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Search Results: 1 - 10 of 170137 matches for " Margie E.; White "
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Adherence: a review of education, research, practice, and policy in the United States
Rickles,Nathaniel M.; Brown,Todd A.; McGivney,Melissa S.; Snyder,Margie E.; White,Kelsey A.;
Pharmacy Practice (Internet) , 2010, DOI: 10.4321/S1886-36552010000100001
Abstract: objective: to describe the education, research, practice, and policy related to pharmacist interventions to improve medication adherence in community settings in the united states. methods: authors used medline and international pharmaceutical abstracts (since 1990) to identify community and ambulatory pharmacy intervention studies which aimed to improve medication adherence. the authors also searched the primary literature using ovid to identify studies related to the pharmacy teaching of medication adherence. the bibliographies of relevant studies were reviewed in order to identify additional literature. we searched the tables of content of three us pharmacy education journals and reviewed the american association of colleges of pharmacy website for materials on teaching adherence principles. policies related to medication adherence were identified based on what was commonly known to the authors from professional experience, attendance at professional meetings, and pharmacy journals. results: research and practice: 29 studies were identified: 18 randomized controlled trials; 3 prospective cohort studies; 2 retrospective cohort studies; 5 case-controlled studies; and one other study. there was considerable variability in types of interventions and use of adherence measures. many of the interventions were completed by pharmacists with advanced clinical backgrounds and not typical of pharmacists in community settings. the positive intervention effects had either decreased or not been sustained after interventions were removed. although not formally assessed, in general, the average community pharmacy did not routinely assess and/or intervene on medication adherence. education: national pharmacy education groups support the need for pharmacists to learn and use adherence-related skills. educational efforts involving adherence have focused on students′ awareness of adherence barriers and communication skills needed to engage patients in behavioral change. policy: sever
Promoting Functional Health in Midlife and Old Age: Long-Term Protective Effects of Control Beliefs, Social Support, and Physical Exercise
Margie E. Lachman,Stefan Agrigoroaei
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013297
Abstract: Previous studies have examined physical risk factors in relation to functional health, but less work has focused on the protective role of psychological and social factors. We examined the individual and joint protective contribution of control beliefs, social support and physical exercise to changes in functional health, beyond the influence of health status and physical risk factors in middle-aged and older adults. Given that functional health typically declines throughout adulthood, it is important to identify modifiable factors that can be implemented to maintain functioning, improve quality of life, and reduce disability.
E Unibus Plurum: Genomic Analysis of an Experimentally Evolved Polymorphism in Escherichia coli
Margie A. Kinnersley,William E. Holben,Frank Rosenzweig
PLOS Genetics , 2009, DOI: 10.1371/journal.pgen.1000713
Abstract: Microbial populations founded by a single clone and propagated under resource limitation can become polymorphic. We sought to elucidate genetic mechanisms whereby a polymorphism evolved in Escherichia coli under glucose limitation and persisted because of cross-feeding among multiple adaptive clones. Apart from a 29 kb deletion in the dominant clone, no large-scale genomic changes distinguished evolved clones from their common ancestor. Using transcriptional profiling on co-evolved clones cultured separately under glucose-limitation we identified 180 genes significantly altered in expression relative to the common ancestor grown under similar conditions. Ninety of these were similarly expressed in all clones, and many of the genes affected (e.g., mglBAC, mglD, and lamB) are in operons coordinately regulated by CRP and/or rpoS. While the remaining significant expression differences were clone-specific, 93% were exhibited by the majority clone, many of which are controlled by global regulators, CRP and CpxR. When transcriptional profiling was performed on adaptive clones cultured together, many expression differences that distinguished the majority clone cultured in isolation were absent, suggesting that CpxR may be activated by overflow metabolites removed by cross-feeding strains in co-culture. Relative to their common ancestor, shared expression differences among adaptive clones were partly attributable to early-arising shared mutations in the trans-acting global regulator, rpoS, and the cis-acting regulator, mglO. Gene expression differences that distinguished clones may in part be explained by mutations in trans-acting regulators malT and glpK, and in cis-acting sequences of acs. In the founder, a cis-regulatory mutation in acs (acetyl CoA synthetase) and a structural mutation in glpR (glycerol-3-phosphate repressor) likely favored evolution of specialists that thrive on overflow metabolites. Later-arising mutations that led to specialization emphasize the importance of compensatory rather than gain-of-function mutations in this system. Taken together, these findings underscore the importance of regulatory change, founder genotype, and the biotic environment in the adaptive evolution of microbes.
Provision of clinical pharmacy services in two safety net provider settings
Connor,Sharon E.; Snyder,Margie E.; Snyder,Zachary J.; Steinmetz Pater,Karen;
Pharmacy Practice (Internet) , 2009, DOI: 10.4321/S1886-36552009000200005
Abstract: objective: the purpose of this report is to characterize the patient population served by the grace lamsam pharmacy program and to describe program outcomes. methods: a chart review was conducted for all patients (n=100) participating in the grace lamsam pharmacy program from january 1, 2007 to february 6, 2008. the primary outcome data collected were the medication related problems (unnecessary drug therapy, needs additional drug therapy, ineffective drug therapy, dosage too low, dosage too high, adverse drug reaction, noncompliance, and needs different drug product) identified by pharmacists, the number and type of pharmacist interventions made, estimated cost savings from perspective of the patient and clinical data (hemoglobin a1c, blood pressure measurements, and ldl-c) for patients with diabetes, hypertension, and hyperlipidemia, respectively. basic demographic data was collected, including: patient gender, age, education level, race/ethnicity, marital status, and income. patients' smoking status, type and number of medical conditions, medications being used at baseline, and number of pharmacist visits per patient during the study review period were also recorded. results: the majority of patients cared for were male, middle-aged, and african-american. the majority (90%) of patients had an income below 150% of the 2007 federal poverty level. patients were most commonly treated for diabetes, hypertension, and hyperlipidemia. during the period of review, 188 medication related problems were identified and documented with noncompliance being the most common medication related problem identified. pharmacists completed 477 pharmaceutical manufacturer assistance program applications for 68 patients. these interventions represented a cost savings from the patients' perspective of approximately 243 usd per month during the review period. blood pressure, a1c, and ldl-c readings improved in patients enrolled in the clinical pharmacy program at the free clinic and the co
Internet Transaction Anxiety & Recognition of Assurance Services
Clinton E. White, Jr.
International Journal of Digital Accounting Research , 2001,
Abstract: Many recent surveys and articles have shown that consumers have “Internettransaction anxiety.” This study explores specific transaction anxieties related to the servicesprovided by several prominent e-commerce assurance services. Results indicate thatconsumers are most concerned about their personal information both as it is being transmittedover the Internet and when it is being handled remotely by an e-commerce vendor. However,there is no significant relationship between having major reservations about purchasing viathe Internet and actually doing so. Also, the majority of subjects in this study did not recognizeassurance service seals designed to alleviate transaction anxieties. A personal safe shoppingguarantee from a reputable e-commerce vendor (e.g. Amazon.com) appears to be as effectiveat alleviating consumer anxiety as a Web assurance seal from an assurance service.
A First Map of the CMB at 0.5Deg Resolution
M. White,E. Bunn
Physics , 1994, DOI: 10.1086/187834
Abstract: We use a Maximum Entropy technique to reconstruct a map of the microwave sky near the star Gamma Ursae Minoris, based on data from flights 2, 3 and 4 of the Millimeter-wave Anisotropy eXperiment (MAX).
Fracture functions in the very forward limit
B. E. White
Physics , 1999, DOI: 10.1016/S0920-5632(00)00553-3
Abstract: This talk gives a brief discussion of extended fracture functions, which parametrise the non-perturbative physics in the target fragmentation region of semi-inclusive DIS. In the forward limit z -> 1, it can be seen that fracture functions can be identified with insertions of composite operators. This enables polarised fracture functions to be used to test a target-independence hypothesis of the ``proton spin effect''.
Stellar X-ray Binary Populations in Elliptical Galaxies
Raymond E. White III
Physics , 2001,
Abstract: Chandra's high angular resolution can resolve emission from stellar X-ray binaries out of the diffuse X-ray emission from gaseous atmospheres within elliptical galaxies. Variations in the X-ray binary populations (per unit galaxian optical luminosity) are correlated with variations in the specific frequency of globular clusters in ellipticals. This indicates that X-ray binaries are largely formed in globular clusters, rather than being a primordial field population.
Factorisation in Deeply Virtual Compton Scattering: Local OPE Formalism and Structure Functions
B. E. White
Physics , 2001, DOI: 10.1088/0954-3899/28/2/302
Abstract: We give a complete treatment of factorisation of Deeply Virtual Compton Scattering (DVCS) in the generalised Bjorken limit, using the local Operator Product Expansion (OPE). The method allows a straightforward proof that, at leading twist, the DVCS amplitude factorises into an integral over coefficient functions and Skewed Parton Distribution Functions (SPDFs). The integral is well defined for on-shell final state photon if the Wilson coefficients satisfy a certain factorisation condition, which we derive. We also show that it enables a simple proof that soft singularities either cancel out or, in the case where the final state photon is on shell, are integrable. This confirms the argument of Collins and Freund. Further, we repeat the tree-level calculation of twist-three contributions to DVCS off a scalar target, where factorisation was found to be violated. We propose a new definition of the structure functions and calculate the coefficient functions, which are such that factorisation works.
NASA's Future Missions in X-ray Astronomy
Nicholas E. White
Physics , 2002,
Abstract: The NASA program in X-ray astronomy has two long term goals: 1) to achieve sufficient angular resolution to image the event horizon of a black hole (0.1 micro arc sec) and 2) to achieve sufficient collecting area (50-150 sq m) and angular resolution (0.1-1.0 arc sec) to observe in detail the first black holes and galaxies at high redshift. These ambitous goals can be used to map out a series of missions and a technology program. The next major mission will be Constellation-X which will be dedicated to high resolution X-ray spectroscopy for launch in ~2010. This mission is a critical step in the roadmap to achieve these goals. Following Constellation-X NASA is considering two very ambitious vision missions: MAXIM and Generation-X that will achieve the ultimate capabilities. The modest missions Astro-E2 and Swift address more focussed science goals on a rapid development cycle and provide important pathfinders to the larger missions.
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