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Search Results: 1 - 10 of 15212 matches for " Marco Casaccia "
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Sister Joseph's nodule in a liver transplant recipient: Case report and mini-review of literature
Fabrizio Panaro, Enzo Andorno, Stefano Di Domenico, Nicola Morelli, Giuliano Bottino, Rosalia Mondello, Marco Miggino, Tomasz M Jarzembowski, Ferruccio Ravazzoni, Marco Casaccia, Umberto Valente
World Journal of Surgical Oncology , 2005, DOI: 10.1186/1477-7819-3-4
Abstract: A 59-years-old Caucasian female underwent liver transplant for end stage liver disease due to hepatitis C with whole graft from cadaveric donor in 2003. After transplantation the patient developed multiple subcutaneous nodules in the umbilical region and bilateral inguinal lymphadenopathy. The excision biopsy of the umbilical mass showed the features of a poorly differentiated papillary serous cystadenocarcinoma. Computed tomographic scan and transvaginal ultrasonography were unable to demonstrate any primary lesion. Chemotherapy was start and the dosage of the immunosuppressive drugs was reduced. To date the patient is doing well and liver function is normal.The umbilical metastasis can arise from many sites. In some cases, primary tumor may be not identified; nonetheless chemotherapy must be administrated based on patient's history, anatomical and histological findings.Metastases to the umbilicus are universally referred to as Sister Joseph's (or Sister Mary Joseph's) nodule. Etiology is related to the presence of primary malignant disease in the abdominal cavity or occasionally in the chest and/or breast [1-5]. Historically, Sister Mary Joseph (1856–1939) was a surgical assistant under the guidance of Dr. William Mayo. She was the first one to note the connection between the umbilical nodule and intra-abdominal cancer. The first case reporting the presence of Sister Mary Joseph's nodule was in 1864 by Storer, however; Hamilton Bailey was the first one to use the term "Sister Mary Joseph's nodule.Although skin metastasis is rare and range between 5% and 9%, it is estimated that 1% to 3% of abdomino-pelvic tumors metastasize to the umbilicus [2,3,5]. The most common primary neoplasm is adenocarcinoma (75%), more rarely squamous cell carcinoma followed by undifferentiated tumors or carcinoid can metastasize to umbilicus. In men, gastrointestinal tract (55%) is the most common location of the primary neoplasm that metastasizes to the umbilicus, followed by stomach, c
El reclamo territorial Ayoreo Totobiegosode
Casaccia,Gladys Margarita;
Av?? , 2009,
Abstract: the legal-administrative process started in 1993 before the paraguayan governmental powers to claim part of the land of the totobiegosode, an indigenous local group of the ayoreo people, is a unique experience in the country. in the process, the legal instruments that guarantee the rights of the indigenous people are not only tested with regards to the coherence of its principles, regulations and procedures, but also with regards to the constraints of the socio-political context. this paper explains the interdisciplinary approach of joint management between the ayoreo totobiegosode and non-indigenous team of professionals, such as the different aspects managed during the land claims: ethnic, environmental, cultural heritage and human rights. the existence of sub-groups of totobiegosode without contact with the surrounding society, currently called "in isolation", and the accelerated transformation of the paraguayan chaco region, are particular conditions of the ongoing procedures.
El reclamo territorial Ayoreo Totobiegosode
Gladys Margarita Casaccia
Avá : Revista de Antropología , 2009,
Abstract: El proceso jurídico-administrativo abierto en 1993 ante los poderes del Estado Paraguayo para la reivindicación de una parte del territorio de los Totobiegosode, grupo local del pueblo Ayoreo, es experiencia singular en el país. En el proceso, los instrumentos jurídicos que garantizan derechos de los pueblos indígenas están sometidos a prueba no sólo en lo relativo a la coherencia de sus postulados, disposiciones y procedimientos, sino también en función a las constricciones del contexto socio-político. El trabajo expone el abordaje interdisciplinario de la gestión conjunta entre los Ayoreo Totobiegosode y profesionales no indígenas, como las distintas dimensiones administradas en la reivindicación territorial: étnica, ambiental, patrimonial cultural y de derechos humanos. La existencia de sub-grupos Totobiegosode sin contacto con la sociedad envolvente, y la transformación acelerada de la región del Chaco Paraguayo, son condiciones particulares de los trámites aún en curso. The legal-administrative process started in 1993 before the Paraguayan governmental powers to claim part of the land of the Totobiegosode, an indigenous local group of the Ayoreo people, is a unique experience in the country. In the process, the legal instruments that guarantee the rights of the indigenous people are not only tested with regards to the coherence of its principles, regulations and procedures, but also with regards to the constraints of the socio-political context. This paper explains the interdisciplinary approach of joint management between the Ayoreo Totobiegosode and non-indigenous team of professionals, such as the different aspects managed during the land claims: ethnic, environmental, cultural heritage and human rights. The existence of sub-groups of Totobiegosode without contact with the surrounding society, currently called "in isolation", and the accelerated transformation of the Paraguayan Chaco region, are particular conditions of the ongoing procedures.
Two-Stage Liver Transplantation with Temporary Porto-Middle Hepatic Vein Shunt
Giovanni Varotti,Enzo Andorno,Marco Casaccia,Stefano Di Domenico,Giuliano Bottino,Pietro Diviacco,Nicola Morelli,Chiara Ferrari,Roberto Ferrante,Umberto Valente
Journal of Transplantation , 2010, DOI: 10.1155/2010/570392
Abstract: Two-stage liver transplantation (LT) has been reported for cases of fulminant liver failure that can lead to toxic hepatic syndrome, or massive hemorrhages resulting in uncontrollable bleeding. Technically, the first stage of the procedure consists of a total hepatectomy with preservation of the recipient's inferior vena cava (IVC), followed by the creation of a temporary end-to-side porto-caval shunt (TPCS). The second stage consists of removing the TPCS and implanting a liver graft when one becomes available. We report a case of a two-stage total hepatectomy and LT in which a temporary end-to-end anastomosis between the portal vein and the middle hepatic vein (TPMHV) was performed as an alternative to the classic end-to-end TPCS. The creation of a TPMHV proved technically feasible and showed some advantages compared to the standard TPCS. In cases in which a two-stage LT with side-to-side caval reconstruction is utilized, TPMHV can be considered as a safe and effective alternative to standard TPCS.
Two-Stage Liver Transplantation with Temporary Porto-Middle Hepatic Vein Shunt
Giovanni Varotti,Enzo Andorno,Marco Casaccia,Stefano Di Domenico,Giuliano Bottino,Pietro Diviacco,Nicola Morelli,Chiara Ferrari,Roberto Ferrante,Umberto Valente
Journal of Transplantation , 2010, DOI: 10.1155/2010/570392
Abstract: Two-stage liver transplantation (LT) has been reported for cases of fulminant liver failure that can lead to toxic hepatic syndrome, or massive hemorrhages resulting in uncontrollable bleeding. Technically, the first stage of the procedure consists of a total hepatectomy with preservation of the recipient's inferior vena cava (IVC), followed by the creation of a temporary end-to-side porto-caval shunt (TPCS). The second stage consists of removing the TPCS and implanting a liver graft when one becomes available. We report a case of a two-stage total hepatectomy and LT in which a temporary end-to-end anastomosis between the portal vein and the middle hepatic vein (TPMHV) was performed as an alternative to the classic end-to-end TPCS. The creation of a TPMHV proved technically feasible and showed some advantages compared to the standard TPCS. In cases in which a two-stage LT with side-to-side caval reconstruction is utilized, TPMHV can be considered as a safe and effective alternative to standard TPCS. 1. Introduction The two-stage total hepatectomy with temporary portocaval shunt and subsequent liver transplantation (LT) were first described by Ringe et al. [1] in 1988. The rationale for the procedure is based upon the concept that patients with fulminant hepatic failure or graft failure that can lead to a toxic hepatic syndrome, or massive haemorrhages resulting in uncontrollable bleeding, can benefit from urgent removal of the native liver followed by LT when an organ becomes available [2, 3]. The first stage of the procedure consists of a total hepatectomy with preservation of the recipient’s inferior vena cava (IVC) and suture of the three hepatic veins. Then a temporary end-to-side portocaval shunt (TPCS) is created to re-establish the splanchnic outflow during the anhepatic phase. The second stage consists of removing the TPCS and implanting the liver graft when one becomes available [4]. We report a case of a two-stage total hepatectomy and LT in which a temporary end-to-end anastomosis between the portal vein and the middle hepatic vein (TPMHV) was performed as an alternative to the classic end-to-end TPCS. 2. Case Report A 43-year-old woman underwent urgent laparotomy for spontaneous massive rupture of a subcapsular liver hematoma associated with HELLP syndrome. The right lobe of the liver was entirely replaced by a large hematoma and areas of necrosis, and there were deep ruptures in both lobes. After establishing that neither conservative surgical treatments nor partial resections would have been effective; a total hepatectomy was performed to
Serotonina e controle hipotalamico da fome: uma revis?o
Feijó, Fernanda de Matos;Bertoluci, Marcello Casaccia;Reis, Cíntia;
Revista da Associa??o Médica Brasileira , 2011, DOI: 10.1590/S0104-42302011000100020
Abstract: this paper reviews involvement of the serotonergic system in the control of food intake and satiety. it is of great interest to understand the relevance of this system for physiological control of energy balance and obesity. over 35 years of research suggest that serotonin (5-ht) plays an important role in satiety. thus, the serotonergic system has been a viable target for weight control. the 5-ht has control over hunger and satiety through different receptors with distinct functions. the 5-ht2c receptor may be more important in the relationship between food intake and energy balance. this review will discuss the mechanisms of the serotonergic system involved in the control of food intake and satiety.
Norovirus in bivalve molluscs: a study of the efficacy of the depuration system
Giovanni Savini,Claudia Casaccia,Nadia B. Barile,Massimiliano Paoletti
Veterinaria Italiana , 2009,
Abstract: Noroviruses are the most common viral agents of acute gastroenteritis in humans and are often associated with the consumption of either fresh or undercooked live bivalve molluscs. The aim of the study was to evaluate the efficacy of the water depuration systems in the presence of Norovirus contamination A total of 96 shellfish samples was examined by reverse transcriptase-polymerase chain reaction, as follows: 58 mussel samples (Mytilus galloprovincialis), 35 Manila clam samples (Tapes decussatus) and 3 Pacific oyster samples (Crassostrea gigas). Of these, 67 were collected before and 29 following depuration. Viral RNA was detected in one of the 67 non-depurated samples examined (1.5%; 95% confidence interval: 0.36-7.92%) and in one of the 29 depurated samples (3.4%; 95% confidence interval: 0.82-17.22%). There were no statistically significant differences between depurated and non-depurated samples which indicated that the purifying systems in place were not able to remove Norovirus contamination from the live bivalve molluscs.
Presenza di Norovirus in molluschi bivalvi e verifica dell'efficacia dei sistemi di depurazione
Giovanni Savini,Claudia Casaccia,Nadia B. Barile,Massimiliano Paoletti
Veterinaria Italiana , 2009,
Abstract: I Norovirus rappresentano una delle maggiori cause di gastroenterite acuta virale nell’uomo spesso associate a tossinfezioni alimentari attraverso il consumo di molluschi crudi. Lo scopo del lavoro è stato di valutare l’efficacia dei sistemi di depurazione attualmente in uso per la purificazione dei molluschi bivalvi nei confronti dei Norovirus. Un totale di 96 campioni di molluschi bivalvi sono stati esaminati attraverso RT-PCR: 58 campioni di cozze (Mytilus galloprovincialis) di cui 11 depurati, 35 campioni di vongole veraci (Tapes decussatus), di cui 15 depurati e 3 campioni di ostriche (Crassostrea gigas) tutti depurati. I risultati ottenuti hanno evidenziato presenza di RNA virale in uno dei 67 campioni non depurati (1.5% intervallo di confidenza 95%, 0.36-7.92%) e in uno dei 29 campioni sottoposti a depurazione (3.4% intervallo di confidenza 95%, 0.82-17.22%). L’elaborazione statistica dei dati ha dimostrato che non esiste differenza statisticamente significativa tra campioni sottoposti a depurazione e quelli non depurati e quindi che i sistemi attualmente proposti non sono in grado di purificare i molluschi bivalvi dalla presenza di norovirus.
Epigenetic Modifiers Are Necessary but Not Sufficient for Reprogramming Non-Myelinating Cells into Myelin Gene-Expressing Cells
Jia Liu,Juan Sandoval,Sung Tae Doh,Li Cai,Gerardo López-Rodas,Patrizia Casaccia
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013023
Abstract: Modifications on specific histone residues and DNA methylation play an essential role in lineage choice and cellular reprogramming. We have previously shown that histone modifications or combinatorial codes of transcription factors (TFs) are critical for the differentiation of multipotential progenitors into myelinating oligodendrocytes. In this study we asked whether combining global manipulation of DNA methylation and histone acetylation together with the expression of oligodendrocyte- specific TFs, was sufficient to switch the identity of fibroblasts into myelin gene-expressing cells.
Identification of a Gene Regulatory Network Necessary for the Initiation of Oligodendrocyte Differentiation
Victoria A. Swiss,Tung Nguyen,Jason Dugas,Adiljan Ibrahim,Ben Barres,Ioannis P. Androulakis,Patrizia Casaccia
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018088
Abstract: Differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes requires extensive changes in gene expression, which are partly mediated by post-translational modifications of nucleosomal histones. An essential modification for oligodendrocyte differentiation is the removal of acetyl groups from lysine residues which is catalyzed by histone deacetylases (HDACs). The transcriptional targets of HDAC activity within OPCs however, have remained elusive and have been identified in this study by interrogating the oligodendrocyte transcriptome. Using a novel algorithm that allows clustering of gene transcripts according to expression kinetics and expression levels, we defined major waves of co-regulated genes. The initial overall decrease in gene expression was followed by the up-regulation of genes involved in lipid metabolism and myelination. Functional annotation of the down-regulated gene clusters identified transcripts involved in cell cycle regulation, transcription, and RNA processing. To define whether these genes were the targets of HDAC activity, we cultured rat OPCs in the presence of trichostatin A (TSA), an HDAC inhibitor previously shown to inhibit oligodendrocyte differentiation. By overlaying the defined oligodendrocyte transcriptome with the list of ‘TSA sensitive’ genes, we determined that a high percentage of ‘TSA sensitive’ genes are part of a normal program of oligodendrocyte differentiation. TSA treatment increased the expression of genes whose down-regulation occurs very early after induction of OPC differentiation, but did not affect the expression of genes with a slower kinetic. Among the increased ‘TSA sensitive’ genes we detected several transcription factors including Id2, Egr1, and Sox11, whose down-regulation is critical for OPC differentiation. Thus, HDAC target genes include clusters of co-regulated genes involved in transcriptional repression. These results support a de-repression model of oligodendrocyte lineage progression that relies on the concurrent down-regulation of several inhibitors of differentiation.
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