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Search Results: 1 - 10 of 18000 matches for " Manuel Paniagua Estévez "
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Ectasias vasculares del antro gástrico como causa de hemorragia digestiva crónica: Presentación de 1 caso
Paniagua Estévez,Manuel; Pi?ol Jiménez,Felipe;
Revista Cubana de Medicina , 1999,
Abstract: a case with history of chronic liver disease of cirrhotic type and non determined cause (diagnosed since 1983) was presented. the patient had had digestive hemorrhages at about 2 years before (1996-1997) and had been transfused due to severe anemia. diffuse vascular ectasias in the distal region of the antrum and in part of the gastric body with signs of active hemorrhage and similar lesions in the colon that were not bleeding, were found in the duodenoscopy and colonoscopy. normal tgp values and negative markers of hbv and hcv were obtained. imaging examination was normal. there was no personal or family history of vascular disorders in any organ. the diagnosis at discharge was diffuse vascular ectasia of the gastric antrum and of the body, and of the cecum and right colon secondary to liver cirrhosis. this patient was admitted again because of high digestive hemorrhage and it was decided to perform surgery. gastric resection was carried out with encouraging results. the case was analyzed and the entity was reviewed.
Citocinas, gastritis crónica y Helicobacter Pylori
Pi?ol Jiménez,Felipe; Paniagua Estévez,Manuel;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2000,
Abstract: the helicobacter pylori is a curve, gram-negative bacteria that lives exclusively in the gastric mucosa. since its discovery and characterization it has been involved in the physiopathology of gastroduodenal diseases, including gastritis, peptic ulcer, gastric carcinoma and malt lymphoma. this has given rise to numerous hypotheses that try to explain the different events that occur in the inflammatory process of the stomach on its arrival, characterized by a marked infiltration of inflammatory cells (neutrophils, monocytes, lymphocytes and others) that once activated release locally various chemical mediators, which are responsible for the tissue damage. cytokines outstand as important mediators of such a process. an updated review of the different biological functions of cytokines in the tissue damage of the gastric mucosa is made
Neuropéptidos y Helicobacter pylori en la gastritis crónica
Pi?ol Jiménez,Felipe; Paniagua Estévez,Manuel;
Revista Cubana de Medicina , 2006,
Abstract: nowadays, the helicobacter pylori infection of the gastric mucosa is closely related to the gastric pathologies (acute gastritis, chronic gastritis, ulcer, cancer and gastric lymphoma), which obey to different physiopathological mechanisms that according to their intensity and persistence appear in the individuals infected by this microorganism. among the proposed mechanisms that are altered during the infection we find the neuroimmune mechanisms of the stomach that loss their regulating and defending action of the mucosa and aggravate the damage initiated by the bacterium that is clinically traduced as ulcerous-like dyspeptic syndrome of gastritis. an updated review of the failures and presence of the neuroimmune substance taking part in the inflammatory process was made. it will allow clinicians, gastroenterologists and general physcians not only to search therapeutics capable to regulate the neuroimmune system before, during and after the infection to attain an adequate histic regeneration, but to improve the functional capacity of the stomach and to prevent the torpid evolution of the disease, at worst, once the helicobacter pylori infection is diagnosed.
Mediadores bacterianos de la inflamación en la gastritis crónica por Helicobacter pylori
Pi?ol Jiménez,Felipe N.; Paniagua Estévez,Manuel;
Revista Cubana de Medicina , 1999,
Abstract: it is known that the chronic inflammation of the stomach is a very controversial topic in medical practice from the clinical, endoscopic, radiological and histological points of view. a detailed investigation is being carried out to reveal the different physiopathological mechanisms causing the histic damage of the stomach. with the discovery and characterization of helicobacter pylori and its close relationship with type b chronic gastritis and gastroduodenal ulcers, the natural history of these affections and their therapeutic approach have changed radically. the different processes that occur after it reaches the stomach are explained in this paper. the actions produced by the bacterial mediators (proinflammatory and antigenic) that take part in the histic damage considered in the clinic as gastritis are also stressed here. this is a topic of great interest for clinicians, gastroenterologists and doctors in general, who are interesed in searching new treatments not only to eradicate the bacteria but also to regulate the action of the bacterial mediators to attain an adequate repair of the gastric mucosa.
Citocinas, gastritis crónica y Helicobacter Pylori Cytokines, chronic gastritis and Helicobacter pylori
Felipe Pi?ol Jiménez,Manuel Paniagua Estévez
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2000,
Abstract: El Helicobacter pylori es una bacteria curva, gramnegativa, que exclusivamente habita en la mucosa gástrica. Desde su descubrimiento y caracterización ha sido implicada en la fisiopatología de las enfermedades gastroduodenales, que incluyen gastritis, úlcera péptica, carcinoma gástrico, y linfoma MALT, dando origen a numerosas hipótesis que tratan de explicar los diferentes eventos que ocurren en el proceso inflamatorio del estómago a su llegada, caracterizado por una marcada infiltración de células inflamatorias (neutrófilo, monocitos, linfocitos y otras), que al ser activadas liberan localmente varios mediadores químicos, responsables del da o tisular; se destacan las citocinas como mediadores importantes de tal proceso. Se realiza una revisión actualizada de las diversas funciones biológicas de las citocinas en el da o tisular de la mucosa gástrica The Helicobacter pylori is a curve, Gram-negative bacteria that lives exclusively in the gastric mucosa. Since its discovery and characterization it has been involved in the physiopathology of gastroduodenal diseases, including gastritis, peptic ulcer, gastric carcinoma and MALT lymphoma. This has given rise to numerous hypotheses that try to explain the different events that occur in the inflammatory process of the stomach on its arrival, characterized by a marked infiltration of inflammatory cells (neutrophils, monocytes, lymphocytes and others) that once activated release locally various chemical mediators, which are responsible for the tissue damage. Cytokines outstand as important mediators of such a process. An updated review of the different biological functions of cytokines in the tissue damage of the gastric mucosa is made
Ectasias vasculares del antro gástrico como causa de hemorragia digestiva crónica: Presentación de 1 caso
Manuel Paniagua Estévez,Felipe Pi?ol Jiménez
Revista Cubana de Medicina , 1999,
Abstract: Se presentó 1 caso con historia de hepatopatía crónica de tipo cirrótica de causa no precisada (diagnosticada desde 1983), que aproximadamente 2 a os antes (1996-1997), hizo cuadros de hemorragias digestivas, por lo cual fue transfundida en varias ocasiones al presentar anemia severa. Se observaron, en la duodenoscopia y colonoscopia, ectasias vasculares difusas en la región distal del antro y parte del cuerpo gástrico con signos de hemorragia activa y lesiones similares en el colon, pero no sangrantes. Se encontraron valores de TGP normales, los marcadores del virus de la hepatitis B y C, negativos y el examen imagenológico, normal. No existían antecedentes personales ni familiares de trastornos vasculares en ningún órgano. El diagnóstico al egreso fue ectasia vascular difusa del antro gástrico y parte del cuerpo, del ciego y colon derecho secundario a cirrosis hepática. Se reingresó nuevamente por hemorragia digestiva alta y se decidió su intervención quirúrgica; se efectuó resección gástrica, con resultados alentadores. Se analizó el caso y se revisó la entidad. A case with history of chronic liver disease of cirrhotic type and non determined cause (diagnosed since 1983) was presented. The patient had had digestive hemorrhages at about 2 years before (1996-1997) and had been transfused due to severe anemia. Diffuse vascular ectasias in the distal region of the antrum and in part of the gastric body with signs of active hemorrhage and similar lesions in the colon that were not bleeding, were found in the duodenoscopy and colonoscopy. Normal TGP values and negative markers of HBV and HCV were obtained. Imaging examination was normal. There was no personal or family history of vascular disorders in any organ. The diagnosis at discharge was diffuse vascular ectasia of the gastric antrum and of the body, and of the cecum and right colon secondary to liver cirrhosis. This patient was admitted again because of high digestive hemorrhage and it was decided to perform surgery. Gastric resection was carried out with encouraging results. The case was analyzed and the entity was reviewed.
Mediadores bacterianos de la inflamación en la gastritis crónica por Helicobacter pylori
Felipe N. Pi?ol Jiménez,Manuel Paniagua Estévez
Revista Cubana de Medicina , 1999,
Abstract: Se conoce que la inflamación crónica del estómago es un tema muy controvertido en la práctica médica, desde los puntos de vista clínico, endoscópico, radiológico e histológico. Se investiga arduamente para revelar los diferentes mecanismos fisiopatológicos que producen el da o hístico del estómago. Con el descubrimiento y caracterización del Helicobacter pylori y su estrecha relación con la gastritis crónica tipo B y las úlceras gastroduodenales, la historia natural de estas afecciones y su abordaje terapéutico han cambiado radicalmente. Se exponen en este trabajo los diferentes procesos que ocurren tras su llegada al estómago, se resaltan las acciones que producen los mediadores bacterianos (proinflamatorios y antigénicos) que participan en el da o hístico, traducido en la clínica como gastritis y que constituye un tema de gran interés para clínicos, gastroenterólogos y médicos en general interesados en la búsqueda de nuevas terapéuticas que no sólo eliminen la bacteria sino que también regulen la acción de los mediadores bacterianos para una reparación adecuada de la mucosa gástrica. It is known that the chronic inflammation of the stomach is a very controversial topic in medical practice from the clinical, endoscopic, radiological and histological points of view. A detailed investigation is being carried out to reveal the different physiopathological mechanisms causing the histic damage of the stomach. With the discovery and characterization of Helicobacter pylori and its close relationship with type B chronic gastritis and gastroduodenal ulcers, the natural history of these affections and their therapeutic approach have changed radically. The different processes that occur after it reaches the stomach are explained in this paper. The actions produced by the bacterial mediators (proinflammatory and antigenic) that take part in the histic damage considered in the clinic as gastritis are also stressed here. This is a topic of great interest for clinicians, gastroenterologists and doctors in general, who are interesed in searching new treatments not only to eradicate the bacteria but also to regulate the action of the bacterial mediators to attain an adequate repair of the gastric mucosa.
Neuropéptidos y Helicobacter pylori en la gastritis crónica Neuropeptides and Helicobacter pylori in chronic gastritis
Felipe Pi?ol Jiménez,Manuel Paniagua Estévez
Revista Cubana de Medicina , 2006,
Abstract: Actualmente, la infección por Helicobacter pylori de la mucosa gástrica está muy relacionada con las patologías gástricas (gastritis aguda, crónica, úlcera, cáncer y linfoma gástrico) las cuales obedecen a diversos mecanismos fisiopatológicos que según su intensidad y persistencia aparecen en los individuos infestados por dicho microorganismo. Dentro de los mecanismos propuestos que se encuentran alterados durante la infección están los mecanismos neuroinmunes del estómago, que pierden su acción reguladora y defensora de la mucosa, y agravan el da o iniciado por la bacteria, clínicamente traducido como síndrome dispéptico de tipo ulceroso de la gastritis. Se presentó una revisión actualizada de los fallos y presencia de las sustancias neuroinmunes que participan durante el proceso inflamatorio lo que facilitará a clínicos, gastroenterólogos y médicos generales, no solo buscar terapéuticas adecuadas para erradicar la bacteria, sino también dirigir sus acciones hacia la búsqueda de terapéuticas capaces de regular el sistema neuroinmune antes, durante y después de la infección, para lograr una regeneración hística adecuada, mejorar la capacidad funcional del estómago e impedir la evolución tórpida de la enfermedad, en el peor de los casos, una vez diagnosticada la infección por Helicobacter pylori. Nowadays, the Helicobacter pylori infection of the gastric mucosa is closely related to the gastric pathologies (acute gastritis, chronic gastritis, ulcer, cancer and gastric lymphoma), which obey to different physiopathological mechanisms that according to their intensity and persistence appear in the individuals infected by this microorganism. Among the proposed mechanisms that are altered during the infection we find the neuroimmune mechanisms of the stomach that loss their regulating and defending action of the mucosa and aggravate the damage initiated by the bacterium that is clinically traduced as ulcerous-like dyspeptic syndrome of gastritis. An updated review of the failures and presence of the neuroimmune substance taking part in the inflammatory process was made. It will allow clinicians, gastroenterologists and general physcians not only to search therapeutics capable to regulate the neuroimmune system before, during and after the infection to attain an adequate histic regeneration, but to improve the functional capacity of the stomach and to prevent the torpid evolution of the disease, at worst, once the Helicobacter pylori infection is diagnosed.
Características de la infección por Helicobacter pylori en pacientes con adenocarcinoma gástrico
Pi?ol Jiménez,Felipe; Salvador Prato,Juan C.; Paniagua Estévez,Manuel; Borbolla,Elvira;
Revista Cubana de Medicina , 2005,
Abstract: a descriptive prospective study was conducted in adults of both sexes with clinical and endoscopic suspicion of malignant gastric neoplasia aimed at describing the behavior of infection caused by helicobacter pylori in patients with histological diagnosis of gastric adenocarcinoma. it was found a frequency of gastric adenocarcinoma of 91 %. 60 % were mainly located in the antral region. it was confirmed by urease test that helicobacter pylori colonizes with low frequency the zones distant from the tumor. the histology of the tumor periphery was analized and it was proved that 70 % of the adenocarcinomas presented helicobacter pylori in this zone. on comparing this frequecny with that of the peritumoral region (75 %), no statistically significant differences were observed. the presence of helicobacter pylori was related to the type of gastritis present in the peritumoral mucosa, according to the localization of the tumor. no statistically significant differences were detected between the presence or not of helicobacter pylori in the different regions where gastritis was studied. in the intestinal histological type it was found a discreet increase of patients with positive helicobacter pylori (80 %). however, there is no a statistically significant relation between the presence of helicobacter pylori and and the histological type of tumor. in all the studied biopsy specimens the helicobacter pylori density was mild. it was concluded that the highest frequency of malignant gastric neoplasia was the adenocarcinoma. there were no significant differences neither in the distribution of hel icobacter pylori according to the histological type of tumor, nor in the gastritis of the peritumoral mucosa
Displasia en pacientes con colitis ulcerativa idiopática de 10 o más a?os de evolución
Paniagua Estévez,Manuel; Pi?ol Jiménez,Felipe; Chao,Liset; Borbolla,Elvira; Cendán,Aracelys;
Revista Cubana de Medicina , 2005,
Abstract: the development of colorectal cancer in patients with idiopathic ulcerative colitis is closely related to the time of evolution of the disease (more than 10 years) and to its extension (universal). the genesis of cancer is correlated with internal and external factors present in the course of the disease, such as the secondary biliary acids, considered by many as cytotoxic and cancerigenic substances for the colonic mucosa in elevated concentrations. a descriptive prospective study was undertaken in 35 patients with idiopathic ulcerative colitis of 10 or more years of evolution to determine if they had dysplasia. dysplasia was found in 14 patients (41 %). 93 % had a low grade dysplasia. in the study group, the most frequently endoscopically diagnosed activity grade of idiopathic ulcerative colitis was grade iv (34.3 %). the activity grade of idiopathic ulcerative colitis was related to the dysplasia grade and no significant association was observed between both variables. 78.6 % of the patients with dysplasia presented elevated total biliary acids in feces. only a moderately differentiated adenocarcinoma was diagnosed in a patient with universal idiopathic ulcerative colitis of more than 20 years of evolution and with elevated total biliary acids in feces. it was concluded that the screening of dysplasia in patients with idiopathic ulcerative colitis of 10 or more years of evolution will allow to carry out a systematic follow-up to adopt an adequate therapeutic conduct to prevent the progression towards malignancy in these patients.
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