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Search Results: 1 - 10 of 597872 matches for " María-Guadalupe Gordillo-Pérez "
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Frequency and Clinical Epidemiology of Canine Monocytic Ehrlichiosis in Dogs Infested with Ticks from Sinaloa, Mexico
Carolina Guadalupe Sosa-Gutierrez,Maria Teresa Quintero Martinez,Soila Maribel Gaxiola Camacho,Silvia Cota Guajardo,Maria D. Esteve-Gassent,María-Guadalupe Gordillo-Pérez
Journal of Veterinary Medicine , 2013, DOI: 10.1155/2013/797019
Abstract: Ehrlichia canis is a rickettsial intracellular obligate bacterial pathogen and agent of canine monocytic ehrlichiosis. The prevalence of this disease in veterinary medicine can vary depending on the diagnostic method used and the geographic location. One hundred and fifty-two canine blood samples from six veterinary clinics and two shelters from Sinaloa State (Mexico) were analyzed in this study. All animals were suspected of having Canine Monocytic Ehrlichiosis (CME). The diagnostic methods used were the ELISA (Snap4Dx, IDEXX) together with blood smear and platelet count. From all dogs blood samples analyzed, 74.3% were positive to E. canis by ELISA and 40.1% were positive by blood smear. The sensitivity and specificity observed in the ELISA test were 78.8% and 86.7%. In addition, thrombocytopenia was presented in 87.6% of positive dogs. The predominant clinical manifestations observed were fever, anorexia, depression, lethargy, and petechiae. Consequently, this is the first report in which the morulae were visualized in the blood samples, and E. canis-specific antibodies were detected in dogs from Sinaloa, Northwest of Mexico. 1. Introduction Ehrlichia canis is the causative agent of canine monocytic ehrlichiosis (CME). Moreover, CME is an emerging disease in veterinary medicine, and E. canis has been considered in the last decade as a potential zoonotic pathogen [1, 2]. It is a worldwide disease transmitted by a tick bite. The competent vector for its transmission is the Ixodidae ticks Rhipicephalus sanguineus and Dermacentor variabilis [3]. In dogs, the CME is a multiphase disorder that progresses in three stages: acute, subclinical, and chronic. Each phase is characterized by several clinical and hematologic abnormalities. Thrombocytopenia is a common finding in E. canis infected dogs and many clinicians tend to use it as an indication for antibiotic treatment, and it is observed in 84% of the cases and its severity varies in the different disease phases [4]. During the subclinical stage a moderate thrombocytopenia is observed, while the chronic phase is characterized by severe leukopenia and anemia. In this stage dogs show other complications such as hypocellular marrow, suppressed splenic sequestration, decreased life of platelets, and an increase of circulating migration-factor platelet inhibitor [3, 4]. The relationship between the magnitude of thrombocytopenia and prevalence of E. canis has been established in countries such as Brazil in 2004 where 84.1% of infected dogs showed thrombocytopenia [3]. Taken together, more data is necessary to
Tick-Borne Rickettsial Pathogens in Rodents from Mexico  [PDF]
Carolina G. Sosa-Gutiérrez, Margarita Vargas, Javier Torres, Guadalupe Gordillo-Pérez
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.711087
Abstract: Tick-Borne Rickettsial Diseases (TBRD) are emerging zoonotic diseases, and a problem of human health and veterinary medication. The distribution of these diseases is related to the distribution of vector. The presence of pathogens in the host is a risk indicator of population exposure to these areas. A total of 478 tissues samples from rodents, A. phagocytophilum 18 (3.7%), E. canis 47 (9.8%), Rickettsia rickettsii 18 (3.7%) and E. chaffeensis 19 (3.9%) were detected using species-specific PCR assay. It is the first report in Mexico the presence of rodents infected with A. phagocytophilum and E. chaffeensis. The rodent Peromyscus spp. were the most commonly prevalent host of infection for all the bacteria’s. We have to consider as host of TBRD transmitter and provide a useful contribution to understanding their epidemiology. The health sector should be considered all the fevers of unknown causes in humans and animals in Mexico as infections by these vector-borne rickettsial pathogens.
Estudio seroepidemiológico de borreliosis de Lyme en la Ciudad de México y el noreste de la República Mexicana
Gordillo-Pérez Guadalupe,Torres Javier,Solórzano-Santos Fortino,Gardu?o-Bautista Verónica
Salud Pública de México , 2003,
Abstract: OBJETIVO: Investigar mediante métodos serológicos la infección por B burgdorferi en individuos del Distrito Federal y la zona noreste de México. MATERIAL Y MéTODOS: Se obtuvo una muestra representativa de sueros del Distrito Federal y la zona noreste de México, obtenidas en la Encuesta Seroepidemiológica Nacional de 1987-1988. Se detectaron anticuerpos IgG vs B burgdorferi por ELISA, confirmados con Western blot. En este trabajo se utilizó estadística descriptiva. RESULTADOS: Fueron estudiados 2 346 sueros; 297 (12.6%) fueron positivos por inmunoensayo enzimático, y 122/297 fueron confirmados por Western blot. La seroprevalencia fue de 3.43% en el Distrito Federal y 6.2% en la zona noreste del país. Tamaulipas fue el estado con la seroprevalencia más alta. CONCLUSIONES: La prevalencia de casos seropositivos sugieren que la infección por B burgdorferi ocurre en el noreste de México y el Distrito Federal. Es necesario identificar casos clínicos y buscar el vector infectado para confirmar la presencia de la enfermedad de Lyme en México.
Estudio seroepidemiológico de borreliosis de Lyme en la Ciudad de México y el noreste de la República Mexicana
Gordillo-Pérez,Guadalupe; Torres,Javier; Solórzano-Santos,Fortino; Gardu?o-Bautista,Verónica; Tapia-Conyer,Roberto; Mu?oz,Onofre;
Salud Pública de México , 2003, DOI: 10.1590/S0036-36342003000500004
Abstract: objective: to detect serological evidence of b burgdorferi infection in individuals from mexico city and from the northeast region of the country. material and methods: a representative sample size of serum from mexico city and the states of the northeast of mexico were taken from serum samples corresponding to the 1987-1988 national survey were obtained from the national serum bank. antibodies against b burgdorferi were detected by elisa and confirmed with western blot (wb) assays. data were analyzed using descriptive statistics. results: a total of 2 346 serum samples were tested; 297 (12.6%) were positive for elisa, and 122 of 297 were confirmed by wb. seroprevalence was 3.43% in mexico city and 6.2% in the northeast region of the country. tamaulipas was the state with the highest seroprevalence. conclusions: the prevalence of seropositive cases shows that borrelial infection is present in the northeast of mexico and mexico city. identification of clinical cases and infected tick vectors is necessary to confirm the presence of lyme disease in mexico.
(E)-(25S)-23-Acetyl-5β-furost-22-ene-3β,26-diol
María-Guadalupe Hernández Linares,Jesús Sandoval Ramírez,Socorro Meza Reyes,Sara Montiel Smith
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808004509
Abstract: The title steroid, C29H46O4, is a furostene derivative with a C=C double-bond length of 1.353 (3) and an E configuration. The side chain is oriented toward the α face of the A–E steroidal nucleus and presents a disordered terminal CH2—OH group [occupancies for resolved sites are 0.591 (9) and 0.409 (9)]. The methyl group at C20 attached to ring E is also oriented toward the α face, avoiding steric hindrance with the carbonyl O atom of the acetyl group. The furostene and acetyl functionalities form an α,β-unsaturated ketone system, with an s-cis configuration. All hydroxy and carbonyl groups are involved in weak intermolecular hydrogen bonds. The absolute configuration was assigned from the synthesis.
Species Distribution Models and Ecological Suitability Analysis for Potential Tick Vectors of Lyme Disease in Mexico
Patricia Illoldi-Rangel,Chissa-Louise Rivaldi,Blake Sissel,Rebecca Trout Fryxell,Guadalupe Gordillo-Pérez,Angel Rodríguez-Moreno,Phillip Williamson,Griselda Montiel-Parra,Víctor Sánchez-Cordero,Sahotra Sarkar
Journal of Tropical Medicine , 2012, DOI: 10.1155/2012/959101
Abstract: Species distribution models were constructed for ten Ixodes species and Amblyomma cajennense for a region including Mexico and Texas. The model was based on a maximum entropy algorithm that used environmental layers to predict the relative probability of presence for each taxon. For Mexico, species geographic ranges were predicted by restricting the models to cells which have a higher probability than the lowest probability of the cells in which a presence record was located. There was spatial nonconcordance between the distributions of Amblyomma cajennense and the Ixodes group with the former restricted to lowlands and mainly the eastern coast of Mexico and the latter to montane regions with lower temperature. The risk of Lyme disease is, therefore, mainly present in the highlands where some Ixodes species are known vectors; if Amblyomma cajennense turns out to be a competent vector, the area of risk also extends to the lowlands and the east coast. 1. Introduction Lyme disease, the most frequently reported tick-borne infectious disease in the United States and Europe [1, 2], is increasingly being reported from Mexico [3, 4], where disease cases are more prevalent during warm-weather months when ticks are active. The etiologic agent, Borrelia burgdorferi, enters the skin at the site of the tick bite; after incubating for 3–30 days, the bacteria migrate through the skin and may spread to lymph nodes or disseminate through the bloodstream to other parts of the body. While B. burgdorferi infection might be endemic in Mexico [3, 4] it is relatively rare in the southern USA making the question of its biogeography a matter of interest. Additionally, in Mexico, the epidemiology and biogeography of Lyme disease are not well understood [5]. Several tick species have recently been identified as containing B. burgdorferi using a DNA polymerase chain reaction and, therefore, may be considered as candidates that may be involved in the enzootic transmission cycle in both Mexico and South America. These include tick species from the genus Ixodes [3, 4] as well as Amblyomma cajennense [5, David Beck, personal communication]. While detection of B. burgdorferi DNA by polymerase chain reaction is not indicative of vector competence, the presence of B. burgdorferi in the molecular surveys does indicate a benefit from modeling the distribution of A. cajennense since it has been shown to feed on reservoirs for B. burgdorferi in Mexico. Additionally, the South American A. cajennense has been shown to be a competent vector for Rickettsia rickettsii [6], the causative agent of
The zwitterion (23′E)-(23R,25S)-23-[1-(oxidoiminio)ethyl]-5β-spirostan-3β-yl acetate
María-Guadalupe Hernández Linares,Jesús Sandoval Ramírez,Socorro Meza Reyes,Sara Montiel Smith
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809044651
Abstract: The title steroidal compound, C31H49NO5, resulted from the selective oximation of (23R)-23-acetylsarsasapogenin acetate. One- and two-dimensional 1H and 13C NMR spectra, as well as IR data, are in agreement with the presence of a ketoxime group at C-23. However, recrystallization in slightly acidic media affords the title compound in the rare zwitterionic oxime form, as a consequence of migration of the hydroxy H atom to the N atom in the oxime group. This H atom is clearly detected and its position was refined from X-ray data. The geometry for the C=N+(H)—O group features long C=N and short N—O bond lengths compared to non-zwitterionic oximes. The ketoxime is stabilized with the E configuration, avoiding steric hindrance between the oxime O atom and H atom at C-23. The sum of the angles around the oxime N atom is 359.6°, giving a planar configuration for that atom, as expected for sp2 hybridization.
(20S,2′′S)-20-[4′-(3′′-Hydroxy-2′′-methylpropyl)-3′-methylisoxazol-5-yl]-5β-pregnan-3β,16β-diol
María-Guadalupe Hernández Linares,Jesús Sandoval Ramírez,Socorro Meza Reyes,Sara Montiel Smith
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809050478
Abstract: The title steroidal compound, C29H47NO4, was prepared in a one-pot reaction starting from a sarsasapogenin derivative of known configuration. The isoxazole heterocycle is oriented towards the α face of the steroid nucleus and, although fully functionalized on C atoms, does not provoke steric hindrance with the adjacent D ring. The absolute configuration observed for chiral centers is as expected, and shows that no epimerization occurred in the precursors. In the crystal, the three OH groups serve as donors for hydrogen bonding with O and N atoms. The isoxazole N atom is involved in O—H...N hydrogen bonds, forming chains along [100]. These chains are further connected via O—H...O and weak C—H...O contacts, giving rise to a three-dimensional supramolecular network.
(R)-1-Phenylethylammonium trifluoroacetate
María-Guadalupe Hernández Linares,Gabriel Guerrero Luna,Sylvain Bernès
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810013565
Abstract: In the crystal structure of the title salt, C8H12N+·C2F3O2 , all of the ammonium H atoms serve as donors for hydrogen bonds to carboxylate O atoms, forming an R43(10) ring motif based on two cations and two anions. Since both cations and anions act as inter-ion bridging groups, R(10) rings aggregate in a one-dimensional supramolecular network by sharing the strongest N—H...O bond. Edge-sharing motifs lie on the twofold screw axis parallel to [010], and antiparallel packing of these 21-column structural units results in the crystal structure. This arrangement is one of the most commonly occurring in conglomerates of chiral 1-phenylethylamine with achiral monocarboxylic acids, confirming that these ionic salts are particularly robust supramolecular heterosynthons useful in crystal engineering.
Temperature Inversions, Meteorological Variables and Air Pollutants and Their Influence on Acute Respiratory Disease in the Guadalajara Metropolitan Zone, Jalisco, Mexico  [PDF]
Hermes U. Ramírez-Sánchez, Mario E. García-Guadalupe, Héctor H. Ulloa-Gódinez, ángel R. Meulenert-Pe?a, Omar García-Concepción, Jaime Alcalá Gutierrez, Sarahi J. Lizarraga Brito
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.48A1016
Abstract:

The presence of temperature inversions (TI), concentration of air pollutants (AP) and meteorological variables (MV) affect the welfare of the population, creating public health problems (acute respiratory diseases ARDs, among others). The Guadalajara Metropolitan Zone (GMZ) experiences high levels of air pollution, which associated with the presence of temperature inversions and meteorological variations is conducive to the incidence of ARDs in children. The aim of this work is to evaluate the TI, MV, AP and their influence on the ARDs in children under five years in the GMZ from 2003 to 2007. In this period, the moderate and strong TI are the most frequent presenting from November to May. The AP shows a variable behavior during the year and between years, with the highest concentration of particles less than 10 microns (PM10), followed by ozone (O3), nitrogen dioxide (NO2), nitrogen oxides (NOX), carbon monoxide (CO) and sulfur dioxide (SO2), the most affected areas are the southeast of the GMZ. Annual arithmetic mean is 213,510 ± 41,209 ARDs consultations. The most important diseases are acute respiratory infections (98.0%), followed by pneumonia and bronchopneumonia (1.1%), asthma and status asthmaticus (0.5%) and streptococcal pharyngitis and tonsillitis (0.4%). Months with most inquiries were from October to March, mainly

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