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Search Results: 1 - 10 of 217254 matches for " Marc L. Otten "
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Chromosome 1p and 11q Deletions and Outcome in Neuroblastoma – A Critical Review
Ricardo J. Komotar,Marc L. Otten,Robert M. Starke,Richard C. E. Anderson
Clinical Medicine : Oncology , 2008,
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma – A Critical Review
Ricardo J. Komotar,Marc L. Otten,Gaetan Moise,E. Sander Connolly
Clinical Medicine : Oncology , 2008,
Treatment of Early Childhood Medulloblastoma by Postoperative Chemotherapy Alone - A Critical Review
Ricardo J. Komotar,Marc L. Otten,Matthew C. Garrett,Richard C.E. Anderson
Clinical Medicine : Oncology , 2009,
Molecular Determinants of Glioblastoma Response to Epidermal Growth Factor Receptor Kinase Inhibitors
Ricardo J. Komotar,Marc L. Otten,Maxwell B. Merkow,Jeffrey N. Bruce
Clinical Medicine : Oncology , 2008,
Complement Inhibition Promotes Endogenous Neurogenesis and Sustained Anti-Inflammatory Neuroprotection following Reperfused Stroke
Andrew F. Ducruet, Brad E. Zacharia, Sergey A. Sosunov, Paul R. Gigante, Mason L. Yeh, Justin W. Gorski, Marc L. Otten, Richard Y. Hwang, Peter A. DeRosa, Zachary L. Hickman, Paulina Sergot, E. Sander Connolly
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038664
Abstract: Background and Purpose The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent reports also implicate C3a in the modulation of tissue repair, suggesting that complement may influence both injury and recovery at later post-ischemic time-points. Methods To evaluate the effect of C3a-receptor antagonism on post-ischemic neurogenesis and neurological outcome in the subacute period of stroke, transient focal cerebral ischemia was induced in adult male C57BL/6 mice treated with multiple regimens of a C3a receptor antagonist (C3aRA). Results Low-dose C3aRA administration during the acute phase of stroke promotes neuroblast proliferation in the subventricular zone at 7 days. Additionally, the C3a receptor is expressed on T-lymphocytes within the ischemic territory at 7 days, and this cellular infiltrate is abrogated by C3aRA administration. Finally, C3aRA treatment confers robust histologic and functional neuroprotection at this delayed time-point. Conclusions Targeted complement inhibition through low-dose antagonism of the C3a receptor promotes post-ischemic neuroblast proliferation in the SVZ. Furthermore, C3aRA administration suppresses T-lymphocyte infiltration and improves delayed functional and histologic outcome following reperfused stroke. Post-ischemic complement activation may be pharmacologically manipulated to yield an effective therapy for stroke.
An investigation of motor learning during side-step cutting, design of a randomised controlled trial
Anne Benjaminse, Koen APM Lemmink, Ron L Diercks, Bert Otten
BMC Musculoskeletal Disorders , 2010, DOI: 10.1186/1471-2474-11-235
Abstract: A randomized controlled laboratory study will be conducted. Healthy basketball players, females and males, 18 years and older, with no previous lower extremity injuries, playing at the highest recreational level will be included. Subjects will receive a dynamic feedback intervention. Kinematic and kinetic data of the hip, knee and ankle and EMG activity of the quadriceps, hamstrings and gastrocnemius will be recorded.Female athletes have a significantly higher risk of sustaining an ACL injury than male athletes. Poor biomechanical and neuromuscular control of the lower limb is suggested to be a primary risk factor of an ACL injury mechanism in females. This randomized controlled trial has been designed to investigate whether individual feedback on task performance appears to be an effective intervention method. Results and principles found in this study will be applied to future ACL injury prevention programs, which should maybe more focus on individual injury predisposition.Trial registration number NTR2250.Of all athletic knee injuries an anterior cruciate ligament (ACL) rupture results in the longest time loss from sport [1]. Regardless of the therapy chosen, conservative or reconstructive, athletes are often forced to reduce their level of physical activity and their involvement in sport [2]. Moreover, a recent review reported prevalences of osteoarthritis ranging from 0% to 13% for patients with isolated ACL injury and 21% to 48% in patients with combined injuries [3], indicating additional long-term medical expenses [4]. The identification of risk factors and the development of prevention strategies may therefore have widespread health and economic implications.The majority of research into noncontact ACL injury risk factors and the accompanying gender disparity has focused on the neuromuscular and biomechanical risk factors because of their potential for modification. Neuromuscular training strategies focussing on warm-up, technique, balance, strengthening an
European clearinghouse: Development areas and priorities in operational experience feedback for nuclear power plants
No?l Marc
Nuclear Technology and Radiation Protection , 2010, DOI: 10.2298/ntrp1002152n
Abstract: Nuclear power plant operational experience has been used for many years in order to improve the safety of nuclear facilities throughout the world. In the European Union, a regional Clearinghouse on Operational Experience Feedback for Nuclear Power Plants has been established to enhance nuclear safety through improvement of the use of lessons learned from operational experience. The EU Clearinghouse is organized as a network operated by a centralized office located at the Joint Research Centre of the European Commission and currently gathering nine European Safety Authorities and two major European Technical Support Organizations. Two years of operation of the EU Clearinghouse have shown the benefits of the common initiative and further areas of development have been identified. Among them, the need for further development of in depth analyses of dedicated families of operational events has been highlighted. The present paper describes the history of the initiative, the current work areas being developed and corresponding priorities for further improvement of the use of lessons learned from operational experience in the European Union.
The Motor System: The Whole and its Parts
E. Otten
Neural Plasticity , 2001, DOI: 10.1155/np.2001.111
Abstract: Our knowledge of components of the human motor system has been growing steadily, but our understanding of its integration into a system is lagging behind. It is suggested that a combination of measurements of forces and movements of the motor system in a functionally meaningful environment in conjunction with computer simulations of the motor system may help us in understanding motor system properties. Neurotrauma can be seen as a natural deviation, with recovery as a slow path to yet another deviant state of the motor system. In that form they may be useful in explaining the close interaction between form and function of the human motor system.
Multi-Joint Dynamics and the Development of Movement Control
E. Otten
Neural Plasticity , 2005, DOI: 10.1155/np.2005.89
Abstract: The movement control of articulated limbs in humans has been explained in terms of equilibrium points and moving equilibrium points or virtual trajectories. One hypothesis is that the nervous system controls multi-segment limbs by simply planning in terms of these equilibrium points and trajectories. The present paper describes a planar computer simulation of an articulated three-segment limb, controlled by pairs of muscles. The shape of the virtual trajectory is analyzed when the limb is required to make fast movements with endpoint movements along a straight line with bell-shaped velocity profiles. Apparently, the faster the movement, the more the virtual trajectory deviates from the real trajectory and becomes up to eight times longer. The complexity of the shape of the virtual trajectories and its length in these fast movements makes it unlikely that the nervous system plans using these trajectories. it seems simpler to set up the required bursts of muscle activation, coupled in the nervous system to the direction of movement, the s peed, and the place in workspace. Finally, it is argued that the two types of explanation do not contradict each other: when a relation is established in the nervous system between muscle activation and movements, equilibrium points and virtual trajectories are necessarily part of that relation.
Review: Helga Kotthoff (Hrsg.) (2002). Kultur(en) im Gespr ch Review: Helga Kotthoff (Ed.) (2002). Kultur(en) im Gespr ch [Culture(s) in Conversation] Rese a: Helga Kotthoff (Ed.) (2002). Kultur(en) im Gespr ch [Cultura(s) en conversación]
Matthias Otten
Forum : Qualitative Social Research , 2003,
Abstract: Viele theoretische und empirische Untersuchungen zur interkulturellen Kommunikation entstehen in Deutschland h ufig an den disziplin ren Grenzfl chen zwischen Sprachwissenschaften, Soziologie, Ethnologie, P dagogik oder Psychologie. Hier l sst sich auch der interdisziplin re Band "Kultur(en) im Gespr ch" verorten, in dem anhand exemplarsicher Gespr chsanalysen in und zwischen Kulturen theoretische Konzepte und methodische Zug nge aus der Soziolinguistik und der linguistischen Anthropologie vorgestellt werden. Besondere Aufmerksamkeit wird der Methodenreflexion gewidmet, aus der sich wertvolle Anregungen für die qualitative interkulturelle Diskurs- und Gespr chsforschung gewinnen lassen. URN: urn:nbn:de:0114-fqs030345 Much of the theoretical and empirical research on intercultural communication in Germany emerges at the disciplinary edges of Linguistics, Sociology, Anthropology, Psychology or Educational Studies. The book "Kultur(en) im Gespr ch"—translated roughly as Culture(s) in Conversation—edited by Helga KOTTHOFF, covers a wide range of theoretical and methodical approaches to the analysis of intercultural conversation and discourse. Most of the contributions refer to concepts of Socio-Linguistics and Linguistic Anthropology. The focus on the reflection of applying qualitative research methods used in the scope of intercultural conversation and discourse analysis let this book become a source of inspiration for the own research practice. URN: urn:nbn:de:0114-fqs030345 Mucha de la investigación teórica y empírica sobre comunicación intercultural en Alemania emerge en los límites disciplinarios de los estudios de la Lingüística, la Sociología, la Antropología, la Psicología y los estudios educativos. El libro "Kultur(en) im Gespr ch" – traducido literalmente como Cultura(s) en Conversación – editado por Helga KOTTHOFF, cubre un amplio rango de enfoque teóricos y metodológicos para el análisis de la conversación y del discurso intercultural. La mayoría de las contribuciones se refieren a conceptos de la Sociolingüística y de la Antropología Lingüística. El foco en la reflexión de los métodos cualitativos de investigación usados en el horizonte de la conversación intercultural y el análisis del discurso, hace que este libro sea una fuente de inspiración para la propia práctica de la investigación. URN: urn:nbn:de:0114-fqs030345
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