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Search Results: 1 - 10 of 4059 matches for " Marcel Kramer "
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NOD2-C2 - a novel NOD2 isoform activating NF-κB in a muramyl dipeptide-independent manner
Marcel Kramer, Janne Boeck, Daniela Reichenbach, Christoph Kaether, Stefan Schreiber, Matthias Platzer, Philip Rosenstiel, Klaus Huse
BMC Research Notes , 2010, DOI: 10.1186/1756-0500-3-224
Abstract: Here, we report a novel alternative transcript of the NOD2 gene, which codes for a truncated tandem CARD only protein, called NOD2-C2. The transcript isoform is highest expressed in leucocytes, a natural barrier against pathogen invasion, and is strictly linked to promoter usage as well as predominantly to one allele of the single nucleotide polymorphism rs2067085. Contrary to a previously identified truncated single CARD NOD2 isoform, NOD2-S, NOD2-C2 is able to activate NF-κB in a dose dependent manner independently of muramyl dipeptide (MDP). On the other hand NOD2-C2 competes with MDPs ability to activate the NOD2-driven NF-κB signaling cascade.NOD2 transcripts having included an alternative exon downstream of exon 3 (exon 3a) are the endogenous equivalents of a previously described in vitro construct with the putative protein composed of only the two N-terminal CARDs. This protein form (NOD2-C2) activates NF-κB independent of an MDP stimulus and is a potential regulator of NOD2 signaling.The innate immune system uses several molecules that sense pathogen-associated molecular patterns (PAMPs) including Toll-like, RIG-1 (retinoic acid inducible gene protein 1)-like and the NOD (nucleotide-binding and oligomerization domain)-like receptors (NLRs) to trigger a protective response against intracellular danger signals, e.g. cytoinvasive pathogens. The NLRs family consists of more than 20 related members defined by a tripartite structure consisting of: (i) a variable N-terminal protein-protein interaction domain, defined by the caspase recruitment domain (CARD), pyrin domain (PYD), or the baculovirus inhibitor domain (BIR); (ii) a centrally located NOD domain facilitating self-oligomerization during activation [1], and (iii) a C-terminal leucine-rich repeat (LRR) responsible for binding/detecting of PAMPs. The N-terminal effector binding domains are essential elements of the NLRs to elicit a signal subsequent to NLR activation. In case of NOD1 and NOD2 (CARD15), the N-
Early Childhood Education: Difficulties Creating and Changing Daily Practice  [PDF]
Sonia Kramer
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.56048
Abstract:

This paper is based on research carried out with children and adults at early childhood education institutions in Rio de Janeiro, Brazil. The research goals were to identify interactions between adults and children and to rethink pedagogical practice. The theoretical-methodological framework was based on language and culture studies, the sociology of childhood and anthropology. After studying children and adults in different contexts and early childhood education public policies and practice, the results present challenges of changing and creating early education practices in difficult contexts, especially with regard to the creation and use of spaces intended for children. This is the focus of the text, which is structured in three sections. Section one presents the theoretical and methodological issues. The second section analyzes three case studies developed in public pre-schools situated in different cities in the state of Rio de Janeiro. Section three presents conclusions and priorities for intervention and change concerning children, adults and their interactions.

Training Needs of International Medical Graduates [IMGs] in Psychiatry  [PDF]
Milton Kramer
Open Journal of Psychiatry (OJPsych) , 2014, DOI: 10.4236/ojpsych.2014.44036
Abstract: The potential shortage of psychiatrists over the next 5 - 10 years has focused attention on the need to recruit more IMGs to fill the needs rather than use nurse practitioners or physician assistants. IMGs make up about 1/3 of first year psychiatry residents. These individuals have been found to provide services to the poor, the elderly and the psychotic. The quality of their medical work has been found to be satisfactory. The training needs of these physicians require an understanding on the part of their teachers that they come from cultures with different values that we have. The extended families of these primarily Asian residents clash with our strong commitment to individualism. It leads to a We-self rather than our I-Self. This difference coupled with the stress of leaving to come to a new culture is a great stress. Their exposure to psychiatry has been limited. They request and need more interview demonstration and practice, ore feedback and examinations. They should have help in accent reduction. They should be exposed to the working of the hospital by sitting on departmental and hospital committees. The faculty should extend their social opportunities and work as mentors on joint projects. Courses on the history of American culture should be taught. Psychotherapy for them should be encouraged as well as teaching medical ethics. They must become the major educational concern for the department that they are in.
Boundaries of Smooth Strictly Convex Sets in the Euclidean Plane R2  [PDF]
Horst Kramer
Open Journal of Discrete Mathematics (OJDM) , 2017, DOI: 10.4236/ojdm.2017.72008
Abstract: We give a characterization of the boundaries of smooth strictly convex sets in the Euclidean plane R2?based on the existence and uniqueness of inscribed triangles.
Making Sense of Environmental Complexity in a Reform Context: The Case of Megaproject Alpha  [PDF]
Marcel Veenswijk
American Journal of Industrial and Business Management (AJIBM) , 2012, DOI: 10.4236/ajibm.2012.24015
Abstract: In this paper, new concepts on environmental complexity and sense making are developed and explored and analysed. The article based on a case study regarding a public-private collaboration in a Dutch infrastructural mega project. It is argued that the ability to influence the direction of the change process of the mega project “Alpha” depends on the way actors are able to influence the so aleed “cultural interfaces” into the power arena by means of a specific group of organizational stakeholders. After a short theoretical introduction, we describe the case in terms of two dominant cultural stages and their specific interface dynamics. The paper concludes with a general reflection on the central concepts.
Alternative 5’ Untranslated Regions Are Involved in Expression Regulation of Human Heme Oxygenase-1
Marcel Kramer, Christoph Sponholz, Monique Slaba, Bianka Wissuwa, Ralf A. Claus, Uwe Menzel, Klaus Huse, Matthias Platzer, Michael Bauer
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077224
Abstract: The single nucleotide polymorphism rs2071746 and a (GT)n microsatellite within the human gene encoding heme oxygenase-1 (HMOX1) are associated with incidence or outcome in a variety of diseases. Most of these associations involve either release of heme or oxidative stress. Both polymorphisms are localized in the promoter region, but previously reported correlations with heme oxygenase-1 expression remain not coherent. This ambiguity suggests a more complex organization of the 5’ gene region which we sought to investigate more fully. We evaluated the 5‘ end of HMOX1 and found a novel first exon 1a placing the two previously reported polymorphisms in intronic or exonic positions within the 5’ untranslated region respectively. Expression of exon 1a can be induced in HepG2 hepatoma cells by hemin and is a repressor of heme oxygenase-1 translation as shown by luciferase reporter assays. Moreover, minigene approaches revealed that the quantitative outcome of alternative splicing within the 5’ untranslated region is affected by the (GT)n microsatellite. This data supporting an extended HMOX1 gene model and provide further insights into expression regulation of heme oxygenase-1. Alternative splicing within the HMOX1 5' untranslated region contributes to translational regulation and is a mechanistic feature involved in the interplay between genetic variations, heme oxygenase-1 expression and disease outcome.
Genetic and health issues emerging from sperm donation—The experiences and views of donors  [PDF]
Ken Daniels, Wendy Kramer
Advances in Reproductive Sciences (ARSci) , 2013, DOI: 10.4236/arsci.2013.13003
Abstract: 164 previous sperm donors completed an online survey regarding health and genetic experiences and views. Results highlight that donors desire to act responsibly with recruiting facilities is not always possible. Objective: Obtaining the views and experiences of sperm donors regarding health and genetic matters. Design: Online survey. Setting: Not applicable. Participants: 164 previous sperm donors. Interventions: Not applicable. Main outcome measures: Views and experiences on health and genetic issues. Results: A variety of approaches are adopted by recruiting facilities in regard to selection and post-donation factors. The vast majority of donors said they had not been contacted by the facility they donated at to update their medical information, while almost one quarter of donors indicated that a health or genetic risk factor had occurred. A great majority of donors felt that they had not received any education or counselling on the potential curiosities of donor conceived people. Donors sought to be honest and open with staff but often found there were difficulties in doing so. Conclusions: Overall, donors indicate that they see donating as involving responsibilities to the offspring and families. The study highlights however that their ability to act responsibly is limited by some of the interactions or lack of them with the facilities where they donated. Implications for recruiting facilities need to be considered.
Interacting electrons in a magnetic field in a center-of-mass free basis
Peter Kramer,Tobias Kramer
Physics , 2014, DOI: 10.1088/0031-8949/90/7/074014
Abstract: We present an extension of the spin-adapted configuration-interaction method for the computation of four electrons in a quasi two-dimensional quantum dot. By a group-theoretical decomposition of the basis set and working with relative and center-of-mass coordinates we obtain an analytical identification of all spurious center-of-mass states of the Coulomb-interacting electrons. We find a substantial reduction in the basis set used for numerical computations. At the same time we increase the accuracy compared to the standard spin-adapted configuration-interaction method (SACI) due to the absence of distortions caused by an unbalanced cut-off of center-of-mass excitations.
Exact electron states in 1D (quasi-) periodic arrays of delta-potentials
Peter Kramer,Tobias Kramer
Physics , 1999,
Abstract: Exact one-electron eigenstates in finite parts of 1D periodic and Fibonacci chains of attractive and repulsive delta potentials are computed and analyzed. Bloch and bound state boundary conditions are related in terms of transfer matrices. Scenarios of positive and negative energy are distinguished. The dependence on the potential strength parameter is analyzed. The scattering matrix is computed. Implications for the interpretation of band germs in quasiperiodic chains are discussed.
Narrating National Geo Information Infrastructures: Balancing Infrastructure and Innovation  [PDF]
Henk Koerten, Marcel Veenswijk
Journal of Service Science and Management (JSSM) , 2009, DOI: 10.4236/jssm.2009.24040
Abstract: This paper examines narratives relating to the development of National Geo Information Infrastructures (NGII) in ethnographic research on a Dutch NGII project which was monitored throughout its course. We used an approach which focuses on narratives concerning the environment, groups and practice to elicit sense-making processes. We assert that narratives are relatively fixed and that they only change under specific circumstances. Moreover, the fixing of or change in narratives takes place in practice, so our research approach aimed at analysing narratives of practice, which we label ‘storyboards’. For this purpose, project meetings and conferences were observed, key persons both within and outside the project environment were interviewed, and an analysis of relevant documents and video footage was undertaken. Storyboards are created by actors as a result of day-to-day challenges related to project goals, technology and infrastructure. In our research we found that these storyboards occur as vicious circles from which actors cannot escape. In the specific case analysed, our interpretation of the narrative storyboards suggested that these vicious circles are caused by the inability of project participants to distinguish between infrastructure and innovation requirements in their daily work.
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