior associa o entre a necessidade de cirurgia e o grupo B3 da CM. N o se verificaram diferen as estatisticamente significativas entre as curvas de sobrevivência e as variáveis sexo, tabaco e idade de diagnóstico. CONCLUS O: A CM é mais sensível na avalia o fenotípica do comportamento da doen a, principalmente após a exclus o da doen a perianal da categoria doen a penetrante. A classifica o da DC por padr o fenotípico poderá eventualmente, no futuro, ser aplicada para predizer a sua história natural. Montreal classification (MC) succeeded Vienna classification (VC) in the characterization of patients with Crohn′s disease (CD). In order to evaluate the differences and potential advantages of the first regarding the last one and validate the MC through the longitudinal analysis of the phenotypic variation of this population, 122 Crohn′s patients were retrospectively analyzed and classified according to both classifications. The evolution of both subgroups and the need for surgery was analysed. Results showed that MC reclassified 6 patients in the criteria age at diagnosis (A), 4 in the criteria location (L) and 18 in the criteria behaviour (B). The disease location (L) remained stable. The behaviour (B) by the VC classification changed at 3 and 5 years. 41,8% of patients underwent major surgery. A higher association between the need for surgery and the group B3 of MC was identified. There were no statistically significant differences between the survival curves and sex, smoking and age at diagnosis. Conclusion: The MC is more sensitive in the phenotypic evaluation of behaviour of CD, especially after exclusion of perianal disease from the category penetrating disease. The classification of CD by phenotypic pattern could possibly, in future, be applied to predict its natural his
Is It Possible to Predict the Presence of Intestinal Angioectasias?
Tiago Cúrdia Gon?alves,Joana Magalh?es,Pedro Boal Carvalho,Maria Joo Moreira,Bruno Rosa,José Cotter
Diagnostic and Therapeutic Endoscopy , 2014, DOI: 10.1155/2014/461602
Abstract: Background and Aim. Angioectasias are the most common vascular anomalies found in the gastrointestinal tract. In small bowel (SB), they can cause obscure gastrointestinal bleeding (OGIB) and in this setting, small bowel capsule endoscopy (SBCE) is an important diagnostic tool. This study aimed to identify predictive factors for the presence of SB angioectasias, detected by SBCE. Methods. We retrospectively analyzed the results of 284 consecutive SBCE procedures between April 2006 and December 2012, whose indication was OGIB, of which 47 cases with SB angioectasias and 53 controls without vascular lesions were selected to enter the study. Demographic and clinical data were collected. Results. The mean age of subjects with angioectasias was significantly higher than in controls ; . The presence of SB angioectasias was significantly higher when the indication for the exam was overt OGIB versus occult OGIB (13/19 versus 34/81, . Hypertension and hypercholesterolemia were significantly associated with the presence of SB angioectasias (38/62 versus 9/38, and 28/47 versus 19/53, , resp.). Other studied factors were not associated with small bowel angioectasias. Conclusions. In patients with OGIB, overt bleeding, older age, hypercholesterolemia, and hypertension are predictive of the presence of SB angioectasias detected by SBCE, which may be used to increase the diagnostic yield of the SBCE procedure and to reduce the proportion of nondiagnostic examinations. 1. Introduction Obscure gastrointestinal bleeding (OGIB) remains one of the most challenging issues for gastroenterologists. It is defined as bleeding from gastrointestinal (GI) tract that persists or recurs without obvious etiology after esophagogastroduodenoscopy (EGD), colonoscopy, and radiologic evaluation of the small bowel (SB). OGIB accounts for about 5% of the cases of gastrointestinal bleeding [1]. The source of bleeding is located in the SB in about 75% of cases, where lesions can be scarcely accessed by standard endoscopy [1, 2]. These patients frequently require several blood transfusions and repeated hospital admissions, being at risk for complications not only related to anemia, but also caused by numerous exploratory procedures [3]. As a consequence, OGIB negatively affects patients’ quality of life and represents a significant burden of healthcare resources [3]. Small bowel capsule endoscopy (SBCE) has become a particularly useful tool in the management of OGIB, which remains the most common indication for the procedure [4]. Several studies have confirmed the higher diagnostic yield of
Intraflagellar Protein 88 Interactome Analysis: A Bioinformatics Approach Highlights Its Role in Testis and Sperm Function  [PDF]
Maria Joo Freitas, Margarida Fardilha
Journal of Biophysical Chemistry (JBPC) , 2014, DOI: 10.4236/jbpc.2014.53011
Abstract:
Intraflagellar transport (IFT) is essential for cilium and flagellar assembly. This movement is accomplished by two IFT complexes: A and B. IFT88, intraflagellar protein 88, is a core element of IFT complex B. This protein has been linked to migration, to olfactory function, spindle formation and to mitosis. Recently, IFT88 was identified as a TCTEX1D4 interacting protein in human testis, suggesting a role in male reproduction. To broaden the knowledge on IFT88 function, particularly in testis and spermatozoa, an in silico analysis of IFT88 and IFT88 interactome was undertaken. IFT88 appears to be prone to protein-protein interactions, involved in spermatogenesis and since it interacts with key proteins related to male fertility, it may have a role in reproduction.
Dynamic Capacity Allocation in OTN Networks  [PDF]
Maria Catarina Taful, Joo Pires
Communications and Network (CN) , 2015, DOI: 10.4236/cn.2015.71005
Abstract: A dynamic Optical Transport Network (OTN) has the advantage of being able to adjust the connection capacity on demand in order to respond to variations on traffic patterns or to network failures. This feature has the potential to reduce operational costs and at the same time to optimize networks resources. Virtual Concatenation (VCAT) and Link Capacity Adjustment Scheme (LCAS) are two techniques that when properly combined can be used to provide improved dynamism in OTN networks. These techniques have been previously standardized in the context of Next Generation SDH/SONET networks. VCAT is used to tailor the capacity of network connections according to service requirements, while LCAS can adjust dynamically that capacity in a hitless manner. This paper presents an overview of the application of VCAT/LCAS techniques in the context of OTN. It explains in detail how these techniques can be employed to resize the connection capacity and analyses its use in network protection solutions. Furthermore, a detailed analysis of the time delays associated with different operations is provided and its application to some reference networks is undertaken. The obtained results provide an idea about the time delays of the capacity adjustment processes and define potential scenarios for implementing VCAT/LCAS techniques.
Application of Molecularly Imprinted Polymers for the Analysis of Pesticide Residues in Food—A Highly Selective and Innovative Approach  [PDF]
Raquel Garcia, Maria Joo Cabrita, Ana Maria Costa Freitas
American Journal of Analytical Chemistry (AJAC) , 2011, DOI: 10.4236/ajac.2011.228119
Abstract: The increasing application of pesticides for agricultural purposes involves serious risk to the environment and human health due to either exposure or through residues in food and drinking water. Since food safety is of mandatory importance there is a growing interest on the development of selective, simple, rapid, cost-effective and reliable analytical methodologies in order to ensure that pesticides residues should not be found at levels above the established maximum pesticide residue limits (MRLs). In recent years, a new methodology based on the development of molecularly imprinting polymers (MIPs) allows not only pre-concentration and cleaning of the sample but also selective extraction of the target analyte, which is crucial, particularly when the sample is complex and impurities can interfere with quantification. The scope of this review is to provide a general overview on MIPs field, with emphasis on MIP preparation and its use as sorbents for solid-phase extraction. This paper will be focused on the review of the current state of the art in the use of MIPs as selective materials in molecularly imprinted solid-phase extraction (MISPE) for the analysis of pesticide residues from food matrices. A review of preparation and application of MIPs in food matrices, will also be discussed.
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