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Search Results: 1 - 10 of 20 matches for " Marchioli "
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Press o arterial e freqüência cardíaca avaliadas pela MAPA em primigestasdurante o trabalho de parto e puerpério imediato
Marchioli Milton
Revista Brasileira de Ginecologia e Obstetrícia , 2004,
Abstract:
Why Do We Still Need Large Scale Clinical Trial: The Case of n?3 PUFA
Roberto Marchioli,Giacomo Levantesi
Frontiers in Physiology , 2012, DOI: 10.3389/fphys.2012.00202
Abstract: After the first reports about a protective effect on coronary heart disease (CHD) published more than 40 years ago, wide interest in the therapeutic use of n?3 polyunsaturated fatty acids (n?3 PUFA) aroused. Since then, many studies and meta-analyses have reported a significantly reduced risk of CHD and CV death due to fish and n?3 PUFA intake. Some of the overviews reported a significant reduction of risk of sudden cardiac death, all-cause death, and nonfatal CV events. On the other side, recent clinical trials had mixed findings, raising concern about the consistency of the evidence on n?3 PUFA. We critically reviewed recent large clinical trials reporting data on the antiarrhythmic effects of n?3 PUFA in different clinical settings, i.e., patients with CHD, heart failure, with implantable cardioverter defibrillator, and at risk of atrial fibrillation, in order to summarize the results which are available up to date and possibly give “substantiated” fuel to the debate on the conflicting results of n?3 PUFA.
Turbulent breakage of ductile aggregates
Cristian Marchioli,Alfredo Soldati
Physics , 2015, DOI: 10.1103/PhysRevE.91.053003
Abstract: In this paper we study breakage rate statistics of small colloidal aggregates in non-homogeneous anisotropic turbulence. We use pseudo-spectral direct numerical simulation of turbulent channel flow and Lagrangian tracking to follow the motion of the aggregates, modelled as sub-Kolmogorov massless particles. We focus specifically on the effects produced by ductile rupture: This rupture is initially activated when fluctuating hydrodynamic stresses exceed a critical value, $\sigma>\sigma_{cr}$, and is brought to completion when the energy absorbed by the aggregate meets the critical breakage value. We show that ductile rupture breakage rates are significantly reduced with respect to the case of instantaneous brittle rupture (i.e. breakage occurs as soon as $\sigma>\sigma_{cr}$). These discrepancies are due to the different energy values at play as well as to the statistical features of energy distribution in the anisotropic turbulence case examined.
Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease
Giacomo Levantesi, Maria Giuseppina Silletta, Roberto Marchioli
Journal of Multidisciplinary Healthcare , 2010, DOI: http://dx.doi.org/10.2147/JMDH.S4743
Abstract: es and benefits of omega-3 ethyl esters in patients with cardiovascular disease Review (5474) Total Article Views Authors: Giacomo Levantesi, Maria Giuseppina Silletta, Roberto Marchioli Published Date July 2010 Volume 2010:3 Pages 79 - 96 DOI: http://dx.doi.org/10.2147/JMDH.S4743 Giacomo Levantesi, Maria Giuseppina Silletta, Roberto Marchioli Laboratory of Clinical Epidemiology of Cardiovascular Disease, Consorzio Mario Negri Sud, Chieti, Italy Abstract: Much evidence on the favorable effects of omega-3 ethyl esters on cardiovascular morbidity and mortality has been obtained in studies performed in healthy subjects and in different clinical settings. Here the clinical effects of omega-3 ethyl ester administration in patients with previous myocardial infarction or heart failure are reviewed, together with a discussion of underlying mechanisms of action. The pharmacokinetic and pharmacodynamic properties of omega-3 ethyl esters, as well as evidence concerning their safety and tolerability, are also reported.
Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease
Giacomo Levantesi,Maria Giuseppina Silletta,Roberto Marchioli
Journal of Multidisciplinary Healthcare , 2010,
Abstract: Giacomo Levantesi, Maria Giuseppina Silletta, Roberto MarchioliLaboratory of Clinical Epidemiology of Cardiovascular Disease, Consorzio Mario Negri Sud, Chieti, ItalyAbstract: Much evidence on the favorable effects of omega-3 ethyl esters on cardiovascular morbidity and mortality has been obtained in studies performed in healthy subjects and in different clinical settings. Here the clinical effects of omega-3 ethyl ester administration in patients with previous myocardial infarction or heart failure are reviewed, together with a discussion of underlying mechanisms of action. The pharmacokinetic and pharmacodynamic properties of omega-3 ethyl esters, as well as evidence concerning their safety and tolerability, are also reported.Keywords: omega-3 ethyl esters, myocardial infarction, heart failure
Some issues concerning Large-Eddy Simulation of inertial particle dispersion in turbulent bounded flows
C. Marchioli,M. V. Salvetti,A. Soldati
Physics , 2008, DOI: 10.1063/1.2911018
Abstract: The problem of an accurate Eulerian-Lagrangian modeling of inertial particle dispersion in Large Eddy Simulation (LES) of turbulent wall-bounded flows is addressed. We run Direct Numerical Simulation (DNS) for turbulent channel flow at shear Reynolds numbers equal to 150 and 300 and corresponding a-priori and a-posteriori LES on differently coarse grids. We then tracked swarms of different inertia particles and we examined the influence of filtering and of Sub-Grid Scale (SGS) modeling for the fluid phase on particle velocity and concentration statistics. We also focused on how particle preferential segregation is predicted by LES. Results show that even ``well-resolved'' LES is unable to reproduce the physics as demonstrated by DNS, both for particle accumulation at the wall and for particle preferential segregation. Inaccurate prediction is observed for the entire range of particles considered in this study, even when the particle response time is much larger than the flow timescales not resolved in LES. Both a-priori and a-posteriori tests indicate that recovering the level of fluid and particle velocity fluctuations is not enough to have accurate prediction of near-wall accumulation and local segregation. This may suggest that reintroducing the correct amount of higher-order moments of the velocity fluctuations is also a key point for SGS closure models for the particle equation. Another important issue is the presence of possible flow Reynolds number effects on particle dispersion. Our results show that, in small Reynolds number turbulence and in the case of heavy particles, the shear fluid velocity is a suitable scaling parameter to quantify these effects.
Direct Numerical Simulation of Turbulent Heat Transfer Modulation in Micro-Dispersed Channel Flow
Francesco Zonta,Cristian Marchioli,Alfredo Soldati
Physics , 2008, DOI: 10.1007/s00707-007-0552-7
Abstract: The object of this paper is to study the influence of dispersed micrometer size particles on turbulent heat transfer mechanisms in wall-bounded flows. The strategic target of the current research is to set up a methodology to size and design new-concept heat transfer fluids with properties given by those of the base fluid modulated by the presence of dynamically-interacting, suitably-chosen, discrete micro- and nano- particles. We run Direct Numerical Simulation (DNS) for hydrodynamically fully-developed, thermally-developing turbulent channel flow at shear Reynolds number Re=150 and Prandtl number Pr=3, and we tracked two large swarms of particles, characterized by different inertia and thermal inertia. Preliminary results on velocity and temperature statistics for both phases show that, with respect to single-phase flow, heat transfer fluxes at the walls increase by roughly 2% when the flow is laden with the smaller particles, which exhibit a rather persistent stability against non-homogeneous distribution and near-wall concentration. An opposite trend (slight heat transfer flux decrease) is observed when the larger particles are dispersed into the flow. These results are consistent with previous experimental findings and are discussed in the frame of the current research activities in the field. Future developments are also outlined.
Time persistency of floating particle clusters in free-surface turbulence
Salvatore Lovecchio,Cristian Marchioli,Alfredo Soldati
Physics , 2013, DOI: 10.1103/PhysRevE.88.033003
Abstract: We study the dispersion of light particles floating on a flat shear-free surface of an open channel in which the flow is turbulent. This configuration mimics the motion of buoyant matter (e.g. phytoplankton, pollutants or nutrients) in water bodies when surface waves and ripples are smooth or absent. We perform direct numerical simulation of turbulence coupled with Lagrangian particle tracking, considering different values of the shear Reynolds number (Re{\tau} = 171 and 509) and of the Stokes number (0.06 < St < 1 in viscous units). Results show that particle buoyancy induces clusters that evolve towards a long-term fractal distribution in a time much longer than the Lagrangian integral fluid time scale, indicating that such clusters over-live the surface turbulent structures which produced them. We quantify cluster dynamics, crucial when modeling dispersion in free-surface flow turbulence, via the time evolution of the cluster correlation dimension.
Press?o arterial e freqüência cardíaca avaliadas pela MAPA em primigestas durante o trabalho de parto e puerpério imediato
Marchioli, Milton;Abbade, Joélcio Francisco;Pera?oli, José Carlos;
Revista Brasileira de Ginecologia e Obstetrícia , 2004, DOI: 10.1590/S0100-72032004000500008
Abstract: objective: to analyze the maternal blood pressure and heart rate variation of primigravid women during labor and early puerperium. methods: sixty primigravid women were included in the study, and submitted to ambulatory blood pressure monitoring (abpm) with spacelabs 90207 monitor during labor and the first 12 h of puerperium. the records of blood pressure and heart rate were done every 15 min during labor and every 30 min during the first 12 h of puerperium. three periods during labor (until cervix dilated 7 cm, cervix dilated between 8 cm and total dilatation, and delivery period) and two during puerperium (first and twelfth hours), were analyzed. first of all the results were analyzed without considering the kind of analgesia used and then the patients were divided into three groups, according to the anesthetic technique: local, lumbar extradural or subarachnoid. results were analyzed by one-way analysis of variance (anova) and paired student's t-test for blood pressure and heart rate in each group during labor and puerperium. the nonpaired student's t-test was used to compare different groups. a p value < 0.05 was regarded as statistically significant. results: when the results were analyzed without considering the analgesic procedure, the values of systolic blood pressure during labor were significantly higher than in early puerperium. during labor, systolic blood pressure values were higher in the periods of later cervical dilatation and delivery than during early cervical dilatation. in the 12th h of puerperium the systolic blood pressure was lower than in the first hour. diastolic blood pressure did not change during labor and was higher than in early puerperium. heart rate increased during labor and decreased during puerperium. the systolic and diastolic blood pressure and heart rate were the same both in local or lumbar extradural anesthesia groups; however, in the subarachnoid group the systolic and diastolic blood pressure did not change during labor. co
Análisis de procedencia de la Formación Falda Ciénaga (Ordovícico Medio, Puna Argentina) por petrografía sedimentaria, elementos trazas e isotopía de Nd Provenance studies of the Falda Ciénaga Formation (Middle Ordovivian, Argentinean Puna) using sedimentary petrography, trace elements and Nd isotopes
Udo Zimmermann,Gabriela Luna Tula,Alfredo Marchioli,Gaspar Narváez
Revista de la Asociación Argentina de Sedimentología , 2002,
Abstract: La Formación Falda Ciénaga aflora entre Salar de Pocitos (24°24'59,5''S 66°55'18,0''W) y la Sierra Calalaste (26°11'52,5''S 67°41'02''W) en la Puna Austral. Incluye arenitas feldespáticas, cuarzosas de grano fino, bien seleccionadas, con cuarzos redondeados; grauvacas subordinadas dominadas por cuarzo y líticos sedimentarios, limolitas y pelitas. Las composiciones de arenitas y grauvacas varían entre 65-78 % Qt , 3-19 % F y 0-22 % L. Las sedimentitas no contienen líticos volcanogénicos ni rocas volcánicas sinsedimentarias. El material fue transportado de fuentes ubicadas al sudoeste y sudeste. Los elementos trazas y tierras raras muestran relaciones muy típicas para la corteza continental superior diferenciada (Th/Sc 0,75-2,81, promedio 1,8; Th/U 3-5,9, promedio 4,15; LaN/YbN 4,69-8,57, promedio 6,75). Una suave anomalía negativa de Ta en algunas muestras reflejaría la influencia del material volcanoclástico, que se interpreta como relicto del arco volcánico activo en el Ordovícico Inferior en el borde oeste de Gondwana (Arco volcánico Puna-Famatina). No ha sido posible observar este registro en la petrografía de los líticos. Debido a ciclos de resedimentación esta información desapareció en el registro petrográfico. Las concentraciones de Hf, Co, Th, Sc y La muestran una procedencia de un margen pasivo, lo que está acuerdo con la petrografía de los componentes modales. Los primeros datos isotópicos indican eNdtsed=450Ma entre -6 y -4,5 y T DM de 1,4 -1,6 Ga. Estos datos isotópicos son similares a las características de las probables fuentes de aporte de la Formación Puncoviscana y magmatitas así como metamorfitas de las Sierras Pampeanas. No es posible observar este registro en la petrografía de los líticos. Un modelo que favorece una fuente con diferentes rocas plutónicas y metamórficas como las Sierras Pampeanas, especialmente la Formación Puncoviscana y sus equivalentes, mezclado con un aporte de rocas magmáticas de la Sierra Famatina es coherente con los datos petrológicos, elementos trazas y de la isotopía de Nd. Se sugiere que esta formación podría representar el momento donde estuvo ausente el vulcanismo del arco-continental Puna-Famatina, activo desde el Tremadociano (Superior?) y es comparable con el Sistema Turbiditas Superior en la Puna Septentrional. The objective of this paper is to provide a provenance study of the Falda Ciénaga Formation and a paleotectonic scenario for the Middle Ordovician combining new data with published information from Ordovician sedimentary successions of the Puna, a highland in the northwestern part of Argentina.
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