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Search Results: 1 - 10 of 195448 matches for " Marcus D. Durham "
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CD4 Cell Counts at HIV Diagnosis among HIV Outpatient Study Participants, 2000–2009
Kate Buchacz,Carl Armon,Frank J. Palella,Rose K. Baker,Ellen Tedaldi,Marcus D. Durham,John T. Brooks
AIDS Research and Treatment , 2012, DOI: 10.1155/2012/869841
Abstract: Background. It is unclear if CD4 cell counts at HIV diagnosis have improved over a 10-year period of expanded HIV testing in the USA. Methods. We studied HOPS participants diagnosed with HIV infection ≤6 months prior to entry into care during 2000–2009. We assessed the correlates of CD4 count <200 cells/mm3 at HIV diagnosis (late HIV diagnosis) by logistic regression. Results. Of 1,203 eligible patients, 936 (78%) had a CD4 count within 3 months after HIV diagnosis. Median CD4 count at HIV diagnosis was 299 cells/mm3 and did not significantly improve over time ( ). Comparing periods 2000-2001 versus 2008-2009, respectively, 39% and 35% of patients had a late HIV diagnosis ( ). Independent correlates of late HIV diagnosis were having an HIV risk other than being MSM, age ≥35 years at diagnosis, and being of nonwhite race/ethnicity. Conclusions. There is need for routine universal HIV testing to reduce the frequency of late HIV diagnosis and increase opportunity for patient- and potentially population-level benefits associated with early antiretroviral treatment. 1. Introduction Recent HIV surveillance data suggest that approximately 33% of HIV-infected persons in the United States present for HIV testing late and have AIDS (CD4+ cell count <200?cells/mL or an AIDS-defining illness) within one year after HIV diagnosis [1, 2]. Patients are less likely to experience the full benefits of highly active combination antiretroviral (cART) therapy if they enter HIV care and initiate treatment at a CD4 count <350?cells/mm3 [3, 4]; the clinical cost is even more profound when the CD4 count is <200?cells/mm3 or the patient has already developed clinical AIDS [5–8]. In addition, persons who remain unaware of their HIV-positive status (estimated 21% to 25% of infected persons in the USA in recent years) [9, 10] may not only miss the benefits of earlier cART treatment, but are also more likely to remain chronically viremic and are thereby more likely to transmit HIV to their sexual and needle-sharing partners [9]. The CDC has been promoting strategies to encourage more widespread HIV screening to diagnose infected persons earlier in the course of their illness, including by releasing in 2006 the guidelines for implementing routine universal opt-out testing in healthcare settings [11]. Yet, the latest HIV surveillance data [1, 2] and epidemiologic studies in multiple US populations indicate that the proportion of persons who are diagnosed late in the course of HIV infection [2, 12, 13] or present late for HIV care [14, 15] remains unacceptably high. Stable or worsening
Acute coronary syndromes: an old age problem
Alexander D Simms,Philip D Batin,John Kurian,Nigel Durham
老年心脏病学杂志(英文版) , 2012,
Abstract: The increasing population in older age will lead to greater numbers of them presenting with acute coronary syndromes (ACS). This has implications on global healthcare resources and necessitates better management and selection for evidenced-based therapies. The elderly are a high risk group with more significant treatment benefits than younger ACS. Nevertheless, age related inequalities in ACS care are recognised and persist. This discrepancy in care, to some extent, is explained by the higher frequency of atypical and delayed presentations in the elderly, and less diagnostic electrocardiograms at presentation, potentiating a delay in ACS diagnosis. Under estimation of mortality risk in the elderly due to limited consideration for physiological frailty, co-morbidity, cognitive/psychological impairment and physical disability, less input by cardiology specialists and lack of randomised, controlled trials data to guide management in the elderly may further confound the inequality of care. While these inequalities exist, there remains a substantial opportunity to improve age related ACS outcomes. The selection of elderly patients for specific therapies and medication regimens are unanswered. There is a growing need for randomised, controlled trial data to be more representative of the population and enroll those of advanced age with co-morbidity. A lack of reporting of adverse events, such as renal impairment post coronary angiography, in the elderly further limit risk benefit decisions. Substantial improvements in care of elderly ACS patients are required and should be advocated. Ultimately, these improvements are likely to lead to better outcomes post ACS. However, the improvement in outcome is not infinite and will be limited by non-modifiable factors of age-related risk.
Los jóvenes y la imaginación social en áfrica: Introducción
Durham,Deborah;
Cuadernos de antropolog?-a social , 2011,
Abstract: youth are an increasingly compelling subject for study in africa, entering into political space in highly complex ways. to pay attention to youth is to pay close attention to the topology of the social landscape - to power and agency; public, national and domestic spaces and identities, and their articulation and disjuntures; memory, history, and sense of change; globalization and governance; gender and class. in this introduction i draw attention to how youth is constructed as a problematic category and how it acts as a "social shifter" engaging the social imagination, to how youth contributes to generational debates and constructions, and to how considerations of youth challenges our thinking about agency.
Web Reviews: Religious Institute—Denominational Statements
Erica Durham
Theological Librarianship , 2011,
Abstract:
Representation of Integers by Ternary Quadratic Forms: A Geometric Approach
Gabriel Durham
Mathematics , 2015,
Abstract: In 1957 N.C. Ankeny provided a new proof of the three squares theorem using geometry of numbers. This paper generalizes Ankeny's technique, proving exactly which integers are represented by $x^2 + 2y^2 + 2z^2$ and $x^2 + y^2 + 2z^2$ as well as proving sufficient conditions for an integer to be represented by $x^2+y^2+3z^2$ and $x^2 + y^2 + 7z^2$.
Acute coronary syndromes: an old age problem

Alexander D Simms,Philip D Batin,John Kurian,Nigel Durham,Christopher P Gale,

老年心脏病学杂志(英文版) , 2012,
Abstract: The increasing population in older age will lead to greater numbers of them presenting with acute coronary syndromes (ACS). This has implications on global healthcare resources and necessitates better management and selection for evidenced-based therapies. The elderly are a high risk group with more significant treatment benefits than younger ACS. Nevertheless, age related inequalities in ACS care are recognised and persist. This discrepancy in care, to some extent, is explained by the higher frequency of atypical and delayed presentations in the elderly, and less diagnostic electrocardiograms at presentation, potentiating a delay in ACS diagnosis. Under estimation of mortality risk in the elderly due to limited consideration for physiological frailty, co-morbidity, cognitive/psychological impairment and physical disability, less input by cardiology specialists and lack of randomised, controlled trials data to guide management in the elderly may further confound the inequality of care. While these inequalities exist, there remains a substantial opportunity to improve age related ACS outcomes. The selection of elderly patients for specific therapies and medication regimens are unanswered. There is a growing need for randomised, controlled trial data to be more representative of the population and enroll those of advanced age with co-morbidity. A lack of reporting of adverse events, such as renal impairment post coronary angiography, in the elderly further limit risk benefit decisions. Substantial improvements in care of elderly ACS patients are required and should be advocated. Ultimately, these improvements are likely to lead to better outcomes post ACS. However, the improvement in outcome is not infinite and will be limited by non-modifiable factors of age-related risk.
Reliable identification of mycobacterial species by PCR-restriction enzyme analysis (PRA)-hsp65 in a reference laboratory and elaboration of a sequence-based extended algorithm of PRA-hsp65 patterns
Erica Chimara, Lucilaine Ferrazoli, Suely Ueky, Maria Martins, Alan Durham, Robert D Arbeit, Sylvia Le?o
BMC Microbiology , 2008, DOI: 10.1186/1471-2180-8-48
Abstract: A total of 434 NTM isolates were obtained from 5019 cultures submitted to the Institute Adolpho Lutz, Sao Paulo Brazil, between January 2000 and January 2001. Species identification was performed for all isolates using conventional phenotypic methods and PRA-hsp65. For isolates for which these methods gave discordant results, definitive species identification was obtained by sequencing a 441 bp fragment of hsp65. Phenotypic evaluation and PRA-hsp65 were concordant for 321 (74%) isolates. These assignments were presumed to be correct. For the remaining 113 discordant isolates, definitive identification was based on sequencing a 441 bp fragment of hsp65. PRA-hsp65 identified 30 isolates with hsp65 alleles representing 13 previously unreported PRA-hsp65 patterns. Overall, species identification by PRA-hsp65 was significantly more accurate than by phenotype methods (392 (90.3%) vs. 338 (77.9%), respectively; p < .0001, Fisher's test). Among the 333 isolates representing the most common pathogenic species, PRA-hsp65 provided an incorrect result for only 1.2%.PRA-hsp65 is a rapid and highly reliable method and deserves consideration by any clinical microbiology laboratory charged with performing species identification of NTM.The genus Mycobacterium comprises organisms that are heterogeneous in terms of metabolism, growth, environmental niche, epidemiology, pathogenicity, geographic distribution and disease association [1]. While there are notable pathogens such as Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium leprae, most are environmental organisms typically acting as opportunistic pathogens. These species, often collectively called nontuberculous mycobacteria (NTM), have been associated with a variety of problems including pulmonary, lymph node, skin, soft tissue, skeletal, and disseminated infections as well as nosocomial outbreaks related to inadequate disinfection/sterilization of medical devices [2]. In recent years, infections due to the subset
A Case of DIPNECH and Review of the Current Literature  [PDF]
Patrick D. Mitchell, Marcus P. Kennedy, Michael T. Henry
Open Journal of Respiratory Diseases (OJRD) , 2013, DOI: 10.4236/ojrd.2013.32011
Abstract: Diffuse Idiopathic Neuroendocrine Cell Hyperplasia (DIPNECH) is a rare pulmonary disease. It was first described by Aguayo et al. in 1992, and recognised by the World Health Organisation in 2004 as a precursor lesion to the development of pulmonary carcinoid tumour. DIPNECH has been described in several isolated case reports and series. This article describes a case of DIPNECH and summaries the recent literature in an attempt to raise awareness of this disease and management options.
The Sphaleron Rate in SU(N) Gauge Theory
Guy D. Moore,Marcus Tassler
Physics , 2010, DOI: 10.1007/JHEP02(2011)105
Abstract: The sphaleron rate is defined as the diffusion constant for topological number NCS = int g^2 F Fdual/32 pi^2. It establishes the rate of equilibration of axial light quark number in QCD and is of interest both in electroweak baryogenesis and possibly in heavy ion collisions. We calculate the weak-coupling behavior of the SU(3) sphaleron rate, as well as making the most sensible extrapolation towards intermediate coupling which we can. We also study the behavior of the sphaleron rate at weak coupling at large Nc.
The Kernel-SME Filter for Multiple Target Tracking
Marcus Baum,Uwe D. Hanebeck
Computer Science , 2012,
Abstract: We present a novel method called Kernel-SME filter for tracking multiple targets when the association of the measurements to the targets is unknown. The method is a further development of the Symmetric Measurement Equation (SME) filter, which removes the data association uncertainty of the original measurement equation with the help of a symmetric transformation. The underlying idea of the Kernel-SME filter is to construct a symmetric transformation by means of mapping the measurements to a Gaussian mixture. This transformation is scalable to a large number of targets and allows for deriving a Gaussian state estimator that has a cubic time complexity in the number of targets.
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