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Search Results: 1 - 10 of 159252 matches for " Marcelo B. Menezes "
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Mass radius relation of compact stars in the braneworld
Luis B. Castro,Marcelo D. Alloy,Débora P. Menezes
Physics , 2014, DOI: 10.1088/1475-7516/2014/08/047
Abstract: The braneworld scenario, based on the fact that the four dimension space-time is a hyper-surface of a five dimensional manifold, was shown to deal in a satisfactory way with the hierarchy problem. In this work we study macroscopic stellar properties of compact stars from the braneworld point of view. Using neutron star equations of state, we test the possibility of extra dimensions by solving the brane Tolman-Oppenheimer-Volkoff equations obtained for three kinds of possible compact objects: hadronic, hybrid and quark stars. By comparing the macroscopic solutions with observational constraints, we establish a brane tension lower limit and the value for which the Tolman-Oppenheimer-Volkoff equations in the braneworld converge to the usual Tolman-Oppenheimer-Volkoff equations.
Muta o BRAF em pacientes idosos submetidos à tireoidectomia BRAF mutation in the elderly submitted to thyroidectomy
Antonio Augusto T. Bertelli,Antonio José Gon?alves,Marcelo B. Menezes,Murilo R. Melo
Revista do Colégio Brasileiro de Cirurgi?es , 2013,
Abstract: OBJETIVO: Avaliar a frequência da muta o V600E do gene BRAF em pacientes com mais de 65 anos de idade submetidos à tireoidectomia, correlacionando sua presen a ou ausência com as diferentes les es histológicas, com as variantes e com fatores prognósticos do carcinoma papilífero. MéTODOS: Foram avaliados 85 pacientes com mais de 65 anos de idade submetidos à tireoidectomia, analisando a muta o BRAF V600E através de rea o de PCR-RT realizada após a extra o do DNA dos blocos de parafina. RESULTADOS: Detectou-se ausência ou presen a da muta o BRAF V600E em 47 pacientes (55,3%). Entre os 17 carcinomas papilíferos estudados, sete apresentavam a muta o (41,2%). Demonstrou-se associa o estatística entre a presen a desta muta o e a variante clássica do carcinoma papilífero, além de tendência de associa o com o extravasamento tireoideano. CONCLUS O: A muta o BRAF nos pacientes idosos também é exclusiva do carcinoma papilífero e tem frequência expressiva. Além disso, está relacionada à variante clássica e, possivelmente, ao extravasamento tireoideano. OBJECTIVE: To evaluate the frequency of the BRAF V600E mutation in patients over 65 years of age undergoing thyroidectomy, correlating its presence or absence with the different histologic lesions, their variants and with prognostic factors of papillary carcinoma. METHODS: We evaluated 85 patients over 65 years of age who underwent thyroidectomy, analyzing the BRAF V600E mutation by RT-PCR performed after DNA extraction from the paraffin blocks. RESULTS: The study detected the presence or absence of BRAF V600E mutation in 47 patients (55.3%). Among the 17 papillary carcinomas studied, seven had the mutation (41.2%). There was a statistical association between the presence of this mutation and the classic variant of papillary carcinoma, and a trend of association with thyroid extravasation. CONCLUSION: BRAF mutation in the elderly is also exclusive of papillary carcinoma and is often significant. Furthermore, it is related to the classic variant and possibly to thyroid extravasation.
A Novel Approach for Inferring the Proportion of Terrestrial Organic Matter Input to Marine Sediments on the Basis of TOC:TN and δ13Corg Signatures  [PDF]
Antonio Fernando Menezes Freire, Marcelo Costa Monteiro
Open Journal of Marine Science (OJMS) , 2013, DOI: 10.4236/ojms.2013.32009
Abstract:

The ratio of total organic carbon to total nitrogen (TOC:TN) and the stable carbon isotope ratio of organic matter (δ13Corg) are widely applied for inferring the origin of organic matter (OM) in Quaternary marine sediments. A plot of TOC:TN vs. δ13Corg is useful for such studies but is strongly based on qualitative constraints. This study is based on the qualitative characterization of the source of Quaternary OM via analysis of TOC:TN and δ13Corg signatures, but also proposes a probability parameter, which combines both signatures, to infer the amount of Terrestrial OM Input (TOMI). This index provides a method for quantifying the proportion of terrestrial OM vs. marine OMin a more comprehensive manner. The TOMI index concept was applied to a study area in theJoetsuBasin, eastern margin of theJapanSea, where previous studies have characterized theOMfrom the Last Glacial Maximum (LGM) to the present. The upwards increase in TOC indicates thatOMproduction during the Holocene was higher than during the LGM. The enriched δ13Corg signature upwards and decrease in TOC:TN suggest predominantly marine phytoplankton OM during the Holocene. Throughout the LGM, low OM production with depleted δ13C

Incidência e fatores de risco para tuberculose em Pelotas, uma cidade do Sul do Brasil
Menezes, Ana M. B.;Costa, Juvenal Dias da;Gon?alves, Helen;Morris, Saul;Menezes, Marcelo;Lemos, Soila;Oliveira, Ricardo K.;Palma, Eduardo;
Revista Brasileira de Epidemiologia , 1998, DOI: 10.1590/S1415-790X1998000100006
Abstract: the aim of this study was to evaluate the incidence and risk factors for tuberculosis, in adults from pelotas. cases were recruited in the sanitary unit of tuberculosis (june/1994 to june/1995). at the same time, population controls matched by sex and age were randomly selected, and the same questionnaire was applied for cases and controls. the notified incidence of tuberculosis in pelotas was 72.4/100.000 inhabitants. statistical analysis showed the following crude odds ratios: 10.8 (social class e), 5.4 (family income < 1 minimum salary) and 6.6 (illiterate people). the risk for non-whites was 4.7; crowding and history of contact with tuberculosis presented risks of 3.1 and 5.3, respectively. alcoholism presented a risk of 4.3 and diseases associated with tuberculosis presented a risk of 3.6; history of diabetes and living near mines did not show an association with tuberculosis. mine workers had a risk of 4.0. in the multivariate analysis using conditional logistic regression the following risks remained statistically significant after controlling for confounding factors: contact with tuberculosis (8.2), alcoholism (4.0), mine worker (4.7) and non-white (3.1). the incidence of tuberculosis in pelotas is very high and most risk factors are preventable and can be reduced.
Controle epidemiológico da tuberculose na cidade de Pelotas, Rio Grande do Sul, Brasil: ades?o ao tratamento
Costa, Juvenal Soares Dias da;Gon?alves, Helen;Menezes, Ana Maria B.;Devens, Eduardo;Piva, Marcelo;Gomes, Maurício;Vaz, Márcia;
Cadernos de Saúde Pública , 1998, DOI: 10.1590/S0102-311X1998000200025
Abstract: this study assesses risk factors for treatment noncompliance by patients registered with the tuberculosis control program who live in the urban area of pelotas, rio grande do sul state. the study lasted from june 1994 to december 1995. all new cases diagnosed as pulmonary tuberculosis in the 20-80-year age bracket were monitored by the tuberculosis unit, hub of the tuberculosis control program in pelotas. all patients was monitored from time of diagnosis through end of treatment, six months later. patients answered a standard questionnaire. from june 1994 to june 1995, 152 cases were recorded, with some 20% treatment noncompliance. we observed no significant association between noncompliance and employment status for head-of-family, age, gender, alcoholism, or presence of symptoms, while the only risk factor significantly associated with noncompliance was non-white skin color, probably due to the study's weak power as a function of sample size.
FAM5C Contributes to Aggressive Periodontitis
Flavia M. Carvalho,Eduardo M. B. Tinoco,Kathleen Deeley,Poliana M. Duarte,Marcelo Faveri,Marcelo R. Marques,Adriana C. Mendon?a,Xiaojing Wang,Karen Cuenco,Renato Menezes,Gustavo P. Garlet,Alexandre R. Vieira
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010053
Abstract: Aggressive periodontitis is characterized by a rapid and severe periodontal destruction in young systemically healthy subjects. A greater prevalence is reported in Africans and African descendent groups than in Caucasians and Hispanics. We first fine mapped the interval 1q24.2 to 1q31.3 suggested as containing an aggressive periodontitis locus. Three hundred and eighty-nine subjects from 55 pedigrees were studied. Saliva samples were collected from all subjects, and DNA was extracted. Twenty-one single nucleotide polymorphisms were selected and analyzed by standard polymerase chain reaction using TaqMan chemistry. Non-parametric linkage and transmission distortion analyses were performed. Although linkage results were negative, statistically significant association between two markers, rs1935881 and rs1342913, in the FAM5C gene and aggressive periodontitis (p = 0.03) was found. Haplotype analysis showed an association between aggressive periodontitis and the haplotype A-G (rs1935881-rs1342913; p = 0.009). Sequence analysis of FAM5C coding regions did not disclose any mutations, but two variants in conserved intronic regions of FAM5C, rs57694932 and rs10494634, were found. However, these two variants are not associated with aggressive periodontitis. Secondly, we investigated the pattern of FAM5C expression in aggressive periodontitis lesions and its possible correlations with inflammatory/immunological factors and pathogens commonly associated with periodontal diseases. FAM5C mRNA expression was significantly higher in diseased versus healthy sites, and was found to be correlated to the IL-1β, IL-17A, IL-4 and RANKL mRNA levels. No correlations were found between FAM5C levels and the presence and load of red complex periodontopathogens or Aggregatibacter actinomycetemcomitans. This study provides evidence that FAM5C contributes to aggressive periodontitis.
Remarks on weak solutions for a nonlocal parabolic problem
S. B. de Menezes
International Journal of Mathematics and Mathematical Sciences , 2006, DOI: 10.1155/ijmms/2006/82654
Abstract: We prove a result on existence and uniqueness of weak solutions for a diffusion problem associated with nonlinear diffusions of nonlocal type studied by Chipot and Lovat (1999) by an application of the fixed point result of Schauder. Moreover, making use of Faedo-Galerkin approximation, coupled with some technical ideas, we establish a result on existence of periodic solution.
IMPACTOS DA LEI GERAL DAS MICRO E PEQUENAS EMPRESAS NO DESENVOLVIMENTO DAS COMPRAS PúBLICAS DO CEARá
Reinaldo Marcelo Lima Braga,Fernando Menezes Xavier
Revista da Micro e Pequena Empresa , 2011,
Abstract: A elabora o da Lei Geral das Micro e Pequenas Empresas surge com a reforma tributária, em 19/12/2003. Em 14/12/2006 é criada a Lei Complementar 123/06 (Lei Geral das Micro e Pequenas Empresas – Simples Nacional), novo estatuto nacional das microempresas e empresas de pequeno porte. O trabalho identifica os ajustes que as micro e pequenas empresas tiveram que implementar para expandir suas vendas aos órg os públicos, a partir do surgimento e implanta o da Lei Complementar 123/06. A metodologia deste estudo consiste na abordagem ao problema e a natureza que é quanti-qualitativa; em rela o aos fins, é exploratória e descritiva; quanto aos meios é bibliográfica, documental, de campo e ex post facto; e efetuou-se um levantamento com cento e catorze micro e pequenas empresas fornecedoras do Estado do Ceará, dos certames eletr nicos de 2008 da BNB, TRE-CE e UFC. Os resultados demonstram a evolu o da participa o das micro e pequenas empresas em 294% (duzentos e noventa e quatro por cento), como fornecedoras de órg os públicos, e mostram que n o houve dificuldades encontradas pelas micro e pequenas empresas do Estado do Ceará em atender aos requisitos da Lei Complementar 123/06. Como possíveis dificuldades em seu desenvolvimento, identificaram-se a contrata o de pessoal especializado em vendas ao governo, aquisi o de softwares e sistemas operacionais. Ainda, como resultados, identificam-se as tecnologias adquiridas como compra de equipamento de informática, contrata o de banda larga e inova es de processo que foram implementadas, em decorrência dos aumentos nas vendas e capacita o de fornecimento com acesso a outros mercados pelas micro e pequenas empresas do Estado do Ceará.
Fatores de risco para acidente vascular encefálico após cirurgia de revasculariza??o do miocárdio
Oliveira, Dinaldo Cavalcanti de;Ferro, Carlos Romerio;Oliveira, Jo?o Bosco de;Malta, Marcelo Menezes;Barros Neto, Plínio;Cano, Silvia J. F.;Martins, Stevan Krieker;Souza, Luis Carlos B.;Jatene, Adib Domingos;Piegas, Leopoldo Soares;
Arquivos Brasileiros de Cardiologia , 2008, DOI: 10.1590/S0066-782X2008001600005
Abstract: background: stroke is a feared complication after coronary artery bypass grafting surgery (cabg), with an incidence between 1.3 and 4.3%. objective: to identify predictive factors for stroke after cabg in the modern era of cardiac surgery. methods: this is a case-control study of 65 pairs of patients, paired by sex, age (+ 3 years) and date of cabg (+ 3 months). the cases were patients submitted to elective cabg with extracorporeal circulation (ecc) that presented stroke (defined as clinical neurological deficit up to 24 hours post-operatively and confirmed by imaging assessment) and the controls were those individuals submitted to elective cabg with ecc, but without stroke. results: the univariate analysis demonstrated that the number of revascularized vessels was associated with the occurrence of stroke after the cabg (3 ± 0.8 vs. 2.76 ± 0.8, p = 0.01). the multivariate analysis by conditional logistic regression showed that systemic arterial hypertension (sah) [or: 6.1 (1.5 - 24), p = 0.009] and diabete mellitus (dm) [or: 3.1 (1.09 - 11), p= 0.03] were the determinants of the highest chance of stroke after cabg, whereas acute myocardial infarction (ami) > 1 month, was the determinant of the lowest chance of stroke [or: 0.1 (0.03 - 0.36), p = 0.003]. conclusion: hypertension and diabete mellitus were identified as independent predictors of stroke within the first 24 postoperative hours after cabg. in patients with such risk factors, it is possible that the knowledge of the causal mechanisms of brain injury represents a strategy capable of decreasing the incidence of stroke after cabg.
Avalia??o do efeito da clorpromazina sobre a fun??o renal de c?es submetidos à isquemia e reperfus?o
de Menezes, Liliana B.;Fioravanti, Maria Clorinda S.;de Brito e Silva, Marcelo S.;Franco, Leandro G.;Sales, Tatyane Penha;Andrascko, Mariana M.;Veado, Julio César C.;de Araújo, Eugênio G.;
Pesquisa Veterinária Brasileira , 2010, DOI: 10.1590/S0100-736X2010000200002
Abstract: renal ischemia may occur in different situations such as vascular or renal surgery and also in renal transplantation. this study evaluates renal function in dogs submitted to ischemia and reperfusion after chlorpromazine application. twelve adult mongrel dogs were distributed into two groups with six animals each. group a was composed of dogs submitted to renal ischemia and reperfusion without previous administration of chlorpromazine. group b was composed of dogs with renal ischemia and reperfusion previously treated with chlorpromazine. in order to evaluate the possible ischemia/reperfusion late effects, blood and urine samples were sampled in four different times: before ischemia, early stages of reperfusion, 120 minutes after reperfusion, and every week until 28th day postsurgery. renal function was evaluated by clinical examination, serum urea and creatinine levels and urinary ggt activity. pu/cu and ggt urinary activity were more sensitive in detecting acute tubular injury than routine urine examination because these variables showed earlier changes. based on urinalysis, urea and creatinine serum levels plus urinary excretion of ggt and pu/cu, no evidences of protective action of chlorpromazine were observed.
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