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Search Results: 1 - 10 of 404996 matches for " Margaret M. Chou "
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Conceptualization of Online Experience  [PDF]
Sophea Chea, Margaret M. Luo
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.37044

This paper proposes a paradigm shift from online service to online experience for online service management and practices. Online experience is conceptualized. The paper further discusses the opportunities and constraints of delivering online experience.

A Novel Role for MAPKAPK2 in Morphogenesis during Zebrafish Development
Beth A. Holloway,Sol Gomez de la Torre Canny equal contributor,Ying Ye equal contributor,Diane C. Slusarski,Christina M. Freisinger,Roland Dosch,Margaret M. Chou,Daniel S. Wagner ,Mary C. Mullins
PLOS Genetics , 2009, DOI: 10.1371/journal.pgen.1000413
Abstract: One of the earliest morphogenetic processes in the development of many animals is epiboly. In the zebrafish, epiboly ensues when the animally localized blastoderm cells spread, thin over, and enclose the vegetally localized yolk. Only a few factors are known to function in this fundamental process. We identified a maternal-effect mutant, betty boop (bbp), which displays a novel defect in epiboly, wherein the blastoderm margin constricts dramatically, precisely when half of the yolk cell is covered by the blastoderm, causing the yolk cell to burst. Whole-blastoderm transplants and mRNA microinjection rescue demonstrate that Bbp functions in the yolk cell to regulate epiboly. We positionally cloned the maternal-effect bbp mutant gene and identified it as the zebrafish homolog of the serine-threonine kinase Mitogen Activated Protein Kinase Activated Protein Kinase 2, or MAPKAPK2, which was not previously known to function in embryonic development. We show that the regulation of MAPKAPK2 is conserved and p38 MAP kinase functions upstream of MAPKAPK2 in regulating epiboly in the zebrafish embryo. Dramatic alterations in calcium dynamics, together with the massive marginal constrictive force observed in bbp mutants, indicate precocious constriction of an F-actin network within the yolk cell, which first forms at 50% epiboly and regulates epiboly progression. We show that MAPKAPK2 activity and its regulator p38 MAPK function in the yolk cell to regulate the process of epiboly, identifying a new pathway regulating this cell movement process. We postulate that a p38 MAPKAPK2 kinase cascade modulates the activity of F-actin at the yolk cell margin circumference allowing the gradual closure of the blastopore as epiboly progresses.
Assessing Clinical and Academic Performance in a Master’s Level Speech Language Pathology Program: A Path Analysis  [PDF]
Margaret M. Kjelgaard, Anthony J. Guarino
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.31023
Abstract: This study assessed a path model to determine the direct and indirect effects on clinical and academic success from students’ undergraduate and graduate performance. Astin’s I-E-O model served as the theoretical foundation for the hypothesized model. Input (I) data included students’ undergraduate information (GPA, major, and GRE scores); Environment (E) data included grades in required graduate courses and formative clinical evaluation; and Output (O) data included PRAXIS score and summative clinical evaluation. The sample was 122 students who completed a SLP Program at a New England graduate school. Results of the path analysis supported the efficacy of the proposed model in determining the direct and indirect effects on professional competence. Graduate students with an undergraduate degree in SLP were at a disadvantage upon entry to the program relative to students from other undergraduate majors. Implications of the study are discussed.
Influences on Adoption of Greenhouse Gas Reduction Targets among US States, 1998-2008  [PDF]
Tabitha M. Cale, Margaret A. Reams
Open Journal of Political Science (OJPS) , 2013, DOI: 10.4236/ojps.2013.31006

While the United States has not established federal regulations for greenhouse gas (GHG) reduction targets, many US states have adopted their own standards and guidelines. In this study we examine state adoption of targets for GHG reductions during the ten-year period of 1998-2008, and identify factors that explain variation in target adoption. Potential influences are drawn from research from the public policy formulation and diffusion literature, and from studies specific to climate policy adoption. Potential influences on GHG reduction efforts among US states include socioeconomic attributes of residents, political and ideological orientations of citizens and state government, interest group activities, environmental pressures, and proximity to other states that have adopted GHG reduction targets. The findings of the multinomial logistic regression analysis indicate that states are more likely to adopt GHG reduction targets if they share a border with another state with a similar climate program and if their citizens are more ideologically liberal. Other factors including socioeconomic resources and interest group activities were not found to be associated with policy adoption. The findings yield insights into the conditions under which states are more likely to take action to reduce GHG’s, and are relevant both to state policy makers and residents with an interest in climate planning, and for researchers attempting to estimate future greenhouse gas reduction scenarios.

Two cases of venous sinus thrombosis in women taking the oral contraceptive pill, Yaz (dropirenone/ ethinyl estradiol), and review of the literature  [PDF]
Margaret A. Riordan, Eric M. Deshaies
Health (Health) , 2013, DOI: 10.4236/health.2013.57A4013

Cerebral venous sinus thrombosis (CVT) is a rare cause of stroke and the clinical presentation is variable, thus mimicking other neurologic pathologies. One of the more common acquired risk factors of venous sinus thrombosis is oral contraceptive medications such as Yaz. While the prognosis for CVT is favorable, it is important to identify and treat early to prevent neurologic deficits. We report two cases of young female patients who presented with sinus thrombosis and review the current literature on this topic. CVT accounts for 0.5% of strokes and most commonly presents with headaches and in many cases focal neurologic deficits. Diagnosis is confirmed with neuroimaging including CT angiography or MR angiography. Treatment consists of anticoagulation and in some cases, thrombolytic therapy is beneficial. The overall prognosis of CVT is favorable but, further research is needed to outline optimal treatment options including the duration of anticoagulation therapy and the role of thrombolytic therapy to prevent serious neurologic deficits.

Evidence of Gene?Environment Interaction for Two Genes on Chromosome 4 and Environmental Tobacco Smoke in Controlling the Risk of Nonsyndromic Cleft Palate
Tao Wu, Holger Schwender, Ingo Ruczinski, Jeffrey C. Murray, Mary L. Marazita, Ronald G. Munger, Jacqueline B. Hetmanski, Margaret M. Parker, Ping Wang, Tanda Murray, Margaret Taub, Shuai Li, Richard J. Redett, M. Daniele Fallin, Kung Yee Liang, Yah Huei Wu-Chou, Samuel S. Chong, Vincent Yeow, Xiaoqian Ye, Hong Wang, Shangzhi Huang, Ethylin W. Jabs, Bing Shi, Allen J. Wilcox, Sun Ha Jee, Alan F. Scott, Terri H. Beaty
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088088
Abstract: Nonsyndromic cleft palate (CP) is one of the most common human birth defects and both genetic and environmental risk factors contribute to its etiology. We conducted a genome-wide association study (GWAS) using 550 CP case-parent trios ascertained in an international consortium. Stratified analysis among trios with different ancestries was performed to test for GxE interactions with common maternal exposures using conditional logistic regression models. While no single nucleotide polymorphism (SNP) achieved genome-wide significance when considered alone, markers in SLC2A9 and the neighboring WDR1 on chromosome 4p16.1 gave suggestive evidence of gene-environment interaction with environmental tobacco smoke (ETS) among 259 Asian trios when the models included a term for GxE interaction. Multiple SNPs in these two genes were associated with increased risk of nonsyndromic CP if the mother was exposed to ETS during the peri-conceptual period (3 months prior to conception through the first trimester). When maternal ETS was considered, fifteen of 135 SNPs mapping to SLC2A9 and 9 of 59 SNPs in WDR1 gave P values approaching genome-wide significance (10?6
Pro: Can neuropathology really confirm the exact diagnosis?
Margaret M Esiri
Alzheimer's Research & Therapy , 2010, DOI: 10.1186/alzrt33
Abstract: There was a time (up to the 1960s and 1970s) when few would have questioned that a neuropathological examination of the brain at autopsy was needed to make a diagnosis of Alzheimer's disease (AD). This was at a time when clinical diagnostic instruments and neuroimaging were in their infancy. It was also a time when dementia was clinically divided into pre-senile and senile forms and the AD pathological label was applied most confidently in pre-senile cases. Much has changed since then, and it is appropriate to ask whether neuropathology is still the gold standard by which to reach such a diagnosis.Many cases of clinical AD are correctly diagnosed in life if the person concerned is seen by a specialist with much experience of the condition. The proportion of cases correctly diagnosed will continue to climb if specialists have access to advancing imaging and other diagnostic procedures. The situation is different, however, if the diagnosis is made by someone without specialised knowledge or without access to state-of-the-art investigations.Even among cases seen by specialists there will be a few that defy a correct diagnosis either because they present atypically or because a rare disease is masquerading as clinical AD. I have seen both. Frontotemporal dementia and AD can sometimes be indistinguishable until microscopic sections have been examined. These cases cannot be correctly diagnosed without recourse to the microscope, and even then may fail to fit criteria for a diagnostic label. Only through the careful pathological assessment of such cases, however, often assisted by new pathological techniques (for example, new antibodies, genetic probes), will progress in delineating new or newly recognised diseases evolve.Although it may at present only be in the minority of cases that neuropathology is required to attach the correct diagnosis to a case of dementia, it can be difficult to predict in life which cases will fall into this category. Furthermore, diseases chang
Lipid emulsions
Robins, Margaret M.
Grasas y Aceites , 2000,
Abstract: Emulsions are liquid-liquid mixtures with one liquid contained as droplets within the other. The droplets are typically 1mm in diameter, and the properties of the emulsions are very dependent on the droplet structure, which is stabilised by surface-active emulsifier molecules. Most food emulsions are made from the raw ingredients using an homogenisation process to form small droplets. The paper describes methods of measuring droplet size and emulsion stability, and discusses the physical origin of emulsion texture, flavour and appearance. Las emulsiones son mezclas líquido-líquido con un líquido contenido en forma de gotas dentro de otro líquido. Las gotas tienen normalmente 1 mm de diámetro y las propiedades de las emulsiones dependen en gran medida de la estructura de la gota, la cual está estabilizada por las moléculas emulsionantes. La mayoría de las emulsiones alimenticias están constituidas a partir de materias primas usando un proceso de homogeneización que permite formar gotas peque as. El artículo describe métodos de medida del tama o de gota y estabilidad de las emulsiones, y discute el origen físico de la textura, flavor y apariencia de la emulsión.
The First National Congress of Scientists in Chile: The Popular Unity Government, Technology, Science, and Development / El Primer Congreso Nacional de Científicos en Chile: Unidad Popular, tecnología, ciencia y desarrollo
Margaret M. Power
Revista SudHistoria , 2011,
Abstract: This article explores how the Unidad Popular (UP) government (1970-1973) of Chile conceptualized the connection between its socialist model of development and science and technology. To do so it focuses on the UP-sponsored National Congress of Scientists, which was held in Santiago in July 1972. This Congress, which was the first of its kind organized in Chile, brought together UP officials, scientists, technologists, workers, and industrialists.
Convergence results for function spaces over o-minimal structures
Margaret E M Thomas
Journal of Logic and Analysis , 2012, DOI: 10.4115/jla.v4i0.136
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