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Search Results: 1 - 10 of 719534 matches for " María José Sánchez-Barrena "
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Structural Biology of a Major Signaling Network that Regulates Plant Abiotic Stress: The CBL-CIPK Mediated Pathway
María José Sánchez-Barrena,Martín Martínez-Ripoll,Armando Albert
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14035734
Abstract: The Arabidopsis SOS2 family of twenty-six protein kinases (CIPKs), their interacting activators, the SOS3 family of ten calcium-binding proteins (CBLs) and protein phosphatases type 2C (PP2C), function together in decoding calcium signals elicited by different environmental stimuli. Biochemical data suggest that stable CBL-CIPK or CIPK-PP2C complexes may be regulating the activity of various substrates controlling ion homeostasis. The available structural information provides a general regulatory mechanism in which calcium perception by CBLs and kinase activation is coupled. The structural basis of this molecular mechanism and the specificity of the network is reviewed and discussed in detail.
Bin2 Is a Membrane Sculpting N-BAR Protein That Influences Leucocyte Podosomes, Motility and Phagocytosis
María José Sánchez-Barrena, Yvonne Vallis, Menna R. Clatworthy, Gary J. Doherty, Dmitry B. Veprintsev, Philip R. Evans, Harvey T. McMahon
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052401
Abstract: Cell motility, adhesion and phagocytosis are controlled by actin and membrane remodelling processes. Bridging integrator-2 (Bin2) also called Breast cancer-associated protein 1 (BRAP1) is a predicted N-BAR domain containing protein with unknown function that is highly expressed in leucocytic cells. In the present study we solved the structure of Bin2 BAR domain and studied its membrane binding and bending properties in vitro and in vivo. Live-cell imaging experiments showed that Bin2 is associated with actin rich structures on the plasma membrane, where it was targeted through its N-BAR domain. Pull-down experiments and immunoprecipitations showed that Bin2 C-terminus bound SH3 domain containing proteins such as Endophilin A2 and α-PIX. siRNA of endogenous protein led to decreased cell migration, increased phagocytosis and reduced podosome density and dynamics. In contrast, overexpression of Bin2 led to decreased phagocytosis and increased podosome density and dynamics. We conclude that Bin2 is a membrane-sculpting protein that influences podosome formation, motility and phagocytosis in leucocytes. Further understanding of this protein may be key to understand the behaviour of leucocytes under physiological and pathological conditions.
Tropicalism and Romanticism: Francisco Mourelle de la Rúa’s Journey around the Pacific Ocean (1780-1781) Tropicalísimo y romanticismo: el viaje de Francisco Mourelle de la Rúa por el Océano Pacífico (1780-1781)
José María GARCíA SáNCHEZ
Cuadernos Dieciochistas , 2011,
Abstract: The torrid or tropical Zone limited by the two tropics of cancer and Capricorn was imagined by the greatest powers of the 18 century, Spain, France, and Great Britain as a meeting area of the otherness where the tropical discourses, ambivalent, appeared written either with dose of ferocity and infertility, or exoticism and abundance. Francisco Mourelle de la Rua was one of the most experienced sailors that plied the international waters during the last third of the eighteenth century, one of his trips included one of the tropical zones par excellence, the trip embarked from San Blas in Nayarit in Mexico and his return to Manila is the object of analysis of this study. La zona tórrida o tropical limitada por los dos trópicos de capricornio y de cáncer fue imaginada por las mayores potencias del siglo XVIII, Espa a, Francia e Inglaterra, como una zona de encuentro de la otredad donde los discursos tropicalistas, ambivalentes, aparecieron escritos con dosis o bien de ferocidad e infertilidad, o bien de exotismo y abundancia. Francisco Mourelle de la Rúa fue uno de los navegantes más experimentados que surcaron las aguas internacionales durante el último tercio del siglo XViii, uno de sus viajes comprendió una de las zonas tropicales por excelencia, el viaje emprendido desde San Blas de nayarit en México hasta Manila y su regreso es el objeto de análisis de este estudio.
La vid y el vino en la meseta meridional castellana (siglos XII-XV)
Sánchez Benito,José María;
Cuadernos de historia de Espa?±a , 2009,
Abstract: the growth of vineyards after repopulation, the characteristics of this cultivation and the wine trade, all go to make up the main themes in this article. by studying them, we can observe the true importance that activity reached in all areas during the medieval era, and the great influence that the political powers had over it, both in its productive side and in the control of mercantile distribution of the obtained product referred to. to prepare this analysis, the southern part of the castilian plateau was chosen because there is no specific bibliography available on this matter.
La Escuela Histórica del Derecho madrile?a: Eduardo de Hinojosa y Claudio Sánchez-Albornoz
López Sánchez,José María;
Cuadernos de historia de Espa?±a , 2007,
Abstract: the foundation of the junta para ampliación de estudios (1907) and the centro de estudios históricos (1910) was of use to a group of spanish researchers and intellectuals, who aimed to revitalize the studies of scientific disciplines in spain. eduardo de hinojosa and claudio sánchez-albornoz were heads of a historical juridical school in the centro de estudios históricos, which became an outstanding model for scientific work in spain. that school was devoted to give the country a new interpretation of its history and cultural roots.
La infancia en la sociedad del conocimiento
Sánchez Bursón,José María;
Revista iberoamericana de ciencia tecnolog?-a y sociedad , 2008,
Abstract: the conceptual context of the knowledge society offers new elements on the position that children and teenagers may be able to hold in the foreseeable future. the variables are registered according to the importance that education and a critical spirit get from the knowledge societies, the perspectives of a global society that operate through the net and that acquire an awareness of the problems in a universal context, the participation and innovation in public spaces for collective decision-making, the determination of a framework of ethical sufficiency based on the rights and interests of new generations, and the construction of new social scenes that place children as the active main characters in collective actions.
Rese a de "El sentido del espacio" de Armando Cisneros Sosa
José María Aranda Sánchez
Economía, sociedad y territorio , 2008,
Abstract:
Rese a de "Entre la ciudad global y la periferia en transición" de Miguel Lacabana y Cecilia Cariola (coords.)
José María Aranda-Sánchez
Economía, sociedad y territorio , 2009,
Abstract:
Terciarización y precarización del trabajo en la Zona Metropolitana de Toluca, 1980-2000
José María Aranda Sánchez
Papeles de población , 2005,
Abstract: El autor analiza las consecuencias que ha tenido la globalización en el empleo en la zona metropolitana de Toluca, particularmente en el periodo 1980-2000. Las evidencias indican que se ha consolidado la terciarización y precarización del trabajo, con la feminización y adolescentización como sus rasgos característicos, en condiciones de alta vulnerabilidad, segmentación del empleo terciario, creciente desocupación y rotación del personal. Es un cambio significativo, donde el empleo informal adquirió mayor peso, así como condiciones laborales sin respeto a los derechos de los trabajadores y carencia de organización gremial.
Macroeconomía y crisis mundial. Diego Guerrero (ed.), Madrid, Ed. Trotta, 2000
José María Martínez Sánchez
Política y Sociedad , 2002, DOI: -
Abstract: Sin resumen
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