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Search Results: 1 - 10 of 71621 matches for " Maria Brigida Ferraro "
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Rigidity and flexibility in protein-protein interaction networks: a case study on neuromuscular disorders
Ankush Sharma,Maria Brigida Ferraro,Francesco Maiorano,Francesca Del Vecchio Blanco,Mario Rosario Guarracino
Quantitative Biology , 2014,
Abstract: Mutations in proteins can have deleterious effects on a protein's stability and function, which ultimately causes particular diseases. Genetically inherited muscular dystrophies (MDs) include several genetic diseases, which cause increasing weakness in muscles and disability to perform muscular functions progressively. Different types of mutations in the gene coding translates into defunct proteins cause different neuro-muscular diseases. Defunct protein interactions in human proteome may cause a stress to its neighboring proteins and its modules. We therefore aimed to understand the effects of mutated proteins on interacting partners in different muscular dystrophies utilizing network biology to understand system properties of these MDs subnetworks .We investigated rigidity and flexibility of protein-protein interaction subnetworks associated with causative mutated genes showing high mean interference values in muscular dystrophy. Rigid component related to EEF1A1 subnetwork and members of 14.3.3 protein family formed the core of network showed involvement in molecular function related to protein domain specific binding. CACNA1S and CALM1 showing functionality related to Voltage-dependent calcium channel demonstrated highest flexibility. The interconnected subnets of proteins corresponding to known causative genes having large genetic variants are shared in different muscular dystrophies inferred towards comorbidity in diseases. The studies demonstrates core network of MDs as highly rigid, constituting of large intermodular edges and interconnected hub nodes suggesting high information transfer flow. The core skeleton of the network is organized in protein specific domain binding. This suggests neuro-muscular disorders may initiate due to interruption in molecular function related with the core and its aggression may depend on the tolerance level of the networks.
Resumos: Teses e Disserta es
Brigida Maria Nogueira Cervantes
Informa??o & Informa??o , 2012,
Abstract: Teses defendidas pelos professores do Departamento de Ciência da Informa o da Universidade Estadual de Londrina no primeiro semestre de 2012.Disserta es defendidas pelos mestrandos do Programa de Pós-Gradua o em Gest o da Informa o (Mestrado Profissional) do Departamento de Ciência da Informa o da Universidade Estadual de Londrina no primeiro semestre de 2012.
Molecular Determinants for the Self-Assembly of Elastin Peptides
Brigida Bochicchio,Maria Rosaria Armenante,Maria Antonietta Crudele,Antonietta Pepe
Conference Papers in Science , 2014, DOI: 10.1155/2014/214235
Abstract: Elastin and elastin-related peptides have great potential in the biomaterial field, because of their peculiar mechanical properties and spontaneous self-assembling behavior. Depending on their sequences and under appropriate experimental conditions, they are able to self-assemble in different fiber morphologies, including amyloid-like fibers. In this work, we will review recent data on elastin peptides derived from exon 30-coded domain of human tropoelastin. This domain has been shown to be fundamental for the correct assembly of elastin. However, the N-terminal region forms amyloid-like fibers, while the C-terminal fragment forms elastin-like fibers. A rationale for the varied aggregation pattern has been sought in the molecular structure of the peptides. Minimal differences in the sequences, adopting alternative conformations, are shown to be responsible for the observed data. 1. Introduction The development of advanced biomaterials is often inspired by the biological self-assembling modules, where simple building blocks such as amino acids, nucleic acids, and lipids are able to form complex natural systems. Peptide-based nanostructure complexes represent an important way toward the production of ordered self-assembling nanostructures with variegated possible applications [1, 2]. The growing interest in protein-inspired bionanotechnology is based on the knowledge of different self-assembling processes involving proteins and peptides. One of the most ubiquitous self-assembly processes in nature is the hierarchical organization of protein monomers into long filaments bundles and networks of nanometric dimensions. Extracellular matrix proteins, such as elastin and collagen, are involved in different self-assembling processes, both producing well-defined fibrils and fibers with specific mechanical and supramolecular properties [3]. Among the proteins able to self-assemble, elastin and elastin-related polypeptides [4, 5] have peculiar characteristics with repetitive sequences of small size and complexity responsible for their self-assembling as well as for the elastic properties. Furthermore, according to their sequences, elastin peptides are able to self-assemble in two different aggregation patterns, the classical elastin-like and the amyloid-type, with mechanical properties tuned by the choice of the sequence building blocks [4]. The peculiar features of elastin-related polypeptides render them a special subject of interest, as bionanomaterial with “smart” behavior [6]. With the aim of exploring the possible use of elastin self-assembling peptides for
Explaining Gender Differences in Caries: A Multifactorial Approach to a Multifactorial Disease
Maria Ferraro,Alexandre R. Vieira
International Journal of Dentistry , 2010, DOI: 10.1155/2010/649643
Abstract: Many studies have demonstrated that caries rates are higher in women than in men. This review attempts to provide an explanation for this trend by examining each factor which contributes to caries and how the factor differs in men and women. Evidence has been provided to demonstrate that caries risk factors for women include a different salivary composition and flow rate, hormonal fluctuations, dietary habits, genetic variations, and particular social roles among their family. Systemic diseases that have been found to be associated with caries have also been found to have an association with the female gender. An extended exposure to the oral cavity or a more cariogenic oral microflora has not been proven to contribute to higher caries in women. Further research in these areas could be done in the future to explain their contribution, or lack thereof, to a higher caries rate in women. 1. Introduction The significant impact of caries on the world’s population makes the disease an important topic of understanding. The development of caries is multifactorial, depending on many interacting variables to promote its development. In particular, the presence of bacteria, a substrate for the bacteria (food/sugars), the host’s oral environment, as well as the passing of time are the main contributing factors in the formation of caries. Epidemiological and clinical studies, through the use of tools such as DMFT and DMFS scores, have revealed a consistent trend in caries development, with females having higher prevalence than males [1]. The mechanisms underlying the reasoning for this trend can possibly be explained by an investigation of the suggested factors involved in caries development. 2. Genetic Contributions: AMELX The underlying mechanisms of any genetic contributions to the increased prevalence of caries in females versus males can be speculated to reside in the sex chromosomes, exhibiting sex-linked modes of inheritance. Genes present on the X or Y chromosome whose function affects those factors which contribute to the development of caries can be investigated. Variations in these genes would alter the host’s oral environment and the host’s response to the initiation of caries. The Amelogenin (AMELX) gene resides on the p arm of the X chromosome. Its locus is Xp22.31-p22.1 [2]. This gene and its protein product contribute to enamel formation in the dentition. The amelogenin protein constitutes 90% of the enamel matrix [3]. A mutation/deletion in the AMELX gene results in X-linked amelogenesis imperfecta [2]. There is a possibility that a deficient
Conceitos na Organiza o e Representa o do Conhecimento - Editorial
Brigida Maria Nogueira Cervantes,Ana Cristina de Albuquerque
Informa??o & Informa??o , 2011, DOI: 10.5433/1981-8920.2011v16n2p
Abstract:
Radiobiological evaluation of forward and inverse IMRT using different fractionations for head and neck tumours
Brigida C Ferreira, Maria do Carmo Lopes, Josefina Mateus, Miguel Capela, Panayiotis Mavroidis
Radiation Oncology , 2010, DOI: 10.1186/1748-717x-5-57
Abstract: Seven patients with head and neck tumours were selected for this retrospective planning study. The PTV1 included the primary tumour, PTV2 the high risk lymph nodes and PTV3 the low risk lymph nodes. Except for the conventional technique where a maximum dose of 64.8 Gy was prescribed to the PTV1, 70.2 Gy, 59.4 Gy and 50.4 Gy were prescribed respectively to PTV1, PTV2 and PTV3. Except for IMRT2, all techniques were delivered by three sequential phases. The IFP technique used five to seven directions with a total of 15 to 21 beams. The IMRT techniques used five to nine directions and around 80 segments. The first, IMRT1, was prescribed with the conventional fractionation scheme of 1.8 Gy per fraction delivered in 39 fractions by three treatment phases. The second, IMRT2, simultaneously irradiated the PTV2 and PTV3 with 59.4 Gy and 50.4 Gy in 28 fractions, respectively, while the PTV1 was boosted with six subsequent fractions of 1.8 Gy. Tissue response was calculated using the relative seriality model and the Poisson Linear-Quadratic-Time model to simulate repopulation in the primary tumour.The average probability of total tumour control increased from 38% with CONVT to 80% with IFP, to 85% with IMRT1 and 89% with IMRT2. The shorter treatment time and larger dose per fraction obtained with IMRT2 resulted in an 11% increase in the probability of control in the PTV1 with respect to IFP and 7% relatively to IMRT1 (p < 0.05). The average probability of total patient complications was reduced from 80% with CONVT to 61% with IFP and 31% with IMRT. The corresponding probability of complications in the ipsilateral parotid was 63%, 42% and 20%; in the contralateral parotid it was 50%, 20% and 9%; in the oral cavity it was 2%, 15% and 4% and in the mandible it was 1%, 5% and 3%, respectively.A significant improvement in treatment outcome was obtained with IMRT compared to conventional radiation therapy. The practical and biological advantages of IMRT2, employing a shorter treatme
Influenze tra processo ed esiti: alleanza, coesione e cambiamento in un gruppo terapeutico a lungo termine
Francesca Giannone,Cinzia Guarnaccia,Anna Maria Ferraro,Maria Rita Infurna
Narrare i Gruppi , 2012,
Abstract: Research is currently moving in the direction of an integration between the outcome measures of the patients and the relational and/or structural factors that can facilitate their change. It is increasingly important to focus studies on the relationship between process and outcome, especially with regard to psychodynamic group therapy. These treatments, very complex and difficult to operationalize, still pose critical questions for research such as what are the main elements of the therapeutic process that are activated in these therapies?Many efforts are to be made in understanding which factors develop in groups and the conditions that positively influence the success of therapy. Important is, moreover, the work of conceptual and "operational" depth on the different constructs, to better understand their nature and differences and build tools to more easily detect their features. Therapeutic alliance and cohesion are among the most investigated process variables, because of their role on the results of therapy.This study investigates these two variables in a therapeutic group with severe patients and analyzes their associations with treatment outcomes in term of symptoms and defenses. A long-term, semi-open group meeting on a weekly basis was examined. The observation was carried out for a period of 18 months, for a total amount of 50 sessions; 11 patients with different diagnoses in Axis I and II DSM IV were examined. Outcome measures: SCL-90 - Symptom Check List; OQ-45 - Outcome Questionnaire 45.2; DSQ - Defense Style Questionnaire.Process measures: CALPAS-G: California Psychotherapy Alliance Scale-Group; GMLCS: Group/Member/Leader Cohesion Scale. The observation period was divided into 3 phases according to re-modulations of the setting (new entries, overcomes, dropout). Significant correlations between alliance, cohesion and outcomes were found in the three phases. During the phase of greater instability, the predominant role of cohesion and, more generally, dimensions related to group commitment emerge. Results offer interesting suggestions about the differentiation between Alliance and Cohesion and their different relationship with outcomes and process evolution.
Disidentità: una chiave di lettura per le nuove forme di psicopatologia?
Anna Maria Ferraro,Francesca Giannone,Girolamo Lo Verso
Narrare i Gruppi , 2012,
Abstract: nsformations society has faced in the transition from modernity to postmodernity have shaken the traditional group dimensions, and thereby, personal identity itself. The stray of the sense of belonging, linked to the consideration of some cultural, linguistic, religious traditions as our own, not only prevents from understanding the world. It also hampers the possibility to internalize all those aspects of the experience of "belonging" which, when lost, become nothing more than fragments of an essentially uncertain and provisional world. Taking up some of the concepts of the subjectual group analysis theory of personality, the article proposes a reflection on why some recent anthropological changes may represent a threat in relation to the development of individual identity, with a special focus on the concept of dis-identity. It will therefore highlight the instability of identification dynamics and the connection of this weak spot to the development of new forms of psychopathology.After illustrating the fragility of the internalization process of the composing elements of individual identity, the article associates the partial shadowing of the intersubjective dimension with the emergence of new psychopathological figures.
La gruppoanalisi soggettuale e la terapia di gruppo: introduzione alla teoria e alla prassi
Anna Maria Ferraro,Emanuela Coppola,Girolamo Lo Verso
Narrare i Gruppi , 2012,
Abstract: rticle explains the theoretical foundations of the group-analysis approach, its main Italian developments, and its link with technique. In particular, after showing the hesitations of the original English model, it illustrates the Italian approach (Subjectual Groupanalysis), its evolution and dialogue with disciplines (complexity theory, cultural anthropology) that contributed to the foundation of its meta-psychological apparatus. Subsequently, it focuses on the relational foundation of psyche, on the therapeutic aspects linked to it, highlighting some key aspects of a classic group-analytic functioning, some of the main therapist’s responsibility, and some of the hardest troubles for the patients.
Synthesis and Biological Properties of Caffeic Acid-PNA Dimers Containing Guanine
Maria Gaglione,Gaetano Malgieri,Severina Pacifico,Valeria Severino,Brigida D'Abrosca,Luigi Russo,Antonio Fiorentino,Anna Messere
Molecules , 2013, DOI: 10.3390/molecules18089147
Abstract: Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is endowed with high antioxidant activity. CA derivatives (such as amides) have gained a lot of attention due to their antioxidative, antitumor and antimicrobial properties as well as stable characteristics. Caffeoyl-peptide derivatives showed different antioxidant activity depending on the type and the sequence of amino acid used. For these reasons, we decided to combine CA with Peptide Nucleic Acid (PNA) to test whether the new PNA-CA amide derivatives would result in an improvement or gain of CA’s biological ( i.e., antioxidant, cytotoxic, cytoprotective) properties. We performed the synthesis and characterization of seven dimer conjugates with various combinations of nucleic acid bases and focused NMR studies on the model compound ga-CA dimer. We demonstrate that PNA dimers containing guanine conjugated to CA exhibited different biological activities depending on composition and sequence of the nucleobases. The dimer ag-CA protected HepG2, SK-B-NE(2), and C6 cells from a cytotoxic dose of hydrogen peroxide (H 2O 2).
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