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Search Results: 1 - 10 of 466275 matches for " María Soledad Santini? "
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Lutzomyia longipalpis in Uruguay: the first report and the potential of visceral leishmaniasis transmission
Salomón, Oscar Daniel;Basmajdian, Yester;Fernández, María Soledad;Santini, María Soledad;
Memórias do Instituto Oswaldo Cruz , 2011, DOI: 10.1590/S0074-02762011000300023
Abstract: phlebotomine captures were performed in february 2010 in salto (salto department) and bella unión-cuarein (artigas department), uruguay. bella unión is located across the paraná river from monte caseros, argentina, where a focus of canine visceral leishmaniasis (vl) was reported in 2009. no vl cases have ever been recorded in uruguay and the last reported capture of phlebotominae was in 1932 (lutzomyia cortelezzii and lutzomyia gaminarai). light traps were placed in peridomestic environments, and lutzomyia longipalpis, the main vector of visceral leishmaniasis, was found in salto and bella unión. this is a first report of an area of potential vl transmission in uruguay. active and coordinated surveillance is required immediately the uruguay-argentina-brazil border area.
Lutzomyia longipalpis abundance in the city of Posadas, northeastern Argentina: variations at different spatial scales
Santini, María Soledad;Fernández, María Soledad;Pérez, Adriana Alicia;Sandoval, Adolfo Enrique;Salomón, Oscar Daniel;
Memórias do Instituto Oswaldo Cruz , 2012, DOI: 10.1590/S0074-02762012000600010
Abstract: the distribution of lutzomyia longipalpis is heterogeneous with a pattern of high abundance areas (haas) embedded in a matrix of low abundance areas (laas). the objective of this study was to describe the variability in the abundance of lu. longipalpis at two different spatial levels and to analyse the relationship between the abundance and multiple environmental variables. of the environmental variables analysed in each household, the condition that best explained the differences in vector abundance between haa-laa was the variable "land_grass", with greater average values in the peridomestic environments within the laa, and the variables "#sp tree", "#pots" and "dist_water" that were higher in the haa. of the environmental variables analysed in the patches, the variable "unpaved_streets" was higher in the laas and the variable "prop_inf_dogs" was higher in the haas. an understanding of the main environmental variables that influence the vector distribution could contribute to the development of strategies for the prevention and control of visceral leishmaniasis (vl). this is the first work in which environmental variables are analysed at the micro-scale in urban areas at the southern edge of the current range of lu. longipalpis. our results represent a significant contribution to the understanding of the abundance of the vector in the peridomestic habitats of the region.
First Comparative Transcriptomic Analysis of Wild Adult Male and Female Lutzomyia longipalpis, Vector of Visceral Leishmaniasis
Christina B. McCarthy, María Soledad Santini, Paulo F. P. Pimenta, Luis A. Diambra
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058645
Abstract: Leishmaniasis is a vector-borne disease with a complex epidemiology and ecology. Visceral leishmaniasis (VL) is its most severe clinical form as it results in death if not treated. In Latin America VL is caused by the protist parasite Leishmania infantum (syn. chagasi) and transmitted by Lutzomyia longipalpis. This phlebotomine sand fly is only found in the New World, from Mexico to Argentina. However, due to deforestation, migration and urbanisation, among others, VL in Latin America is undergoing an evident geographic expansion as well as dramatic changes in its transmission patterns. In this context, the first VL outbreak was recently reported in Argentina, which has already caused 7 deaths and 83 reported cases. Insect vector transcriptomic analyses enable the identification of molecules involved in the insect's biology and vector-parasite interaction. Previous studies on laboratory reared Lu. longipalpis have provided a descriptive repertoire of gene expression in the whole insect, midgut, salivary gland and male reproductive organs. Nevertheless, the study of wild specimens would contribute a unique insight into the development of novel bioinsecticides. Given the recent VL outbreak in Argentina and the compelling need to develop appropriate control strategies, this study focused on wild male and female Lu. longipalpis from an Argentine endemic (Posadas, Misiones) and a Brazilian non-endemic (Lapinha Cave, Minas Gerais) VL location. In this study, total RNA was extracted from the sand flies, submitted to sequence independent amplification and high-throughput pyrosequencing. This is the first time an unbiased and comprehensive transcriptomic approach has been used to analyse an infectious disease vector in its natural environment. Transcripts identified in the sand flies showed characteristic profiles which correlated with the environment of origin and with taxa previously identified in these same specimens. Among these, various genes represented putative targets for vector control via RNA interference (RNAi).
Distribución de vectores de leishmaniasis visceral en la Provincia de Corrientes, 2008
Salomón,Oscar Daniel; Ramos,Ladys K.; Quintana,María Gabriela; Acardi,Soraya A.; Santini,María Soledad; Schneider,Adolfo;
Medicina (Buenos Aires) , 2009,
Abstract: visceral leishmaniasis (vl) is a relevant parasitic disease in public health, produced by leishmania infantum chagasi. since the urbanization and emergence in southern brazil and paraguay, the vector lutzomyia longipalpis in formosa, 2004, and the first human visceral leishmaniasis case in misiones, 2006, have been reported in argentina. due to the reports of canine vl, a search of the vector in the province of corrientes, contiguous to misiones, was performed during december 2008. standarized trapping detected 376 lu. longipalpis in ituzaingó, virasoro, santo tomé, garruchos, riachuelo, corrientes and monte caseros localities. the risk of autochtonous vectorial transmission was then confirmed in the province of corrientes. the distribution of vectors in populated urban areas, with intense transit of canine reservoirs from localities with high transmission, and the existence of infected reservoirs, also implies epidemic risk.
Detection of Leishmania infantum in naturally infected Lutzomyia longipalpis (Diptera: Psychodidae: Phlebotominae) and Canis familiaris in Misiones, Argentina: the first report of a PCR-RFLP and sequencing-based confirmation assay
Acardi, Soraya Alejandra;Liotta, Domingo Javier;Santini, María Soledad;Romagosa, Carlo Mariano;Salomón, Oscar Daniel;
Memórias do Instituto Oswaldo Cruz , 2010, DOI: 10.1590/S0074-02762010000600011
Abstract: in this study, a genotypification of leishmaniawas performed using polimerase chain reaction-restriction fragment length polymorfism (pcr-rflp) and sequencing techniques to identify species of leishmaniaparasites in phlebotomine sand flies and dogs naturally infected. between january-february of 2009, cdc light traps were used to collect insect samples from 13 capture sites in the municipality of posadas, which is located in the province of misiones of argentina. sand flies identified as lutzomyia longipalpiswere grouped into 28 separate pools for molecular biological analysis. canine samples were taken from lymph node aspirates of two symptomatic stray animals that had been positively diagnosed with canine visceral leishmaniasis. one vector pool of 10 sand flies (1 out of the 28 pools tested) and both of the canine samples tested positively for leishmania infantumby pcr and rflp analysis. pcr products were confirmed by sequencing and showed a maximum identity with l. infantum. given that infection was detected in one out of the 28 pools and that at least one infected insect was infected, it was possible to infer an infection rate at least of 0.47% for lu. longipalpisamong the analyzed samples. these results contribute to incriminate lu. longipalpis as the vector of l. infantumin the municipality of posadas, where cases of the disease in humans and dogs have been reported since 2005.
Lutzomyia longipalpis Presence and Abundance Distribution at Different Micro-spatial Scales in an Urban Scenario
María Soledad Santini,María Eugenia Utgés?,Pablo Berrozpe?,Mariana Manteca Acosta?,Natalia Casas?,Paola Heuer?,O. Daniel Salomón
PLOS Neglected Tropical Diseases , 2015, DOI: 10.1371/journal.pntd.0003951
Abstract: The principal objective of this study was to assess a modeling approach to Lu. longipalpis distribution in an urban scenario, discriminating micro-scale landscape variables at microhabitat and macrohabitat scales and the presence from the abundance of the vector. For this objective, we studied vectors and domestic reservoirs and evaluated different environmental variables simultaneously, so we constructed a set of 13 models to account for micro-habitats, macro-habitats and mixed-habitats. We captured a total of 853 sandflies, of which 98.35% were Lu. longipalpis. We sampled a total of 197 dogs; 177 of which were associated with households where insects were sampled. Positive rK39 dogs represented 16.75% of the total, of which 47% were asymptomatic. Distance to the border of the city and high to medium density vegetation cover ended to be the explanatory variables, all positive, for the presence of sandflies in the city. All variables in the abundance model ended to be explanatory, trees around the trap, distance to the stream and its quadratic, being the last one the only one with negative coefficient indicating that the maximum abundance was associated with medium values of distance to the stream. The spatial distribution of dogs infected with L. infantum showed a heterogeneous pattern throughout the city; however, we could not confirm an association of the distribution with the variables assessed. In relation to Lu. longipalpis distribution, the strategy to discriminate the micro-spatial scales at which the environmental variables were recorded allowed us to associate presence with macrohabitat variables and abundance with microhabitat and macrohabitat variables. Based on the variables associated with Lu. longipalpis, the model will be validated in other cities and environmental surveillance, and control interventions will be proposed and evaluated in the microscale level and integrated with socio-cultural approaches and programmatic and village (mesoscale) strategies.
Patrimonio e identidad en Aconquija (Departamento de Andalgalá, Catamarca)
Gianfrancisco,María Soledad;
La zaranda de ideas , 2010,
Abstract: the archaeological deposit alamito is part of the cultural archaeological heritage of the aconquija district. over the last few years, it has suffered a substantial destruction process that affected its physical integrity. this work proposes a reflective evaluation of factors related to academic hermeticism, cultural undervaluation, economic inequality and political neglect. it also considers how these elements have generated an improper protection and valuation of the alamito sites. in order to solve this problem, we propose a program of workshops with the community and the authorities, which would address issues of valuation, preservation and conservation of archaeological heritage. this would allow for participants to discover the symbolic capacity of heritage to represent identities.
Construcción de una escala de observación del vínculo madre-bebé internado en UCIN: Resultados preliminares de la aplicación del protocolo de observación
Santos,María Soledad;
Anuario de investigaciones , 2008,
Abstract: in this article the observation scale of the bond mother - baby interned in neonatal intensive care unit (nicu), and the preliminary results obtained in the administration, will be presented. the scale includes 5 functions: approach, corporal, visual, verbal and posture function. the observations took place in the nicu of three hospitals, in buenos aires, argentina. the frequencies of the communicative behaviours observed and the analysis of the punctuations, will be presented. in order to study the capacity of the scale detecting cases of "adequate bond mother -baby" and "risk in the bond" , we estimated the sensitivity (0.75), specificity (1), positive predictive value (1), negative predictive value (0.84) and total of correct predictions (0.89). the existence of a observational method for the bond will allow to enhance preventive interventions in the perinatal mental health area.
Epitafios: Enfoques teóricos en Arqueología de la Muerte
Gheggi,María Soledad;
Av?? , 2009,
Abstract: we intend to approach diachronically to the theoretical foundations of the current corpus of knowledge addressed by the archaeology of death, derived from many disciplines. some studies identify that mortuary ritual is a proper mean to symbolic and material expression of social aspects. this premise was later incorporated into the new archaeology of the '70s. by criticizing this argument, recent investigations propose a more complex relation between the aspects recognized during mortuary ritual and its material expression. finally, we are interested in examining briefly the recent trends applied to the study of societies from the past, for example, those derived from the archaeology of the body.
El significado de la preposición 'de': un enfoque cognitivo-prototípico
Funes,María Soledad;
Boletín de filología , 2012, DOI: 10.4067/S0718-93032012000100005
Abstract: the lexical nature of the preposition 'de' has not always been recognized duly. this is because prepositions cannot work independently and also because of the variety of meanings that they convey. in view of this theoretical gap, the present study -in line with the prototypical-cognitive approach (lakoff 1987, langacker 1987, 1991, hopper 1988, geeraerts 2007, among others)- formulates the following hypotheses: a) the different semantic values of the preposition 'de' (in nominal constructions) are systematically organized and constitute a polysemous item; b) the polysemous item 'de' is characterized by being organized (1) by a radial structure (lakoff 1987), (2) on the basis of the idealized cognitive model of 'reference point' (langacker 1991); and (3) through taylor's (1995) attributes for possessive use, which is its prototypical meaning. finally, the constructions with 'de' which deviate from the prototypical values maintain a semantico-pragmatic relationship with them by means of the notion of 'family resemblance' (wittgenstein 1988[1953]; lakoff 1987). this resemblance relationship includes both the loss and addition of attributes not present within the prototypical area. in order to test hypotheses, different examples of the semantic extensions derived from the central meaning of possession were analysed qualitatively. the data being described was selected from an oral corpus of buenos aires spanish.
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