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Search Results: 1 - 10 of 85438 matches for " Maria Cristina; Migliaccio "
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Translational research on advanced therapies
Belardelli,Filippo; Rizza,Paola; Moretti,Franca; Carella,Cintia; Galli,Maria Cristina; Migliaccio,Giovanni;
Annali dell'Istituto Superiore di Sanità , 2011, DOI: 10.4415/ANN_11_01_15
Abstract: fostering translational research of advanced therapies has become a major priority of both scientific community and national governments. advanced therapy medicinal products (atmp) are a new medicinal product category comprising gene therapy and cell-based medicinal products as well as tissue engineered medicinal products. atmp development opens novel avenues for therapeutic approaches in numerous diseases, including cancer and neurodegenerative and cardiovascular diseases. however, there are important bottlenecks for their development due to the complexity of the regulatory framework, the high costs and the needs for good manufacturing practice (gmp) facilities and new end-points for clinical experimentation. thus, a strategic cooperation between different stakeholders (academia, industry and experts in regulatory issues) is strongly needed. recently, a great importance has been given to research infrastructures dedicated to foster translational medicine of advanced therapies. some ongoing european initiatives in this field are presented and their potential impact is discussed.
Physical exercise intensity prescription to improve health and fitness in overweight and obese subjects: A review of the literature  [PDF]
Gian Pietro Emerenziani, Silvia Migliaccio, Maria Chiara Gallotta, Andrea Lenzi, Carlo Baldari, Laura Guidetti
Health (Health) , 2013, DOI: 10.4236/health.2013.56A2017

Obesity is one of the greatest public health challenges of the 21st century. Overweight and obesity drastically increase a person’s risk of developing chronic non-communicable diseases (NCDs), including cardiovascular disease, cancer and diabetes. Furthermore, obesity is already responsible for 2% -8% of health costs and 10% -13% of deaths in several industrialized countries. Lifestyle modifications involving changes in exercise, diet and psychological support are effective in reducing the incidence of overweight. Moreover, positive effects of physical activity (PA) for weight loss and prevention of weight regain are well documented. It was recognized that health benefits regarding both psychological and physiological aspects, such as improving cardiorespiratory and muscular fitness and/or decreasing depression symptoms, can be obtained from numerous activities. Public health institutions (American College of Sports Medicine, World Health Organization) provide recommendations for PA (volume, frequency, intensity and type of exercise) to achieve positive effects, at all ages and for many diseases and disorders situations. Although exercise under guidelines can be safely performed by obese subjects, several questions still need to be fully answered. In facts, the exercise program should be tailored according to an individual’s habitual physical activity, physical function, health status, exercise responses, and stated goals. Thus, this review analyzes the intensity of PA parameters. In the last years, research has been focused on the individualization of the right intensity in which different types of subjects’ condition must undergo to achieve the health goals. Aerobic exercise has been commonly used to reach weight loss goal. Prescription of aerobic exercise in clinical practice is frequently based on the percentage of maximum heart rate (%HRmax), heart rate reserve (%HRreserve), rating of perceived exertion (RPE), maximal oxygen consumption (%VO2max

Poemas de mármore: Michelangelo escultor e poeta nas Lezioni de Benedetto Varchi
Migliaccio, Luciano;
Revista Brasileira de História , 1998, DOI: 10.1590/S0102-01881998000100009
Abstract: in 1547 the florentine philosopher benedetto varchi gave some lectures, denominated lezione about michelangelo's sonnet non há l'ottimo artista alcun concetto and the issue of superiority of sculpture, painting or poetry in the hierarchy of arts. varchi added to his lectures, published in 1550, letters written by famous florentine artists and by michelangelo himself. taking lezione de varchi as a point of departure this text intend to contribute to understand how michelangelo's poetry express his thought toward sculpture and the artist creation and how it has influenced the theoretical interpretation of the master's work at his time.
Poemas de mármore: Michelangelo escultor e poeta nas Lezioni de Benedetto Varchi
Migliaccio Luciano
Revista Brasileira de História , 1998,
Abstract: Em 1547, o filósofo florentino Benedetto Varchi pronunciou uma série de conferências, chamadas de Lezioni, sobre o soneto de Michelangelo "Non há l'ottimo artista alcun concetto" e sobre a quest o da superioridade da escultura, da pintura ou da poesia na hierarquia das artes. Varchi acrescentou ao texto das conferências, publicado em 1550, cartas de famosos artistas florentinos e do próprio Michelangelo sobre essa quest o. A partir das Lezioni de Varchi, este escrito pretende contribuir para entender de que maneira a poesia de Michelangelo exprime seu pensamento em rela o à escultura e à cria o artística e como isso influenciou a interpreta o da obra do mestre dada pelo teóricos da época.
Molecular Evaluation of the Enterotoxigenicity of Clostridium difficile and Clostridium perfringens Swine Isolates by PCR Assays  [PDF]
Maria Cristina Ossiprandi, Laura Zerbini
Advances in Microbiology (AiM) , 2013, DOI: 10.4236/aim.2013.32024

Clostridium difficile and C. perfringens are enteric pathogens affecting a variety of mammals. This study evaluated the molecular enterotoxigenicity of Clostridium swine isolates by PCRs. One hundred and ten swine faeces were analyzed by culture assay. The faecal samples were from sixty-seven healthy animals and 43 with gastrointestinal tract disease. C. difficile strains were PCR-screened for the presence of tcdA/tcdB and cdtA/cdtB genes. All C. perfringens isolates were tested for the characterization of the toxinotype. Overall, sixty-five swine resulted positive: 38 for C. difficile and 17 for C. perfringens. One sample tested C. perfringens and C. difficile-positive, at the same time: on the whole, 39 C. difficile strains were isolated. Thirty-eight C. difficile isolates (all from healthy animals) resulted tcdA/tcdB and cdtA/cdtB-negative by PCRs and toxins A/B-negative by immunological tests. All C. perfringens strains were type A; eight were also cpb2-positive. In the sample (diarrhoeic), with double infection, C. difficile tested tcdA/tcdB and cdtA/cdtB-positive by PCRs and toxins A/B-positive by immunoassays; C. perfringens resulted cpb2-positive. The molecular genotypeing/toxinotyping should be applied to establish a final diagnosis and to assess properly the full implications and the epidemiological impact of these findings in particular in samples of healthy animals and aid in the development of effective intervention methods for controlling clostridial disease outbreaks.

Diagnosis of carotid arterial injury in major trauma using a modification of Memphis criteria
Marco Ciapetti, Alessandro Circelli, Giovanni Zagli, Maria Migliaccio, Rosario Spina, Alessandro Alessi, Manlio Acquafresca, Marco Bartolini, Adriano Peris
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2010, DOI: 10.1186/1757-7241-18-61
Abstract: Trauma patients consecutively admitted to Intensive Care Unit (ICU) from Jan 2008 to Oct 2009 were considered for the study. Memphis criteria comprehend: basilar skull fracture with involvement of the carotid canal, cervical spine fracture, neurological exam not explained by brain imaging, Horner's syndrome, LeFort II-III fractures, and neck soft tissue injury. As single criteria modification, we included all patients with petrous bone fracture, even without carotid canal involvement. In all patients at risk of BCVI, 64-slice angio-CT-scans was performed.During the study period, 266 patients were admitted to the ICU for blunt major trauma. Among them, 162 presented traumatic brain injury or cervical spine fracture. In accordance with the proposed modified-Memphis criteria, 53 patients showed risk factors for BCVI compared to 45 using the original Memphis criteria. Among the 53 patients, 6 resulted as having carotid lesions (2.2% of all blunt major traumas; one patient more than when using Memphis criteria). Anticoagulant therapy with low molecular weight heparin was administered in all patients. No stroke or hemorrhagic complications occurred. Clinical examination at 6-months showed no central neurological deficit.A modification of a single criteria of Memphis screening protocol might permit the identification of a higher percentage of BCVI. Limited by sample size, this study needs to be validated.The incidence of Blunt Cerebrovascular Injuries (BCVI) varies from 0.5% to 1% of all admissions for blunt trauma, but this relatively small percentage of patients is affected by a stroke rate ranging from 25% to 58% and a mortality rate ranging from 31% to 59% [1-5].Although BCVIs are related to severe complications and high mortality rate, controversy exists in literature when defining the patient at risk for these injuries. Four-vessel angiography has been considered the gold standard diagnostic test for the presence of BCVI for a long time. With the increasing availabil
Wavelet Bases Made of Piecewise Polynomial Functions: Theory and Applications  [PDF]
Lorella Fatone, Maria Cristina Recchioni, Francesco Zirilli
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.22022
Abstract: We present wavelet bases made of piecewise (low degree) polynomial functions with an (arbitrary) assigned number of vanishing moments. We study some of the properties of these wavelet bases; in particular we consider their use in the approximation of functions and in numerical quadrature. We focus on two applications: integral kernel sparsification and digital image compression and reconstruction. In these application areas the use of these wavelet bases gives very satisfactory results.
A Simple Empirically Motivated Template for the Unresolved Thermal Sunyaev-Zeldovich Effect
George Efstathiou,Marina Migliaccio
Physics , 2011, DOI: 10.1111/j.1365-2966.2012.21059.x
Abstract: We develop a model for the power spectrum of unresolved clusters of galaxies arising from the thermal Sunyaev-Zeldovich (tSZ) effect. The model is based on a'universal' gas pressure profile constrained by X-ray observations and includes a parameter to describe departures from self-similar evolution. The model is consistent with recent Planck observations of the tSZ effect for X-ray clusters with redshifts z<1 and reproduces the low amplitude for the tSZ inferred from recent ground based observations. By adjusting two free parameters, we are able to reproduce the tSZ power spectra from recent numerical simulations to an accuracy that is well within theoretical uncertainties. Our model provides a simple, empirically motivated tSZ template that may be useful for the analysis of new experiments such as Planck.
Biodiversity Assessment of Sugar Beet Species and Its Wild Relatives: Linking Ecological Data with New Genetic Approaches  [PDF]
Filipa Monteiro, Maria M. Romeiras, Dora Batista, Maria Cristina Duarte
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.48A003

The value of crop wild relatives has long been acknowledged and this wild resource has been used to improve crop performance with clear economic benefits. Sugar beet (Beta vulgaris subsp. vulgaris) is the most economically valuable crop species in the order Caryophyllales, B. vulgaris subsp. maritima being the ancestor of the cultivated beets. The wild species of the genus Beta s.l. are commonly found in coastal areas of Europe and Mediterranean Region, where a rich genetic heritage still exists. Broadening the genetic base of sugar beet by introgression with wild relatives is a growing need regarding the maintenance of ecologically important traits. Since wild relatives have adapted to specific habitats, they constitute an important source of novel traits for the beet breeding pool. So, we conducted a broader research project aiming to delimit taxa and identify priority locations to establish genetic reserves of the wild Beta species occurring in Portugal (Western Iberian Peninsula). The aim of this study was: 1) to identify and characterize the main habitats of these wild Beta species; and 2) to present a review of some genetic tools available for future application in sugar beet breeding. In this review, we have focused on EcoTILLING as a molecular tool to assess DNA polymer

A Preliminary Study of Three Finishing Materials for Traditional Chinese Furniture  [PDF]
Xin You Liu, Timar Maria Cristina, Varodi Anca Maria
Advances in Materials Physics and Chemistry (AMPC) , 2014, DOI: 10.4236/ampc.2014.45011
Abstract: The traditional Chinese furniture evolved as an important part of the Chinese culture and civilization. Alongside design, structure, ornaments, the original finishes applied define the particularities and value of traditional Chinese furniture. This is because wood finishing not only enhances wood natural beauty by colour, gloss and highlighting of wooden texture, but also can be a means of exquisite decoration (e.g. engraved, gilded or painted lacquer works). Chinese lacquer, Tung oil and Chinese wax represent some of the most important finishing materials employed and were, therefore, selected for this study. The paper presents a brief macroscopic, microscopic and FTIR characterization of these materials. These results will be used as starting data in a further study on the ageing properties of these traditional finishing materials, useful for scientific conservation purposes.
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